The Korean Journal of Physiology and Pharmacology

The Korean Society of Pharmacology (대한약리학회)
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The effect of fibroblast growth factor receptor inhibition on resistance exercise training-induced adaptation of bone and muscle quality in mice

  • Cho, Suhan (Department of Physiology, Seoul National University College of Medicine) ;
  • Lee, Hojun (Department of Sport and Exercise Science, Seoul Women's University) ;
  • Lee, Ho-Young (Department of Nuclear Medicine, Seoul National University Bundang Hospital) ;
  • Kim, Sung Joon (Department of Physiology, Seoul National University College of Medicine) ;
  • Song, Wook (Health and Exercise Science Laboratory, Institute of Sport Science, Seoul National University)
  • Received : 2022.02.16
  • Accepted : 2022.03.24
  • Published : 2022.05.01
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Abstract

Aging in mammals, including humans, is accompanied by loss of bone and muscular function and mass, characterized by osteoporosis and sarcopenia. Although resistance exercise training (RET) is considered an effective intervention, its effect is blunted in some elderly individuals. Fibroblast growth factor (FGF) and its receptor, FGFR, can modulate bone and muscle quality during aging and physical performance. To elucidate this possibility, the FGFR inhibitor NVP-BGJ398 was administrated to C57BL/6n mice for 8 weeks with or without RET. Treatment with NVPBGJ398 decreased grip strength, muscular endurance, running capacity and bone quality in the mice. FGFR inhibition elevated bone resorption and relevant gene expression, indicating altered bone formation and resorption. RET attenuated tibial bone resorption, accompanied by changes in the expression of relevant genes. However, RET did not overcome the detrimental effect of NVP-BGJ398 on muscular function. Taken together, these findings provide evidence that FGFR signaling may have a potential role in the maintenance of physical performance and quality of bone and muscles.

Keywords

Acknowledgement

This work was supported by the National Research Foundation of Korea funded by the Ministry of Science, ICT, and Future Planning (NRF-2013M3A9B6046417, NRF-2021R1A2C2007243, Korea Mouse Phenotyping Project NRF-2013M3A9D5072550, 2013M3A9D5072560 and MEST 2011-030135), and by the Ministry of Education (NRF-2014R1A1A2058645).

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