동의생리병리학회지 (Journal of Physiology & Pathology in Korean Medicine)

  • 제37권2호
  • /
  • Pages.36-44
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  • 2023
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  • 1738-7698(pISSN)
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  • 2288-2529(eISSN)
대한동의생리학회·한의병리학회 ( The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine)
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Investigation of Anxiolytic- and Antidepressant-like Effects of Essential Oils from Six Traditional Korean Herbal Prescriptions

  • Ly Thi Huong Nguyen (Department of Physiology, College of Korean Medicine, Dongguk University) ;
  • Nhi Phuc Khanh Nguyen (Department of Physiology, College of Korean Medicine, Dongguk University) ;
  • Khoa Nguyen Tran (Department of Physiology, College of Korean Medicine, Dongguk University) ;
  • Heung-Mook Shin (Department of Physiology, College of Korean Medicine, Dongguk University) ;
  • In-Jun Yang (Department of Physiology, College of Korean Medicine, Dongguk University)
  • 투고 : 2023.02.06
  • 심사 : 2023.04.26
  • 발행 : 2023.04.25
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초록

Essential oils and aromatherapy have traditionally been used for the treatment of anxiety and depression with few side effects. This study aimed to investigate the effects of essential oils from six herbal prescriptions known to be effective in treating anxiety and depression in Korean medicine. The neuroprotective and anti-neuroinflammatory effects of six essential oils, including Gamisachil-tang (GMSCT), Guibi-tang (GBT), Sihogayonggolmoryeo-tang (SYM), Danchisoyosan (DCSYS), Sihosogansan (SHSGS), and Soyosan (SYS), were examined in PC12 and BV2 cells. In corticosterone (CORT)-stimulated PC12 cells, all six essential oils ameliorated the CORT-induced decrease in cell viability at a concentration of 10 ㎍/ml. GMSCT, GBT, and SHSGS recovered CORT-induced cytotoxicity at concentrations of 1 ㎍/ml and 10 ㎍/ml. In lipopolysaccharide (LPS)-stimulated BV2 cells, GBT (10 ㎍/ml) decreased interleukin (IL)-1β production, whereas SHSGS (1 ㎍/ml) inhibited tumor necrosis factor (TNF)-α production. In the MK-801-induced anxiety in zebrafish, electroencephalogram (EEG) assessment indicated that GMSCT and SHSGS induced recovery in the delta and beta power densities and reduced theta/beta and delta/beta ratios. DCSYS and SYS decreased theta power density and theta/beta ratio, whereas GBT and SYM showed no effects on EEG signals. In the tail suspension test (TST) in mice, GBT, DCSYS, SHSGS, and SYS exhibited antidepressant-like effects by decreasing immobility time. These results suggest that the essential oils from the six herbal prescriptions, except SYM, may have beneficial effects on anxiety and/or depression. Further studies should be conducted to investigate the molecular signaling pathways that mediate the effects of these essential oils on anxiety and depression.

키워드

과제정보

This work was supported by the Dongguk University Research Fund (2022) and the Korean Health Technology R&D Project, Korean Ministry of Health and Welfare (No. HF22C0005).

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