• The Korean Journal of Archival Studies
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• no.34
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• pp.57-105
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• 2012

The CAMS(Central Archives Management System) of NAK(National Archives of Korea) is an important system which receives and manages large amount of electronic records annually from 2015. From the point of view in database design, this paper analyzes the database schema of CAMS and discusses the direction of overall improvement of the CAMS. Firstly this research analyzes the tables for records and folders in the CAMS database which are core tables for the electronic records management. As a result, researchers notice that it is difficult to trust the quality of the records in the CAMS, because two core tables are entirely not normalized and have many columns whose roles are unknown. Secondly, this study suggests directions of normalization for the tables for records and folders in the CAMS database like followings: First, redistributing the columns into proper tables to reduce the duplication. Second, separating the columns about the classification scheme into separate tables. Third, separating the columns about the records types and sorts into separate tables. Lastly, separating metadata information related to the acquisition, takeover and preservation into separate tables. Thirdly, this paper suggests considerations to design and manage the database schema in each phase of archival management. In the ingest phase, the system should be able to process large amount of records as batch jobs in time annually. In the preservation phase, the system should be able to keep the management histories in the CAMS as audit trails including the reclassification, revaluation, and preservation activities related to the records. In the access phase, the descriptive metadata sets for the access should be selected and confirmed in various ways. Lastly, this research also shows the prototype of conceptual database schema for the CAMS which fulfills the metadata standards for records.

• Transactions of the Korean Society of Mechanical Engineers
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• v.17 no.6
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• pp.1361-1371
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• 1993

The effort of this paper is to develop a methodology of computer aided design and manufacture of spatial cams. The integrated CAD/CAM systems for spatial cams are developed to enable manufacturer to design and machine them readily. The contour of spatial cams can be obtained by applying envelope theory to the cam/follower motion. The mathematical cam contour is evaluated at some increment to generate the numerical data for the CNC programming. Incremental generation of points along a cam contour can be accomplished in consideration with the specified tolerance. The computerized procedure is described in detail with accompanying examples.

• Journal of Veterinary Clinics
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• v.20 no.1
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• pp.86-90
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• 2003

Little is known to data about the in vitro activity of antimicrobial agents aganist Brucella cams (B cams) isolated from Korea. Our study aimed at determining the in vitro activities of 15 antimicrobial agents against 3 isolates and 52 isolates of B cams from dogs in 1994 and 2002, respectively. In minimal inhibitory concentration (MIC) study, minocycline and doxycycline showed the lowest MICs ( < 0.06-0.5 ug/ml). Gentamicin, streptomycin, ciprofloxacin, norfloxacin and rifampin showed MICs in the range of less than 1 ug/ml. Lincomycin and sulfisox azole showed the highest MICs ( > 32 ug/ml). Interestingly, MICs of macrolides (erythromycin, spiramycin, tylosin) against 52 isolates in 2002 were 16-64 times higher than that of 3 isolates in 1994. In minimal bactericidal concentration (MBC) study, gentamicin, streptomycin, ciprofloxacin and norfloxacin showed the lowest MBCs [0.12-1 ug/ml (1-2 times higher than MIC)], but minocycline and doxycycline showed the highest MBCs [8-32 ug/ml (128 times higher than MIC)]. Rifampin showed the MBCs in the range from 2 to 4 ug/ml (2-4 times higher than MIC).

• 연구논문집
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• s.22
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• pp.75-83
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• 1992

The beating motion of a high speed shuttleless loom is driven by cams. Two cams become one system and their shaft laid across each other. Moreover, the shape of the cams is very complex and requires high precision for successful weft insertion and good interlacing with warp yarn. The iterative contact method is developed for use in design and analysis of the driving mechanism of a disk type cam with oscillating roller follower. The optimum design is performed by utilizing a CAD program, DISKCAM. The 8th order polynomial is selected to interpolate the desired shape trajectory of the cam, the optimal shape of the cams is defined based on the demension of the follower. The kinematic motion of the beating cam mechanism is investigated. The phase angle is determined to achive harmonious cam motions

• Molecules and Cells
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• v.37 no.3
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• pp.213-219
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• 2014

MicroRNAs (miRNAs) represent a class of small non-coding regulatory RNAs that play important roles in normal hematopoiesis, including erythropoiesis. Although studies have identified several miRNAs that regulate erythroid commitment and differentiation, we do not understand the mechanism by which the crucial erythroid transcription factors, GATA-1and NF-E2 directly regulate and control differentiation via miRNA pathways. In this study, we identified miR-199b-5p as a key regulator of human erythropoiesis, and its expression was up-regulated during the erythroid differentiation of K562 cells. Furthermore, the increase of miR-199b-5p in erythroid cells occurred in a GATA-1- and NF-E2-dependent manner during erythrocyte maturation. Both GATA-1 and NF-E2 bound upstream of the miR-199b gene locus and activated its transcription. Forced expression of miRNA-199b-5p in K562 cells affected erythroid cell proliferation and maturation. Moreover, we identified c-Kit as a direct target of miR-199b-5p in erythroid cells. Taken together, our results establish a functional link among the erythroid transcription factors GATA-1/NF-E2, miR-199b-5p and c-Kit, and provide new insights into the coupling of transcription and post-transcription regulation in erythroid differentiation.

• CELLMED
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• v.2 no.2
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• pp.18.1-18.16
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• 2012

An oncology-specific database called OncoRx (http://bit.ly/cancerRx) was previously set up in cyberspace to aid clinicians in identifying interactions of anticancer drugs (ACDs) and chemotherapy regimens with traditional Chinese medicines (TCMs) and complementary and alternative medicines (CAMs). Since then, users have requested the drug-CAM interactions (DCIs) of 5 specific CAMs (cranberry, melatonin, co-enzyme Q10, huachansu, reishi mushroom) to be updated in the database. Pharmacokinetic properties (metabolism, enzyme induction/inhibition, elimination), TCM properties and DCIs of each CAM were collated with 117 ACDs using 9 hardcopy compendia and online databases as resources. Additionally, individual ACDs and CAMs were used as keywords for PubMed searches in combination with the terms 'anticancer drugs', 'drug interactions', 'herb-drug/drug-herb interactions', 'pharmacokinetic interactions' and 'pharmacodynamic interactions'. DCI parameters consisted of interaction effects, evidence summaries, proposed management plans and alternative non-interacting CAMs, together with relevant citations and update dates of the DCIs. OncoRx is also used as a case to introduce the "Four Pharmaco-cybernetic Maxims" of quality, quantity, relationship and manner to developers of digital healthcare tools. Its role in Hayne's "5S" hierarchy of research evidence is also presented. OncoRx is meant to complement existing DCI resources for clinicians and alternative medicine practitioners as an additional drug information resource that provides evidence-based DCI information for ACD-CAM interactions.

• Journal of Environmental Science International
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• v.25 no.7
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• pp.1029-1042
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• 2016

The initial and boundary conditions are important factors in regional chemical transport modeling systems. The method of generating the chemical boundary conditions for regional air quality models tends to be different from the dynamically varying boundary conditions in global chemical transport models. In this study, the impact of real time Copernicus atmosphere monitoring service (CAMS) re-analysis data from the modeling atmospheric composition and climate project interim implementation (MACC) on the regional air quality in the Korean Peninsula was carried out using the community multi-scale air quality modeling system (CMAQ). A comparison between conventional global data and CAMS for numerical assessments was also conducted. Although the horizontal resolution of the CAMS re-analysis data is not higher than the conventionally provided data, the simulated particulate matter (PM) concentrations with boundary conditions for CAMS re-analysis is more reasonable than any other data, and the estimation accuracy over the entire Korean peninsula, including the Seoul and Daegu metropolitan areas, was improved. Although an inland area such as the Daegu metropolitan area often has large uncertainty in PM prediction, the level of improvement in the prediction for the Daegu metropolitan area is higher than in the coastal area of the western part of the Korean peninsula.

• KSBB Journal
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• v.20 no.1 s.90
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• pp.46-49
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• 2005

Curdlan, a natural $\beta-1,3-glucan,$ has been studied as drug carrier due to its unique properties including its thermal gelling characters. In this study, curdlan was chemically acetylated for pH-sensitive drug delivery. Curdlan acetate microspheres(CAMs) were prepared by the solvent evaporation method. The size of the CAMs was below $200{\mu}m.$ The drug loading efficiency of microspheres was approximately $58.44\%$. In the swelling test, the CAMs showed pH-sensitive behavior. The swelling capacity of microspheres at pH 7.4 was much greater than at pH 1.4. Also, release rate of indomethacin(IND) at pH 7.4 from the CAMs was faster than that at pH 1.4. Therefore the CAMs have potential for the controlled release of IND over an extended period of time.

• 제어로봇시스템학회:학술대회논문집
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• 2004.08a
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• pp.1012-1016
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• 2004

In this paper, we propose a simple but optimized NC code generating technique for disk cams by means of tool path error control in a five-axis CNC machining center. Using the geometric theorem of the triangle made between manufacturing points and error checkpoint, the tool path error has been studied for disk cams profile generation and an improvement in the profile has been obtained. Then, based on the present manufacturing approach a computer program is developed on $C^{++}$ language to perform and to verify the shape design, the manufacturing simulation, and the optimized generation of the NC code.

• Proceedings of the PSK Conference
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• 2003.04a
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• pp.221.2-222
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• 2003

Expressions of cellular adhesion molecules (CAMs) are closely related to the formation of early atherosclerosis, an age-dependent vascular disorder. However. previous research provided only limited and conflicted reports on age-related alterations of CAMs' expressions and even much less is known the modulation of CAMs by calorie restriction (CR), In this study, expression of vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), E-selectin, P-selectin and platelet/endothelial cell adhesion molecule-1 (PECAM-1) in aorta and kidney were investigated by western blot and immuno-histochemical stain utilizing ad libitum (AL) and CR rat. (omitted)