• 약학회지
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• 제54권6호
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• pp.494-499
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• 2010

We have been focussing on discovery of natural compounds that have immunoregulatory activities for many years. In the present study, we investigated if chlorogenic acid (CRA), a polyphenolic compound, has an immunoadjuvant activity. Prior to examining the immunoadjuvant activity, effect of CRA on proliferation of T- or B-lymphocyte was determined. Results showed that CRA enhanced the proliferation of those lymphocytes in dose-dependant manner (P<0.05), and the proliferation enhancement by CRA was appeared to be more effective to B-cells than to T-cells. Based on these observations, it was tested with bovine serum albumin (BSA) and Candida albicans cell wall (CACW) as antigenic sources if CRA has an immunoadjuvant activity. In experiments, BSA alone or a mixture of BSA plus CRA was injected intraperitoneally to mice (BALB/c strain). For a negative control, mice were given only diluent (DPBS) by the same route. In other experiment, CACW was tested by the same way as did with BSA. Three weeks after the first immunization these animals were boosted. Antisera collected from the mice one week after the booster were analyzed by ELISA. Results displayed that the induction of anti-BSA antibody was increased in mice that received the mixture of BSA and CRA as compared to anti-BSA induction in BSA only-given mice groups (P<0.05). In case of CACW, a similar observation as did with BSA was made, resulting in that there was app. 40% increased production of the anti-CACW antiserum from the combination (CACW plus CRA)-received mice as compared to antiserum induction from CACW alone-given animals. Taken all together, these data indicate that CRA has an ability of enhancing antibody production regardless of nature of antigenic sources. Presumably, activation of B-cell proliferation by CRA may plays an important role in the immunoadjuvant activity of the polyphenolic compound.

• 대한물리의학회지
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• 제10권2호
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• pp.29-34
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• 2015

PURPOSE: The purpose of present study was to introduces an exceptional case in measurement methods (CVA, CRA and Cobb angle) to identify the FHP with verified reliability and validity. Subjects: Three males aged 30 years were recruited: A Normal, B and C who have FHP. METHODS: All the subjects were measured CVA, CRA and Cobb angle with the Photogrammetry and Radiography. RESULTS: The results revealed that it is not enough for measurement methods to identify the FHP using CVA, CRA and Cobb angle. On Photogrammetry values; CVA had $65^{\circ}$, CRA was $148^{\circ}$ of Normal subject A and CVA had $61^{\circ}$, CRA was $149^{\circ}$ of FHP subject B and CVA had $51^{\circ}$, CRA was $149^{\circ}$ of FHP subject C. On Radiography values; CVA had $73^{\circ}$, CRA was $148^{\circ}$ and Cobb was $50^{\circ}$ of Normal subject A and CVA had $70^{\circ}$, CRA was $150^{\circ}$ and Cobb was $53^{\circ}$ of FHP subject B and CVA had $61^{\circ}$, CRA was $153^{\circ}$ and Cobb was $31^{\circ}$ of FHP subject C. CONCLUSION: The reliable CVA, CRA and Cobb angle use methods from the previous studies might not be suitable for the diagnose the FHP. We think that it is necessary to have more detailed evaluation methods and the radiography is also needed for clear evaluations because of some possible exceptions.

• 한국노년학
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• 제29권2호
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• pp.407-424
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• 2009

본 연구의 목적은 일상생활을 독립적으로 수행하기 어려워 도움이 필요한 노인을 돌보는 가족부양자의 부양경험을 다차원적으로 평가하기 위해 서양에서 개발된 부양자반응척도(CRA)를 우리나라 가족부양자에게 적합하도록 수정하여 한국형 부양자반응척도(K-CRA)를 제시하는 것이다. 이를 위해 우리나라 가족부양자를 대상으로 부양자반응척도(CRA)를 조사한 결과를 문항분석, 탐색적 요인분석, 타당도분석 등을 실시하였다. 연구의 대상은 조사시점을 기준으로 6개월 이상동안 일주일에 최소 7시간 이상의 돌봄을 일상생활수행능력에 제약이 있는 노인에게 제공한 253명의 가족부양자이었다. 분석결과를 통해 최종적으로 수정된 한국형 부양자반응척도(K-CRA)가 만족스러운 수준의 내적신뢰도, 구조적 타당도, 기준타당도, 수렴타당도를 지닌 것으로 나타났다. 본 연구를 통해 제시된 한국형 부양자반응척도(K-CRA)는 노인복지연구와 실천현장에서 가족부양자의 경험을 다차원적으로 평가할 수 있는 도구로 활용될 것으로 기대된다.

• 대한의생명과학회지
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• 제13권2호
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• pp.149-152
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• 2007

Mast cells play important roles in immune-related diseases, in particular, allergic diseases. Although 9-cis retinoic acid (9CRA) has been known as an immune regulator, its function in mast cells is not characterized well. In a previous paper, we demonstrated that 9CRA differentially decreases both CCR2 expression and the MCP-1-induced chemotactic activity of the human mast cell line, HMC-1 cells. In the present study, we examined the effects of 9CRA on the migration and expressions of inflammatory cytokines in HMC-1 cells. It was found that 9CRA significantly inhibited the migration of HMC-1 cells in response to stem cell factor (P<0.01), and it had no effect on the mRNA and protein expression of c-kit, a receptor binding to SCF. We further investigated the alternation of inflammatory cytokine expression and identified that 9CRA blocked the mRNA and protein expressions of Th2 cytokines such as interleukin (IL)-4 and IL-5. Taken together, our results demonstrate that 9CRA blocks SCF-induced cell movement and the protein secretion of IL-4 and IL-5, and this indicates that 9CRA may have anti-inflammatory effects on mast cells.

• 한국해양공학회지
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• 제28권1호
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• pp.85-92
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• 2014

Offshore fields are increasingly important for the development of offshore resources due to the growing energy needs. However, an offshore field for oil and gas production has difficult development conditions, e.g., high temperature, high pressure, sweet/sour compositions of fluids, etc. Corrosion is one of the biggest issues for offshore pipeline engineering. In this study, a Corrosion Resistant Alloy (CRA) pipe for corrosion prevention was investigated through its global demand and trends, and three types of CRA pipelines were introduced with detailed explanations. The usefulness of CRA was also evaluated in comparison to a carbon steel pipeline in terms of the structural strength, cost, and other factors. Offshore pipeline engineering, including mechanical design and verification of the results through an installation analysis based on numerical software, was performed for the carbon steel type and solid CRA type. The results obtained from this study will be useful data for CRA pipeline designers and researchers.

• 전력전자학회논문지
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• 제12권2호
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• pp.183-190
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• 2007

본 논문에서는 PWM 컨버터의 강인제어기를 제안한다. 제안된 컨버터제어기는 DC 출력전압 제어를 위한 PI 제어기와 입력전류를 전원과 동상인 정현파로 제어하기 위해 오차공간에서 제어 문제를 해결한 전류제어기로 구성되어있다. 종래에는 전류제어기의 설계과정에서 소자의 스위칭주파수 및 디지탈제어기의 샘플링 주파수 등을 고려하여 제어기 게인값에 대한 해를 구하는 과정에서 시행착오 방법을 사용하여야 했다. 그러나 제안된 제어기는 CRA 기법을 적용하여 원하는 응답속도 및 오버슈트를 가지도록 최적의 게인값을 설정하도록 하였다. 먼저 CRA 기법을 적용한 전류제어기 알고리즘을 설명하고 PSiM 시뮬레이션 및 실험을 통하여 제안된 제어기의 타당성을 검증한다.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2006년도 제37회 하계학술대회 논문집 B
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• pp.980-981
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• 2006

전력변환 장치에서 기존의 PID 제어기의 해석적인 해를 얻는 것은 매우 어려운 일이다. 최근에 단상 UPS용 인버터 시스템에서 CRA 기법을 이용한 새로운 제어알고리즘을 바탕으로 시스템의 제어기의 제어상수를 해석적으로 접근하여 좋은 성능을 얻은 바 있다. CRA 기법은 해석적으로 시스템의 응답속도 및 오버슈트를 임의의 제한범위 내로 설계할 수 있도록 하는 장점이 있다. 이러한 CRA 기법을 사용하여 컨버터 제어기 설계부분에 적응하여 해석적인 해를 얻고 PSiM 시뮬레이션을 통해 오버슈트와 빠른 응답을 확인한다.

• 한국농촌생활과학회지
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• 제6권1호
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• pp.41-54
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• 1995

This study is to investigate the marital conflict resolution acts (CRA) of rural spouses and to explore the relationship between the CRA and several important factors : socio-demographic, marital relation and drinking pattern factors. Participants in this study are 150 rural women who are married and live with their husband. A modification of the Conflict Tactics Scale is used to measure the CRA of four levels, reasoning, verbal aggression, minor physical violence, and heavy physical violence. The major findings of this study are as follows. First the frequencies of each type of the CRA-reasoning, verbal aggression, minor physical violence and heavy physical violence-are 12.1%, 57.9%, 17.1% and 12.9% respectively. Therefore, the verbal aggression is the most prevalent type of the CRA Second, the result from multiple regression shows that the conflict from husband's whoring, husband's drinking capacity and family type have a meaningful impact on husband's physical violence.

• Nuclear Engineering and Technology
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• 제51권1호
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• pp.31-44
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• 2019

This study simulated a control rod assembly (CRA), which is a part of reactor shutdown systems, in immersed and fluid flow conditions. The CRA was inserted into the reactor core within a predetermined time limit under normal and abnormal operating conditions, and the CRA (which consists of complex geometric shapes) drop behavior is numerically modeled for simulation. A full-scale prototype CRA drop test is established under room temperature and water-fluid conditions for verification and validation. This paper describes the details of the numerical modeling and analysis results of the several conditions. Results from the developed numerical simulation code are compared with the test results to verify the numerical model and developed computer code. The developed code is in very good agreement with the test results and this numerical analysis model and method may replace the experimental and CFD method to predict the drop behavior of CRA.

• 한국압력기기공학회 논문집
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• 제12권1호
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• pp.134-140
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• 2016

The Control Rod Assembly (CRA) controls the reactor power by adjusting its position in the reactor core during normal operation and should be quickly inserted into the reactor core by free drop under scram condition to shut down chain reactions. Therefore, the drop time of the CRA is one of important factors for the safety of the nuclear reactor and must be experimentally verified. This study presents the drop performance test of the CRA which has been conceptually designed for the Proto-type Generation IV Sodium-cooled Fast Reactor. During the test, the CRA was free dropped from a height of 1 m under different flow rate conditions and its drop time was measured. The results showed that the drop time of the CRA increased as the flow rate increased; the average drop times of the CRA were approximately 1.527 seconds, 1.599 seconds and 1.676 seconds at 0%, 100% and 200% of design flow rates, respectively.