Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Metal arsenic mediated enhancement of type-2 immunity in brains with altered locomotive activities in mice with autism-like behavioral characteristics

  • Han, Ha‑Jung (College of Bio and Medical Sciences, Department of Occupational Health, Daegu Catholic University) ;
  • Lee, JaeHee (College of Bio and Medical Sciences, Department of Occupational Health, Daegu Catholic University) ;
  • Lim, GyeongDong (College of Bio and Medical Sciences, Department of Occupational Health, Daegu Catholic University) ;
  • Park, JungEun (College of Bio and Medical Sciences, Department of Occupational Health, Daegu Catholic University) ;
  • Gautam, Ravi (College of Bio and Medical Sciences, Department of Occupational Health, Daegu Catholic University) ;
  • Jo, JiHun (College of Bio and Medical Sciences, Department of Occupational Health, Daegu Catholic University) ;
  • Kim, ChangYul (Graduate School Department of Toxicology, Daegu Catholic University) ;
  • Heo, Yong (College of Bio and Medical Sciences, Department of Occupational Health, Daegu Catholic University)
  • Received : 2021.05.25
  • Accepted : 2021.08.25
  • Published : 2022.01.15
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Abstract

Exposure to metal arsenic (As) has been proposed as a risk factor for autism spectrum disorders (ASDs), which are neurode-velopmental disorders with worldwide increasing in its incidence. In the present study, BTBR T+tf/J (BTBR) mice with ASD-like behavioral characteristics and control highly social FVB mice were orally exposed to 0.1 mM arsenic(III)oxide for 4 weeks, and were compared to investigate neuroimmunological or behavioral abnormalities. IgG1:IgG2a ratios in brain tissues from BTBR mice exposed to As (BTBR-As) were signifcantly higher than those of BTBR-control mice (BTBR-C), but this change did not occur in FVB mice exposed to As. Levels of IL-4, IFN-γ, IL-1β, IL-17, and TNF-α in brain tissue were lowered in BTBR-As relative to BTBR-C, but this tendency was not observed with FVB mice. BTBR-As mice demonstrated decrease in relative travel distance and time spent in the center vs. the periphery of open feld arena compared to BTBR-C. Sociability evaluation using three-way chamber test did not clearly demonstrate As-mediated alteration in social interaction in BTBR mice. These fndings suggest the potential for As-driven predominant TH2-like reactivity profle in the brain microenvironment of BTBR mice and for As-mediated locomotive impairment probably associated with ASD.

Keywords

Acknowledgement

This work was supported by research grant from Daegu Catholic University in 2019.

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