• 동의생리병리학회지
• /
• 제21권6호
• /
• pp.1407-1410
• /
• 2007

We designed to investigate the relationship the cold-hot theory of herbology and body temperature in experimental model. we prepared four kinds of oriental medicine, which consisted of two cold herbs, Daehwang and Seokgo, and two hot herbs, Buja and Padu. Decrease of body temperature by cold exposure for 12 hour was not inhibited by four herbs oral administration for two weeks. Thermogenesis in mammals is an essential physiological function to maintain the body temperature. Mitochondrial uncoupling proteins(UCPs), which have a potential to generate heat by uncoupling oxidative phosphorylation, apper to play a crucial role in thermogenesis. Therefore UCP is commonly recognized as a key molecule in metabolic thermogenesis and its dysfunction contributes to the development of obesity. In these experiments, Daehwang water extracts inhibited the UCP1 mRNA expression increase by cold exposure in brown adipose tissue. But other herbs did not significantly influence on UCPs mRNA expression in white adipose tissue and seleus muscle tissue. Based on this experiment, we will try to clarify the effects of Daehwang water extracts on UCP1 expression and function.

• 사상체질의학회지
• /
• 제29권3호
• /
• pp.211-223
• /
• 2017

Objectives The purpose of this study is to understand the formation of Jogakdaehwang-tang(JD-T)'s patholoy and the compositional change of it in Sasang Constitutional Medicine(SCM). Methods The pathologic condition in which JD-T was used and the change of its composition was studied in SCM Results and Conclusions 1. Jogak and Daehwang in "Dongmuyoogo Haedong" were presented with Ungdam because of the common purpose flowing the energy of lung. Therapeutic method for exogenous Ungibyeong in "Dongyisusebowon sangchobongwon" was subdivided into Hangwul's treated by Ungdam, and the heat pattern featuring contagious cold and constipation, treated by Jogakhwanggeumdaehwang-tang(JHD-T). 2. JD-T in "Dongyisusebowon Gabogubon" was used for Yangdok and Onbyeong which are exogenous disease causing by heat. The composition of JD-T has been completed as it included Mahwang, Gilgyeong, and Seungma derived from prescriptions relevant with Yangdok. 3. JD-T in "Dongyisusebowon Sinchukbon(Sinchukbon)" was included in pathology of Ganyeol, and it substituted Galgeunhaegi-tang(GH-T) for Onbyeong, not for Yangdok, so Galgeun and Seungma became the main drug in JD-T. Galgeunseung-gitang(GS-T) was created for treating heat pattern owing to Daehwang, its main drug, and moreover Jogak's effect is too strong. Therefore, Mahwang, Hwanggeum and Gilgyeong was excluded from the composition of JD-T. 4. The origins of JD-T could be Yiseonggugo-hwan, Daesiho-tang, Jowiseungchung-tang, Heukno-hwan, and GH-T. The change of JD-T went for them throughout JHD-T to JD-T. JD-T in "Sinchukbon" consists of Galgeun and Daehwang which directly gets rid of severe heat from small intestine, and Jogak and Seungma which help to eliminate mild heat existing from small intestine throughout nose to flesh.

• 한국식품조리과학회지
• /
• 제19권4호
• /
• pp.470-476
• /
• 2003

식품 위해성 세균과 곰팡이에 대하여 대황 메탄을 추출물의 항균활성을 paper disc법으로 조사하였고 최소생육저해농도를 결정하였다. 또한 GC/MS를 이용하여 대황 메탄을 추출물에서 분리된 각 peak의 성분과 함량을 분석하였다. 대황 메탄을 추출물은 p. aeruginosa에 대해 강한 항균활성을 보였으며 S. aureus와 S. typhimurium에 대해서도 상당한 항균활성을 나타내었다. 대황 메탄을 추출물은 250mg/$m\ell$농도에서 S. aureus의 생육을 저지시켰으며 300mg/$m\ell$농도에서 p. aeruginosa와 S. typhimurium의 생육을 억제시켰다. 대황 메탄을 추출물을 GC/MS로 분석한 결과 전체 120가지의 성분이 분석되었으며 이 중 추출물에 함유된 ketones 화합물이 39%로 가장 많은 부분을 차지하고 있었다. 항균물질로 알려진 phenol성 화합물인 2-methoxy-phenol, 4-vinyl-2-methoxy-phenol 등이 대황 메탄을 추출물에서도 검출되었다.

• 사상체질의학회지
• /
• 제29권1호
• /
• pp.1-13
• /
• 2017

Objectives The purpose of this study is to understand the influence of Daesihog-tang on Taeeum-in's patholoy and prescription in "Donguisusebowon" of Sasang Constitutional Medicine. Methods The pathologic condition in which Daesihog-tang used and the relevant herbs and prescriptions in "Sanghanron", "Donguibogam", "Dongmuyoogo haedong", "Chobongwon", and "Donguisusebowon". Results and Conclusions 1. Daesiho-tang in "Sanghanron" was used to the symptom of Yangmyung disease merging with Soyang disease. In "Donguibogam", its indications were mainly used to the severe fever-symptom of Yangmyung disease and expanded to Onbyeong and so on. 2. The concept of Daesiho-tang in "Donguibogam" was changed into Hwanggeumdaehwang-tang in "Chobongwon", which can be used to treat Onbyeong with heat-dysenteric diarrhea, and severe fever of Taeeum-in. 3. The notion of combination between Daehwang and hwanggeum used in "Dongmuyoogo haedong" and "Chobongwon" was connected to Chungmongsukgondamhwan or Jogakhwanggeumdaehwang-tang in "Chobongwon". Especially, Jogakhwanggeumdaehwang-tang for Yeokkigammo and severe constipation was formed while the concept of Onbyeong in Hwanggeumdaehwang-tang' merged with the usage of Jogak and Daehwang or Yisunggugo-hwan. 4. Jogakhwanggeumdaehwang-tang influenced on the usage of Jogakdaehwang-tang for Yangdok and Onbyeong, while the usage of Chungmongsukgondamhwan was not found in "Donguisusebowon". 5. As a result, Daesiho-tang may be presented without usages for a specific patholoy in "Donguisusebowon" because it indirectly influenced on the concept of Yangdok and Onbyeong of Taeeum-in, and the formation of Jogakdaehwang-tang in "Donguisusebowon".

• 한방안이비인후피부과학회지
• /
• 제24권3호
• /
• pp.37-54
• /
• 2011

Background and Objective : Recently it is true that increasing interest in Oriental medicine and usage of herbal medicine. On the other hand, there are many concerns about the stability of herbal medicine. So, this study is carried out to see whether or not the treatment with Sanghan-Bang(傷寒方) is effective on the liver function besides its effectiveness in treating facial palsy. Methods : We examined serum TP, Albumin, TB, AST, ALT, ALP, LDH, ${\gamma}$-GGT levels, and facial palsy states in 37 patients with facial palsy who had admission treatment in an oriental medical hospital. Results and Conclusion : 1. We found the levels of TP, albumin, TB, and ${\gamma}$-GGT had decreased statistically significant. Also, AST, ALT, LDH and ALP levels had decreased however it was not statistically significant. 2. We analyzed the herbal group that may be efficient to the liver function; Daehwang-Jae(16 case), Injin-Jae(12 case), and Chija-Jae(6 case) in this order. 3. From the eight cases using oriental medicinal concoctions using one of Daehwang, Injin-Jae or Chija as their main component, the liver function test results displayed decreasing values, re-entering into normal LFT ranges. 4. As we compared the admission House-Brackmann Scale with discharge, the treatment was efficient and statistically significant.

• 동의생리병리학회지
• /
• 제22권2호
• /
• pp.446-452
• /
• 2008

To evaluate the anti-obesity efficacy of Gamitaeeumjowi-tang consisting of Taeeumjowitang and Daehwang. Eleven male(n=4) and female(n=7), obesity patients were recruited by Tenten Diet Network from November 2005 to February 2006. All the subjects were treated with Gamitaeeumjowi-tang 3 times a day for 12 weeks. Weight, BMI, body fat weight, Total cholesterol, LDL, HDL, Triglycerides, GOT, GPT, and CT results were evaluated before and after the 12 week treatment. Weight, BMI, body fat weight, total cholesterol, triglyceride, and subcutaneous fat in upper and lower abdomen all showed significant decrease after 12 weeks of administration. Also Gamitaeeumjowi-tang showed no toxic effects based on liver function test. Taken together, The potentials of Gamitaeeumjowi-tang as a safe and effective treatment for obesity has been recognized through this study. Further large sample sized and double blinded randomized control trials are needed to fully confirm the findings of this study.

• 혜화의학회지
• /
• 제13권1호
• /
• pp.269-277
• /
• 2004

1. The frequency of source of prescriptions is Dongweonshibse(東垣十書), Hagansanghansamyukse(河間傷寒三六書), Senmyoungronbang(宣明論方), Gogumuigam(古今醫鑑), Dangyesimbob(丹溪心法), Uihakgangmok(醫學綱目), Taepyonghyeininhwajekukbang(太平惠民和劑局方) in sequence. 2. The classification of prescriptions by efficacy is Haepyoy(解表藥), Igiyak(理氣藥), Boikyak(補益藥), Sahayak(瀉下藥), Chongyo1yak(淸熱藥等), etc., in sequence. 3. The frequency of used medicine is Gangwhal(羌活), Insam(人蔘), Hwangbaek(黃柏), Gamsu(甘遂), Jadakek(紫大戟), Daehwang(大黃), Seungma(升麻), Shiho(紫胡), Bangpung(防風), Jinpi(陳皮), Oyak(烏藥), Chongung(川芎), Changchul(蒼朮), Gobon(藁本), etc., in sequence. 4. The Song(性) of used medicine is mainly Onsong(溫性) and Hansong(寒性), the mi(味) is Sinmi(辛味), Gomi(苦味), Gammi(甘味), Hammi(鹹味) in sequence, the Gwigyong(歸經) is Bigyong (脾經), Wigyong(胃經), Gangyong(肝經), Paegyong(肺經), etc., in seguence.

• 대한한의진단학회지
• /
• 제18권1호
• /
• pp.45-50
• /
• 2014

Objectives This study was designed to report the effect of Samultang-gamibang(四物湯加味方) for insomnia caused by blood deficiency (syndrome) after excessive weight control treatment with herbal medication Methods This is a retrospective case report. We reviewed the patient's medical record after taking the patient's informed consent. Results After treatment, a patient feels calm and satisfaction emotionally as sleeping time has increased from 2hours to 6hours, the fatigue after sleeping has been reduced, and the quality of sleep has become better. Conclusions This case report suggests that Samultang-gamibang can be effective in improving sleep duration and quality if the patient suffers insomnia due to hyul-heo syndrome. Also the woman who have symptom of hyul-heo(血虛) after weight control through decreased food consumption, should bo-hyul(補血).

• 대한한의학방제학회지
• /
• 제12권1호
• /
• pp.29-77
• /
• 2004

After this study: I report the following result from it. 1. Beriberi is defined as sensory or motor disorder of leg with a painful-swelling and pyrexia. If it progress severely, the disease transmits to heart and cause numbness of the lower abdomen, vomiting, anorexia, palpitation, chest distress and confusion. 2. The external etiologic factors of Beriberi are wind-toxic pathogen, dampness, improper diet and climate sickness, the internal etiologic factors are deficiencies of the kidney, both Gi and blood and original vital energy. 3. The treatment of Beriberi is free-going of blockage, because it is a blocked disease. 4. Danggwiy-juntongtang and Ganghwar-dochetang is the most in the order of frequency of use. Mahwang-juagyongtang, Banha-juagyongtang, Daehwang-juagyongtang, Shinbi-juagyongtang are used in sequence. 5. The prescriptions of Beriberi are made up of the herbs that clear heat, for example, Ganghwar, Changchul, Mahwang and Bangpung, and the herbs that reinforces Gi, for example, Insam and Bakchul.

• 사상체질의학회지
• /
• 제21권2호
• /
• pp.72-78
• /
• 2009

1. Objectives : This paper was written in order to understand the origin and changes of Galgeunhaegi-tang. 2. Methods : We analysis Galgeunhaegi-tang through pathology and new prescription in "Donguibogam(東醫寶鑑)", "Chobongwon(草本卷)", "Gabobon(甲午本)" and "Sinchukbon(辛丑本)" of "Dongyi Suse Bowon". 3. Results and Conclusions : We can find the first origin of Galgeunhaegi-tang in "Sinchukbon(辛丑本)" in "Donguibogam(東醫寶鑑)" which invelves Galgeunhaegi-tang in the categories of pestilence(瘟疫) and Yangmyeonggyeongbyeong(陽明經病). Also, we can find the origin in Jugoeng(朱肱)' Jojung-tang. Seungeumgalgeun-tang in the "Chobongwon(草本卷)" developed by a Galgeunhaegi-tang of "Gabobon(甲午本)", and Galgeunnabokja-tang in the "Chobongwon(草本卷)" developed by a Galgeunhaegi-tang of "Sinchukbon(辛丑本)". It is considered that Galgeunhaegi-tang of "Gabobon(甲午本)" solves heat depression(鬱熱), due to not throwing off, by using Galgeun(葛根) and Daehwang(大黃), and accompanied dryness(燥) by using Hangin(杏仁) and Sanjoin(酸棗仁) which moisten dryness(燥). It is considered that Galgeunhaegi-tang of "Sinchukbon(辛丑本)" solves heat depression(鬱熱) by using Galgeun(葛根) and accompanied dryness(燥) by using Gobon(藁本) which sets free dryness(燥).