• 대한세포병리학회지
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• 제19권2호
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• pp.86-98
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• 2008

Cerebrospinal fluid (CSF) cytology is based on the cytopathologic findings of other body fluids. However, CSF's cytologic features are less familiar to physicians than are those of the other body fluid's cytology because of the small number of cases. The low overall diagnostic accuracy and the presence of false positivity still remain as problems. The incidence of lymphoreticular malignancies and metastatic carcinomas are rather higher than that of primary brain tumors. In this review, the characteristic cytologic findings of conventional CSF cytology are reviewed along with a brief note on the technical preparation and diagnostic pitfalls.

• 한국전산유체공학회지
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• 제6권1호
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• pp.40-46
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• 2001

Pressure-flow control characteristics of a commercially available cerebrospinal flow(CSF) control shunt valve was studied using flow/structure interaction analyses. Pre-stress of the valve diaphragm(membrane) was accounted for the simulation of an actual valve. The present results were in good agreement with the valve specification listed in the commercially available CSF control valve. The flow/structure interaction analysis of the present study can be effectively used to design a variety of CSF control shunt valves.

• 대한수의학회지
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• 제36권3호
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• pp.743-745
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• 1996

가축 특히 대동물에 있어서 전방수의 화학조성에 관한 보고는 극히 드물다. 따라서 본 연구에서는 한우 및 유우(Holstein)를 대상으로 전방수에 대해 화학조성을 검토하였다. 유의의 protein, urea nitrogen, creatinine, cholesterol, calcium, sodium, potassium과 chloride 등이 분석 검출되었다. 이러한 조성분포는 혈장에서 보다는 수액(cerebrospinal fluid)의 조성에 더 유사한 것으로 나타났으며, 한우 및 유우에 있어서 조성에 관한 차이는 거의 인정되지 않았다.

• 한국전산유체공학회:학술대회논문집
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• 한국전산유체공학회 2000년도 춘계 학술대회논문집
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• pp.21-26
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• 2000

Pressure-flow control characteristics of a commercially available cerebrospinal flow(CSF) control shunt valve was tested using fluid-solid interaction analysis. Pre-stress of the valve diaphragm(membrane) was computed for proper valve opening. The results were ir good agreements with the valve specification listed in the commercially available CSF control valve. The results of the study can be effectively used to design variety of CSF control shunt valves.

• The Korean Journal of Physiology and Pharmacology
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• 제2권2호
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• pp.193-199
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• 1998

To elucidate the mechanism involved in the cerebral vascular spasm following subarachnoid hemorrhage (SAH), the effects of the cerebrospinal fluid (CSF) obtained from the SAH patients on the resting tension and its influence on the contractile responses to various vasoactive agents and to hypoxia were investigated in isolated porcine cerebral arteries. All the CSFs containing hemoglobin (Hb) produced contraction and some Hb-free CSFs also elicited contraction. When the Hb-free CSF was separated by microfilter, the filtrate of ＜30,000 MW did not produce contraction, while the fraction above 30,000 MW elicited more marked contractile responses than the unfractionated CSF. The CSF contraction was significantly attenuated in the presence of indomethacin or nimodipine, whereas the contractions induced by KCl, prostaglandin $F_{2{\alpha}}$ ($PGF_{2{\alpha}}$), or endothelin-1 (ET-1) were not affected by the CSF pretreatment. However, the contractile responses induced by 5-hydroxytryptamine (5-HT) and phenylephrine (PE) were markedly potentiated by the pretreatment. Hypoxia-induced vasoconstriction was significantly potentiated by the pretreatment with either unfractionated CSF or the CSF fraction of above 30,000 MW. These results suggest that unknown vasocontractile substance(s) exists in the Hb-free CSF and that the substance, with its MW above 30,000, is activated by hypoxia and acts synergistically with 5-HT and PE, and that extracellular calcium influx and cyclooxygenase are also involved in the cerebral vasoconstrictory effect of Hb-free CSF.

• Journal of Microbiology and Biotechnology
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• 제12권3호
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• pp.508-513
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• 2002

Human endogenous retroviral long terminal repeats (LTRs) have been found to be coexpressed with sequences of genes located nearby. It has been suggested that the LTR elements have contributed to the structural change or genetic variation of human genome connected to various diseases. The HERV-W family has been identified in the cerebrospinal fluids and brains of individuals with schizophrenia. Using a cDNA library derived from a human brain, the HERV-W LTR elements were examined and five new LTR elements were identified. These elements were examined using a YAC clone panel from the Xq21.3 region linked to psychosis that was replicated on the Y chromosome after the separation of the chimpanzee and human lineages. Fourteen elements of the HERV-W LTR were identified in that region. Those LTR elements showed a high degree of sequence similarity ($91.8-99.5\%$) with previously reported HERV-W LTR. A phylogenetic tree obtained from the neighbor-joining method revealed that new HERV-W LTR elements were closely related to the AXt000960, AF072504, and AF072506 from the GenBank database. The data indicates that several copy numbers of the HERV-W LTR elements exist on the Xq21.3 region and are also expressed in the human brain. These LTR elements need to be further investigated as potential leads to neuropsychiatric diseases.

• Journal of Life Science
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• 제11권2호
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• pp.83-86
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• 2001

The long terminal repeat (LTR) elements of human endogenous retrovirus (HERV) have been found to be coexpressed with genes located nearby. It has been suggested that the LTR elements have contributed to the genetic variation of human genome connected to various diseases. Recently, HERV-W family was identified in the cerebrospinal fluids and brains of individuals with schizophrenia. Using genomic DNAs derived from schizophrenia, we performed PCR amplification and identified six HERV-W LTR elements. Those LTR elements showed a high degree of sequence similarity (87.7-99.5%) with HERV-W LTR (AF072500). Sequence analysis of the HERV-W LTR elements revealed that clone W-sch1 showed identical sequence with the AC003014 (PAC clone RP1-290B4) derived from human Xq23. Clone W-sch2 was closely related to the AC0072442 derived from human Y chromosome by phylogenetic analysis. Our data suggest that new HERV-W LTR elements in schizophrenia may be very useful for further studies to understand neuropsychiatric diseases.

• 생명과학회지
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• 제11권4호
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• pp.379-384
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• 2001

Long terminal repeats(LTRs) of the human endogenous retrovirus(HERV) heve been found to be coexpresed with genes located nearby. It has been suggested that the LTR elements have contributed to the genetic variation of human genome connected to various diseases. Recently, HERV-W family was identified in the cerebrospinal fluids and brains of individuals with schizophrenia. Using cHNA library derived from human fetal brain, we performed PCR amplification and identified seven new HERV-W LTR elements. Those LTR elements showed a high degree of sequence similarity(98∼99%) with HERV-W (AF072500). A phylogentic tree obtained by the neighbor-joining method revealed that seven new HERV-W LTR elements(FB-1, 2, 4, 8, 9, 10, 12) were closely related to the AX000960, AF072504, and AF072506 from Gen Bank database. Our data suggest that several copy numbers of the HERV-W LTR elements are expressed in human feta brain and may contribute to an understanding of biological function connected to neuropsychiatric diseases.

• 한국방사선학회논문지
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• 제7권4호
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• pp.265-269
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• 2013

뇌척수액을 생산하고 있는 choroid plexuse를 확산강조영상 검사기법에 따라 신호강도를 분석하여 임상적인 유용성을 알아보고자 하였다. $T2^*$-DW-EPI 기법을 적용하여 choroid plexus가 고 신호 강도를 보이는 대상자를 추가적으로 FLAIR-DW-EPI 기법을 적용하여 영상을 얻었다. 두 기법으로 얻은 확산강조영상을 가지고 choroid plexus의 신호강도와 확산계수를 구하여 비교하였다. 그 결과 FLAIR-DW-EPI 기법에서는 choroid plexus의 신호가 뇌 실질과 같거나 저 신호로 나타나 두 기법간의 신호강도의 차이가 있음을 확인하였다. 이는 $T2^*$-DW-EPI 확산강조영상에서 choroid plexus가 고 신호를 보인 환자의 경우 FLAIR-DW-EPI 기법을 추가로 검사하여 정보를 제공함으로서 choroid plexus의 질병 유무를 진단하는데 도움이 될 것으로 생각한다.

• Pediatric Infection and Vaccine
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• 제6권2호
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• pp.210-218
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• 1999

목 적 : 저자들은 소아에서 배양으로 확진된 장바이러스 감염의 역학 및 임상적 특성을 규명하고자 하였다. 방 법 : 1996년 1월부터 1998년 12월까지 한림대학교 부속 한강, 강암, 동산, 강동 및 춘천 성심병원 소아과에 입원하여 장바이러스가 배양된 환아를 대상으로 각 바이러스의 유행 양상, 성별, 연령 및 임상양상을 분석하였다. 결 과 : 장바이러스는 대변 245례중 126례(51.4%), 비인두흡인물 89례중 15례(16.8%) 뇌척수액 1,835례중 195례 (10.6%)에서 배양되었다. 이중 echovirus (Echo)는 273(30형 197, 9형 46, 6형 17, 미분류 13)례. coxsackievirus B(CB)는 24(2형 11, 5형 2, 미분류 11)례. coxsackievirus A(CA) 24형이 7례, 분류되지 않은 장바이러스가 32례이었다. 2) 장바이러스는 '96년에 65례 (Echo 9형 46례), '97년에 239례 (Echo 30형 197례), '98년에 32례 (CB 15례 : CB 2형 9례)가 분리되었으며, '66년은 8~10월, '97년과 '98년은 5~7월에 주로 발생하였다. 3) 장바이러스 감염아의 평균 연령은 $62.1{\pm}38.0$개월이었고 74.6%가 7세 미만이었으며, 남아 203명 (67%), 여아 100명 (33%)으로 남아에서 많이 발생하였다. 4) 장바이러스가 배양된 305명 환아 중 242명 (79.3%)에서 무균성 뇌막염이 확진되었으며, 사망한 환아는 없었다. 결 론 : 장바이러스 유행은 늦봄부터 가을 사이에 발생하였고, '96년은 Echo 9형, '97년은 Echo 30형, '98년은 CB 2형이 주된 원인이었으며, 대변의 배양율이 가장 높았다. 장바이러스가 배양된 한아는 남아가 많았고 학동 전기 소아에서 호발하였으며, 79.3%가 무균성 뇌막염으로 진단되었다.