• Journal of Pharmacopuncture
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• v.10 no.2 s.23
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• pp.25-30
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• 2007

Objectives : Free radical metabolism seems to occupy a remarkably common position in the mechanisms of aging and aging related disease. Oxidative damage to DNA, lipids. proteins and other molecules may contribute to the development of cancer, cardiovascular disease and possibly neurodegenerative disease. This study was designed to find out whether Carthami Flos Herbal-Acupuncture Solution can scavenge Nitric Oxide(NO) or not. SNAP is NO generator. NO concentration was estimated after 2,6, 12 and 24 hrs in no treatment group, after treatment with Vit. C or 1, 10, 100${\mu}$g/m1 of Carthami Flos Herbal-Acupuncture Solution. There was no significant scavenging effect of Carthami Flos Herbal-Acupuncture Solutionon NO after 2 hrs. But there was a significant scavenging effect of Cafhami Flos Herbal-Acupuncture Solution on NO in 10${\mu}$/m1 group after 6hrs. And there was a significant scavenging effect of carthami Flos Herbal-Acupuncture Solution on NO in 1, 10${\mu}$g/ml group after 12, 24 hrs. These results suggest that Carhami Flos Herbal-Acupuncture Solution has scavenging effect on NO. This study shows that Carthami Flos Herbal-Acupuncture Solution can be used for aging related disease and further studies are required to investigate the antioxidative effects of it.

• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.4
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• pp.1228-1231
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• 2004

There are little report on treatment of compression fracture with Traditional Korean Acupuncture Therapy. We suggest to treat Lumbar compression fracture with the SAAM(사암) Acunpture, Carthami-Flos Herbal Acupuncture Therapy. The Treatment methods of the SAAM(사암). Acnpucture, Eliminating extravasated Blood, was apllied at SP3, LU9, LI11 and Carthami-Flos Herbal Acupuncture at the waist. We treated the patient who was diagnosed as lumbar compression fracture by MRI. After 15 days of Treatment, SAAM Acupuncture and Carthami-Flos Herbal Acupuncture, a remarkable improvement was made for Lumbar compression fracture. There was reports about SAAM Acupuncture and Carthami-Flos Herbal Acupuncture of Patient with Lumbar Compression Fracture. It is very effective to reduce the pain and shortening the period of therapy.

• Journal of Acupuncture Research
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• v.19 no.4
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• pp.112-123
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• 2002

Objective : This study was designed to find out the effects of Carthami-Flos herbal acupuncture theraphy on neck pain due to soft tissue damage. Methods : This study was carried out for 34 patients who had neither structural defectiveness of cervical spine nor neural injury but simple soft tissue damage among poeple who visited Hye-dang Oriental Hospital from December 1, 2001 to June 15, 2002. Group A of 17 patients was taken Carthami-Flos herbal acupuncture treatment. Group B of 17 patients was taken common acpuncture treatment. Results : We have found out the good effects of Cathami-Flos herbal acupuncture on the patients due to soft tissue damage. Conclusion : The Carthami-Flos herbal acupuncture treatment is useful on the patients of neck pain due to soft tissue damage.

• Journal of Pharmacopuncture
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• v.7 no.2
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• pp.91-96
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• 2004

Objective : Alopecia areata is a common disease and the difficulty of its medical management is well known. This study was designed to investigate the effect of bee venom and Carthami Flos herbal acupuncture. Method : The patient was managed by bee venom, carthami-flos herbal acupuncture and General acupunture. Herbal acupuncture was injected subcutaneously into the lesion. We checked involvement in plaque, according to evaluation of the effect on alopecia areata. Results : After 5 month of treatment, the lesion had been replaced with new terminal hair. Evaluation of the effect on alopecia areata The score changed from 0 to 3 point. Conclusion : These result suggest that bee venom and Carthami Flos herbal acupuncture has good effect on alopecia areata. But further studies are required to concretely prove the effectiveness of bee venom and Carthmi Flos herbal acupuncture for treating alopecia areata.

• Journal of Acupuncture Research
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• v.23 no.6
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• pp.85-101
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• 2006

Objectives : This study was designed to find out correlation of filtration rate of herbal-acupunctures and pain score of herbal acupuncture stimulation. Methods : Filtration rate of Hwangryunhaedoktang herbal acupuncture, Kidney yang deficiency number two herbal acupuncture, Hominis Placenta herbal acupuncture, Cervus Elaphus herbal acupuncture, BUM herbal acupuncture and Carthami Flos herbal acupuncture were measured at the korean institute of herbal acupuncture. And Hwangryunhaedoktang herbal acupuncture, Kidney yang deficiency number two herbal acupuncture, Hominis Placenta herbal acupuncture, Cervus Elaphus herbal acupuncture, BUM herbal acupuncture and Carthami Flos herbal acupuncture were injected at Xie points of the subjects. Results : Ranking of herbal acupunctures filtration rates is the same as ranking of pain score and duration time of herbal acupuncture. Correlation analysis result of herbal acupunctures filtration rates and herbal acupuncture VAS with a simple linear regression analysis is that correlation coefficient of Hwangryunhaedoktang herbal acupuncture, Kidney Yang Deficiency Number Two herbal acupuncture, Hominis Placenta herbal acupuncture, Cervus elaphus herbal acupuncture, BUM herbal acupuncture. Carthami Flos herbal acupuncture is 0.44, 0.53, 0.58, 0.76, 0.47 and 0.54. Correlation analysis result of herbal acupuncture's filtration rates and herbal acupuncture stimulation's duration time is that correlation coefficient of Hwangryunhaedoktang herbal acupuncture, Kidney Yang Deficiency Number Two herbal acupuncture, Hominis Placenta herbal acupuncture, Cervus Elaphus herbal acupuncture, BUM herbal acupuncture, Carthami Flos herbal acupuncture is -0.09, 0.11, -0.07, 0.28, -0.11 and -0.09. Conclusion : We found the correlation of filtration rate of herbal-acupunctures and pain score of herbal-acupuncture stimulation. This study help to control pain amount and pain duration time of herbal acupuncture treatment. And this study improve acupuncture theory of herbal acupuncture.

• Journal of Acupuncture Research
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• v.21 no.5
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• pp.205-218
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• 2004

Objectives : The purpose of this experiment is to study on the anti-cancer, anti-metastasis and immune response improvement effects of Herbal-acupuncture with Carthami Flos infusion solution(CTT-HAS). Methods : We injected Carthami Flos infusion solution into Chung-wan(CV12) of C57BL/6 mouse which is corresponding to human Chung-wan(CV12). We observed its effect on the number of $CD25^{+}/CD4^{+}$, $CD8^{+}/CD3e^{+}$, $CD69^{+}/B220^{+}$, $NK^{+}/CD3e^{+}$ cells in mouse PBMCs, the number of the pulmonary colony, and the effect on MST and ILS of C57BL/6 mice implanted intravenously with B16-F10 melanoma. Results Conclusions : 1. The spleen cells proliferation of the sample groups treated with CTT-HAS extract has increased significantly compared with that of the control group. 2. The percentage of the $CD25^{+}/CD4^{+}$, $CD8^{+}/CD3e^{+}$, $CD69^{+}/B220^{+}$, $NK^{+}/CD3e^{+}$ cells in C57BL/6 mouse PBMCs of the sample groups treated with CTT herbal-acupuncture has increased compared with that of the control group. 3. The lung colony number of the sample groups CTT Herbal-acupuncture has decreased significantly compared with that of the control group. 4. MST and ILS of the sample groups CTT herbal-acupuncture have increased significantly compared with those of the control group.

• Journal of Acupuncture Research
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• v.21 no.6
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• pp.291-298
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• 2004

Objective : This study was designed to investigate the effect of Carthami Flos Herbal-Acupuncture(CF) on Subluxation of the Head of the Radius. Methods : CF was administered one time per 2days. The following points were selected : TE10(天井), LI11(曲池), LI10(手三里). After CF administration conventional body-acupuncture was performed at the same points. We evaluated the patient through Visual Analogue Scale(VAS) and Elbow Range of Motion(ROM). Results : After 6 times of treatment, the patient showed that clinical symptoms was disappeared, VAS changed from 10 to 1 and there was no limitation of ROM. Conclusions : According to the results, CF and early Exercising may have rapid effects on the Subluxation of the Head of the Radius. But further studies are required to prove the effect of CF on Subluxation of the Head of the Radius.

• Journal of Pharmacopuncture
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• v.8 no.2
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• pp.47-52
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• 2005

Objectives : This study was performed to examine effects of herbal acupuncture therapy on shoulder pain. Methods : Control group were treated by common acupuncture therapy and sample group were treated by common acupuncture therapy and herbal acupuncture therapy. We compared control group with sample group by VAS and ROM. Results : VAS of sample group were more decreased than control group. ROM of sample group were more improved than control group. Conclusion : The herbal acupuncture therapy may be good effects on the shoulder pain.

• Journal of Acupuncture Research
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• v.24 no.6
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• pp.45-61
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• 2007

Objectives : The purpose of this study is to observe the effects of Carthami Flos herbal-acupuncture (CF-HA) at Joksamni($ST_{36}$) on arthritis in mice induced by Collagen II. Methods : The author performed several experimental items, including arthritis evaluation, change in weight, spleen size and stenosis rate, change in cytokine level, IgG, IgM and anti-collagen II, change of immunocyte count and histological change of the CIA mouse joint. Conclusions are as follows: Results : 1. In the CF-HA, the arthritis index and rate and the incidence of arthritis were decreased as the experiment proceeded. 2. In the CF-HA, spleen swell and stenosis, joint edema and change were decreased. 3. In the CF-HA, the level of $IL-1{\beta}$, IL-6, $TNF-{\alpha}$ and $IFN-{\gamma}$ in blood serum were significantly decreased. 4. In the CF-HA, the level of IgG, IgM and anti-collagen II were decreased. 5. In the CF- HA, $IFN-{\gamma}$, $IFN-{\gamma}/IL-4$, IL-10 of the culture fluid was decreased. 6. In the CF-HA, the cell rate of $CD3e^+$ and $CD45R^+$, $CD4^+$ and $CD8^+$, $CD4^+/CD25^+$ in spleen was similar to the cell rate of the normal group. 7. In the CF-HA, the cell rate of $CD4^+/CD25^+$, $CD45R^+/CD69^+$ in a lymph node was decreased as in the normal group. 8. In the CF-HA, the cell rate of $CD3^+/CD69^+$, $CD11b^+/Gr-1^+$ in joints was decreased as in the normal group. 9. In the CF-HA, the cartilage destruction and the inflammation cell growth in the H&E stain were decreased. The collagen fiber in the M&T stain were less destructed, therefore the result was similar to the normal group. Conclusions : These results suggest that CH-HA at $ST_{36}$ has an effect in controlling immune reaction and suppressing inflammation in rheumatoid arthritis therefore, the continuous flow of the following study is expected.

• The Journal of Korean Medicine
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• v.28 no.2 s.70
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• pp.93-113
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• 2007

Objective : To research Trends of studies about anti-inflammation and pain relief, obesity, and safety of herbal acupuncture therapy by analyzing domestic theses, published since 2001, about herbal acupuncture therapy. Methods : Domestic theses, published since 2001, mentioning anti-inflammation or pain relief, obesity, or safety of herbal acupuncture therapy were reviewed and analyzed. These theses were then classified by university, year, and subject. Results : The following results were obtained in this study. 1. Among published theses related to anti-inflammation effects of herbal-acupuncture, studies about arthritis comprised the most part, 52. In theses relating to causes of arthritis, 16 were about adjuvant, which was the most, followed by Type II collagen, LPS and carrageenan. Blood test, reactions of inflammation and revelation of cytokine and immune cellswere methods for evaluating anti-inflammation effect. The tendency of experimental methods was to focus on molecular biologic method. 2. In theses related to pain relief, many clinical attempts with herbal injection were carried out, and Carthami Flos and Scolopendrawere used most. Observing reduction of pain inducing factor and checking behavioral change were methods for evaluating pain relief. 3. In theses related to obesity, research focused on effects in association with spots on the body suitable for acupuncture. There were also attempts comparing effectiveness between single injections and complex injections. Astraball Radix, Angelica Gigantis Radix, Coicis Semen and Taeumjowetang were used. Evaluation of anti-obesity effects were by weight loss, food efficiency, blood lipid profile and evaluation of liver function. 4. In theses related to safety of herbal-acupuncture, Herba Chelidonii Chaenonelis Fructus, Clematis Florida Thunb, Corydalidis Tuber, Paeoniae Radix, and Carthami Flos which marked 2 theses each were most studied. Methods of evaluating safety were mostly by observing liver and kidney functions based on blood test, and by applying herbal injections to clinical treatment. Conclusion : Herbal acupuncture is being used in various ways associating with its anti-inflammation, pain relief and anti-obesity effect. Studies on efficacy and mechanism of herbal acupuncture are being conducted even at the molecular biology level.