Animal Bioscience

  • 제37권6호
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  • Pages.982-992
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  • 2024
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  • 2765-0189(pISSN)
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  • 2765-0235(eISSN)
아세아태평양축산학회 (Asian Australasian Association of Animal Production Societies)
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Multiomics analyses of Jining Grey goat and Boer goat reveal genomic regions associated with fatty acid and amino acid metabolism and muscle development

  • Zhaohua Liu (Institute of Animal Science and Veterinary Medicine, Shandong Key Lab of Animal Disease Control and Breeding, Shandong Academy of Agricultural Sciences) ;
  • Xiuwen Tan (Institute of Animal Science and Veterinary Medicine, Shandong Key Lab of Animal Disease Control and Breeding, Shandong Academy of Agricultural Sciences) ;
  • Qing Jin (Institute of Animal Science and Veterinary Medicine, Shandong Key Lab of Animal Disease Control and Breeding, Shandong Academy of Agricultural Sciences) ;
  • Wangtao Zhan (Shandong Animal Husbandry General Station) ;
  • Gang Liu (Shandong Animal Husbandry General Station) ;
  • Xukui Cui (Institute of Animal Science and Veterinary Medicine, Shandong Key Lab of Animal Disease Control and Breeding, Shandong Academy of Agricultural Sciences) ;
  • Jianying Wang (Institute of Animal Science and Veterinary Medicine, Shandong Key Lab of Animal Disease Control and Breeding, Shandong Academy of Agricultural Sciences) ;
  • Xianfeng Meng (Institute of Animal Science and Veterinary Medicine, Shandong Key Lab of Animal Disease Control and Breeding, Shandong Academy of Agricultural Sciences) ;
  • Rongsheng Zhu (Institute of Animal Science and Veterinary Medicine, Shandong Key Lab of Animal Disease Control and Breeding, Shandong Academy of Agricultural Sciences) ;
  • Ke Wang (Institute of Animal Science and Veterinary Medicine, Shandong Key Lab of Animal Disease Control and Breeding, Shandong Academy of Agricultural Sciences)
  • 투고 : 2023.08.23
  • 심사 : 2023.10.31
  • 발행 : 2024.06.01
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초록

Objective: Jining Grey goat is a local Chinese goat breed that is well known for its high fertility and excellent meat quality but shows low meat production performance. Numerous studies have focused on revealing the genetic mechanism of its high fertility, but its highlighting meat quality and muscle growth mechanism still need to be studied. Methods: In this research, an integrative analysis of the genomics and transcriptomics of Jining Grey goats compared with Boer goats was performed to identify candidate genes and pathways related to the mechanisms of meat quality and muscle development. Results: Our results overlap among five genes (ABHD2, FN1, PGM2L1, PRKAG3, RAVER2) and detected a set of candidate genes associated with fatty acid metabolism (PRKAG3, HADHB, FASN, ACADM), amino acid metabolism (KMT2C, PLOD3, NSD2, SETDB1, STT3B, MAN1A2, BCKDHB, NAT8L, P4HA3) and muscle development (MSTN, PPARGC1A, ANKRD2). Several pathways have also been detected, such as the FoxO signaling pathway and Apelin signaling pathway that play roles in lipid metabolism, lysine degradation, N-glycan biosynthesis, valine, leucine and isoleucine degradation that involving with amino acid metabolism. Conclusion: The comparative genomic and transcriptomic analysis of Jining Grey goat and Boer goat revealed the mechanisms underlying the meat quality and meat productive performance of goats. These results provide valuable information for future breeding of goats.

키워드

과제정보

This research was funded by The Shandong Provincial Sheep and Goat Industry Technology System (SDAIT-10-02); Agricultural Variety Improvement Project of Shandong Province (2021LZGC010); Ministry of Finance and Ministry of Agriculture and Rural Affairs: China Agriculture Research System of Mutton Sheep (CARS-38); Natural Science Foundation of Shandong Province (ZR2022MC077), and Agricultural Scientific and Technological Innovation Project of Shandong Academy of Agricultural Sciences (CXGC2023A33).

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