• 기록학연구
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• 제34호
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• pp.57-105
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• 2012

국가기록원 영구기록물관리시스템 CAMS(Central Archives Management System)는 2015년부터 매년 대량의 전자기록물을 이관받아 관리해야 할 중요한 시스템이다. CAMS 데이터베이스를 스키마 설계의 관점에서 진단해보고 전반적인 개선방향을 논의하는 일이 시급하다. CAMS 데이터베이스의 중심부분인 기록물철 및 기록물건 테이블을 살펴본 결과 두 테이블 모두 정규화가 되어 있지 않으며, 용도 불명의 칼럼들이 혼재하고 있어 기록물 데이터의 품질을 신뢰하기 어려운 상황임을 알 수 있었다. 이 논문에서는 다음과 같이 기록물철 및 기록물건 테이블의 정규화방향을 제시하였다. 첫째, 두 테이블 간 중복 항목을 최소화하는 방향으로 칼럼을 재배치할 것. 둘째, 분류체계 정보 항목을 별도 테이블로 분리할 것. 셋째, 기록물의 형태 및 유형별 기술 항목을 별도 테이블로 분리할 것. 넷째, 인수 및 인계, 보존처리 등 기록관리 과정의 기술 항목을 별도 테이블로 분리할 것. 나아가 이 논문에서는 기록물의 입수, 보존, 제공 단계별로 데이터베이스 스키마 설계 및 관리 시 고려할 사항을 제시하였다. 입수단에서는 매년 대량의 이관기록물을 정해진 기간 안에 일괄처리할 수 있어야 한다는 점, 보존단에서는 재분류, 재평가, 보존처리와 같은 다양한 관리이력을 남길 수 있어야 한다는 점, 제공단에서는 접근도구에 필요한 데이터를 정해야한다는 점 등을 논의하고 있다. 또한, 메타데이터 표준을 준수하는 방향에서 일부 개념 스키마를 개발하여 예시하고 있다.

• 대한기계학회논문집
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• 제17권6호
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• pp.1361-1371
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• 1993

본 연구에서는 여러가지 입체 캠 기구에 대하여 기구학적인 구성조건과 캠 곡선을 바탕으로 매개변수형태의 포락면이론에 의하여 캠 형상을 구하고, 이를 직접 가공할 수 있는 NC 파트프로그램을 얻는 CAD/CAM 소프트웨어를 구성하여 정밀성, 생산성, 효율성 등을 증진하고자 한다.

• 한국임상수의학회지
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• 제20권1호
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• pp.86-90
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• 2003

Little is known to data about the in vitro activity of antimicrobial agents aganist Brucella cams (B cams) isolated from Korea. Our study aimed at determining the in vitro activities of 15 antimicrobial agents against 3 isolates and 52 isolates of B cams from dogs in 1994 and 2002, respectively. In minimal inhibitory concentration (MIC) study, minocycline and doxycycline showed the lowest MICs ( < 0.06-0.5 ug/ml). Gentamicin, streptomycin, ciprofloxacin, norfloxacin and rifampin showed MICs in the range of less than 1 ug/ml. Lincomycin and sulfisox azole showed the highest MICs ( > 32 ug/ml). Interestingly, MICs of macrolides (erythromycin, spiramycin, tylosin) against 52 isolates in 2002 were 16-64 times higher than that of 3 isolates in 1994. In minimal bactericidal concentration (MBC) study, gentamicin, streptomycin, ciprofloxacin and norfloxacin showed the lowest MBCs [0.12-1 ug/ml (1-2 times higher than MIC)], but minocycline and doxycycline showed the highest MBCs [8-32 ug/ml (128 times higher than MIC)]. Rifampin showed the MBCs in the range from 2 to 4 ug/ml (2-4 times higher than MIC).

• 연구논문집
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• 통권22호
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• pp.75-83
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• 1992

The beating motion of a high speed shuttleless loom is driven by cams. Two cams become one system and their shaft laid across each other. Moreover, the shape of the cams is very complex and requires high precision for successful weft insertion and good interlacing with warp yarn. The iterative contact method is developed for use in design and analysis of the driving mechanism of a disk type cam with oscillating roller follower. The optimum design is performed by utilizing a CAD program, DISKCAM. The 8th order polynomial is selected to interpolate the desired shape trajectory of the cam, the optimal shape of the cams is defined based on the demension of the follower. The kinematic motion of the beating cam mechanism is investigated. The phase angle is determined to achive harmonious cam motions

• Molecules and Cells
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• 제37권3호
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• pp.213-219
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• 2014

MicroRNAs (miRNAs) represent a class of small non-coding regulatory RNAs that play important roles in normal hematopoiesis, including erythropoiesis. Although studies have identified several miRNAs that regulate erythroid commitment and differentiation, we do not understand the mechanism by which the crucial erythroid transcription factors, GATA-1and NF-E2 directly regulate and control differentiation via miRNA pathways. In this study, we identified miR-199b-5p as a key regulator of human erythropoiesis, and its expression was up-regulated during the erythroid differentiation of K562 cells. Furthermore, the increase of miR-199b-5p in erythroid cells occurred in a GATA-1- and NF-E2-dependent manner during erythrocyte maturation. Both GATA-1 and NF-E2 bound upstream of the miR-199b gene locus and activated its transcription. Forced expression of miRNA-199b-5p in K562 cells affected erythroid cell proliferation and maturation. Moreover, we identified c-Kit as a direct target of miR-199b-5p in erythroid cells. Taken together, our results establish a functional link among the erythroid transcription factors GATA-1/NF-E2, miR-199b-5p and c-Kit, and provide new insights into the coupling of transcription and post-transcription regulation in erythroid differentiation.

• 셀메드
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• 제2권2호
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• pp.18.1-18.16
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• 2012

An oncology-specific database called OncoRx (http://bit.ly/cancerRx) was previously set up in cyberspace to aid clinicians in identifying interactions of anticancer drugs (ACDs) and chemotherapy regimens with traditional Chinese medicines (TCMs) and complementary and alternative medicines (CAMs). Since then, users have requested the drug-CAM interactions (DCIs) of 5 specific CAMs (cranberry, melatonin, co-enzyme Q10, huachansu, reishi mushroom) to be updated in the database. Pharmacokinetic properties (metabolism, enzyme induction/inhibition, elimination), TCM properties and DCIs of each CAM were collated with 117 ACDs using 9 hardcopy compendia and online databases as resources. Additionally, individual ACDs and CAMs were used as keywords for PubMed searches in combination with the terms 'anticancer drugs', 'drug interactions', 'herb-drug/drug-herb interactions', 'pharmacokinetic interactions' and 'pharmacodynamic interactions'. DCI parameters consisted of interaction effects, evidence summaries, proposed management plans and alternative non-interacting CAMs, together with relevant citations and update dates of the DCIs. OncoRx is also used as a case to introduce the "Four Pharmaco-cybernetic Maxims" of quality, quantity, relationship and manner to developers of digital healthcare tools. Its role in Hayne's "5S" hierarchy of research evidence is also presented. OncoRx is meant to complement existing DCI resources for clinicians and alternative medicine practitioners as an additional drug information resource that provides evidence-based DCI information for ACD-CAM interactions.

• 한국환경과학회지
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• 제25권7호
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• pp.1029-1042
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• 2016

The initial and boundary conditions are important factors in regional chemical transport modeling systems. The method of generating the chemical boundary conditions for regional air quality models tends to be different from the dynamically varying boundary conditions in global chemical transport models. In this study, the impact of real time Copernicus atmosphere monitoring service (CAMS) re-analysis data from the modeling atmospheric composition and climate project interim implementation (MACC) on the regional air quality in the Korean Peninsula was carried out using the community multi-scale air quality modeling system (CMAQ). A comparison between conventional global data and CAMS for numerical assessments was also conducted. Although the horizontal resolution of the CAMS re-analysis data is not higher than the conventionally provided data, the simulated particulate matter (PM) concentrations with boundary conditions for CAMS re-analysis is more reasonable than any other data, and the estimation accuracy over the entire Korean peninsula, including the Seoul and Daegu metropolitan areas, was improved. Although an inland area such as the Daegu metropolitan area often has large uncertainty in PM prediction, the level of improvement in the prediction for the Daegu metropolitan area is higher than in the coastal area of the western part of the Korean peninsula.

• KSBB Journal
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• 제20권1호
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• pp.46-49
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• 2005

생분해성인 curdlan을 아세틸화하여 소수성 약물인 IND의 치료효과를 증진시킬 수 있는 약물전달시스템 개발을 위한 실험을 수행한 결과, IND가 포함된 CAMs를 제조할 수 있었고, IND의 loading efficiency는 $58.44\%$였다. 약물 방출 거동에 영향을 미치는 요인 중 제조한 CAMs의 swelling 특성은 처음 1시간 동안 pH 1.4에서는 아무런 변화가 없었고 PH 7.4에서는 $30\%$의 swelling을 보였고 pH 1.4에서보다 pH 7.4에서의 swelling이 약 3배 높았다. 또한 CAMs로부터 IND의 방출은 pH 1.4에서보다 pH 7.4에서 약 15배 이상 증가하였다. 이러한 결과로 CAMs는 IND의 약물전달시스템으로 유용할 것이며 특히 pH에 의존하는 약물방출 경향을 보였다.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2004년도 ICCAS
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• pp.1012-1016
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• 2004

In this paper, we propose a simple but optimized NC code generating technique for disk cams by means of tool path error control in a five-axis CNC machining center. Using the geometric theorem of the triangle made between manufacturing points and error checkpoint, the tool path error has been studied for disk cams profile generation and an improvement in the profile has been obtained. Then, based on the present manufacturing approach a computer program is developed on $C^{++}$ language to perform and to verify the shape design, the manufacturing simulation, and the optimized generation of the NC code.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.221.2-222
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• 2003

Expressions of cellular adhesion molecules (CAMs) are closely related to the formation of early atherosclerosis, an age-dependent vascular disorder. However. previous research provided only limited and conflicted reports on age-related alterations of CAMs' expressions and even much less is known the modulation of CAMs by calorie restriction (CR), In this study, expression of vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), E-selectin, P-selectin and platelet/endothelial cell adhesion molecule-1 (PECAM-1) in aorta and kidney were investigated by western blot and immuno-histochemical stain utilizing ad libitum (AL) and CR rat. (omitted)