Animal Bioscience

Asian Australasian Association of Animal Production Societies (아세아태평양축산학회)
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Expression of FKBP prolyl isomerase 5 gene in tissues of muscovy duck at different growth stages and its association with muscovy duck weight

  • Hu, Zhigang (College of Animal Science and Technology, Northwest A&F University) ;
  • Ge, Liyan (College of Animal Science and Technology, Northwest A&F University) ;
  • Zhang, Huilin (College of Animal Science and Technology, Northwest A&F University) ;
  • Liu, Xiaolin (College of Animal Science and Technology, Northwest A&F University)
  • Received : 2020.09.14
  • Accepted : 2021.04.25
  • Published : 2022.01.01
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Abstract

Objective: FKBP prolyl isomerase 5 (FKBP5) has been shown to play an important role in metabolically active tissues such as skeletal muscle. However, the expression of FKBP5 in Muscovy duck tissues and its association with body weight are still unclear. Methods: In this study, real-time quantitative polymerase chain reaction was used to detect the expression of FKBP5 in different tissues of Muscovy duck at different growth stages. Further, single nucleotide polymorphisms (SNPs) were detected in the exon region of FKBP5 and were combined analyzed with the body weight of 334 Muscovy ducks. Results: FKBP5 was highly expressed in various tissues of Muscovy duck at days 17, 19, 21, 24, and 27 of embryonic development. In addition, the expression of FKBP5 in the tissues of female adult Muscovy ducks was higher than that of male Muscovy ducks. Besides, an association analysis indicated that 3 SNPs were related to body weight trait. At the g.4819252 A>G, the body weight of AG genotype was significantly higher than that of the AA and the GG genotype. At the g.4821390 G>A, the genotype GA was extremely significantly related to body weight. At the g.4830622 T>G, the body weight of TT was significantly higher than GG and TG. Conclusion: These findings indicate the possible effects of expression levels in various tissues and the SNPs of FKBP5 on Muscovy duck body weight trait. FKBP5 could be used as molecular marker for muscle development trait using early marker-assisted selection of Muscovy ducks.

Keywords

Acknowledgement

This study was supported by funds from the National Waterfowl Industrial Technology System of China (CARS-42-2) and the Research on the Effect of New Breeding of the Black Muscovy Duck of Shaanxi (2019QYPY-130).

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