• Journal of the Korean Wood Science and Technology
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• v.26 no.4
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• pp.61-70
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• 1998

Xylem, bark and flower buds of Magnolia kobus DC. var. borealis Sarg. were extracted with ethanol. And then the ethanol extracts were fractionated with diethyl ether. The lignans structure of the diethyl ether fractions were determined by spectroscopic methods. The results are summarized as follows : 1. Three compounds, aschantinn(X-I), yangambin(X-II), (-)syringaresinol(X-III), tetrahydrofurofuranoid lignans were isolated from the xylem. 2. Five compounds were isolated from the bark. These are all tetrahydrofurofuranoid lignans, aschantin(B-I), yangambin(B-II), medioresinol(B-III), (+)syringaresinol(B-IV), and tetrahydrofuranoid, kobusinol B(B-V). 3. Three tetrahydrofurofuranoid lignans, kobusin(F-I), aschantin(F-II), yangambin(F-III) were isolated from the flower buds. 4. Isolated lignans from the each tissue were two types of tetrahydrofurofuran type and tetrahydrofuran type. 5. The tetrahydrofurofuranoid lignans were five compounds such as kobusin, aschantin, yangambin, medioresinol, and syringaresinol, while the tetrahydrofuranoid lignans was kobusinol B. 6. Most of these lignans were substituted with the methylenedioxy or methoxyl groups.

• Korean Journal of Pharmacognosy
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• v.33 no.4 s.131
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• pp.272-276
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• 2002

This study was carried out to establish the quantitative analysis of lignans for the quality evaluation of fruit from Schizandra chinensis. Five lignans, gomisin N, schizandrin, gomisin C, schisantherin C, and gomisin A were isolated from the fruits of S. chinensis and identified by the spectroscopic methods. Quantitative determination of three lignans, schizandrin, gomisin A, gomisin N, was conducted using HPLC. Average contents of three lignans in collected lines were 0.70% of schizandrin, 0.20% of gomisin A, 0.57% of gomisin N, and 1.47% of total lignans.

• Journal of Dairy Science and Biotechnology
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• v.36 no.2
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• pp.81-94
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• 2018

This review discusses the characteristics of major lignans and related studies and provides a basis for future studies. Lignans are present in various food products consumed daily, such as flaxseed and other seeds, vegetables, fruits, and beverages including coffee, tea, and wine. Lignans are natural phytoestrogens with a structure similar to that of secoisolariciresinol (Seco), mataireinol (Mat), pinoresinol (Pin), medioresinol (Med), lariciresinol (Lari), and syringaresinol, which is then converted to enterodiol (END) and enterolactone (ENL), which are mammalian lignans and the primary biologically active enterolignans, by the intestinal microflora. The associations between lignans and a decreased risk of cardiovascular disease are promising; however, they are not yet well-established, probably owing to low lignan intake in habitual Western diets. Nonetheless, these associations were more prominent at the higher doses in interventional studies. Many studies on humans and animals have reported the benefits of lignan consumption in protecting against CVD and metabolic syndrome by reducing lipid and glucose concentrations. END and ENL reportedly exert protective effects including phytoestrogenic, antioxidant, anti-inflammatory, and anticancer effects through various mechanisms. Moreover, lignans reportedly exert beneficial effects in breast, colon, and prostate cancer and osteoporosis have reported that. However, future studies are required to confirm the association between lignan and disease.

• Journal of the Korean Wood Science and Technology
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• v.25 no.4
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• pp.1-9
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• 1997

The Abies koreana Wilson has been unique species of Korea and has not been clearly investigated about lignans of extractives. This studies have been carried out from the isolation and determination of lignans from alcoholic extractives in its xylem. Six lignans were isolated and their structures were determined by spectroscopic methods. They were two new compounds, (+)-koreslactol and (-)koreanol and four known compounds, lariciresinol p-coumarate, (+)-todolactol C, (-)-${\alpha}$-intermedianol, and (+)-pinoresinol.

• Korean Journal of Medicinal Crop Science
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• v.23 no.5
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• pp.385-394
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• 2015

Background : Dibenzocyclooctadiene lignans are secondary metabolites present abundantly in the fruits belonging to the genus Schisandra. According to previous studies, Schisandra lignans exhibit anti-inflammatory, anti-cancer and anti-diabetic properties, as well as an inhibitory effect on platelet aggregation. Therefore, establishing the Korean "Omija" (Schisandra chinensis) as a lignan-rich source, in addition to identifying and quantifying the lignans, is extremely valuable. Methods and Results : Dibenzocyclooctadiene lignans were analyzed with liquid chromatography using diode array detection/mass spectrometry, from methanol extracts subsequently identified by a constructed chemical library of 50 lignans. A total of 27 components of lignan including gomisin S were identified, of which schisandrin, gomisin A, gomisin N, deoxyschisandrin, ${\gamma}$-schisandrin, and schisandrin C were identified as the major components in the Korean Omija, Schisandra chinensis. These compounds were divided into two groups, S-biphenyl and R-biphenyl based on the configurations of the stereoisomers structures with contents of 661.7 and 1350.1mg per 100 g dry weight, respectively. The total lignan content averaged 2011.4mg per 100 g dry weight, of which schisandrin and gomisin N comprised the majority (771.8 and 420.5mg per 100 g dry weight respectively). Conclusions : Lignans which are present in high quantities in the ripe fruit of Schisandra chinensis are important functional compounds that play a major role in the prevention and treatment of human diseases.

• Food Science and Biotechnology
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• v.15 no.1
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• pp.102-106
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• 2006

The phytoestrogens including isoflavones (genistein, daidzein, biochanin A, formononetin, and glycitein), coumestrol, and lignans (secoisolariciresinol, matairesinol, and anhydrosecoisolariciresinol) were quantified in edible sea vegetables from Korea. Sea vegetable samples were collected based on domestic consumption data. After hydrolysis of phytoestrogen glycosides in prepared samples, aglycones of phytoestrogens were extracted with diethyl ether and analyzed with isotope dilution gas chromatography-mass spectrometry in selected ion monitoring mode (ID-GC-MS-SIM). Total samples included 19 samples representing eight species. Most of the samples showed rather low concentrations, ranging from not determinated to $79.2\;{\mu}g/kg$ for isoflavones and from 106.4 to $694.8\;{\mu}g/kg$ for lignans. The daily intake of phytoestrogen from sea vegetables, estimated from the present data and domestic consumption data, was about $0.13\;{\mu}g/day$ for isoflavones and $2.0\;{\mu}g/day$ for lignans. When we compared these results with those from legumes, sea vegetables would not be considered the major source of phytoestrogens in the Korean diet.

• Korean Journal of Pharmacognosy
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• v.21 no.4
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• pp.270-273
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• 1990

Antioxidant activity of diarylbutane type lignans was evaluated in TBA-reactant assay to elucidate the structure-activity relationship. The antioxidant potency of lignans increased with increasing the number of hydroxyl groups, with the exception of macelignan(I), which showed a more potent activity than demethyl meso-dihydroguaiaretic acid(III).

• YAKHAK HOEJI
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• v.46 no.2
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• pp.98-101
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• 2002

The phytochemical study of nutmeg, the seeds of Myristica fragrans Houttuyn (Myristicaceae) led to the isolation of three lignans, safrole (I), macelignan (III), and a 3,4 : 3',4'-bis(methylenedioxy)lignan (II). The compound II was identified by a mixture (1:1) of (8S, 8'R)- and (8S, 8'S)-forms of bis(3, 4-methylenedioxy)-8, 8'-neolignan by $^1$H-, $^{13}$ C-NMR and $^1$H-$^1$H COSY spectral data. The compound II was isolated for the first time from Myristica fragrans.

• Archives of Pharmacal Research
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• v.18 no.5
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• pp.361-363
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• 1995

Two furofuran lignans, sesamolin and sesangolin were isolated from the seeds of Sesamum indicum and S.angolense, respectively. Detailed analysis of the $^1H-and^{13}C-NMR$ spectra of these lignans was carried out by the application of two-dimensional $^1H-^1/H\; COSY\; and^1/H^{13}C$ multiple-bond, multiple-quantum spectroscopic correlation techniques.

• YAKHAK HOEJI
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• v.43 no.3
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• pp.285-288
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• 1999

Two lignans, (+)-8-hydroxypinoresinol (compound) and (-)-olivil (compound 2), were isolated together with betulin (compound 3) from the aerial parts of Sorbaria sorbifolia var. stellipila Max. (Rosaceae). Their structures were characterized by physicochemical and spectral means.