• Preventive Nutrition and Food Science
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• 제10권3호
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• pp.298-309
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• 2005

As the population of the elderly grows, the prevalence of osteoporosis and its related fractures will increase in both men and women. The etiology, preventive and curative strategies of male osteoporosis are relatively unknown and understudied in comparison with those of female osteoporosis. Even currently approved therapies, e.g. bisphophonates, parathyroid hormone, and testosterone for male osteoporosis are in need of further investigation to test their safety and efficacy. Isoflavones which are found in soy have been shown to positively affect bone by stimulating bone formation while concurrently slowing down bone resorption. These observations mainly come from studies that have employed women or female animal models of osteoporosis. Therefore, there is a need to explore the role of soy and its isoflavones in preventing bone loss or rebuilding bone utilizing men or animal models of .male osteoporosis. From the review of existing literature it is too early to state the extent to which men with osteoporosis can benefit from consumption of soy or its isoflavones. In this review, the efficacy of soy and its isoflavones as alternative and/or adjunctive treatment for male osteoporosis will be discussed.

• 국제물리치료학회지
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• 제5권2호
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• pp.772-780
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• 2014

The purpose of this study is to identify the practical knowledge about osteoporosis and health promoting behavior possessed by male and female university students in their twenties. Next, the study seeks to analyze the difference in the degree of knowledge and practice of health promoting behavior depending on the students' area of study (health-related or non-health-related major) and previous education about osteoporosis. A survey was given to 300 male and female university students in Jeju Island from November 18 to December 6, 2013. Regarding knowledge about osteoporosis, the accuracy rate of health science major participants was 16.8 % higher than that of those of non-health science, and the accuracy rate of participants with previous education about osteoporosis was 12.9 % higher than those who had not. Health promoting behavior showed a higher degree of practice among students in health-related majors and those with previous applicable education. There were significant differences between the knowledge of osteoporosis and major and the presence and absence of prior education. Regarding the degree of health promoting behavior and major, the presence or absence of prior education showed significant differences. Among male and female students in their twenties, the recognition of knowledge about osteoporosis is very low. There is a need to develop various programs that focus on osteoporosis prevention rather than treatment, to improve the quality of education and training content according to the individual, and to lower the target age for osteoporosis education.

• 한국콘텐츠학회논문지
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• 제8권10호
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• pp.241-250
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• 2008

의학과 과학의 발전으로 인한 고령인구의 증가로 여성에게 뿐만이 아니라 남성에서도 골다공증에 의한 골절의 빈도가 증가하면서 남성 골다공증에 대한 관심이 높아지고 있다. 이에 본 연구는 40세 이후 남성의 골밀도에 관련된 요인을 알아보고 이러한 병인으로 인한 골다공증의 유병률을 조사하여 남성 골다공증의 예방과 치료대책을 위한 기초 자료를 제공하고자 한다. 건강 검진에서 골밀도 검사를 시행한 40세 이후 남성을 대상으로 한 본 연구에서 L-spine의 골감소증과 골다공증은 각각 45%, 12.9%의 유병률을 보였고, Femur에서는 51.9%, 7.63%의 유병률을 보여 미국이나 유럽에서 50세 이상 남성을 대상으로 한 연구 결과 수치보다 높게 관찰되었다. L-spine의 경우 연령과 골감소증 및 골다공증 유병률이 유의한 차이를 보였고, Femur에서 역시 연령과 골다공증의 유병률이 유의한 연관성을 가지는 것으로 조사되었다. 연령이 증가할수록 L-spine, Femur 두 부위 모두 평균 BMD가 낮아지는 것으로 조사되었고, 체중이 증가할수록, 체질량지수(BMI, kg/$m^2$)가 높을수록 골다공증의 유병률은 감소하는 음의 상관관계를 가졌다. 운동, 흡연, 음주는 골다공증의 유병율과 유의한 연관성이 없는 것으로 조사되었으나, 운동의 횟수, 흡연기간, 음주횟수는 골 양을 변화시켜 남성 골밀도에 영향을 주는 인자가 되고 있다.

• 동의생리병리학회지
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• 제33권1호
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• pp.56-62
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• 2019

To investigate the effect of Bombycis Corpus on male osteoporosis, we performed Dual Energy X-Ray Absorptiometry(DEXA) and histochemical methods. The animals were used ICR-based male mice of 8 weeks and 50 weeks, respectively. ICR male mice at 8 weeks were used in the control group, and ICR male mice at 50 weeks were used in aging group and Bombycis Corpus group(BC group). In the aging group, 0.5 ml of distilled water was administered once a day for 6 months. In BC group, Bombycis Corpus(0.78g/kg) was dissolved in distilled water for 6 months once a day. As a result, Bombycis Corpus decreased bone loss, increased bone density by reducing the loss of bone matrix in the femur due to aging, and increased osteoblast - induced osteopontin(OPN) and osteocalcin(OPC) positivite reaction. In addition, administration of Bombycis Corpus decreased Reaction of activation of nuclear factor kappa B ligand(RANKL) positive reaction, increased osteoprotegerin(OPG) positive reaction, and decreased matrix metalloproteinase-3(MMP-3) and 8-hydroxy-2'-deoxyguanosine(8-OHdG) positivite reaction. Taken together, Bombycis Corpus increases the activity of osteoblasts, inhibits osteoclast function, promotes osteoblast function, inhibits bone tissue degradation, and inhibits bone loss due to oxidative stress. It was observed that Bombycis Corpus reduced bone loss and increased bone density caused by aging to improve male osteoporosis. Therefore, Bombycis Corpus may be used as a preventive and therapeutic agent for male osteoporosis.

• Clinical Pain
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• 제19권2호
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• pp.111-115
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• 2020

We report a case of a healthy 38-year-old man presenting with insufficiency fracture of proximal tibia associated with unrecognized osteoporosis. Radiologic bone DEXA (Dual Energy X-ray Absorptiometry) assessment revealed osteoporosis, but the patient displayed no apparent risk factors for insufficiency fractures and osteoporosis except for a history of smoking. Following right proximal tibial open reduction and internal fixation, the patient commenced smoking cessation and began taking alendronate. The patient was treated for gait rehabilitation, which included quadriceps strengthening exercises and his condition improved with independent walking. This report highlights an unusual site of proximal tibial insufficiency fractures and the potential effect of smoking on low bone mineral density in a young male patient.

• 대한디지털의료영상학회논문지
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• 제10권2호
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• pp.5-10
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• 2008

Thanks to recent development of science and technology, economic standard has been improved and life expectation has been gradually increased. Accordingly, disease aspect and demand for health have been changed in the concept from conventional center of disease to health improvement As the health issue in middle and senior age has also been vital in the national health, osteoporosis, one of the physical maladies occuring in these age group, is on the rise as a matter of important concern so that the researches on the osteoporosis have being accomplished actively in several medical domains. Research has been earned out for 735 examined objects, who have received medical examination of bone mineral density in the volunteer medical service of Daegu and Kyungbuk province for recent 4 years. The result indicated that serious osteoporosis prevailed over osteoporosis for male while osteopenia was majority to osteoporosis and that abnormal bone mineral density was more prominent than normal bone mineral density for both male and female. This study is to present basic data which is indispensible to preparation of senior citizen dominated society afterward, investigating the prevalence rate of osteoporosis.

• 한국가축번식학회지
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• 제24권2호
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• pp.189-197
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• 2000

본 연구는 골다공증유발 rat에 녹용추출물의 투여가 예방 및 치료효과에 미치는 영향을 구명하고자, 양측 난소를 적출한 후 골다공증이 유발된 rat에 암, 수녹용 추출물 525, 1,250 mg/kg을 투여했을 때 체중, 대퇴골의 중량, 장기중량, 골회분량의 측정 및 조직학적, 전자현미경적 검사 등을 실시하였다. 1. 골다공증유발 rat에 암, 수녹용 추출물을 투여했을 때 체중은 정상대조군에 비하여 유의한 증가를 나타냈다 (p＜0.05). 2. 골다공증유발 rat에 암, 수녹용 추출물을 투여했을 때 우측, 좌측의 femur 중량은 정상대조군에 비하여 감소하였다. 3. 골다공증유발 rat에 암, 수녹용 추출물을 투여했을 때 골회분량은 정상대조군에 비하여 약간 감소된 치를 나타냈으나 유의성은 인정되지 않았다. 4. 골다공증유발 rat에 암, 수녹용 추출물을 투여했을 때 간과 비장 및 신장의 각각 정상대조군에 비하여 감소된 치를 나타냈다. 5. 골다공증유발 rat에 암, 수녹용 추출물을 투여했을 때 조직학적 및 전자현미경적 소견은 정상대조군에서는 소주골간의 연결이 비교적 잘 유지되어 있고 골소실을 발견할 수 없었으나 난소적출군은 정상군에 비하여 소주골이 가늘어졌거나 소주골간 연결부분의 대다수가 끊어져 골양이 많이 소실되었음이 관찰되었으며, 녹용처리군에서는 소주골의 형태가 굵고 연결부분이 잘 유지되어 정상군과 유사한 소견이 관찰되었다. 위의 결과들에서 암, 수녹용 추출액은 난소제거후의 골소설을 억제하므로 골다공증의 예방과 치료에 효과가 있는 것으로 판단된다.

• 한국가축번식학회지
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• 제24권2호
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• pp.179-188
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• 2000

본 연구는 골다공증유발 rat에 녹용추출물의 투여가 예방 및 치료효과에 미치는 영향을 구명하고자, 양측 난소를 적출한 후 골다공증이 유발된 rat에 암, 수녹용 추출물 625, 1,250 mg/kg을 5 주간 투여하면서 혈청중 estradiol, progesterone, calcitonin, osteocalcin 농도와 Ca, P 및 ALP 함량변화등을 조사하였다. 1. 난소적출 후 골다공증이 유발된 rat에 암, 수녹용 추출물 625mg/kg, 1,250 mg/kg을 각각 투여했을 때 혈청내 estradiol 수준은 난소적출군이 20.80$\pm$1.86~40.50$\pm$pg/$m\ell$로서 정상대조군의 49.50 :t2. 70-50.80 :t3.13 pg/$m\ell$에 비하여 유의한 감소를 나타냈다 (p<0.05). 2. 골다공증 유발 rat 에 암 수녹용 추출물 625 mg/kg, 1,250 mg/kg을 각각 투여했을 때 혈청중 progesterone 수준은 정상대조군의 50.90$\pm$3.63~53.40$\pm$2.74 ng/$m\ell$에 비하여 큰 차이를 나타내지 않았다. 3. 골다공증 유발 rat 에 암, 수녹용 추출물 625 mg/kg, 1,250 mg/kg을 투여했을 때 혈청중 calcitonin 수준은 정상대조군의 0.64$\pm$0.03~0.68$\pm$0.04 pg/$m\ell$에 비 하여 약간 높은 증가를 나타냈으며 특히, 난소적출군은 대조군에 비해 현저한 감소를 나타냈다. 4. 골다공증 유발 rat 에 암, 수녹용 추출물 625 mg/kg, 1,250 mg/kg을 각각 투여했을 때 혈청중 osteocalcin 수준은 정상대 조군의 0.28$\pm$0.02 ~0.31$\pm$0.02 ng/$m\ell$에 비하여 약간 높은치를 나타냈다. 한편, 암, 수녹용 추출물의 처리군의 osteocalcin 치는 암컷녹용 추출물처리군이 약간 높았으나 유의성은 인정되지 않았다. 5. 골다공증유발 rat에 암, 수녹용 추출물을 투여했을 때 혈청중 Ca, P 함량은 각각 정상대조군에 비하여 약간 높은 치를 나타냈으며, 난소적출 무처치군은 대조군에 비해 유의한 증가를 나타냈다 (p＜0.05). 6. 골다공증유발 rat에 암, 수녹용 추출물을 투여했을 때 혈청중 ALP 함량은 정상대조군에 비하여 증가치를 나타냈으며, 암, 수사슴녹용 추출물의 처리군중 대조군과 FA1,250 처리군과 MA625 처리군간에 유의한 변화가 인정되었다 (p＜0.05). 위의 결과들에서 암, 수녹용 추출액은 난소제거후의 estrogen의 감소를 억제시키고 골소실을 억제하므로 골다공증의 예방과 치료에 효과가 있는 것으로 판단된다.

• Journal of Acupuncture Research
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• 제26권2호
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• pp.91-101
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• 2009

Objectives: Osteoporosis is the most common metabolic disease of the bone, and is one of the most important major public health problems world wide. It is more occurred in female than male, but as the osteoporosis of men is increasing, therefore bone fractures of men are increasing. So we investigated the factors which are related to Bone Mineral Density(BMD) of male for prevention of osteoporosis. Methods: We measured the Bone Mineral Density(BMD) of lumbar spine($L_2$-$L_4$) and femoral neck in 5198 male, using dual energy X-ray absorptionmetry(DEXA; DPX-alpha). And then we analysed the 8 factors - age group, bone mass index(BMI), amount of smoking, drinking, exercise, and fast blood sugar, gastric disease, thyroid disease - which are related to BMD of male. Results: 1. In age group according to ${\ll}$Hwangjaenaekyong Somun, 黃帝內徑 素問${\gg}$, T-score was the highest at 17-24(三八歲) years group and decreased rapidly after 57-64(八八歲) years group in both lumbar spine($L_2$-$L_4$) and femoral neck. Therefore we concluded that T-score of male in lumbar spine($L_2$-$L_4$) and femoral neck change according to age group in ${\ll}$Hwangjaenaekyong Somun, 黃帝內徑 素問${\gg}$. 2. In BMI(body mass index), T-score of lumbar spine($L_2$-$L_4$) and femoral neck were the highest in obese group than non-obese group. In comparison of age group according to BMI, T-score of lumbar spine($L_2$-$L_4$) was significant difference in 17-72 years group and T-score of femoral neck was in 25-72 years group. 3. In exercise, T-score of lumbar spine($L_2$-$L_4$) and femoral neck was increasing as exercising more. In comparison of age group according to exercise, Both T -score of lumbar spine and femoral neck were significant difference in 25-72 years old. 4. T-score of lumbar spine($L_2$-$L_4$) was the highest in men who have taken exercise daily, and T-score of femoral neck was the highest in men who have taken exercise 1-3 times for a week. Conclusions : The age group in ${\ll}$Hwangjaenaekyong Somun, 黃帝內徑 素問${\gg}$ is related to BMD of men. And risk factors - BMI, exercise - are related to BMD of men. Therefore we expect that this study will help for prevention of osteoporosis of men.

• Asian Pacific Journal of Cancer Prevention
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• 제15권8호
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• pp.3377-3381
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• 2014

Background: The incidence of colorectal cancer increases with vitamin D deficiency as shown in recently published studies. In addition, prospective investigations have indicated that low vitamin D levels may be associated with increased mortality of colorectal cancer, especially in stage III and IV cases. However, the exact incidence of vitamin D deficiency and the relation between vitamin D deficiency and osteopenia/osteporosis is still not known. The aim of this study is to identify severity of vitamin D deficiency and absolute risk factors of osteopenia/osteoporosis in colorectal cancer survivors. Materials and Methods: A total of 113 colorectal cancer survivors treated with surgery and/or chemotherapy ${\pm}$ radiotherapy were recruited from medical oncology outpatient clinics during routine follow-up visits in 2012-2013. Bone mineral densitometry (BMD) was performed, and serum 25-OH vitamin D levels were also checked on the same day of the questionnaire. The patients was divided into 2 groups, group A with normal BMD and group B with osteopenia/osteoporosis. Results: The median age of the study population was 58 (40-76). Thirty (30.0%) were female, whereas 79 (70.0%) were male. The median follow-up was 48 months (14-120 months). Vitamin D deficiency was found in 109 (96.5%); mild deficiency (20-30 ng/ml) in 19 (16.8%), moderate deficiency (10-20 ng/ml) in 54 (47.8%) and severe deficiency (<10 ng/ml) in 36 (31.9%). Osteopenia was evident in 58 (51.4%) patients whereas osteoporosis was noted in 17 (15.0%). Normal BMD was observed in 38 (33.6%). No apparent effects of type of surgery, presence of stoma, chemotherapy, radiotherapy and TNM stage were found regarding the risk of osteopenia and osteoporosis. Also, the severity of the vitamin D deficiency had no effect in the risk of osteopenia and osteporosis (p=0.93). In female patients, osteopenia/osteoporosis were observed in 79.5% patients as compared to 60.7% of male patients (p=0.04). Conclusions: In our study, vitamin D deficiency and osteopenia/osteoporosis was observed in 96.5% and 66.4% of colorectal cancer survivors, respectively. There is no defined absolute risk factor of osteopenia and osteoporosis in colorectal cancer survivors. To our knowledge, in the literature, our study is the first to evaluateall the risk factors of osteopenia and osteoporosis in colorectal cancer survivors.