• Journal of the Korean Society of Radiology
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• v.15 no.5
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• pp.603-612
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• 2021

The effect of Advanced Modeled Iterative Reconstruction (ADMIRE) on the coronary artery calcium (CAC) score of computed tomography was evaluated. Coronary artery calcium images (348 calcium, 6 groups, total of 2088 calcium) were acquired by 128-slice dual-source CT of 89 patients.Volume score and Agatston score were measured from images reconstructed with filtered back projection (FBP) and ADMIRE (1-5). The difference between FBP and ADMIRE Strength (1-5) was confirmed through the Kruskal-Wallis test, and the post-hoc analysis was performed using the Mann-Whitney U test based on FBP. Both volume score and Agatston score showed statistically significant differences between FBP and ADMIRE (1-5) (P=0.015, P=0.0.38). As a result of post hoc analysis, the volume score decreased to 9.5% in ADMIRE 4 (Z=-2.359, P=0.018) and 13.2% in ADMIRE 5 (Z=-3.113, P=0.002) based on FBP. Agatston score decreased to 10.4% in ADMIRE 4 (Z=-2.051, P=0.040) and 14.0% in ADMIRE 5 (Z=-2.718, P=0.007) based on FBP. High ADMIRE strength affected the volume score and Agatston score due to the decrease in calcium area. In addition, the change in the Density factor due to the decrease in Maximum HU may affect the calculation of the Agatston score.

• Journal of the Institute of Electronics Engineers of Korea TE
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• v.42 no.1
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• pp.21-28
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• 2005

In this paper, we studied resolution to the FBP(Filtered Back-Propagation) tomographic image reconstruction algorithms. In order to analyze the resolution to the tomographic images, we derived ambiguity function to this algorithm which can be reconstructed from the improved FBP image reconstruction algorithm by using fixed coordinate system practically. Through simulation using this function, we determined the lateral and depth resolution quantitively and then analyzed respectively. Simulation results show that the lateral and depth resolution to the improved FBP image reconstruction algerian was determined $0.27\lambda\;and\;0.70\lambda$ at the 3dB, and also $0.89\lambda\;and\;0.96\lambda$ at the 6dB respectively. This results proved that improved FBP reconstruction algorithms for diffraction tomography of incident planar wave is useful to developed the tomographic image system, analyze the resolution to the tomographic images, we derived ambiguity function to this algerian which can be reconstructed from the improved FBP image reconstruction algorithm by using fixed coordinate system.

• The Korean Journal of Nuclear Medicine Technology
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• v.14 no.2
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• pp.122-127
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• 2010

Purpose: The Xpress3.$cardiac^{TM}$ which is a kind of wide beam reconstruction (WBR) method developed by UltraSPECT (Haifa, Israel) enables the acquisition of at quarter time while maintaining image quality. The purpose of this study is to investigate the usefulness of WBR method for decreasing scan times and to compare to it with filtered back projection (FBP), which is the method routinely used. Materials and Methods: Phantom and clinical studies were performed. The anthropomorphic torso phantom was made on an equality with counts from patient's body. The Tl-201 concentrations in the compartments were 74 kBq (2 ${\mu}Ci$)/cc in myocardium, 11.1 kBq (0.3 ${\mu}Ci$)/cc in soft tissue, and 2.59 kBq (0.07 ${\mu}Ci$)/cc in lung. The non-gated Tl-201 myocardial perfusion SPECT data were acquired with the phantom. The former study was scanned for 50 seconds per frame with FBP method, and the latter study was acquired for 13 seconds per frame with WBR method. Using the Xeleris ver. 2.0551, full width at half maximum (FWHM) and average image contrast were compared. In clinical studies, we analyzed the 30 patients who were examined by Tl-201 gated myocardial perfusion SPECT in department of nuclear medicine at Asan Medical Center from January to April 2010. The patients were imaged at full time (50 second per frame) with FBP algorithm and again quarter-time (13 second per frame) with the WBR algorithm. Using the 4D MSPECT (4DM), Quantitative Perfusion SPECT (QPS), and Quantitative Gated SPECT (QGS) software, the summed stress score (SSS), summed rest score (SRS), summed difference score, end-diastolic volume (EDV), end-systolic volume (ESV) and ejection fraction (EF) were analyzed for their correlations and statistical comparison by paired t-test. Results: As a result of the phantom study, the WBR method improved FWHM more than about 30% compared with FBP method (WBR data 5.47 mm, FBP data 7.07 mm). And the WBR method's average image contrast was also higher than FBP method's. However, in result of quantitative indices, SSS, SDS, SRS, EDV, ESV, EF, there were statistically significant differences from WBR and FBP(p<0.01). In the correlation of SSS, SDS, SRS, there were significant differences for WBR and FBP (0.18, 0.34, 0.08). But EDV, ESV, EF showed good correlation with WBR and FBP (0.88, 0.89, 0.71). Conclusion: From phantom study results, we confirmed that the WBR method reduces an acquisition time while improving an image quality compared with FBP method. However, we should consider significant differences in quantitative indices. And it needs to take an evaluation test to apply clinical study to find a cause of differences out between phantom and clinical results.

• The Korean Journal of Nuclear Medicine Technology
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• v.16 no.2
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• pp.29-34
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• 2012

Purpose : Presently, hardwares and softwares for reducing radiation exposure are continually developed for PET/CT examination. Purpose of this study is to evaluate effectiveness of reducing radiation exposure dose of CT and SUV changes of PET when applied each kernel to ACCT (Attenuation Correction Computed Tomography) according to adopted IRIS (Iterative Reconstruction in Image Space) software. Materials and Methods : Biograph mCT (Siemens, Germany) was used as a PET/CT scanner. Using AAPM CT performance phantom, from standard (120 kVp, 100 mAs), 7 scans were conducted by reducing 15 mAs each. After image reconstruction by FBP (Filtered Back Projection) and IRIS, noise and spatial resolution were evaluated. The same method was applied to anthropomorphic chest phantom and acquired images were compared. NEMA IEC body phantom was used for SUV evaluation. Injected dose rate for hot sphere (hot) and background cylinder (BKG) were 1:8. CT dose condition (120 kVp, 50 mAs) was the same for each scan and PET scan durations were 1, 2, 3 and 4min. After scanning, each kernel of IRIS was applied to ACCT. And PET images were reconstructed by ACCT adopted IRIS for comparing SUV changes. Results : AAPM phantom test for noise evaluation, SD for FBP 100 mAs, IRIS 55 mAs were 8.8 and 8.9. FBP 85 mAs, IRIS 40 mAs were 9.5 and 9.7. FBP 70 mAs, IRIS 25 mAs were 11.9 and 11.1. Above mAs condition for FBP and IRIS, SD showed similar values. And for spatial resolution test, there was no significant difference. For chest phantom test, when applied the same mAs and kernel to both of FBP and IRIS, every applied kernels showed reduced noise. Lower mAs and higher kernel value showed higher noise reduction. There was no considerable difference only except for I70 very sharp kernel for SUV comparison using NEMA IEC body phantom. Conclusion : In this study, low mAs (55 mAs) applied IRIS and standard mAs (100 mAs) applied FBP showed similar noise. And only except for I70 kernel, there was no significant SUV changes. It is possible to reduce needless radiation exposure and acquire better image quality than FBP's through applying appropriate kernel of IRIS to PET/CT.

• Journal of the Korean Society of Radiology
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• v.17 no.1
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• pp.37-46
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• 2023

This study aims to evaluate the usefulness of Deep Learning Image Reconstruction (TrueFidelity, TF), the image quality of existing Filtered Back Projection (FBP) and Adaptive Statistical Iterative Reconstruction-Veo (ASIR-V) were compared. Noise, CNR, and SSIM were measured by obtaining images with doses fixed at 17.29 mGy and altered to 10.37 mGy, 12.10 mGy, 13.83 mGy, and 15.56 mGy in reconstruction techniques of FBP, ASIR-V 50%, and TF-H. TF-H has superior image quality compared to FBP and ASIR-V when the reconstruction technique change is given at 17.29 mGy. When dose changes were made, Noise, CNR, and SSIM were significantly different when comparing 10.37 mGy TF-H and FBP (p<0.05), and no significant difference when comparing 10.37 mGy TF-H and ASIR-V 50% (p>0.05). TF-H has a dose-reduction effect of 30%, as the highest dose of 15.56 mGy ASIR-V has the same image quality as the lowest dose of 10.37 mGy TF-H. Thus, Deep Learning Reconstruction techniques (TF) were able to reduce dose compared to Iterative Reconstruction techniques (ASIR-V) and Filtered Back Projection (FBP). Therefore, it is considered to reduce the exposure dose of patients.

• Nuclear Engineering and Technology
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• v.53 no.3
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• pp.888-893
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• 2021

The International Atomic Energy Agency has developed a tomographic imaging system for accomplishing the total fuel rod-by-rod verification time of fuel assemblies within the order of 1-2 h, however, there are still limitations for some fuel types. The aim of this study is to develop a deep learning-based denoising process resulting in increasing the tomographic image acquisition speed of fuel assembly compared to the conventional techniques. Convolutional AutoEncoder (CAE) was employed for denoising the low-quality images reconstructed by filtered back-projection (FBP) algorithm. The image data set was constructed by the Monte Carlo method with the FBP and ground truth (GT) images for 511 patterns of missing fuel rods. The de-noising performance of the CAE model was evaluated by comparing the pixel-by-pixel subtracted images between the GT and FBP images and the GT and CAE images; the average differences of the pixel values for the sample image 1, 2, and 3 were 7.7%, 28.0% and 44.7% for the FBP images, and 0.5%, 1.4% and 1.9% for the predicted image, respectively. Even for the FBP images not discriminable the source patterns, the CAE model could successfully estimate the patterns similarly with the GT image.

• Asian-Australasian Journal of Animal Sciences
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• v.20 no.9
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• pp.1319-1326
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• 2007

Fructose-1,6-bisphosphatase (FBP1) is a key regulatory enzyme of gluconeogenesis that catalyzes the hydrolysis of fructose-1,6-bisphosphate to generate fructose-6-phosphate and inorganic phosphate. Deficiency of fructose-1, 6-bisphosphatase is associated with fasting hypoglycemia and metabolic acidosis. The enzyme has been shown to occur in bacteria, fungi, plants and animals. The bovine FBP1 gene was cloned and characterized in this study. The full length (1,241 bp) FBP1 mRNA contained an open reading frame (ORF) encoding a protein of 338 amino acids, a 63 bp 5' untranslated region (UTR) and a 131 bp 3' UTR. The bovine FBP1 gene was 89%, 85%, 82%, 82% and 74% identical to the orthologs of pig, human, mouse, rat and zebra fish at mRNA level, and 97%, 96%, 94%, 93% and 91% identical at the protein level, respectively. This gene was broadly expressed in cattle with the highest level in testis, and the lowest level in heart. An intronic single nucleotide polymorphism (SNP) (A/G) was identified in the $5^{th}$ intron of the bovine FBP1 gene. Genotyping of 133 animals from four beef breeds revealed that the average frequency for allele A (A-base) was 0.7897 (0.7069-0.9107), while 0.2103 (0.0893-0.2931) for allele B (G-base). Our preliminary association study indicated that this SNP is significantly associated with traits of Average Daily Feed Intake (ADFI) and Carcass Length (CL) (p<0.01). In addition, the FBP1 gene was assigned on BTA8 by a hybrid radiation (RH) mapping method.

• The Journal of Engineering Research
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• v.2 no.1
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• pp.49-56
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• 1997

In emission computed tomography, statistical reconstruction methods in the context of a Bayesian framework have been a topic of interest over the last decade. This was mainly due to the fact that Bayesian approaches can incorporate a priori information into the reconstruction algorithm. Although these approaches can exhibit good performance, their applications to the clinic is hindered mainly by their high computational cost. On the other hand, the speed and simplicity of the filtered backprojection (FBP) algorithm have led to its widespread use in most clinical applications. In this work, we use spline models, which have been quite useful in Bayesian reconstruction, as regularizers for high-frequency apodization in FBP algorithm and show that the effects of using spline models as priors in Bayesian reconstruction can also be achieved in FBP reconstruction.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.3 no.2
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• pp.65-71
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• 2017

To assess the effects of filter and reconstruction of Cu-64 PET data on Siemens scanner, the various reconstruction algorithm with various filters were assessed in terms of spatial resolution, non-uniformity (NU), recovery coefficient (RC), and spillover ratio (SOR). Image reconstruction was performed using filtered backprojection (FBP), 2D ordered subset expectation maximization (OSEM), 3D reprojection algorithm (3DRP), and maximum a posteriori algorithms (MAP). For the FBP reconstruction, ramp, butterworth, hamming, hanning, or parzen filters were used. Attenuation or scatter correction were performed to assess the effect of attenuation and scatter correction. Regarding spatial resolution, highest achievable volumetric resolution was $3.08mm^3$ at the center of FOV when MAP (${\beta}=0.1$) reconstruction method was used. SOR was below 4% for FBP when ramp, Hamming, Hanning, or Shepp-logan filter were used. The lowest NU (highest uniform) after attenuation & scatter correction was 5.39% when FBP (parzen filter) was used. Regarding RC, 0.9 < RC < 1.1 was obtained when OSEM (iteration: 10) was used when attenuation and scatter correction were applied. In this study, image quality of Cu-64 on Siemens Inveon PET was investigated. This data will helpful for the quantification of Cu-64 PET data.

• Journal of the Korean Society of Radiology
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• v.13 no.1
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• pp.95-101
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• 2019

The purpose of this study is to reduce the dose to the patient by different application of ASIR according to the Body Mass Index (BMI). In particular, we wanted to find out the application values of ASIR that are most appropriate for the standard weight. Studies have shown that increasing the application of ASIR to 50% in patients with a body mass index of 25 or less reduces CTDIvol 58.17% and DLP 60.49% compared to using only FBP. A comparative analysis of the noise by the BMI and the SNR values found that the noise increased as the BMI increased, but the application of ASIR resulted in less noise than the FBP alone. In addition, it was found that the more ASIR is applied, the more SNR is increased.