• Journal of Physiology & Pathology in Korean Medicine
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• v.28 no.1
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• pp.53-58
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• 2014

The object of this study was to evaluate the single dose toxicity of Choweseuncheng-tang (CWS), a polyherbal formula have been traditionally used as prevention or treatment agent for various diseases as Tae-eumin prescription on Korean medicinal theory, Sasang-euihak, in male and female mice. Aqueous extracts of CWS (yield = 11.00%) was administered to female and male mice as an oral dose of 2,000, 1,000 and 500 mg/kg (body weight) according to the recommendation of Korea Food and Drug Administration (KFDA) Guidelines. Animals were monitored for the mortality and changes in body weight, clinical signs and gross observation during 14 days after dosing, upon necropsy; organ weight and histopathology of 14 principle organs were also examined. As results, we could not find any CWS treatment related mortality and clinical signs, changes in the body and organ weights, gross findings and changes in histopathology of principle organs, except for some dose-independent accidental findings. The results obtained in this study suggest that the 50% lethal dose and approximate lethal dose of CWS aqueous extracts in both female and male mice were considered as over 2,000 mg/kg, the limited highest dosage recommended by KFDA Guidelines, and can be safety used in clinics.

• Journal of Acupuncture Research
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• v.22 no.3
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• pp.145-153
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• 2005

Objective : This study was designed to investigate the effects and adverse effects of Choweseuncheng-tang on obesity patients Methods : Choweseuncheng-tang was given to 20 obesity patients who have no abnormality of GOT, GPT and past medical history. Additionally, electroacupuncture was performed on Fuchao(腑巢) with 60Hz. We compared body weight, body fat and laboratoy test(GOT, GPT, BUN, Creatinine) between before and after treatment. Blood pressure, heart rate and clinical symptoms were checked to investigate the side effects. Decrease of body weight was checked in accordance with Sasang constitutional type, appetite type, and BMI. Results : 6 patients(BMI 23-24.9), 10 patiets(BMI 25-29.9), and 4 patients(BMI over 30) were showed decrease of body weight. We found body fat was decerased $3.16{\pm}1.25%$. BUN, Creatinine, GOT and GPT were increased within normal range. There were adverse event of autonomic hyperactivity(11 patients), gastrointestinal symptoms(7 patients) and others(3 patients). Conclusions : According to above results, Choweseuncheng-tang could be used effectively, but should be taken cautiously on obese patients.

• Journal of Sasang Constitutional Medicine
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• v.29 no.3
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• pp.248-261
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• 2017

Objectives The purpose of this study is to analyze the decision making process of prescribing Yeoldahanso-tang and Taeeumjowi-tang Choweseuncheng-tang using decision tree. Methods We used collected the prospective clinical data of TE type from September 2012 to July 2015. In this study, we used gender, BMI, blood pressure, pulse and clinical symptoms (digestion, sweat, defecation, urination, sleep, physical status, emotion, heat-coldness, water consumption, facial color) as variables. Decision trees were analyzed using open source R version 3.3.2. Results & Conclusions We found that the decision trees differed among institutions. However, in all institutions, it was found that stool type (ordinary symptom), urine frequency (ordinary and present symptom) and anxiety (ordinary symptom) were important in the decision of prescription. Besides, clinical informations such as sex, Body Mass Index and blood pressure affected the prescription decision.

• Journal of Sasang Constitutional Medicine
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• v.29 no.2
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• pp.202-209
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• 2017

Objectives The purpose of this study is to investigate the effect of Choweseuncheng-tang on Underlying Edema and weakness by Deep Vein Thrombosis(DVT) in a 74-year-old female patient. Methods Patient was treated with Jowiseungcheong-tang. Patient's symptom was assessed NRS, Tape measurement, Motor grade. The treatment was executed three times everyday from May 19th to May 23th, 2017. Patient was observed from May, 18th to May, 23th. Results After 5 days of using Jowiseungcheng-tang, patient's edema symptoms and weakness were evaluated by NRS, Tape measurement, Motor grade. After the treatment, Tape measurement score decreased. The score of Motor grade increased. However, the score of NRS was nonsignificant. Conclusions The results suggest that Jowiseungcheng-tang can be a valuable option in treating Underlying Edema and weakness by DVT.

• The Journal of Korean Medicine
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• v.32 no.4
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• pp.37-47
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• 2011

Objectives: This study investigated the effects of Choweseuncheung-tang (CWSCT, Tiaoweishengqing-tang) on body weight, serum lipid level, serum insulin level and serum leptin level in high-fat-diet-induced obese mice. Methods: Four-week-old male C57BL/6 mice were randomly divided into three groups (7 mice in each group), including a normal group, control group, and CWSCT group. The normal group was fed a general diet, but the other groups were fed a high fat diet. The CWSCT group was administered CWSCT for 4 weeks. Animals were weighted weekly and blood lipids, insulin and leptin levels were measured after 4 weeks. Results: The results were as follows. 1. In the CWSCT group, compared with the control, body weight gain was significantly inhibited. 2. In the CWSCT group, compared with the control, the level of HDL cholesterol in serum increased significantly. 3. In the CWSCT group, compared with the control, the ratio of total cholesterol to HDL cholesterol decreased significantly. 4. In the CWSCT group, compared with the control, the elevation of serum leptin level was significantly inhibited. Conclusions: Choweseuncheung-tang treatment has inhibitory effects on obesity and hyperlipidemia in high-fat-dietinduced obese mice.

• Journal of Korean Medicine for Obesity Research
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• v.7 no.1
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• pp.87-96
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• 2007

Objectives : This study was performed to evaluate the effect of oriental medical treatment on aged female obese patient. Methods : We experienced an aged female obese patient. We applied herbal medication(Choweseuncheng-tang), electrolipolysis, auricular acupuncture to her from 26th, March. 2007 to 25th, May. 2007. And we examined the changes of her weight, body composition, body size, skin resistance variability, visual analogue scale of knee pain. Results : 1. Her weight decreased from 73.5kg to 71.1kg and body mass index(BMI) decreased from $29.46kg/m^2$ to $28.11kg/m^2$. 2. Body fat mass(BFM) decreased from 25.7kg to 21.6kg but body muscle mass(BMM) increased from 45.1kg to 46.7kg. 3. Waist-hip ratio(WHR) decreased from 0.96 to 0.92. 4. Basal metabolic rate(BMR) increased from 1,273kcal to 1,314kcal. 5. The circumference of upper extremity decreased 1.03cm and lower extremity decreased 1.30cm but the circumference of the muscle of upper extremity increased 0.41cm and lower extremity increased 0.63cm. 6. The circumference of chest and hip are decreased. In addition to the circumference and fat of abdomen are decreased. 7. The visual analogue scale of knee pain is improved. Conclusions : According to above results, oriental medical treatment could be used safety to aged obese patients without loss of fat free mass. The study is more required to aged obese patient from now on.