대한융합한의학회지 (Journal of Convergence Korean Medicine)

대한융합한의학회 (Academy of Convergence Korean Medicine)
권호 표지

긴병꽃풀 추출물의 oxazolone-유도 아토피 피부염 개선 효과

Ameliorative effects of Glechoma hederacea var. longituba extract on oxazolone-induced atopic dermatitis-like skin lesions

  • 김대용 (우석대학교 한의과대학)
  • Dae Yong Kim (College of Korean Medicine, Woosuk University)
  • 발행 : 2023.12.31
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초록

Objectives: This study aimed to investigate the anti-atopic properties of Glechoma hederacea var. longituba extracts (GHE) in murine atopic dermatitis model. Methods: BALB/c mouse ear stimulated with oxazolone (OX) for 4 weeks, then 1% GHE was topically applied every two days for 3 weeks to mouse. Ear thickness was measured by a digital thickness gauge. The ears tissues were collected and subjected to hematoxylin-eosin (H&E) and toluidine blue (TB) staining. Results: Treatment with GHE successfully alleviated the symptoms of atopic dermatitis, such as erythema, horny substance, and swelling. The infiltration of lymphocytes and mast cells were significantly reduced following GHE treatment. Conclusion: Taken together, our results showed that GHE possessed the potential to be a novel immunomodulatory drug against atopic dermatitis.

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참고문헌

  1. Leung, D. Y. M. (1999). Pathogenesis of atopic dermatitis. The Journal of Allergy and Clinical Immunology, 104(3), 99-108. https://doi.org/10.1016/S0091-6749(99)70051-5
  2. Koblenzer, C. (1999). Itching and the atopic skin. The Journal of Allergy and Clinical Immunology, 104(3), 109-113. https://doi.org/10.1016/S0091-6749(99)70052-7
  3. Deo, S. S., Mistry, K. J., Kakade, A. M., Niphadkar, P. V. (2010). Role played by Th2 type cytokines in IgE mediated allergy and asthma. Lung India, 27(2), 66-71. https://doi.org/10.4103/0970-2113.63609
  4. Leung, D. Y. M. (1992). Immunopathology of atopic dermatitis. Springer Seminars in Immunopathology, 13(3-4), 427-440. https://doi.org/10.1007/BF00200539
  5. Branco, A. C. C. C., Yoshikawa, F. S. Y., Pietrobon, A. J., Sato, M. N. (2018). Role of Histamine in Modulating the Immune Response and Inflammation. Mediators of Inflammation, 2018, 952407.
  6. Furue, M. (2020). Regulation of Skin Barrier Function via Competition between AHR Axis versus IL-13/IL-4-JAK-STAT6/STAT3 Axis: Pathogenic and Therapeutic Implications in Atopic Dermatitis. Journal of Clinical Medicine, 9(11), 3741.
  7. Kim, H. S.; Cho, S..H. (2014). Treatment for atopic dermatitis. Journal of the Korean Medical Association, 57(3), 226-233. https://doi.org/10.5124/jkma.2014.57.3.226
  8. Berger, T. G., Duvic, M., Van Voorhees, A. S., Frieden, I.J., (2006). The use of topical calcineurin inhibitors in dermatology: Safety concerns. Report of the American Academy of Dermatology Association Task Force. Journal of the American Academy of Dermatology, 54(5), 818-823. https://doi.org/10.1016/j.jaad.2006.01.054
  9. Dohil, M.A., (2013). Natural ingredients in atopic dermatitis and other inflammatory skin disease. Journal of Drugs in Dermatology, 12(9), 128-132.
  10. Dawid-Pa'c, R., (2013). Medicinal plants used in treatment of inflammatory skin diseases. Advances in Dermatology and Allergology, 30(3), 170-177. https://doi.org/10.5114/pdia.2013.35620
  11. Wu, S., Pang, Y., He, Y., Zhang, X., Peng, L., Guo, J., Zeng, J. (2021). A comprehensive review of natural products against atopic dermatitis: Flavonoids, alkaloids, terpenes, glycosides and other compounds. Biomedicine & Pharmacotherapy, 140, 111741.
  12. Ullah, A., Munir, S., Badshah, S.L., Khan, N., Ghani, L., Poulson, B.G., Emwas, A.-H., Jaremko, M. (2020). Important Flavonoids and Their Role as a Therapeutic Agent. Molecules, 25(22), 5243.
  13. Jo D., Lee J., Noh J., Kim O. K., Kwon J. H. (2001). Chemical Composition and Electron Donating and Nitrite Scavenging Activities of Glechoma hederacea var. longituba NAKAI. Journal of the Korean Society of Food Science and Nutrition, 6(3), 142-146.
  14. Yamauchi H., Kakuda R., Yaoita Y., Machida K., Kikuchi M. (2007). Two New Glycosides from the Whole Plants of Glechoma hederacea L. Chemical and Pharmaceutical Bulletin, 55(2), 346-347. https://doi.org/10.1248/cpb.55.346
  15. Kim J., Lee I., Ha D., Seo J., Min B., Yoo I., Bae K. (2011). New sesquiterpene lactones from Glechoma hederacea L. and their cytotoxic effects on human cancer cell lines Planta Medica, 77(09), 955-957. https://doi.org/10.1055/s-0030-1250665
  16. Kim J., Song S., Lee I., Kim Y., Yoo I., Ryoo I., Bae K. (2011). Anti-inflammatory activity of constituents from Glechoma hederacea var. longituba. Bioorganic & Medicinal Chemistry Letters, 21(11), 3483-3487. https://doi.org/10.1016/j.bmcl.2011.02.002
  17. Zhu Q. F., Wang Y. Y., Jiang W., Qu H. B. (2013). Three new norlignans from Glechoma longituba. Journal of Asian Natural Products Research, 15(3), 258-264. https://doi.org/10.1080/10286020.2012.762640
  18. Shan Q, Cao G, Cai H, Cai B. (2013). Simultaneous determination of four bioactive compounds in Glechoma longituba extracts by high performance liquid chromatography. Pharmacognosy Magazine, 9(35), 216-219. https://doi.org/10.4103/0973-1296.113269
  19. Zhu Y. D, Zou J, Zhao W. M. (2008). Two new monoterpenoid glycosides from Glechoma longituba. Journal of Asian Natural Products Research, 10(1-2), 199-204. https://doi.org/10.1080/10286020701394480
  20. Bae Y., Kim T., Park N., Choi S., Yi D., Soto S., Zamora N., Kim S., Yang M. (2022). Ameliorative Effects of Daphnopsis costaricensis Extract against Oxazolone-Induced Atopic Dermatitis-like Lesions in BALB/c Mice. Nutrients, 14(21), 4521.
  21. Lee S., Jegal H., Bong S. K., Yoon K. N., Park N. J., Shin M. S., Yang M. H., Kim Y. K., Kim S. N. (2019). Anti-Atopic Effect of Acorn Shell Extract on Atopic Dermatitis-Like Lesions in Mice and Its Active Phytochemicals. Biomolecules, 10(1), 57.
  22. Lee T. K., Kim D. W., Ahn J. H, Lee C. H, Lee J. C, Lim S. S, Kang I. J., Hong S., Choi S. Y., Won M. H., Park J. H. (2022). Protective Effects of Topical Administration of Laminarin in Oxazolone-Induced Atopic Dermatitis-like Skin Lesions. Marine Drugs, 20(11), 669.
  23. Kim D. H., Ham S. L., Khan Z., Kim S. Y., Choi S. U., Kim C. S., Lee K. R. (2022). Terpenoids from Glechoma hederacea var. longituba and their biological activities. Beilstein Journal of Organic Chemistry, 18, 555-566. https://doi.org/10.3762/bjoc.18.58
  24. Kim J., Song S., Lee I., Kim Y., Yoo I., Ryoo I., Bae K. (2011). Anti-inflammatory activity of constituents from Glechoma hederacea var. longituba. Bioorganic & Medicinal Chemistry Letters. 21(11), 3483-3487.  https://doi.org/10.1016/j.bmcl.2011.02.002