• 동의생리병리학회지
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• 제34권6호
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• pp.279-284
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• 2020

The theory of "eccentric diseases are generally due to phlegm (怪病多屬痰)" means that phlegm is a major cause for intractable diseases including cerebrovascular accident, depression, insanity, and shock from strange things or evil sprint. It has been a key foundation for the diagnosis and treatment of phlegm in traditional Korean medicine. However, the origin of the theory is not clear and controversial. In this study, we critically reviewed the origin and developing process of the theory in the viewpoints of philology and pathology in Korean medicine. Wang Yin-Jun (王隱 君) did not claim that eccentric diseases are generally due to phlegm in Taidingyangshengzhu-lun (泰定養生主論). The miscitation by following medical literature caused the misunderstanding in the meaning of Taidingyangshengzhu-lun, that phlegm can cause variable symptoms and signs. In the Ming dynasty, some poor medical doctors had tended to diagnose any difficult case as phlegm syndrome and to use Kuntan-huan (滾痰丸) as a standard herbal formula for treating phlegm syndrome. However, the tendency to categorize delicate cases easily to phlegm syndrome is not desirable. Besides, the tendency to use Kuntan-huan as a basic formula for the phlegm syndrome might cause diverse and severe adverse effects. Thus, we cannot accept the theory of eccentric diseases is generally due to phlegm without a doubt. In conclusion, this theory might be a valuable aphorism in terms of considering the possibility of the secondary pathologic factors including phlegm and blood stasis which should be considered first in case of intractable diseases.

• 한국한의학연구원논문집
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• 제13권3호
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• pp.29-37
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• 2007

Narratives are the old stories handed down for a long time, which are not personal creations but common ones for ages. They were formed from the public consciousness, passed orally and recorded in letters. There have been lots of studies on narratives about characters, whereas there have been poor in the studies on the great doctors. The author examined the narratives about great doctors in literature for successive generations, and made researches on world view and consciousness of reality reflected on the age directly or indirectly. The author inquired into the descriptions and constructions of the narratives separately, and classified the great doctors in literature into the miraculous doctors, eccentric doctors and righteous doctors. Therefore truly great doctor is the one who treats not only personal diseases but also social problems, and who tries to harmonize with human beings and nature.

• 한국운동역학회지
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• 제30권1호
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• pp.111-119
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• 2020

Objective: The purpose of this study is to apply exercise learning effect to various subjects through training effect and information accumulation based on verification of the effect on dumbbell curl exercises applied with virtual reality. Method: To analyze the effect on the dumbbell curl exercise in the virtual environment, a total of 20 persons with 10 males and 10 females who does not have orthopedics diseases were selected. The dumbbell weight of the subjects was set to a weight of 70% strength of 1RM. At this time, the virtual environment situation was set to four types; presence/absence of virtual environment, preferred colors, and unfavorable colors to perform dumbbell curl exercise. The anaysis of muscle activity was conducted by adhering four surface electrodes (Biceps Brachii, Triceps Brachii, Brachioradialis Muscle, Extensor Carpi Radialis Longus Muscle) on the right upper limbs. Independent sample t-test using SPSS (24.0) program was carried out to analyze average values and standard deviations for each variable depending on the presence/absence of virtual environments and changes in color (preferred colors, unfavorable colors) and the level of significance was set to a=.05. Results: In the eccentric contraction, males showed high muscle activity in the Biceps Brachii under virtual reality. On the other hand, females had high muscle activity in the Biceps Brachii in the absence of virtual reality. Also, in case of a change of colors in the virtual environment, females had the high muscle activity in the unfavorable color in the eccentric contraction. Conclusion: During the dumbbell curl exercise, results of different exercises present depending on gender. When males put VR on and performs a basic dumbbell curl exercise, the effect of Biceps presents Brachii for them while exercising in unfavorable colors. However, since it is the basic research data of muscle exercise using virtual reality, it is necessary to verify whether or not it is effective for myopachynsis through long-term training rather than unity.

• 한국임상수의학회지
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• 제24권4호
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• pp.613-617
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• 2007

중성화된 1년령 말티즈 개(2.4kg)가 간헐적인 기침, 호흡곤란, 운동 불내성을 주요 증상으로 내원하였다. 신체검사 시 제 2음 모순 분열, 확장기 역류성 잡음이 관찰되었으며, 심장초음파에서 주폐동맥의 확장, 심실 중격 비대를 동반한 우심실 편심성 비대, 심각한 삼첨판 역류증과 폐동맥 역류증(5.4m/sec, 3.4m/sec)이 관찰되었다. 이러한 진단 검사 결과를 바탕으로, 본 증례를 선천성 심장 내 단락, 폐쇄성 폐질환, 그리고 우심계의 압력 과부하 또는 폐혈관계과관류와 관련된 전신질환과 감별하여 원발성 폐동맥 고혈압증으로 잠정진단 하였다. 환자는 furosemide와 aspirin을 투여하여, 산소요법을 실시하였다. 본 증례는 드물게 발생하는 개의 원발성 폐동맥 고혈압이다.

• Tuberculosis and Respiratory Diseases
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• 제66권6호
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• pp.482-485
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• 2009

종격동은 다양한 기관들이 밀집되어 있는 구조라서 종양 등 질병이 발생하더라도 위치상 심장이나 대혈관의 음영과 중첩되어 보이기 때문에 단순 흉부 X-선 촬영상 정상 소견으로 오인할 수 있다. 종격동 종양의 경우 주위조직의 침범 여부나 주위 림프절 크기 이외에도 환자의 연령, 종양의 크기 및 위치, 환자의 증세 유무가 중요한 고려사항이다. 저자들은 흉부 불쾌감이 지속되어 내원한 56세 여자 환자에게서 단순 흉부 X-선 사진의 면밀한 관찰을 통해 기관 분지부의 종격동 종양을 발견한 증례를 통해, 다시 한번 단순 흉부 X-선 촬영의 진단적인 중요성을 임상의들에게 환기시키고자 한다.

• Journal of Korean Neurosurgical Society
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• 제56권5호
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• pp.395-399
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• 2014

Objective : Blood blister-like aneurysms (BBAs) resemble arterial dissections. The purpose of this study was to investigate the relationship between these two disease entities and highlight commonalities and distinct features. Methods : Among 871 consecutive patients with aneurysmal subarachnoid hemorrhage, 11 BBAs of internal carotid artery and seven vertebral artery dissections (VADs) with a short segmental eccentric dilatation (Mizutani type 4), which is morphologically similar to a BBA, were selected. The following clinical factors were studied in each group : age, gender, risk factors, Hunt and Hess grade (HHG), Fisher grade (FG), vasospasms, hydrocephalus, perioperative rebleeding rate, and treatment outcome. Results : The mean age was 47.9 years in the BBAs group and 46.4 years in the type 4 VADs group. All the BBA patients were female, whereas there was a slight male predominance in the type 4 VAD group (male : female ratio of 4 : 3). In the BBA and type 4 VAD groups that underwent less aggressive treatment to save the parent artery, 29% (n=2/7) and 66.6% (n=2/3), respectively, eventually required retreatment. Perioperative rebleeding occurred in 72.7% (n=8) and 28.6% (n=2) of patients in the BBA and type 4 VAD groups, respectively. There was no statistical difference in the other clinical factors in both groups, except for the male dominancy in the type 4 VAD group (p=0.011). Conclusion : BBAs and ruptured type 4 VADs have a similar morphological appearance but there is a distinct clinical feature in gender and perioperative rebleeding rates. Complete isolation of an aneurysm from the parent artery might be the most important discipline for the treatment of these diseases.

• 대한정형도수물리치료학회지
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• 제25권2호
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• pp.73-81
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• 2019

Background: Patellofemoral pain is one of the common diseases of the musculoskeletal system. Many previous studies have recommended the application of exercise therapy to patellofemoral pain patients for treatment. The purpose of this study was to investigate effect of coordinative locomotor training (CLT) and sling exercise combined program on knee pain and functional movement in patellofemoral pain patient. Methods: In this study, single-subject design (A-B-A') was conducted for 6 weeks. A repeted-measure analysis was conducted to assess results of the anterior knee pain scale (AKPS), Clarke's test (CT), eccentric step down test (ESDT). During the intervention (B), the CLT and sling exercise combined program was conducted three times a week for 4 weeks. Results: From baseline period A to intervention period B, the AKPS, CT, ESDT were improved from 61 to 48 (27%), from 8.33 to 3 (64%), from 7.67 to 3,58 (53%). From baseline period A to baseline period A', the AKPS, CT, ESDT were improved from 70.67 to 48 (47%), from 0.67 to 3 (92%), from 1.33 to 3,58 (83%). Conclusion: Based on the results of this study, we recommend the application of CLT and sling exercise combined program to improve the pain and functional movement in patellofemoral pain patients.

• Tuberculosis and Respiratory Diseases
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• 제48권4호
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• pp.478-486
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• 2000

연구배경 : 급성폐손상에서 폐포대식세포는 초기에 일어나는 염증반응 뿐 아니라, 후기의 복구 및 섬유화 과정에 관여하는 중요한 세포로 형태, 기능면에서 특성이 다른 여러 세포군으로 구성되어져 있는 것으로 알려져 있다. 95% 이상의 고농도산소로 폐손상을 일으킨 쥐를 12시간군, 24시간군, 48시간군으로 나누어서 고농도 산소 투여시기에 따른 폐포대식세포의 숫적인 변화 및 아형군의 분포변화를 관찰하고, 이들 아형군세포의 형태학적인 차이를 통해서 고농도 산소에 의한 폐손상시에 관련되는 특정 아형세포군이 있는지를 알아보고 이러한 분포의 차이와 조직병리적인 변화를 비교 관찰하였다. 방 법 : Sprague-Dawley계 흰쥐를 대상으로 고농도 산소 투여 후 12시간, 24시간, 48시간 경과시의 폐포대식세포를 추출하여 아형세포군의 분포 및 형태 변화와 조직의 변화를 비교 관찰하였다. 결 과 : 1) 총 폐포대식세포는 정상군 $171.6{\pm}24.1({\times}10^5)$, 12시간군 $194.8{\pm}17.9$, 24시간군 $207.6{\pm}27.1$, 48시간군 $200.0{\pm}77.8$개로 초기 장시간까지는 증가하나 이후에는 유의한 차이를 보이지 않았다. 2) 광학현미경 관찰로 측정한 폐포간질의 두께는 정상군 $0.7{\pm}0.2{\mu}m$, 12시간군 $1.5{\pm}0.4{\mu}m$, 24시간군 $2.3{\pm}0.4{\mu}m$, 48시간군 $2.5{\pm}0.4{\mu}m$로 24시간까지는 시간에 따라서 증가하나 24시간 이후로 유의한 차이는 없었다. 3) 폐포대식세포 분포의 시간 경과에 따른 변화는 fraction 1과 fraction 2는 의미 있게 증가되었으며 fraction 3는 의미 있게 감소하였다. fraction 4는 감소되어지는 양상을 보이나 통계적인 의의는 없었다. 4) 고밀도군에서 주로 관찰되는 세포는 세포 및 핵의 모양이 불규칙적이며 크기가 작고 한쪽으로 치우쳐 있으며, pseudopod, electron dense inclusion의 수가 현저히 많이 관찰됐다. 반면 저밀도군에서 주로 관찰되는 세포는 크기가 크고 세포 및 핵이 둥근형태를 보였다. heterogenous, empty inclusion이 보다 많이 관찰되었고 전반적인 inclusion의 수도 증가했다. 결 론 : 이상의 결과로 고농도산소에 의한 폐손상에서 특정한 폐포대식세포아형군이 폐손상에 중요한 역할을 할 것으로 보여지며 추후 이들 세포군이 증가한 이유 및 기전과 이들 세포군의 기능 및 표현형등에 관한 연구가 계속되어야 할 것이다.