• 대한소아치과학회지
• /
• 제26권2호
• /
• pp.310-316
• /
• 1999

외상받은 치아에서 치수강폐쇄, 치수괴사, 치근흡수, 인접치조골소실, 치근단염증성변화 및 치아상실 등의 부작용이 나타날 수 있으며, 이는 치근형성정도, 탈구의 종류, 고정의 기간에 따라 예후가 달라진다. 외상후 부작용의 빈도를 줄이기 위해서는 조기에 치수생활력 유무를 판단하는 것이 중요하다. 그러나 미성숙치근을 가진 치아는 치수내 신경발달분포가 불완전하고, 환자의 연령이 어려 술식에 대한 이해력이 부족하고 치과에 대한 공포감 때문에 전기치수검사등의 전통적인 치수생활력 방법의 신뢰도가 떨어진다. 반면 laser Doppler flowmetry는 치수혈류량을 측정하여 치수생활력을 검사하는 방법으로서 보존적이며 객관적이고, 외상후 비교적 조기에 치수생활력을 측정할 수 있는 신뢰도가 높은 치수생활력 검사방법이다. 이에 저자는 외상받은 미성숙치아를 대상으로 냉검사, 전기치수검사, laser Doppler flowmetry를 이용하여 치수생활력을 검사하여 다음과 같은 결과를 얻었다. 1. 외상받은 치아의 치수생활력은 초기에는 음성으로 나타날 수 있으나 시간의 경과에 따라 양성으로 회복될 수 있어 장기간의 관찰이 필요하다. 2. 치수생활력은 냉검사, 전기치수검사 보다 laser Doppler flowmetry 에서 더 빨리 나타났다. 3. 냉검사와 전기치수검사의 두가지 치수생활력 검사방법중 전기치수검사 보다 냉검사가 신뢰도가 더 높았다.

• Journal of Periodontal and Implant Science
• /
• 제28권2호
• /
• pp.309-320
• /
• 1998

The periodontal health has been evaluated clinically by various epidemiological indices, and in researches by measurement of gingival crevicular fluid. Laser Doppler flowmetry is a reliable and objective method that allows immediate measurement of erythrocyte flux in approximately one cubic mm of the capillary bed without disturbing the tissues. The purpose of the present study was to determine whether human gingival blood flow was different according to measuring area, measuring time, and sex or not. Forty volunteers with good general and periodontal health, aged early twenties and unmarried, were selected. Laser Doppler flowmetry($floLAB^{(R)}$, Moor Instruments Ltd., England) was applied to measure the gingival blood flow of marginal gingiva, interdental papilla, attached gingiva and alveolar mucosa. The blood flow of interdental papilla was measured at 9-10 AM, 1-2 PM, and 5-6 PM. The difference of blood flow according to measuring area and measuring time was statistically analyzed by one way AOVA and Dunkan test, and the difference of blood flow between men and women was statistically analyzed by t-test. (1) Mean blood flow was significantly higher in alveolar mucosa than in the gingiva(p<0.05), and there was no significant difference in blood flow between marginal gingiva and interdental papilla(p>0.1). (2) Mean blood flow was significantly higher at 5-6 PM than at 9-10 AM and 1-2 PM(p<0.05). But there was no significant difference in gingival blood flow between 9-10 AM and 1-2 PM(p>0.1). (3) There was no significant difference in gingival blood flow between men and women(p>0.1). The above results suggest that the measurment of gingival blood flow using laser Doppler flowmetry may be clinically applicable to early determination of gingival inflammation and evaluation of healing status, but further studies are necessary to standardize and simplify the measuring procedure.

• 대한치주과학회:학술대회논문집
• /
• 대한치주과학회 2001년도 제41회 종합학술대회 연제초록
• /
• pp.51-51
• /
• 2001

• 대한의용생체공학회:의공학회지
• /
• 제20권6호
• /
• pp.531-537
• /
• 1999

본 연구에서는 FFT와 파라메트릭 방법에 의한 혈류 추정방법을 연구하고 디지털 신호처리 프로세서를 이용하여 레이저 도플러 혈률계를 구현하였다. 레이저 도플러 혈류계는 피부의 모세혈류의 흐름을 측정할수 있는 장비로서 다양한 분야에 활용이 가능하다. 구현된시스템은 TI사의 TMS320C32 DSP를 사용하였으며, 전력 스펙트럼의 모멘트값을 이용하여 혈류를 추정하였다. 혈류 추정 값은 매 0.5초마다 그래픽 사용자 인터페이스를 통해서 표시하도록 하였다. 시스템의 성능을 평가하기 위해서 혈류 시뮬레이터에 흐르는 혈류를 계단함수, 삼각함수, 사인함수로 제어하여 그 결과를 비교하였으며 인체 부위에 따른 혈류를 측정하였다. 실험결과 구현된시스템의 혈류 추정성 및 재현성이 보장되고있음을 확인할수 있었다.

• 대한치주과학회:학술대회논문집
• /
• 대한치주과학회 1998년도 제38회 종합학술대회 연제초록
• /
• pp.99-99
• /
• 1998

• Journal of Periodontal and Implant Science
• /
• 제32권2호
• /
• pp.291-302
• /
• 2002

In most of the previous studies, invasive and discrete techniques have been used to monitor the healing process of the gingival graft. However, Laser Doppler Flowmetry(LDF, floLAB(R), Moor Instruments Ltd., England) is a non-invasive technique for measurement of blood flow in the tissue and also allows continuous monitoring. Thus, we tested the usefulness of LDF in monitoring the healing process of free gingival graft at gingival recession. Eleven gingival graft site of 7 patients, including 5 males and 2 females, aged between 21 and 41 years (mean age 28.5) were monitored for the blood flow. The blood flow in gingival graft at coronal site, central site, apical site, mesial site and distal site was measured using LDF. Blood flow was measured at 1- week, 2- week, 3- week and 4- week after gingival graft surgery from 10 a.m. to 2 p.m. Time-course of the healing process was evaluated by statistical analysis using repeated ANOVA and Duncan test. The results were as follows : (1) Blood flow stayed increased for 2 weeks, and then, it was a tendency to decrease. (2) The blood flow at distal site had always higher than mesial site during the measuring periods. (3) The blood flow was high orderly after 1 week ; most coronal site, most apical site, central site. But that was high orderly after 2 week, 3 week, 4 week ; most coronal site, central site, most apical site. In conclusion, LDF was a useful and clinically adaptable method to monitor wound healing process. Our study suggested that it was important to protect surgical site to promote initial wound healing.

• Journal of Periodontal and Implant Science
• /
• 제33권2호
• /
• pp.139-147
• /
• 2003

The roots of teeth exposed by gingival recession, may be successfully covered by various type of gingival grafting procedures. Vascularization of the recipient site is an essential determinant of the grafts' survival during the first healing stages. It has been suggested that a procedure by which they stimulate the periosteum presurgically will induce the proliferation of neo-endothelium in the site to be operated. The purpose of this study is to evaluate the variations in the gingival blood flow during 4weeks after periosteal stimulation in patient scheduled to receive gingival grafts and to compare variations in the gingival blood flow between smoker and non-smoker. Laser Doppler Flowmetry(floLAB(R), Moor Instruments Ltd, England ; wave length = 780mm. Max. power =l.6mW) was used to measure the gingival blood flow. 112 sites of 68 male patients (32 smokers and 36 non-smoker), aged between 23 and 48 years (smoker : 24-44 years. mean=32.6, non-smoker : 23-48 years, mean=28.5) were monitored for the blood flow. Gingival blood flow measured at before periosteal stimulation, 1-, 2-, 3-, and 4-weeks after periosteal stimulation from 10 a.m. to 2 p.m. The difference of blood flow in each measuring time, each measuring site and between smokers and non-smokers were statistically analyzed by MANOVA. The results were as follows : (1) Blood flow stayed increased for 2 weeks, and then, it was a tendency to decrease(p<0.05). (2) There was no statistically significant difference of blood flow change between smokers and non-smokers. (3)The blood flow at middle site had lower than mesial and distal site during the measuring periods(p<0.05). The present study suggested that blood flow change following periosteal stimulation was significant difference, thus periosteal stimulation before gingival graft might induce favorable results in gingival recession patient.

• 한국임상수의학회지
• /
• 제34권4호
• /
• pp.249-254
• /
• 2017

The cutaneous microcirculation plays a role in various physiological processes and pathological conditions. Two non-invasive methods were used in this study to obtain reference values for cutaneous microcirculation in intact male beagles. Twenty intact male beagles were used. The experimental environments were standardized. Laser Doppler flowmetry was used to measure cutaneous blood flow, and an infrared thermometer was used to measure cutaneous temperature. The blood flow and temperature were measured from the right side of the subjects at 20 cutaneous sites. Based on the laser Doppler flowmetry, the region with the highest blood flow was the periocular region that with the lowest was the forelimb foot pad. In addition, the standard deviation of the chest wall was the highest while that of the periocular region was the lowest. For skin temperature, the inguinal region had the highest mean skin temperature and the forelimb foot pad had the lowest. The correlation coefficient between the two methods was 0.72. Similar to a previous study, the values derived from repeated measurements at the 20 regions are reproducible and can contribute to research. Compared to the results of a previous study, the temperatures of the two smallest skin regions were the same; however, no specific trend was observed. The correlation coefficient between the two methods was significantly comparable, and this good correlation can reduce their limitations and variables complementarily. In addition to possible use in human studies, accumulated resources on measurements of skin blood flow in the future will potentiate its use in the veterinary medicine field.

• 대한의용생체공학회:의공학회지
• /
• 제19권4호
• /
• pp.369-377
• /
• 1998

본 논문에서는 레이저 다이오드의 자기혼합 효과를 이용한 레이저 도플러 혈류계를 위한 신호처리 알고리즘들에 대한 in vitro적인 실험결과를 비교하였다. 단순하고 유연성있는 레이저 도플러 시스템을 구성함으로써 디지털 신호해석 방법에 의하여 여러 가지 신호처리 알고리즘들을 비교할 수 있도록 하였다. 이 시스템은 다양한 알고리즘을 퍼스널 컴퓨터를 사용하여 소프트웨어로 제어하므로써 다양한 알고리즘을 선택하여 비교 연구할 수 있도록 하였다. 또한, 유체 흐름의 재현성과 조직의 혈류 흐름을 모의하기 위하여 두 개의 실험적인 혈류모델을 제작하여 적용하였다. 광원은 파장 780nm의 레이저 다이오드를 사용하였으며, 3 종류의 입자 농도와 속도를 갖는 액체를 두 개의 실험모델에 흘리면서 측정된 결과들을 비교하였다. 그 결과 주파수로 가중되지 않은 알고리즘(0차 모멘트)이 속도와 농도변화를 잘 나타내는 반면에 주파수로 가중된 알고리즘들(1차와 2차 모멘트, 0차 모멘트와의 비)은 농도보다는 속도 변화를 잘 나타내었다.

• 동의생리병리학회지
• /
• 제17권4호
• /
• pp.1013-1018
• /
• 2003

Cheonghunhwadam-tang(CHT) have been used in oriental medicine for many centuries as a therapeutic agent of vertigo by wind, fire and phlegm. CTG was CHT adding Aurantii FructusㆍGastrodae Rhizoma. CTG was significantly increased regional cerebral blood f1ow(rCBF) in a dose-dependent, and CTG was decreased mean arterial blood pressure(MABP) compared with normal MABP(100%) in a low dosage, but was increased MABP in a dose-dependent, was aliked with normal MABP in a high-dosage. Therefore, purpose of this Study was to investigate experimental mechanism of CHTAG on the cerebral hemodynamics(rCBF, MABP) in rats. The changes of rCBF and MABP were determinated by Laser-Doppler Flowmetry(LDF). The results were as follows ; Pretreatment with indomethacin(3㎎/㎏, i.v.) was significantly inhibited CTG induced increase of rCBF and pretreated with propranolol(3㎎/㎏, i.v.) was inhibited CTG induced increase of rCBF, but pretreatment with methylene blue(10㎍/㎏, i.v) was increased CTG induced increase of rCBF. Pretreatment with indomethacin was decreased CTG induced increase of MABP, but pretreatment with propranolol and methylene blue were increased CTG induced increase of MABP. This results suggest that the mechanism of CTG is mediated by cyclooxygenase.