Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Mibyeong, Prodromal Parkinson's Disease, and Dopaminergic Circadian Rhythm Impairment

도파민 일주기 리듬 손상과 미병, 파킨슨병 전구기 증상의 연관성에 관한 고찰

  • Miso Park (Clinical Trial Center, Daejeon Korean Medicine Hospital of Daejeon University) ;
  • Wangjung Hur (Department of Cardiology and Neurology of Korean Medicine, College of Korean Medicine, Daejeon University) ;
  • Junghyo Cho (Department of Hepatology and Hematology of Korean Medicine, College of Korean Medicine, Daejeon University) ;
  • Seong-Il Park (Dr. Park Seong-Il Clinic) ;
  • Horyong Yoo (Department of Cardiology and Neurology of Korean Medicine, College of Korean Medicine, Daejeon University)
  • 박미소 (대전대학교 대전한방병원 임상시험센터) ;
  • 허왕정 (대전대학교 한의학과 심계내과학교실) ;
  • 조정효 (대전대학교 한의학과 간계내과학교실) ;
  • 박성일 (박성일한의원) ;
  • 류호룡 (대전대학교 한의학과 심계내과학교실)
  • Received : 2023.06.23
  • Accepted : 2023.08.29
  • Published : 2023.10.25
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Abstract

Awareness of Mibyeong, a key concept in preventive Korean medicine, leads to preventive health care by focusing on clinical symptoms and risk factors that appear before disease, as well as improving health by changing one's circadian rhythm and lifestyle. Parkinson's disease motor symptoms, such as bradykinesia, tremor, rigidity, and postural instability, appear after more than half of the dopaminergic neurons in the substantia nigra are lost. Non-motor symptoms such as hyposmia, sleep disturbance, depression, fatigue, and foveal visual impairment, on the other hand, appear from the prodromal stage of Parkinson's disease. Dopamine is secreted in different areas of the brain under circadian control and is known to interact closely with circadian clock genes. The loss of normal dopaminergic rhythm in the midbrain, striatum, retina, and olfactory bulbs has recently been linked to Parkinson's disease non-motor symptoms such as circadian disruption, REM sleep behavior disorder, foveal vision loss, and hyposmia. Furthermore, circadian disruption is linked to several pathological mechanisms of Parkinson's disease, hastening disease progression. There is a growing awareness that early diagnosis and preventive measures of Parkinson's disease should be prioritized. Parkinson's disease must be prevented at the prodromal stage through increased awareness and active preventive treatment.

Keywords

Acknowledgement

본 연구는 보건복지부의 재원으로 한국보건산업진흥원의 보건의료기술연구개발사업 지원에 의하여 이루어진 것임 (과제고유번호: HF20C0174).

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