• 대한한의진단학회지
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• 제22권1호
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• pp.11-18
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• 2018

Objectives The incidence of degenerative diseases is increasing as society ages, and this increased the economic burden on society. Oxidative stress was also under suspicion as one of the causes. Recent studies have found that Curcuma longa Rhizoma had antioxidant, anti-inflammatory, antimutagenic, and anticancer effects. Through this study, we figure out trends in Curcuma longa Rhizoma research and evaluate the therapeutic potential of Curcuma longa Rhizoma for dementia. Methods The search was made using domestic and international internet search sites. "Naver academic," "Google scholar," "Korea institute of oriental medicine (KIOM OASIS)," "Korean traditional knowledge portal (KTKP)," "Library of Congress," "Research information sharing service (RISS)," "National Digital Science Links (NDSL)," and "Pub med" are used to search. The searched for words were "turmeric," "Curcuma longa Rhizoma," "antioxidant," and "nerve regeneration." Results It could be seen that a lot of research done on Curcuma longa recently. In previous studies, the most common research disease was cancer. In previous studies, the most common effects of Curcuma longa was antioxidant and anticancer. Curcumin, Vitamin B1, and various essential oils were the functional components of Curcuma longa Rhizoma. Curcuma longa Rhizoma performs DPPH radical scavenging activity and ABTS radical cation decolorization activity; it inhibits NO and iNOS. Conclusion The destruction of nerve cells due to oxidative stress is a cause of dementia. Curcuma longa Rhizoma have antioxidant effects. Therefore, we believed that it is an effective treatment for dementia. Various studies will be made on Curcuma longa Rhizoma.

• 대한본초학회지
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• 제20권4호
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• pp.27-31
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• 2005

Objectives : The anticancer response of three different types of water extracts of Zingiberaceae Curcuma longa L. tested for sarcoma 180. Only few studies carried out to investigate the effects of other contents of Curcuma longa L. in anticancer activities, therefore, in this study we have investigated the effects of other component then curcumin in Curcuma longa L. for anticancer a activities. Methods : Three different types of water extracts of Curcuma longa L. were prepared as follows. The sarcoma cells (S180) were maintained in Dulbecco's modified Eagle's medium (DMEM) and were seeded on 24-well cell culture cluster flat bottom with lid tissue culture treated non-pyrogenic polystyrene. The growth of sarcoma 180 was monitored for 1, 2 and 5 days. The sarcoma cells were pictured using inverted microscope and cell density was counted using hemocytometry. Results : After 5 days in the culture medium the results showed high growth of sarcoma 180 for control condition and the surface of CCP plates were fully covered with the cells. In case of medium in which the 10% of filtered water extract of Curcuma longa L. was added a very limited growth of sarcoma 180 was observed. The results were showed only small difference in cell density for two different concentrations of unfiltered water extracts of Curcuma longa L. whereasin case of filtered water extracts the control of sarcoma growth shows better result. Conclusion : The filtered water extracts showed the best result relatively to the unfiltered water extracts for two different concentrations. This indicates that the water extracts of Curcuma longa L. can have anticancer activities possibly without curcumin.

• 한국조리학회지
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• 제20권1호
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• pp.143-158
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• 2014

본 연구는 울금 농축액을 첨가한 불고기 소스의 이화학적 특성 및 관능특성에 대하여 연구하였다. 불고기 소스의 울금 농축액의 첨가량이 증가할수록 pH가 높아지는 경향을 나타내었으며 불고기 소스의 울금 농축액의 첨가량이 증가할수록 색도(명도; L, 적색도; a, 황색도; b)도 높아지는 경향을 나타내었다. 울금 농축액 첨가 불고기 소스의 DPPH 라디컬 소거능은 울금 농축액의 첨가비율이 증가할수록 높아지는 경향을 나타내었으나, 총 폴리페놀 함량은 각 시료간 유의적인 차이를 나타내지 않았다. 관능평가에서는 울금 농축액 10% 첨가 소스가 맛 기호도 측면에서 가장 우수했던 반면, 전반적인 기호도 측면에서는 울금 농축액 20% 첨가 소스가 가장 우수하였다. 또한, 울금 농축액 20% 첨가 쇠고기 구이가 관능 기호도 측면에서 가장 우수하였다. 이상으로써, 불고기 소스의 관능적 기호성을 위해서는 울금 농축액 20%를 첨가하는 것이 가장 적합할 것으로 판단된다.

• 한국약용작물학회지
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• 제22권2호
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• pp.121-126
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• 2014

This study was designed to evaluate antioxidant activity of Curcuma longa L. leaves treated by ultra high pressure extraction. Curcuma longa L. leaves was subjected to 5,000 bar for 5 and 15 min at $25^{\circ}C$ The highest phenolics and flavonoids content was observed in the treatment of high pressure extraction for 15 min ($308.28{\mu}g/mg$, $124.33{\mu}g/mg$). The DPPH scavenging activity was 82.34% at $1.0mg/m{\ell}$ of Curcuma longa L. leaves treated by ultra high pressure process for 15 min. The highest SOD-like acitivity of Curcuma longa L. leaves ($1.0mg/m{\ell}$) was observed at ultra high pressure extraction for 15 min (67.54%). The high pressure extraction significantly increased the contents of phenolics and flavonoids and also enhanced the antioxidant activity. These results provide useful information for enhancing biological properties of Curcuma longa L. leaves.

• 대한한방종양학회지
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• 제9권1호
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• pp.15-37
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• 2003

Objective: We are aimed to identify anti-tumor effects of Curcuma longa L. on the stomach cancer cells through molecular biologic methods. Material & Methods: We used AGS as human stomach cancer cells obtained from American Type Culture Collection. The boiled extract of Curcuma longa L. $5{\mu}l$ (Sample I), $10{\mu}l$ (Sample II) was treated to cultural media(ml) for 0, 6, 12, 24, 48 hours. We measured the killing effect on stomach cancer cells through Trypan blue exclusion test and the suppressive effect on viability of stomach cancer cells via MTT assay. For identification of its anticancer mechanism, the revelation of Bcl-2, Bcl-XL, and Bax which are genes related to apoptosis using the quantitative RT-PCR, change of mitochondria membrane permeability and membrane potential via flow cytometry, the cycle of cell mitosis, caspase cleavage and annexin V staining were examined. Results: 1. showed significant killing effect on stomach cancer cell than the control group with a time(6 hours later) and density dependent manner, which was statistical significance. 2. Extract of Curcuma longa L. showed suppressive effect on viability of stomach cancer cells that each test groups had more suppressive effects on viability of stomach cancer cells than the control group with a time(6 hours later), which was statistical significance.(p<0.05) 3. In the test about the revelation of genes related to apoptosis, the revelation of Bcl-2 and Bcl-XL decreased with a density manner which was statistical significance. but the revelation of Bax was not changed with statistical significance. 4. Extract of Curcuma longa L. caused apoptosis by decreasing the absorbance of mitochondria with statistical significance, and also induced apoptosis by decreasing the membrane potential of mitochondria. 5. Extract of Curcuma longa L. destructed the cell cycle of cell mitosos. 6. Cell apoptosis was induced by extract of Curcuma longa L. certificated by method of caspase cleavage and annexin V staining. Conclusion: This experiment showed that Curcuma longa L. has anti-tumor effect with statistical significance. This is in vitro experiment and basic experiment on Curcuma longa L.. We hope more progressive research on Curcuma longa L. will go on and its anti-tumor effects will be more practically identified.

• 대한한방내과학회지
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• 제30권2호
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• pp.355-364
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• 2009

Objectives : Benign prostatic hyperplasia (BPH) is one of the most common diseases among elderly men. Though medicines such as 5${\alpha}$-reductase inhibitor (finasteride) have recently been developed for treating BPH, their adverse effects and low efficacy should not be overlooked. Curcuma longa has a long history of use in traditional medicines of Asian countries. Many reports conclude the component curcumin in Curcuma lonfa, has the potential to treat various diseases including prostate cancer. In this study, we investigated the therapeutic effects and action mechanism of Curcuma longa with a BPH rat model. Methods : Sprague-Dawley rats were used with subcutaneous injection of testosterone after castration, which were histologically similar to human BPH. A total of 30 rats were equally divided into five groups: Group 1 served as control (sham-operated group): Group 2 was the model group: Group 3 and Group 4 animals were administered Curcuma longa at dose levels of 0.5g/kg and 1.0g/kg: Group 5 served as a positive control group and was treated with finasteride at a dose of 1 mg/kg. The drugs were administered orally once a day for 30 days consecutively. After 31 days, the prostates were removed, and analyzed for their prostatic weight and histological examination. Results : The oral Curcuma longa ingestion group showed statistically significant decreases in their prostatic weights compared with the BPH-induced group and the oral finasteride ingestion group (p<0.05). Curcuma longa is also very safe in liver and kidney up to a dose of lg/kg. Injected testosterone histologically led to prostatic hyperplasia in rats, but oral Curcuma longa ingestion decreased this change. Conclusions : These results suggest that Curcuma longa has a definite inhibitory effect on BPH and might be an alternative medicine for treatment and prevention of human BPH.

• 한국자원식물학회지
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• 제26권4호
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• pp.450-456
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• 2013

파종기에 따른 울금의 초장, 경직경 및 엽수는 5월 10일 파종구에서 가장 양호하였다. 생육단계에 따른 울금의 생육변화를 살펴본 결과 울금의 생육최성기인 10월에 초장은 121 cm로 가장 길게 나타났고, 경직경 또한 3.45 cm로 가장 두꺼웠다. 엽수는 9월 20일 6매로 조사되었으나 이후 엽수가 감소함이 관찰되었다. 생육단계에 따른 울금 지하경 무게 변화는 생육기간에 경과함에 따라 지하경의 무게 증가가 비례하였으며, 11월 20일 조사에서 울금의 수량이 가장 크게 나타났다. 울금을 건조하는데 가장 적합한 온도는 $40^{\circ}C$로 확인되었다. 부형제를 달리하여 제조한 울금환의 관능검사 결과는 향, 색, 맛, 조직감 및 종합적 기호도에서 찹쌀과 꿀을 부형제로 사용한 시험구의 기호도가 가장 우수하였으며 밀가루만을 사용한 시험구의 선호도는 낮게 나타났다.

• 대한한방내과학회지
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• 제27권2호
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• pp.429-443
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• 2006

Objectives : The Purpose of this study was to identify anti-tumor effects of Curcuma longa L. on some kinds of cancer cells through molecular biologic methods. Materials & Methods : We used 4 kinds of cancer cell lines such as glioma cells(A172), cervical cancer cells(HeLa), Prostate cancer cells(PC3), lung cancer cells(A549). We injected the boiled extract of Curcuma longa L. $5{\mu}g,\;10{\mu}g$ to culture media(ml) for 24 hours. We measured the cytotoxic effect on 4 kinds of cancer cells through trypan blue exclusion test and the suppressive effect on viability of 4 kinds of cancer cells via MTT assay. We measured the change of mitochondria membrane potential via flow cytometry. The quantitative RT-PCR was used to examine the effect on the revelation of Bcl-2 and Bax which genes are related to apoptosis. We examined the effect on the revelation of Bcl-2 protein and Bax protein by western blot analysis. Results: 1. Extract of Curcuma longa L. showed significant cytotoxic effect on A172, HeLa, PC3 compared to the control group with density dependent manner. 2. Extract of Curcuma longs L. showed significant suppressive effect on viability of A172, HeLa, PC3 compared to the control group with density dependent manner. 3. Curcuma longs L. induced apoptosis by decreasing the membrane potential of mitochondria in A172, HeLa, PC3. 4. In the test about the revelation of genes related to apoptosis, the revelation of Bcl-2 decreased and the revelation of Bax increased in A172. HeLa, PC3 treated with Curcuma longa L. with density dependent manner. 5. In the test about the revelation of protein related to apoptosis, the protein levels of Bcl-2 decreased and the protein levels of Bax increased in A172, HeLa, PC3 treated with Curcuma longa L. Conclusions: This experiment shewed that Curcuma longs L. has anti-tumor effect on glioma, cervical, Prostate cancer cells except on lung cancer. We hope that anti-tumor effects of Curcuma longa L. will be more Practically identified.

• 한국식품저장유통학회지
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• 제14권6호
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• pp.624-632
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• 2007

가을울금과 봄울금의 채취시기에 따른 일반성분, 아미노산, 유리당 및 환원당 및 비타민 C와 $B_1$ 등의 함량을 비교분석 하였다. 가을울금과 봄울금의 수분, 조회분, 조단백 및 조지방 함량은 채취시기가 늦을수록 증가하였고, 가용성무질소분 함량은 채취시기가 늦을수록 감소하는 경향을 보였다. 구성아미노산은 채취시기가 늦을수록 아미노산의 함량이 증가하다가 다음해인 1월말에는 약간 감소하였으며, 총 아미노산에 대한 필수아미노산의 비율도 증가하였다. 유리 아미노산의 경우는 주된 성분은 구성아미노산과 비슷하였으나, 채취시기가 늦을수록 아미노산의 함량은 계속 증가 하였으며 총 아미노산에 대한 필수아미노산의 비율은 감소하였다. 구성아미노산과 유리아미노산 모두 가을울금이 더 높은 함유량을 보였다. 울금의 유리당 중 fructose는 채취시기가 늦어질수록 점차 증가하였으나, glucose와 sucrose는 감소하였으며, 총 함량은 채취시기가 늦어질수록 점차 감소하는 경향을 보였다. 유리당과 환원당 모두 가을울금이 더 높은 함유량을 보였다. 비타민 C와 $B_1$은 채취시기가 늦어질수록 그 함량이 가을울금은 감소하였으나 봄울금은 증가하였으며, 비타민 C는 가을울금이 더 높았으나 $B_1$의 경우는 봄울금이 더 높게 나타나 유의적인 차이를 보였다(p<0.05).

• 한국식품영양학회지
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• 제25권4호
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• pp.833-841
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• 2012

본 연구는 높은 생리활성효과로 인해 높은 섭취관심도에도 불구하고 식품소재로서의 활용도가 낮은 울금을 어묵제조에 부재료로 첨가하여 제품화의 가능성을 살펴보았다. 울금 분말을 어묵 제조 부재료인 밀가루 양 대비 0, 1, 3, 5, 7%를 첨가한 어묵을 제조한 다음, 수분, pH, 색도, 절곡 검사, 조직감 특성, 관능적 특성 및 관능 기호도를 측정, 평가하였다. 울금 분말을 첨가한 어묵의 수분 함량은 울금 분말의 첨가 여부 및 첨가량의 증가에 관계없이 각각 71.35~72.97%의 범위를 나타내었으며, pH는 울금 분말의 첨가량 증가에 따라 낮아지는 경향을 나타내었다. 울금 분말을 첨가한 어묵의 L값(lightness)은 낮아졌으며, a값과 b값은 높아지는 경향을 나타내어 각 시료간 매우 유의적인 차이를 나타내었다. 울금 분말 첨가 어묵의 절곡 검사 결과는 울금 분말 첨가유무와 첨가량 증가에 관계없이 AA로 측정되었으며, 어묵의 조직감의 특성 중 강도(strength)는 울금 분말 첨가량이 증가할수록 높아졌으며, 탄력성(springiness)은 울금 분말 첨가량 증가에 따라 낮아졌고, 응집성(cohesiveness)은 울금 분말 7% 첨가구만 유의적으로 높게 측정되었다. 울금 분말 첨가 어묵의 관능 특성 중 색의 진한 정도는 울금 분말의 첨가량이 증가할수록 색이 진한 것으로 평가되었으며, 울금 냄새의 정도는 울금 분말의 첨가량이 증가할수록 매우 강하게 평가되었고, 생선 비린내는 울금첨가량의 증가에 따라 매우 약하게 평가되어 울금 특유의 냄새가 비린내가 감소시키는 것으로 평가되었다. 구수한 맛의 정도는 울금 분말 무첨가구가 가장 강한 것으로 평가되었으며, 울금 분말 7% 첨가구가 가장 낮은 점수를 나타내었다. 반면, 느끼한 맛의 정도는 울금 분말의 첨가량 증가에 따라 감소하는 것으로 평가되어 울금 분말 무첨가구가 가장 강하게 평가되었으며, 관능적 조직감의 항목 중 강도와 탄력성은 울금 첨가 유무와 첨가량 증가에 따른 유의적인 차이가 나타나지 않았다. 울금 분말 첨가량에 따른 어묵의 관능적 기호도는 어묵 제조시의 부재료인 밀가루 양 대비 3%의 울금 분말을 첨가하는 것이 냄새, 맛, 전체적인 기호도의 측면에서 가장 우수한 것으로 평가되었다. 이상의 결과로써, 어묵의 제조시에 울금 분말을 첨가하는 것은 외관(색)의 기호도를 높이고, 생선 특유의 비린내를 감소시키며, 느끼한 맛을 감소시키므로 제품화의 가능성이 충분할 것으로 생각된다. 그 중에서도 어묵 제조시에 첨가하는 부재료인 밀가루 양 대비 3%의 울금 분말을 첨가하는 것이 가장 적합할 것으로 판단된다.