Animal Bioscience

  • 제35권9호
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  • Pages.1434-1443
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  • 2022
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  • 2765-0189(pISSN)
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  • 2765-0235(eISSN)
아세아태평양축산학회 (Asian Australasian Association of Animal Production Societies)
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Effects of quercetin and coated sodium butyrate dietary supplementation in diquat-challenged pullets

  • Zhou, Ning (College of Animal Science and Technology, Nanjing Agricultural University) ;
  • Tian, Yong (State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Institute of Animal Science & Veterinary, Zhejiang Academy of Agricultural Sciences) ;
  • Liu, Wenchao (Huzhou Lvchang Ecoagriculture Co., Ltd.) ;
  • Tu, Bingjiang (Huzhou Wuxing District Animal Disease Prevention and Control Center) ;
  • Gu, Tiantian (State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Institute of Animal Science & Veterinary, Zhejiang Academy of Agricultural Sciences) ;
  • Xu, Wenwu (State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Institute of Animal Science & Veterinary, Zhejiang Academy of Agricultural Sciences) ;
  • Zou, Kang (College of Animal Science and Technology, Nanjing Agricultural University) ;
  • Lu, Lizhi (College of Animal Science and Technology, Nanjing Agricultural University)
  • 투고 : 2021.11.01
  • 심사 : 2022.03.02
  • 발행 : 2022.09.01
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초록

Objective: This study was designed to investigate the hypothesis that dietary quercetin (QUE) and coated sodium butyrate (SB) supplementation alleviate oxidative stress in the small intestine of diquat (DIQ)-challenged pullets. Methods: A total of 200 13-week-old pullets were divided into four groups: the control group (CON), the DIQ group, the QUE group, and the coated SB group, and injected intraperitoneally with either saline (CON) or diquat (DIQ, QUE, and SB) to induce oxidative stress on day 0. Results: On the first day, the malondialdehyde and superoxide dismutase (SOD) concentrations in the SB group were significantly different from those in the DIQ and QUE groups (p<0.05), and dietary supplementation with SB increased serum glutathione peroxidase (GSH-PX) levels compared with the DIQ group (p<0.05). Quercetin and SB increased the levels of CLAUDIN-1 and zonula occludens-1 (ZO-1) in the jejunum. On the tenth day of treatment, QUE attenuated the decrease in GSH-PX levels compared to those of the CON group (p<0.05), while SB increased SOD, GSH-PX, and total antioxidant capacity levels compared to those of the DIQ group. Nuclear factor erythroid 2-related factor 2 (NRF2) and heme oxygenase-1 (HO-1) mRNA levels in the QUE and SB groups increased (p<0.05) and CLAUDIN-1 mRNA levels in the QUE and SB groups were upregulated compared to those in the DIQ group ileum tissue. Conclusion: Supplementation of QUE and SB demonstrated the ability to relieve oxidative stress in pullets post DIQ-injection with a time-dependent manner and QUE and SB may be potential antioxidant additives for relieving oxidative stress and protecting the intestinal barrier of pullets.

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과제정보

This work was supported by Zhejiang Provincial Key Research and Development Plan (Grant NO. 2021C02034), Zhejiang Provincial Team Special Commissioner Project of Science and Technology (Xianju Chicken Industry, 2020-2024) and the agricultural (livestock and poultry) new breed selection and breeding major science and technology special projects of Zhejiang Province (2021C02068).

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