대한융합한의학회지 (Journal of Convergence Korean Medicine)

대한융합한의학회 (Academy of Convergence Korean Medicine)
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가자(訶子)의 급성 췌장염 보호 효과

Protective effects of Terminalia chebula Retzins (TC) water extract on acute pancreatitis

  • 권빛나 (원광대학교 한의과대학 약리학교실) ;
  • 김동욱 (원광대학교 한의과대학 약리학교실) ;
  • 배기상 (원광대학교 한의과대학 약리학교실)
  • Bitna Kweon (Department of Pharmacology, School of Korean Medicine, Wonkwang University) ;
  • Dong-Uk Kim (Department of Pharmacology, School of Korean Medicine, Wonkwang University) ;
  • Gi-Sang Bae (Department of Pharmacology, School of Korean Medicine, Wonkwang University)
  • 발행 : 2023.12.31
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초록

Objectives: Terminalia chebula Retzins (TC) has been used as a traditional remedy to treat gastrointestinal infectious and inflammatory diseases. However, the protective effect of TC on acute pancreatitis (AP) has not been studied. In this study, we tried to investigate the protective effect of TC water extract on cerulein-induced AP. Methods: To measure the protective effect of TC on AP, mice were injected with cerulein (50 ㎍/kg) hourly for 6 times. TC water extract (200 or 400 mg/kg) or saline was administered orally 1 h before the first injection of cerulein. The mice were sacrificed at 6 h after the last injection of cerulein. Pancreas tissues were taken for further analysis. Results: The administration of TC water extract showed an inhibitory effect on the increase of pancreas weight/body weight ratio and mitigated pancreatic damage in mice. Also, mRNA level of pro-inflammatory cytokines was inhibited by administration of TC water extract. Conclusion: Taken together, we found that administration of TC water extract ameliorates the severity of cerulein-induced AP, which suggests the potential to be an effective treatment on AP.

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과제정보

이 논문은 정부(교육부)의 재원으로 한국연구재단의 지원을 받아 수행된 연구임(NRF-2021R1I1A2053285).

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