• 한국약용작물학회지
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• 제11권4호
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• pp.274-278
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• 2003

The various plant organs of fennel (Foeniculum vulgare Mill.) were investigated to identify their volatile components using Dynamic Headspace (purge & trap). They showed slight differences concerning the volatile components both qualitatively and quantitatively. Results revealed that trans-anethole (12.65%) was the major compound in the leaf. The highest compound was ${\alpha}-pinene$ (28.78%), and trans-anethole (7.90%) was highly detected in the stem. The maximum values were 5.64, 4.59, 1.58, 1.51, and 1.04% for ${\alpha}-pinene,\;{\gamma}-terpinene,\;{\beta}-pinene$, 1,8-cineol and fenchone, respectively in the flower. However, very little trans-anethole was detected (0.27%) in the flower. From these results, it was suggested that the major components were different depending on the plant organs. However it was demonstrated that the related plant organs like flower-fruit and leaf-stem contained the similar components.

• The Korean Journal of Physiology and Pharmacology
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• 제19권2호
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• pp.183-189
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• 2015

Foeniculum vulgare Mill. (fennel) is used to flavor food, in cosmetics, as an antioxidant, and to treat microbial, diabetic and common inflammation. No study to date, however, has assessed the anti-inflammatory effects of fennel in experimental models of inflammation. The aims of this study were to investigate the anti-inflammatory effects of fennel in model of lipopolysaccharide (LPS)-induced acute lung injury. Mice were randomly assigned to seven groups (n=7~10). In five groups, the mice were intraperitoneally injected with 1% Tween 80-saline (vehicle), fennel (125, 250, $500{\mu}l/kg$), or dexamethasone (1 mg/kg), followed 1 h later by intratracheal instillation of LPS (1.5 mg/kg). In two groups, the mice were intraperitoneally injected with vehicle or fennel ($250{\mu}l/kg$), followed 1 h later by intratracheal instillation of sterile saline. Mice were sacrificed 4 h later, and bronchoalveolar lavage fluid (BALF) and lung tissues were obtained. Fennel significantly and dose-dependently reduced LDH activity and immune cell numbers in LPS treated mice. In addition fennel effectively suppressed the LPS-induced increases in the production of the inflammatory cytokines interleukin-6 and tumor necrosis factor-alpha, with $500{\mu}l/kg$ fennel showing maximal reduction. Fennel also significantly and dose-dependently reduced the activity of the proinflammatory mediator matrix metalloproteinase 9 and the immune modulator nitric oxide (NO). Assessments of the involvement of the MAPK signaling pathway showed that fennel significantly decreased the LPS-induced phosphorylation of ERK. Fennel effectively blocked the inflammatory processes induced by LPS, by regulating pro-inflammatory cytokine production, transcription factors, and NO.

• 한방비만학회지
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• 제5권1호
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• pp.9-20
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• 2005

Objectives : This study was performed to investigate the effect of Aromatherapy using Foeniculum vulgare Mill(Fennel) for decrease in the appetite of female obese patients. Methods : We analyzed 32 obese patients who had been hospitalized in Kirin Oriental Hospital from October 1, 2004 to January 30, 2005. The patient were classified in two groups, aroma inhalation group(IH group), and non-inhalation group(NIH group). Test was applied 2 times a week(Inhalation and Non-inhalation test) for 4 weeks. The effect of both groups was analyzed by using VAS scores about appetite. The scores were checked before inhalation, and 0, 15, 30, 45, 60 minutes after inhalation. Results : The VAS appetite scores decreased more significantly in inhalation group than non-inhalation group on every checked time(15, 30, 45, 60 minutes after inhalation)(p<0.05). And VAS scores of aroma inhalation group decreased more significantly on every checked time(0, 15, 30, 45, 60 minutes after inhalation) than pre-inhalation(p<0.05), and morbid obesity group is more sensitive than obesity group shortly after the inhalation(0 minute after inhalation)(p<0.05). Conclusions : In this study, we can conclude that aromatherapy using Foeniculum vulgare Mill(Fennel) has an effect on decreasing appetite of female obese patients.

• Toxicological Research
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• 제13권3호
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• pp.193-196
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• 1997

Matricaria Chammomillal L., Foemiculum Vulgare mill, and Plantago Psylium L. have been screened for their hepato protective activities against liver damge induced by $CCl_4$ intoxication in mice. Hydroalcoholic extractions (2:8) of herbal drugs were concentrated in vacuo and concentrated crude extracts of Matrica Chammomilla L. and Foeniculum Vulgare mill were orally administered at doses of 100 mg/kg, 200 mg/kg, 400 mg/kg, and 800 mg/kg. Plantago Psyllium was given at doses of 50 mg/kg, 100 mg/kg, 200 mg/kg, and 400 mg/kg. Liver protective activities of these herbs were determined after administration of $CCl_4$ Liver size, serum enzyme activities, sleeping time, and histopatology of the liver were examined one hour after administration of $CCl_4$. ALT and AST activities, liver weight and sleeping time decreased in groups that received 400 mg/kg of Matricaria Chammomilla L. or Foeniculum Vulgare. Histological investigation showed significant increase in hepatic cell regeneration and reduction in liver injury. The group that received 100 mg/kg Plantago Psylium showed liver protection but protection was not significant in other doses.

• 한국식품조리과학회지
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• 제20권5호
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• pp.505-510
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• 2004

이물질 침입에 대한 인식의 결과 NO, PGE$_2$, TNF-, IL-6와 같은 여러 신호전달물질의 분비가 개시되며 이들을 억제하는 물질을 항염증제라고 볼 수 있다. 본 연구에서는 회향(Foeniculum vulgare Mill.) 열매 추출물이 mouse macrophages RAW264.7 세포에서 lipopolysaccharide(LPS)로 유도한 NO(iNOS 산물), PGE$_2$(COX-2 산물) 및 cytokines (TNF-$\alpha$, IL-6) 생성 억제에 미치는 영향을 살펴보았다. 회향 열매의 methanol 추출물 및 분획물(chloroform, butanol, and aqueous fractions)은 4～100$\mu$g/mL 농도에서 LPS가 활성화된 대식 세포에서 NO 생성을 억제하였으며 독성을 나타내지 않았다. LPS가 유도한 PGE$_2$ 생성은 butanol 분획(100 $\mu$g/mL)에 의해서만 유의적으로 감소하였다(P<0.05). 회향 열매 추출물 및 분획물은 TNF-$\alpha$의 생성을 유의적으로 감소시켰으며 IL-6의 생성은 methanol extract(4～100 $\mu$g/mL), chloroform fraction(4 $\mu$g/mL), butanol fraction(4 and 100$\mu$g/mL) 및 aqueous fraction(4～100 $\mu$g/mL)에 의해 감소되었다(P<0.05). 이는 회향 열매 추출물은 염증 상태에서 유용할 것이며 COX-2와 iNOS를 억제하는 butanol 분획은 새로운 항염증제 개발에 사용될 수 있음을 시사하여 주었다.

• 한국약용작물학회지
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• 제11권4호
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• pp.259-263
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• 2003

This study was carried out to get basic information about the morphological and production characteristics of fennel populations different origin under different ecological conditions in Hungary. The Korean population can be registered as a medium high genotype and showed a more accelerated growth characters than Hungarian taxon and the two populations have a medium homogeneity $(CV\;=\;4{\sim}22%)$. In the second year plant height in Hungarian taxon was significantly higher than that of the Korean population. The shooting dynamic of individual plants might be heterogeneous in both taxa and the Korean population was not only shorter in the height but had also less shoots by 16% than the Hungarian one. The Hungarian taxon exceeded the umbel size and numbers to the Korean one (by 3.62 cm in the average) and the variability in the populations was high $(CV\;=\;29{\sim}49%)$. Seed size was proved to be also a discriminative feature between the examined taxa. With small deviations (CV < 2) the Hungarian population produced seeds longer by 38%. Homogeneity in the populations was dependent more on the vegetation years and on the characteristics measured but less on the origins, respectively.

• 한국약용작물학회지
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• 제11권2호
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• pp.115-121
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• 2003

전통적인 향기치료제로 쓰여 온 회향, 유향 그리고 노간주를 사용하여 최근 신기술로 평가되고 있는 초임계 유체추출법을 통해 생체 조절기능을 지닌 기능성 정유 성분을 추출하였다. 기존의 SDE 추출법과 비교하여 추출수율 측면에서 비교적 높은 결과를 얻어내어 정유 추출시 장차 SDE 추출법을 대체할 신기술로 평가되었다. 추출용매를 사용해야 하는 SDE 추출법과는 달리 무색, 무취인 $CO_2$를 이용하여 정유 성분을 분리하는 초임계 추출법은 인체에 무해한 정유 성분을 얻을 수 있다는 것이 가장 큰 장점이라 사료되며, 분리된 정유 물질에 대해 성분 분석 결과 대부분이 휘발성 알코올 계열에 물질임을 확인할 수 있었다. 정유 성분들에 대한 생리활성 실험결과 항암, 항 돌연변이 그리고 신경활성이 아주 높은 것으로 나타나 aroma-theraphy로서의 가능성을 제시하였다고 사료된다. 나아가 이 정유성분에 대한 in vivo 실험을 통해 기초 의약품으로서 연구가 수행되어진다면 전통적인 치료제로서 사용된 천연물에 대한 현대적 가치부여가 가능하다고 생각된다.

• Current Research on Agriculture and Life Sciences
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• 제9권
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• pp.115-125
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• 1991

우리나라와 일본(日本)에서 야생 또는 재배되고 있는 약용식물(藥用植物)의 바이러스병을 조사한 결과 33종의 식물이 자연상태에서 오이 모자이크 바이러스(CMV)에 감염되어 있음을 알았다. 이들 중에서 개맨드라미(Celosia argenteia)와 쇠비름(Portulaca oleracea)의 모자이크병(가칭(假稱)), 쥐방울덩굴(Aristolochia debilis)과 번행초(Tetragonia expansa)의 괴저(壞疽)모자이크병(가칭(假稱)), basella(Basella rubra)윤문병(輪紋病)(가칭(假稱)), 석결명(Cassia torosa)과 시호(Bupleurum falcatum), 당귀(Angelica acutiloba), 구릿대(A. keiskei), 회향(Foeniculum vulgare), peucedanum(Peucedanum japanicum)의 반문병(斑紋病)(가칭(假稱))등 11종의 바이러스병명(病名)을 새로히 명명(命名)하였다.

• 생명과학회지
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• 제25권8호
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• pp.880-888
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• 2015

회향은 미나리과에 속하는 다년생식물인 Foeniculum vulgare Mill.의 성숙한 과실로서 항염, 진통, 피부노화방지 등의 효과를 가지고 있어 다양한 질환에 우수한 치료효과를 나타내는 것으로 알려져 왔다. 따라서 본 연구에서는 기능성이 우수한 회향 열매 추출물을 이용하여 피부 질환 치료제 및 피부장벽 기능 개선 소재로서의 적용가능성을 확인하였다. 이를 위해 각질형성세포주인 HaCaT에 회향 열매 메탄올 추출물과 그 분획물(hexane, methyl chloride, ethyl acetate, butanol)을 처리한 후, involucrin, loricrin, filaggrin의 발현과 hyaluronic acid의 생성 및 β-defensin -1, -2, -3, LL-37의 mRNA 발현을 측정하였다. 그 결과butanol 분획물 50 μg/ml을 24시간 동안 처리시 involucrin과 filaggrin단백질 발현을 각각122.8%, 105%로 유의하게 증가시킴을 확인하였다. Elisa assay를 통해 분석한 결과, ethyl acetate와 butanol 분획물은 대조군에 비해 hyaluronic acid의 생성을 각각17%, 11% 증가시켰으며, 이는 hyaluronic acid synthesis-1의 mRNA 발현 증가에 의한 것임을 확인하였다. 그러나 회향 열매 메탄올 추출물과 분획물 모두에서 β-defensin -1, -2, -3, LL-37의 mRNA 발현은 증가되지 않았다. 이러한 결과는 회향 열매 butanol 분획물이 각질형성세포에서 물리적 장벽을 형성하고 보습인자 조절을 통해 피부장벽 기능을 강화하는데 효과적임을 의미한다.

• Journal of Nutrition and Health
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• 제53권5호
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• pp.445-451
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• 2020

Purpose: Breastfeeding is the optimal method for feeding a newborn. But insufficient breast milk is the major reason why mothers give up breastfeeding. Herbal galactagogues have been used increasingly to treat postpartum hypogalactia. This study examined the effect of an herbal tea containing Chrysanthemum indicum, as the main ingredient, on milk production in lactating rats. Methods: The herbal tea contained C. indicum (27%), Foeniculum vulgare Mill (21%), Pimpinella anisum (18.2%), Carum carvi (16.1%), Urtica dioica (14.7%), and Gardenia jasminoides (3%). Sixteen lactating Sprague-Dawley (SD) rats were divided randomly into 2 groups, the normal control group (NC; n = 8), and the galactagogue herbal tea group (GHT; n = 8) for 7 days. Lactating rats were administered the decoction of an herbal galactagogue mixture by oral gavage or the same amount of distilled water and milk production was assessed by measuring the pups' weights during the suckling period. The blood concentrations of prolactin, cortisol, oxytocin levels and mammary gland tissues were examined to assess the effects of the galactagogue. Results: Milk production was 9.2% higher in the GHT group given the herbal tea than in the NC group and the difference was statistically significant. The cortisol level in the GHT group was 17.2% higher than the NC group. The herbal tea containing C. indicum increased the size of the alveoli epithelium cells and the mammary lobe. Conclusion: The present study revealed the potential of herbal tea containing C. indicum to enhance milk production in postpartum SD rats.