• 동의생리병리학회지
• /
• 제16권2호
• /
• pp.322-326
• /
• 2002

Artemisia iwayomogi has been used in Korea for many centuries as a treatment for anemia. The effect of Artemisia iwayomogi on tracheal smooth muscle is not known. The purpose of the present study is to determine the effect of Artemisia iwayomogi on histamine induced tracheal smooth muscle contraction in guinea pigs. Guinea pigs(500g, male) were killed by CO₂ exposure and a segment (8-10mm) of the thoracic trachea from each rat and guinea pig was cut into equal segments and mounted ‘in pairs’ in a tissue bath. Contractile force was measured with force displacement transducers under 0.5g loading tension. The dose of histamine (His) which evoked 50% of maximal response (ED/sub 50/) was obtained from cumulative dose response curves for histamine (10/sup -7/～10/sup -4/M). Contractions evoked by His (ED/sub 50/) were inhibited significantly by Artemisia iwayomogi. In guinea pig tracheal smooth muscle, the mean percent inhibition of histamine induced contraction was 31.9% (p<0.05) after 100㎕/㎖ Artemisia iwayomogi. L-NNA slightly but significantly attenuated the inhibitory effects of Artemisia iwayomogi. Following treatment with L-NNA, the mean percent inhibition caused by 100㎕/㎖ Artemisia iwayomogi fell to 44.6% in guinea pig induced by histamine contraction. Propranolol, indomethacin and methylene blue did not significantly alter the inhibitory effect of Artemisia iwayomogi. These results indicate that Artemisia iwayomogi can relax histamine induced contraction of guinea pig, and that this inhibition related to nitric oxide formation.

• 한국자원식물학회지
• /
• 제11권3호
• /
• pp.279-282
• /
• 1998

This expriment was carried out to get basic information on composition and yield of aromatic constituents in leaves of four medicinal plants, Angelica tenuissima, Chrysanthemum zawadskii. ssp. latilobum, Artemisia iwayomogi and Artemisia capillaris. Volatile aromatic constituents, 28 compounds in Angelica tenuissima were identified and 19 compounds were indentified in Chrysanthemum zawadskii ssp. latilobum. Volatile aromatic constituents, 23 compounds in Artemisia iwayomogi and Artemisia capillaris were identified. Major volatile aromatic consitiuents analyzed by GC/MS in four plants were $\alpha$-pinene, camphene, sabinene, cis-2-hexanol, and camphor etc. Content of essential oils in Angelica tenuissima, Chrysanthemum zawadskii ssp. latilobum, Artemisia iwayomogi and Artemisia capillaris were 0.014, 0.275, 0.785, and 0.452%, respectively. As a result, it was suggested that a medicinal plant, Artemisia iwayomogi, was worthy of using as a useful material of perfume.

• Journal of Ecology and Environment
• /
• 제32권1호
• /
• pp.9-12
• /
• 2009

Artemisia capillaris and Artemisia iwayomogi are weeds used as medicinal plants in Korea under the name "Injin". I collected leaves of A. capillaris and A. iwayomogi, examined them for phytotoxic effects from volatile substances and determined the composition of monoterpenes in the leaves. The effects of volatile substances from each species on seed germination and radicle elongation in each of the two Artemisia species were assessed. The volatile substances of A. capillaris did not negatively affect the seed germination of A. capillaris, but they did inhibit radicle elongation. Rates of seed germination of A. iwayomogi decreased when the seeds were exposed to high concentration of A. capillaris volatile substances. The inhibition of seed germination and radicle elongation by volatile substances from both Artemisia species was stronger for A. iwayomogi than for A. capillaris. I identified the monoterpenoids from the leaves with a gas chromatograph-mass spectrometer (GC-MS). The main constituents of A. capillaris were acenaphthylene (37.91%), $\beta$-pinene (12.08%), 4-carene (10.61%) and $\gamma$-curcumene (9.92%), while those of A. iwayomogi were germacrene-$\delta$ (32.15%), borneol (21.24%), camphor (20.45%) and trans-caryophyllene (7.75%).

• 한국자원식물학회지
• /
• 제24권1호
• /
• pp.10-16
• /
• 2011

본 실험은 인진으로 쓰이는 사철쑥과 더위지기의 항미생물활성을 검정한 것으로 추출용매에 따른 항미생물활성은 gram양성균 3종과 gram음성균 2종 모두에서 ethylacetate 추출물들이 ether추출물들보다 전반적으로 높았다. 실험미생물 중 B. subtilis와 B. cereus에 대한 추출물들의 활성이 다른 실험미생물에 비하여 강하게 나타났으며 더위지기 추출물들이 사철쑥 추출물들에 비하여 높은 활성을 보였다. 추출용매에 따른 최소저해농도는 ethylacetate추출물이 ether추출물보다 낮은 농도에서 대부분의 미생물들의 생육을 억제하였고, 더위지기와 사철쑥 부위별로는 잎과 줄기에서 잎에 비하여 낮은 농도에서 미생물들의 생육을 억제하였으며 더위지기 추출물들의 최소저해농도가 사철쑥 추출물들보다 낮았다.총 폴리페놀함량은 사철쑥 잎과 줄기 추출물에서 27.57 mg/g으로 가장 높게 나타났으며 대체로 잎과 줄기 추출물에서 잎 추출물에서보다 높은 함량을 나타내었다.

• Journal of Ecology and Environment
• /
• 제33권2호
• /
• pp.141-147
• /
• 2010

This study compared the antimicrobial activity and chemical composition of two plants used as "Injin" (Korean herbal medicine), namely, Injinho (Artemisia capillaris Thunberg) and Haninjin (Artemisia iwayomogi Kitamura). The ethyl acetate and ether fractions of crude methanol extracts from A. capillaris and A. iwayomogi were tested against three grampositive bacteria (Bacillus cereus, Bacillus subtilis, Staphylococcus aureus), two gram-negative bacteria (Escherichia coli, Pseudomonas fluorescens), and a yeast (Saccharomyceus cerevisiae). The antimicrobial activity of the ethyl acetate and ether fraction of both plants was strong, but that of A. iwayomogi extracts was higher than that of A. capillaris extract for the microbes tested. The minimum inhibitory concentration of the ether and ethyl acetate fraction of A. iwayomogi was highest for P. fluorescens and lowest for S. aureus and E. coli. We analyzed the chemical composition of the ethyl acetate fraction of A. capillaris and A. iwayomogi using gas chromatography-mass spectrometry. The main components of A. capillaris and A. iwayomogi were escoparone (86.82%) and scopoletin (20.47%), respectively.

• 한국식품영양학회지
• /
• 제17권1호
• /
• pp.86-91
• /
• 2004

강화에 자생하는 사자발쑥(Artemisia princeps), 황해쑥(Artemisia argyi) 그리고 인진쑥(Artemisia iwayomogi)의 에탄을 추출물과 열수 추출물을 각각 제조하여 항산화 효과와 아미노산 및 당 성분을 분석하였다. 총 페놀함량은 사자발쑥 10.2 mg/$m\ell$, 황해쑥 4.7 mg/$m\ell$ 그리고 인진쑥 7.0 mg/ml로 나타나 사자발쑥의 총 페놀함량이 가장 많았다. 플라보노이드함량은 사자발쑥 6.1 mg%, 황해쑥 3.6 mg% 그리고 인진쑥 1.8 mg%로 나타나 역시 사자발쑥의 함량이 가장 많았다. DPPH법에 의한 전자공여능 측정 실험에서 사자발쑥 19.0%, 황해쑥 24.4% 그리고 인진쑥 14.3%로 나타나 황해쑥의 항산화 능력이 다소 높았다. HPLC를 이용한 아미노산분석에서 총 아미노산함량은 사자발쑥이 가장 많았으며 모든 쑥에서 proline이 비교적 많았다. 당분석에서는 총 당함량은 인진쑥이 가장 많았고 모든 쑥에서 당성분중 glucose가 가장 많았으며 fructose는 인진쑥＞황해쑥＞사자발쑥 순이었다.

• 한국환경과학회지
• /
• 제24권5호
• /
• pp.633-639
• /
• 2015

The experience of natural dyeing is expected to be effective in promoting health through good exercise, in giving emotional stability based on the functional aromatic components of the dyeing material, and in improving self-esteem and increasing positive experiences through the behavior of creation. A natural dyeing material easily found around us, artemisia has long been used in food and Oriental medicine and was recently found to contain antioxidative, anticancer, deodorizing, antibacterial, anti-obesity, and anti-diabetes substances through chemical analysis. It has also been reported that group reminiscence therapy using the fragrance of artemisia is effective in relieving pain and depression and in promoting ego integrity in the elderly population. This study aimed to make a comparative analysis of dyeability, washing fastness, and deodorization between Artemisia princeps, Artemisia iwayomogi, and Artemisia annua, all of which are considered to be healthful and functional dyeing materials, among about thirty domestic plants in the genus of Artemisia and to provide basic data concerning natural dyeing in mind-peace education for the silver generation. The fabric dyed and post-mordanted at $80^{\circ}C$ for 40 minutes showed the greatest surface color variation; in this condition, artemisia princes (32.29) gave the greatest color difference, followed by artemisia iwayomogi (31.07) and artemisia annua (26.17). While all the types of artemisia were excellent in washing fastness, dry-cleaning fastness, and rubbing fastness at the fourth- or fifth-grade, light fastness was at the third grade for artemisia princes, at the second to third grade for artemisia annua, and at the second grade for artemisia iwayomogi; therefore, artemisia princes was found to give better fastness than the other two types of artemisia. In determining functionality of the fabric dyed with artemisia, deodorization test also found that the fabric dyed with artemisia princes had 20% higher deodorization.

• 대한본초학회지
• /
• 제33권3호
• /
• pp.55-61
• /
• 2018

Objectives : Artemisia capillaris Thunberg (AC) and Artemisia iwayomogi Kitamura (AI) have been used without distinguishment since ancient times due to similar appearance. In this study, we compared the inhibitory effects of AC and AI on the expression of inflammatory cytokines induced by lipopolysaccharide (LPS) in murine macrophages. Methods : AC and AI were extracted by reflux with distilled water (DW) and 70% ethanol (EtOH). We investigated the inhibitory effects of AC and AI on the expression of nitric oxide (NO), inducible NO synthase (iNOS) and tumor necrosis $factor-{\alpha}$($TNF-{\alpha}$) induced by LPS in macrophages. Results : Firstly, yield of the samples was higher in order of Artemisia iwayomogi DW Extract (AID), Artemisia iwayomogi 70% EtOH Extract (AIE), Artemisia capillaris DW Extract (ACD) and Artemisia capillaris 70% EtOH Extract (ACE). All of the samples were not toxic in macrophages. The inhibitory effect of the samples on LPS-induced NO expression was stronger in the order of AIE, ACE, AID and ACD. The inhibitory effect of the samples on LPS-induced inducible iNOS expression was stronger in the order of AIE, ACE and AID. Effect of ACD was same with that of AID. In addition, inhibitory effect of the samples on LPS induced $TNF-{\alpha}$expression wes stronger in the order of AIE, ACE, AID and ACD. Conclusion: These results showed that AI would be more effective than AC and 70% EtOH would be more effective than DW as an extraction solvent in inflammatory diseases.

• 대한한의학방제학회지
• /
• 제7권1호
• /
• pp.183-188
• /
• 1999

Though development of diverse and highly value-added commodities in Artemisia Iwayomogi, we can expect such effects as procurement of secure farm's production bases and promotion of consumer's demands. Thus, as a first step for development of funtional foods of Artemisia Iwayomogi, solids yield, physical properties and scopoletin contents which is main component of Artemisia Iwayomogi, were investigated according to extration solvents and temperatures. The main result of this experiment were as following: solid yield in 50% ethanol extracts showed higher than those of water extracts at the same temperature. In condition of 50% ethanol extracts, solid yield, degree of browing and scopoletin contents showed increasing, but turbidities which mean transmittance(%T) showed decreasing sa temperature rise. In water extracts, pH values showed increasing as temperature rise.

• 한국식품영양과학회지
• /
• 제28권1호
• /
• pp.199-204
• /
• 1999

This study has attempted to examine the effect of Artemisia iwayomogi extract on antioxidant and liver function related enzymes in rats fed high fat diet along with B( )P administration. The activities of the serum glutamic oxaloacetic transaminase, glutamic pyruvate transaminase and alkaline phosphatase of the rats fed Artemisia iwayomogi ethanol extract were decreased compared to the control. Similarily, the activities of the enzymes were also decreased when the combination of B( )P and ethanol extracts were administered compared to the group adminstered only B( )P. On the other hand, high fat diet increased the above liver function related enzymes. The activities of antioxidant enzymes including GST, catalase and Cu,Zn SOD were significantly increased by feeding the extracts (p<0.01) in addition to the increase of tocopherol contents in the serum. These results suggest that Artemisia iwayomogi extracts can protect cell membranes from the damages by free radicals or hydroperoxides and further may lead to the protection from cancer risks.