동의생리병리학회지 (Journal of Physiology & Pathology in Korean Medicine)

  • 제36권1호
  • /
  • Pages.11-17
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  • 2022
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  • 1738-7698(pISSN)
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  • 2288-2529(eISSN)
대한동의생리학회·한의병리학회 ( The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine)
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Scopolamine으로 유도된 인지장애 마우스의 기억력 개선 효과에 대한 인삼, 생지황, 발효홍삼 추출물의 비교 연구

Comparative Study of Ginseng Radix, Rehmanniae Radix and Fermented Red-ginseng Extracts Effects on Memory Improvement in Scopolamine-induced Memory Impaired Mice

  • 김지현 (우석대학교 식품과학대학 식품생명공학과) ;
  • 김종욱 (우석대학교 한의과대학 침구학교실) ;
  • 이창현 (우석대학교 한의과대학 해부학교실)
  • Kim, Ji Hyun (Department of Food & Biotechnology, College of Food Science, Woosuk University) ;
  • Kim, Jong Uk (Department of Acupuncture & Moxibustion, College of Korean Medicine, Woosuk University) ;
  • Lee, Chang Hyun (Department of Anatomy, College of Korean Medicine, Woosuk University)
  • 투고 : 2022.12.10
  • 심사 : 2022.02.28
  • 발행 : 2022.02.25
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초록

In this study, we investigated the effects of Ginseng Radix (G), Rehmanniae Radix (R), and Fermented red-ginseng extracts (FRG) on cognitive function in scopolamine-induced memory-impaired mice. We measured the effects of G, R, and FRG on the improvement of memory and cognition via behavior analysis. In addition, we measured the acetylcholinesterase (AChE) activity in the hippocampus of each group of mice. The expression of β-amyloid, Tau, and BDNF in the brain tissues were observed through immunohistochemical staining. Ginseng Radix (G) and Fermented red-ginseng (FRG) have effectively improved cognitive function in the water maze test. Ginseng Radix (G), Rehmanniae Radix (R), and Fermented red-ginseng (FRG) have improved the willingness of mice to explore the new environment, as confirmed by Y maze test. In addition, immunohistochemical staining revealed that Ginseng Radix (G) decreased the expression of β-amyloid and Tau in the hippocampus. In addition, fermented red-ginseng (FRG) increased the expression of BDNF. Ginseng Radix (G), Rehmanniae Radix (R), and Fermented red-ginseng (FRG) have decreased the concentration of acetylcholinesterase in the hippocampus as compared with the control group of mice. In conclusion, Ginseng Radix (G), Rehmanniae Radix (R), and Fermented red-ginseng (FRG) are considered to have the potential for development as candidate drugs to control the progression of Alzheimer's disease (AD).

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