Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Regulatory Mechanisms Governing the Autophagy-Initiating VPS34 Complex and Its inhibitors

  • Yongook Lee (BK21 FOUR Team and Integrated Research Institute for Drug Development, College of Pharmacy, Dongguk University) ;
  • Nguyen Minh Tuan (BK21 FOUR Team and Integrated Research Institute for Drug Development, College of Pharmacy, Dongguk University) ;
  • Gi Jeong Lee (BK21 FOUR Team and Integrated Research Institute for Drug Development, College of Pharmacy, Dongguk University) ;
  • Boram Kim (BK21 FOUR Team and Integrated Research Institute for Drug Development, College of Pharmacy, Dongguk University) ;
  • Jung Ho Park (BK21 FOUR Team and Integrated Research Institute for Drug Development, College of Pharmacy, Dongguk University) ;
  • Chang Hoon Lee (BK21 FOUR Team and Integrated Research Institute for Drug Development, College of Pharmacy, Dongguk University)
  • Received : 2024.06.07
  • Accepted : 2024.06.26
  • Published : 2024.11.01
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Abstract

VPS34 is a crucial protein in cells, essential for handling cellular stress through its involvement in autophagy and endocytosis. This protein functions as a Class III phosphatidylinositol 3-kinase, producing phosphatidylinositol 3-phosphate, which is necessary for autophagy and vesicle trafficking. Additionally, VPS34 forms two mutually exclusive complexes, each playing a vital role in autophagy and endocytic sorting. These complexes share common subunits, including VPS15, VPS34, and Beclin 1, with complex I having ATG14 as a specific subunit. Due to its association with various human diseases, regulation of the VPS34 complex I has garnered significant interest, emerging as a potential therapeutic target for drug discovery. Summaries of the structure, function of VPS34 complexes, and developed VPS34 inhibitors have been provided, along with discussions on the regulation mechanism of VPS34, particularly in relation to the initiation complex I of autophagy. This offers valuable insights for treating autophagy-related diseases.

Keywords

Acknowledgement

This study was supported by grants from the Basic Science Research Program through the NRF (NRF-2020R1A2C3004973), NRF (NRF-2018R1A5A2023127), and the BK21 FOUR program through the National Research Foundation (NRF) of Korea funded by the Ministry of Education (MOE, Korea).

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