• Journal of Physiology & Pathology in Korean Medicine
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• v.22 no.1
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• pp.189-193
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• 2008

We analyzed the research type and statistical methods in Korean Journal of Oriental Physiology and Pathology for describing the trends of Oriental medicine research. The data for the analysis of trends in Oriental medicine research was taken from a total 808 articles published in Korean Journal of Oriental Physiology and Pathology from 2004 to 2006. We surveyed the number of authors, the institutes involved in each study, and used languages in each study. Also we seperated by epidemiological study design, the studies into categories and statistical methods into 13 categories. Results showed that descriptive statistics was used in 125(14.4%) papers. Also t-test, analysis of variance, multiple comparison, chi-square test, and non-parametric test were used in 338(38.9%), 147(16.9%), 81(9.3%), 27(3.1%), 23(2.6%) papers, respectively. And 62(7.1%) papers of the involved papers didn't use statistical methods. To improve the quality of Oriental medicine related articles, we have to use proper statistical methods with consultation of statistician or other experts before accepting a manuscript are needed.

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.5
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• pp.1162-1168
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• 2005

For raising to the significance of whole Dody form diagnosis, I studied comparatively oriental medicine's whole body form diagnosis, biological evolution and physiognomy. In the oriental medicine, the whole body form diagnosis was recognized a means to deal with 'an individual physiology-pathology' and applied practically 'the typing of whole body form'. The physiognomy was applied to whole body form for the conversion of conception in social science and attached great importance to 'the face of human'. The biological evolution was applied to whole body form for the means by grasping the human individual characteristic, so much as magnified to the size of unconscious body-language(Synergologie, Tells exe.).

• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.6
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• pp.1617-1621
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• 2004

The aim of this study was to investigate the apoptotic effect and its mechanism on Radix Paeoniae Alba Extract(RPAE) in DU145 human prostate cancer cell line. RPAE induced apoptosis in a dose-dependent manner in DU145 cells as confirmed by both discontinuous DNA fragmentation using Hoechst33342 staining and poly-(ADP-ribose) polymerase(PARP) cleavage, which are apoptotic signs. To clarify the mechanisms on RPAE-induced apoptosis, we examined the p50(NF-κB subunit), IκBα, PTEN and Par-4 protein expression using Western blotting. Treatment with RPAE resulted in the decrease of p50 expression by IκBα increase, which resulted in Par-4 increase and bcl-2 decrease in DU145 cells. These results suggest that apoptosis of DU145 cells by RPAE involved decreases of NF-κB activation and bcl-2 expression, increase of Par-4 protein expression.

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.2
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• pp.347-357
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• 2005

The medicine through I Ching(The Book of Changes, 易經) is a field of the medical science, which studies physiology, pathology and Yin-Yang philosophy. From ancient times so many scholars have studied I Ching and they are divided into two different school. one is the school of Image and Number(象數學派), the other is the school of reason(義理學派). Dasan Jung Yak-Yong(茶山 丁若鏞) is a distinguished scholar in the I-Ching study, and he had a unique opinion in the analysis about sentences of I Ching. He has done his best to make 'Image and Number(象數)' harmonize with reason(義理). I Ching is the book about changes, which includes everything like natural phenomena, human body and mind. So we can understand human physiology and pathology through I Ching.

• Journal of Physiology & Pathology in Korean Medicine
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• v.17 no.1
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• pp.25-30
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• 2003

On the ground of researches in social consciousness about the folk remedies, both of them, people and oriental medicine doctors, feel strongly the relative importance and the necessity of the folk remedies. But the folk remedy had not groped for proper adoption and not shared in the benefits actually. Therefore the oriental medicine doctors present a direct guide for use, instead of leaving people to use improperly. And the oriental medicine doctors are in need of making a guide for efficient use of the folk remedies at the existing disease types.

• Journal of Physiology & Pathology in Korean Medicine
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• v.16 no.3
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• pp.443-451
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• 2002

In the present social-communicating situation of the folk remedies, we can say there is no responsible main group of it. When we look for recent published remedy books, their authors' background is too various. The folk remedy only focuses on the generality but it does not understand the problem of misusing with lack of explanation and classification in view of the oriental medicine. In conclusion, current folk remedies have formed a figure out of irresponsibility.

• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.6
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• pp.1129-1133
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• 2010

The treatment of Atopic dermatitis and its untapped herbal elements are recognized as possible solutions to incurable diseases stemming from overdosage of chemical drugs. Synthesizing clinical results from the Oriental medicine with scientific results from the field of Molecular biology is in the mainstream. The main goal of this research is, by objectifying the methodology of abstracting information into a compendium, to establish knowledge-based database on natural materials mingling every single related information from both Oriental and Western medicine. The constructed system, ATODERM, is the first database system about the medical herb for the treatment of Atopic Dermatitis which bearing the integrated information on Oriental medicine and Western medicine. The construction of this database renders new ways of treatment and prescriptions for researchers in the field of the Oriental medicine. Using the database that has been intensively accumulated, the possibility of creating the plausible cure for the disease can be anticipated.

• Korean Journal of Acupuncture
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• v.26 no.4
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• pp.107-118
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• 2009

Objectives : This study was performed to investigate physiology, pathology and clinical applications for cosmetology in Traditional Chinese Medicine. We hope most clinicians practicing cosmetic acupuncture to understand theoretical background well and to treat cosmetic diseases more diversely by this paper. Methods : We collected useful informations from 35 papers in Chinese at website www.cnki.net about TCM treatments including acupuncture, moxibustion and herbal medicine. And we could see important factors connected with physiology, pathology and clinical applications within this field. Conclusions : Liver, lung, stomach, mental disorders and yin-deficiency constitution were connected each other in cosmetic physiology. Blood stasis and congestion were thought highly in cosmetic pathology. In clinical applications, wet cupping therapy on the acupoints located in the back line of Governor Vessel(GV), ear-acupuncture, acupuncture using local facial acupoints, pharmacopuncture, moxibustion were used diversely for each case with cosmetic disorders. Especially, local acupoints and remote acupoints were selected at the same time for wrinkle care. And studies on plastic surgery sequelae, dark skin, acne and melasma were more published than those on wrinkle care.

• Journal of Physiology & Pathology in Korean Medicine
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• v.16 no.2
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• pp.215-219
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• 2002

Over the past decade there has been a resurgence of interest in botanical products for their medicinal uses. This present study was designed to screen medicinal plants for the treatment of brain diseases such as Alzheimer's disease or aging. We tested the effects of the water extracts from 41 species medicinal plants on acetylcholinesterase (AChE) inhibition and antioxidant activity in vitro. Among them, Euodia rutaecarpa, Rubus coreanus, Achyranthes japonica, Morus alba, Salvia miltiorrhiza, Liriope platyphylla, and Rheum palmatum showed relatively AChE inhibition potency over 80%. Among the 7 medicinal plants investigated, E. rutaecarpa showed an 25%, 65%, and 93% inhibitions on AChE activity at 2.5, 12.5, and 25 ㎍/㎖ of the extract, respectively and was found to be one of most potent AChE inhibitor. The water extracts from 4 species (E. rutaecarpa, R. coreanus, A. iaponica, and M. alba) were tested on their antioxidant capacities using radical scavenging effect against ABTS/sup ㆍ+/. Among the 4 medicinal plants investigated, both R. coreanus and E. rutaecarpa showed significant antioxidant capacity. Therefore, E. rutaecarpa and R. coreanus are expected to ameliorate the clinical symptoms in Alzheimer's disease due to significant AChE inhibition and radical scavenging effect.

• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.1
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• pp.9-14
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• 2010

The purpose of this study was to review the direction of Korean medicine treatment in hyperlipidemia, focusing on Korean herbal medicine and to suggest sources for drug development in treatment of hyperlipidemia. We searched 115 articles which had been published from 1997 to 2009 in journals in Korean Oriental Medical Society and its sub-societies. Those articles were selected from the search engine of web site of each journal with the key words 'hyperlipidemia'. Excluding 21 articles in no relation to herbs, we finally reviewed 94 articles. There are many studies of 'hyperlipidemia' in Korean Medicine. Analyzing the articles, we found that the medicinal effects of the herbs used in recent studies and patents coincides with treatment of hyperlipidemia in Korean medicine. Although many herbs in articles is granted patent, it doesn't proceeds to develop herbal drug. It requires to study in treatment of hyperlipidemia in Korean medicine and then to develop herbal drug.