• Asian Pacific Journal of Cancer Prevention
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• v.17 no.5
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• pp.2719-2722
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• 2016

Circulatory miR-133a is a marker shared by several types of cancer. In this study we evaluated the feasibility of using miR-133a levels in gastric juice to screen for gastric cancer. A total of 204 samples of gastric juice and mucosa from gastric cancer, atrophic gastritis, gastric ulcer, superficial gastritis and healthy cases were collected by gastroscopy. The results showed that miR-133a levels in gastric juice and carcinoma tissues of patients with gastric cancer were significantly downregulated and positively correlated. Moreover, miR-133a in gastric juice has high operability, high reliability, high sensitivity, high specificity and relative stability, fit for clinical diagnosis of gastric cancer.

• BMB Reports
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• v.52 no.1
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• pp.86-108
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• 2019

In multi-cellular organisms, the control of gene expression is key not only for development, but also for adult cellular homeostasis, and gene expression has been observed to be deregulated with aging. In this review, we discuss the current knowledge on the transcriptional alterations that have been described to occur with age in metazoans. First, we discuss age-related transcriptional changes in protein-coding genes, the expected functional impact of such changes, and how known pro-longevity interventions impact these changes. Second, we discuss the changes and impact of emerging aspects of transcription in aging, including age-related changes in splicing, lncRNAs and circRNAs. Third, we discuss the changes and potential impact of transcription of transposable elements with aging. Fourth, we highlight small ncRNAs and their potential impact on the regulation of aging phenotypes. Understanding the aging transcriptome will be key to identify important regulatory targets, and ultimately slow-down or reverse aging and extend healthy lifespan in humans.

• 한국노년학
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• v.28 no.4
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• pp.831-846
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• 2008

The purpose of this study was to review papers published in the Journal of Korean Gerontological Society(1980-2008). For this purpose, the 55 articles on the educational gerontology were collected from the Journal. The published time, the number of authors, the author's positions, subjects, type of the researches, methods, the statistical techniques, topics of the educational gerontology, and so on were analyzed for this research. The results of this study were as follows: (1)The articles regarding on the educational gerontology took 7.14% in the Journal of Korean Gerontological Society. (2)The case of the quantitative researches for the elderly done by single author, performed without fund, through the questionnaire survey, and with more than two statistical techniques were the most common. Based on this researches, the organization of the major field or some courses on the educational gerontology, more research funds for the educational gerontology, and the efforts on the various research methods of themes and objects are recommended for better researches on the educational gerontology. Finally, we must expand our interests for the elderly's empowerment as a learner and the educational gerontology.

• Proceedings of the Ginseng society Conference
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• 1978.09a
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• pp.19-20
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• 1978

• Journal of the Korean Home Economics Association
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• v.18 no.2
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• pp.41-48
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• 1980

It has been more than ten years that the studies in the field of social gerontology I Korean had begun. But there had been no empirical study on this field about the published articles. This study intend to analyze and evaluate those achievements synthetically focusing on the past articles on the aged in Korea which had been published till March, 1980. And also intend to prepare a movement for the purpose of utilizing and fixing those past articles in order to contribute to the social gerontology I Korean. Used raw materials are as follows; 1) research papers of every college 2) thesis of annex research institute of every college 3) reports of academic institutes and organizations annex research institute of every college 30 reports of academic institutes and organizations 4) 42 copies of raw materials of seminars and doctoral dissertations and 3 independent volumes. In order to describe what kind of researches has been done in the field of social gerontology, categorized in six items focusing on the selected studies. 1) Process of unfolding and definitions of social gerontology 2) Economic life of old people 3) Works, Retirement, loneliness and alienation of the old people 4) Domestic management of old people 5) Medical and health aspects of old people 6) Welfare of old people These problems has been exposed through this research. Firstly almost every studies are descriptive and diagnostic rather than scientific for the theoretic development of gerontology. secondly it is difficult to generalize for the purpose of utilizing the outcome of researches I the broader and deeper sense those researches has been done in regional level. Thirdly there hadn't been any researches over the entire country in the governmental level. Thus it is impossible to deduce and analyze comparatively on the ground of governmental data.

• The Journal of Korean Academic Society of Nursing Education
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• v.10 no.1
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• pp.7-19
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• 2004

This study has a purpose to devise an education program in relation to Gerontology and geriatrics applicable to Korean nurses through literature review and analysis of education programs utilized by the Geriatric Education Centers (GECs) of USA. Educational contents on gerontology and geriatrics are very diverse in precedent literatures. The education programs of GECs for health care personnel are equally very diverse. Among educational contents, subjects considered important are age-related changes, health problems of the aged, pharmacology, death, fall and osteoporosis, delirium, dementia, depression, urinary incontinence, communication with elderly. Methods used in education program are mainly seminar, workshop and lecture through internet. In addition, case study, small-group discussion and conference are also adopted. The program proposed in this study for nurses in relation to gerontology and geriatrics consists of 32 hours' education; 6 hours for age-related changes, 10 hours for health problems of the elderly, 14 hours for health problems in old age and 2 hours of communication technique. Educational method proposed is to utilize lecture through internet, direct education, workshop, practical exercise, case study and role play in parallel. This study proposed an education program on the basis of precedent literature and the program of GECs. Therefore, it is desirable to develop in the future more practical education program applicable to and required in practicing fields. Of course, this development needs to be based on nurses' educational needs by field in relation to gerontology and geriatrics.

• The Korean Journal of Physiology and Pharmacology
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• v.23 no.4
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• pp.251-261
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• 2019

Allergic asthma, is a common chronic inflammatory disease of the airway presenting with airway hyperresponsiveness and airway remodelling. T helper cells-derived cytokines are critically associated with asthma pathogenesis. Janus kinase-signal transduction and activation of transcription (JAK/STAT) signaling is found to be involved in asthma. Magnolol is a plant-derived bioactive compound with several pharmacological effects. The study aimed to assess the effects of magnolol in ovalbumin (OVA)-induced asthmatic model. BALB/c mice were sensitized and challenged with OVA. Magnolol (12.5, 25, or 50 mg/kg body weight) was administered to separate groups of animals. Dexamethasone was used as the positive control. Cellular infiltration into the bronchoalveolar lavage fluid (BALF) were reduced on magnolol treatment. The levels of Th2 and Th17 cytokines were reduced with noticeably raised levels of interferon gamma. Lung function was improved effectively along with restoration of bronchial tissue architecture. OVA-specific immunoglobulin E levels in serum and BALF were decreased by magnolol. Magnolol reduced Th17 cell population and effectively modulated the JAK-STAT and Notch 1 signaling. The results suggest the promising use of magnolol in therapy for allergic asthma.

• The Korean Journal of Physiology and Pharmacology
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• v.25 no.5
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• pp.425-437
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• 2021

Although the contributions of sitagliptin to endothelial dysfunction in diabetes mellitus were previously reported, the mechanisms still undefined. Autophagy plays an important role in the development of diabetes mellitus, but its role in diabetic macrovascular complications is unclear. This study aims to observe the effect of sitagliptin on macrovascular endothelium in diabetes and explore the role of autophagy in this process. Diabetic rats were induced through administration of high-fat diet and intraperitoneal injection of streptozotocin. Then diabetic rats were treated with or without sitagliptin for 12 weeks. Endothelial damage and autophagy were measured. Human umbilical vein endothelial cells were cultured either in normal glucose or in high glucose medium and intervened with different concentrations of sitagliptin. Rapamycin was used to induce autophagy. Cell viability, apoptosis and autophagy were detected. The expressions of proteins in c-Jun N-terminal kinase (JNK)-Bcl-2-Beclin-1 pathway were measured. Sitagliptin attenuated injuries of endothelium in vivo and in vitro. The expression of microtubuleassociated protein 1 light chain 3 II (LC3II) and beclin-1 were increased in aortas of diabetic rats and cells cultured with high-glucose, while sitagliptin inhibited the over-expression of LC3II and beclin-1. In vitro pre-treatment with sitagliptin decreased rapamycin-induced autophagy. However, after pretreatment with rapamycin, the protective effect of sitagliptin on endothelial cells was abolished. Further studies revealed sitagliptin increased the expression of Bcl-2, while inhibited the expression of JNK in vivo. Sitagliptin attenuates injuries of vascular endothelial cells caused by high glucose through inhibiting over-activated autophagy. JNK-Bcl-2-Beclin-1 pathway may be involved in this process.

• 한국노년학
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• v.38 no.3
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• pp.685-703
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• 2018

The purpose of this study was to critically review articles published in the Journal of the Korean Gerontological Society(2008-2017). The 70 articles on the field of educational gerontology were collected from the journal. Research subjects, types of research, data collection methods, data analysis methods, and topics of research were analyzed. For recent ten years, the proportion of articles about educational gerontology took only 10.7%. Normal older adults(52.9%) for research subjects, experimental research(41.4%) for types of research, using questionnaires(42.9%) for data collection methods, analyzing differences between experimental and control group(22.9%) for data analysis methods, and education for older adults(72.9%) for topics of research were showed the highest proportion. Future research on educational gerontology needs to investigate informal educational experiences, consider diversity of older adults, and have more critical opinions on educational gerontology.

• The Korean Nurse
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• v.24 no.2 s.130
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• pp.6-8
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• 1985