• Asian Pacific Journal of Cancer Prevention
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• 제17권5호
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• pp.2719-2722
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• 2016

Circulatory miR-133a is a marker shared by several types of cancer. In this study we evaluated the feasibility of using miR-133a levels in gastric juice to screen for gastric cancer. A total of 204 samples of gastric juice and mucosa from gastric cancer, atrophic gastritis, gastric ulcer, superficial gastritis and healthy cases were collected by gastroscopy. The results showed that miR-133a levels in gastric juice and carcinoma tissues of patients with gastric cancer were significantly downregulated and positively correlated. Moreover, miR-133a in gastric juice has high operability, high reliability, high sensitivity, high specificity and relative stability, fit for clinical diagnosis of gastric cancer.

• BMB Reports
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• 제52권1호
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• pp.86-108
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• 2019

In multi-cellular organisms, the control of gene expression is key not only for development, but also for adult cellular homeostasis, and gene expression has been observed to be deregulated with aging. In this review, we discuss the current knowledge on the transcriptional alterations that have been described to occur with age in metazoans. First, we discuss age-related transcriptional changes in protein-coding genes, the expected functional impact of such changes, and how known pro-longevity interventions impact these changes. Second, we discuss the changes and impact of emerging aspects of transcription in aging, including age-related changes in splicing, lncRNAs and circRNAs. Third, we discuss the changes and potential impact of transcription of transposable elements with aging. Fourth, we highlight small ncRNAs and their potential impact on the regulation of aging phenotypes. Understanding the aging transcriptome will be key to identify important regulatory targets, and ultimately slow-down or reverse aging and extend healthy lifespan in humans.

• 한국노년학
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• 제28권4호
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• pp.831-846
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• 2008

본 연구의 목적은 지난 30년 동안 <한국노년학>에 게재되었던 노년교육 관련 연구논문들을 분석해 봄으로써 왜 아직까지 노년교육학이 우리 사회에서 그리고 노년학 안에서 제 위치를 확보하지 못하고 있는지 그 원인을 분석해보고, 앞으로의 노년교육학이 독립적인 학문분야로서 성장하고 발전하기 위해서 어떤 변화가 요구되는지에 대하여 전망해 보는 데 있다. 이를 위해 "한국노년학" 1권(1980년)부터 28권 3호(2008년 8월)까지에 게재된 논문 770편 중 노년교육 관련 논문 55편을 대상으로 게재시기, 연구비 지원기관, 저자들의 소속기관, 연구대상, 연구유형, 자료수집 방법, 자료분석 방법, 연구 주제 등을 분석하였다. 그 결과, 지난 30년간 "한국노년학"에 게재된 논문 770편 중 노년교육 관련 논문은 단 55편뿐이었다. 그 중 대학에 소속된 연구자가 단독으로, 연구비를 지원받지 않고, 노인을 대상으로, 설문조사를 통하여, 두 가지 이상의 통계방법을 적용하여 노인을 위한 교육을 주제로 행한 조사연구가 가장 많은 비중을 차지하였다. 따라서 향후 노년교육 연구의 발전을 위해서는 노년교육 전문학자 양성을 위한 전공 및 교과목 설치, 노년교육에 대한 연구지원 확대, 다양한 연구방법과 다주제, 대상을 지향하는 연구노력 등이 요구된다. 그리고 무엇보다도 이러한 노력들 이전에 우리 사회 전반에서 노인들의 학습자로서의 역량 및 노년교육에 대한 관심이 확대되어야 할 것이다.

• 고려인삼학회:학술대회논문집
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• 고려인삼학회 1978년도 학술대회지
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• pp.19-20
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• 1978

• 대한가정학회지
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• 제18권2호
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• pp.41-48
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• 1980

It has been more than ten years that the studies in the field of social gerontology I Korean had begun. But there had been no empirical study on this field about the published articles. This study intend to analyze and evaluate those achievements synthetically focusing on the past articles on the aged in Korea which had been published till March, 1980. And also intend to prepare a movement for the purpose of utilizing and fixing those past articles in order to contribute to the social gerontology I Korean. Used raw materials are as follows; 1) research papers of every college 2) thesis of annex research institute of every college 3) reports of academic institutes and organizations annex research institute of every college 30 reports of academic institutes and organizations 4) 42 copies of raw materials of seminars and doctoral dissertations and 3 independent volumes. In order to describe what kind of researches has been done in the field of social gerontology, categorized in six items focusing on the selected studies. 1) Process of unfolding and definitions of social gerontology 2) Economic life of old people 3) Works, Retirement, loneliness and alienation of the old people 4) Domestic management of old people 5) Medical and health aspects of old people 6) Welfare of old people These problems has been exposed through this research. Firstly almost every studies are descriptive and diagnostic rather than scientific for the theoretic development of gerontology. secondly it is difficult to generalize for the purpose of utilizing the outcome of researches I the broader and deeper sense those researches has been done in regional level. Thirdly there hadn't been any researches over the entire country in the governmental level. Thus it is impossible to deduce and analyze comparatively on the ground of governmental data.

• 한국간호교육학회지
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• 제10권1호
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• pp.7-19
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• 2004

This study has a purpose to devise an education program in relation to Gerontology and geriatrics applicable to Korean nurses through literature review and analysis of education programs utilized by the Geriatric Education Centers (GECs) of USA. Educational contents on gerontology and geriatrics are very diverse in precedent literatures. The education programs of GECs for health care personnel are equally very diverse. Among educational contents, subjects considered important are age-related changes, health problems of the aged, pharmacology, death, fall and osteoporosis, delirium, dementia, depression, urinary incontinence, communication with elderly. Methods used in education program are mainly seminar, workshop and lecture through internet. In addition, case study, small-group discussion and conference are also adopted. The program proposed in this study for nurses in relation to gerontology and geriatrics consists of 32 hours' education; 6 hours for age-related changes, 10 hours for health problems of the elderly, 14 hours for health problems in old age and 2 hours of communication technique. Educational method proposed is to utilize lecture through internet, direct education, workshop, practical exercise, case study and role play in parallel. This study proposed an education program on the basis of precedent literature and the program of GECs. Therefore, it is desirable to develop in the future more practical education program applicable to and required in practicing fields. Of course, this development needs to be based on nurses' educational needs by field in relation to gerontology and geriatrics.

• The Korean Journal of Physiology and Pharmacology
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• 제23권4호
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• pp.251-261
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• 2019

Allergic asthma, is a common chronic inflammatory disease of the airway presenting with airway hyperresponsiveness and airway remodelling. T helper cells-derived cytokines are critically associated with asthma pathogenesis. Janus kinase-signal transduction and activation of transcription (JAK/STAT) signaling is found to be involved in asthma. Magnolol is a plant-derived bioactive compound with several pharmacological effects. The study aimed to assess the effects of magnolol in ovalbumin (OVA)-induced asthmatic model. BALB/c mice were sensitized and challenged with OVA. Magnolol (12.5, 25, or 50 mg/kg body weight) was administered to separate groups of animals. Dexamethasone was used as the positive control. Cellular infiltration into the bronchoalveolar lavage fluid (BALF) were reduced on magnolol treatment. The levels of Th2 and Th17 cytokines were reduced with noticeably raised levels of interferon gamma. Lung function was improved effectively along with restoration of bronchial tissue architecture. OVA-specific immunoglobulin E levels in serum and BALF were decreased by magnolol. Magnolol reduced Th17 cell population and effectively modulated the JAK-STAT and Notch 1 signaling. The results suggest the promising use of magnolol in therapy for allergic asthma.

• The Korean Journal of Physiology and Pharmacology
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• 제25권5호
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• pp.425-437
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• 2021

Although the contributions of sitagliptin to endothelial dysfunction in diabetes mellitus were previously reported, the mechanisms still undefined. Autophagy plays an important role in the development of diabetes mellitus, but its role in diabetic macrovascular complications is unclear. This study aims to observe the effect of sitagliptin on macrovascular endothelium in diabetes and explore the role of autophagy in this process. Diabetic rats were induced through administration of high-fat diet and intraperitoneal injection of streptozotocin. Then diabetic rats were treated with or without sitagliptin for 12 weeks. Endothelial damage and autophagy were measured. Human umbilical vein endothelial cells were cultured either in normal glucose or in high glucose medium and intervened with different concentrations of sitagliptin. Rapamycin was used to induce autophagy. Cell viability, apoptosis and autophagy were detected. The expressions of proteins in c-Jun N-terminal kinase (JNK)-Bcl-2-Beclin-1 pathway were measured. Sitagliptin attenuated injuries of endothelium in vivo and in vitro. The expression of microtubuleassociated protein 1 light chain 3 II (LC3II) and beclin-1 were increased in aortas of diabetic rats and cells cultured with high-glucose, while sitagliptin inhibited the over-expression of LC3II and beclin-1. In vitro pre-treatment with sitagliptin decreased rapamycin-induced autophagy. However, after pretreatment with rapamycin, the protective effect of sitagliptin on endothelial cells was abolished. Further studies revealed sitagliptin increased the expression of Bcl-2, while inhibited the expression of JNK in vivo. Sitagliptin attenuates injuries of vascular endothelial cells caused by high glucose through inhibiting over-activated autophagy. JNK-Bcl-2-Beclin-1 pathway may be involved in this process.

• 한국노년학
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• 제38권3호
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• pp.685-703
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• 2018

본 연구는 한국노년학의 30년(1980년-2008년)간의 노년교육 분야 논문을 분석한 한정란(2008) 이후 최근 10년간 "한국노년학"에 게재된 노년교육 관련 연구를 분석함으로써 우리 사회에서 노년교육학의 연구동향을 파악하고 이를 통해 미래에 노년교육학이 나아가야 할 바를 전망하는 것을 목적으로 한다. 이를 위해 '한국노년학' 28권 3호(2008년 8월)부터 27권 4호(2017년 11월)까지 게재된 총 655편중에서 노년교육 관련 논문 70편을 대상으로 연구대상, 연구유형, 자료수집방법, 자료분석방법, 연구 주제를 분석하였다. 분석 결과 최근 10년간 노년교육 관련 연구는 "한국노년학"에 전체 게재된 연구 중 10.7%에 불과하였으며, 연구대상은 (60세 이상) 일반노인(52.9%)이, 연구유형은 실험연구(41.4%)가, 자료수집방법은 설문조사(42.9%)가, 자료분석방법은 처치-실험집단 간 차이검증(22.9%)이, 마지막으로 연구주제는 노인을 위한 교육(72.9%)이 가장 높은 비율을 차지하였다. 향후 노년교육 연구의 발전을 위해서는 비형식 교육을 넘어서 삶의 경험과 무형식 학습을 통한 교육과 관련한 연구 진행, 노인 집단 내 다양성을 고려한 연구 진행, 비판적 시각을 통해 노년교육에 대한 새로운 견해 제공 등의 노력이 필요할 것이다.

• 대한간호
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• 제24권2호통권130호
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• pp.6-8
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• 1985