• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.21 no.3
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• pp.10-19
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• 2008

Objective : To investigate the effects of Radix Ophiopogon japonieus on atopic dermatitis, I prepared DNCB(2,4-dinitrochlorobenzen) induced atopic dermatitis NC/Nga mice and observed the mice by four ways; eye observation, the number of skin behavior times, histological changes of skin and cytokine(Total IgE, IL-4, $IFN-{\gamma}$). Methods : After prepare Radix Ophiopogon japonicus extract, DNCB induced atopic dermatitis NC/Nga mice were divided into three groups. The first is Control group which was intact group. The second is Medication group which was orally medicated Radix Ophiopogon japonicus extract one time a day for consecutive 5 days. The third group is Application group which was applied Radix Ophiopogon japonicus extract externally one time a day for consecutive 5 days. After that, the effect of Radix Ophiopogon japonicus on atopic dermatitis was observed. Statistical analysis was performed by using Kmskal-Wallis test and statistical significance was set at less than 5%. Results : 1. Radix Ophiopogon japonicus showed some in both Medication group and Application At observation of skin morphologic change, effects to prevent erythema reaction on skin group. 2. At the number of scratching behavior times, Radix Ophiopogon japonicus showed an effect to decrease scratching behavior times, but there was no statistical significance among three groups. 3. At skin tissue H-E stain, Radix Ophiopogon japonicus showed an effect to prevent skin epidermal tissue damages and also showed that it could keep the skin healthy in both Medication group and Application group. Especially in Application group, the skin of mouse showed almost normal recovery. 4. At cytokines, there was no statistical significance among three groups in IgE and IL-4. But Radix Ophiopogon japonicus showed an significant effect to suppress $IFN-{\gamma}$ in both Medication group and Application group. There was no significant difference between two groups. Conclusion : Radix Ophiopogon japonicus has some effects on atopic dermatitis in both internal medication and external application.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.47 no.3
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• pp.236-239
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• 2002

Saponin is one of major conponents in oriental medicine, which':s present in Ophiopogoneae. Saponin composition on ethyl acetate fractions from the butanolic extracts of two species, Liriope platyphylla and Ophiopogon japonicus was measured using high performance liquid chromatography (HPLC). HPLC analysis revealed that spicatoside A and B were identified in the tuber of L. platyphylla. However, spicatoside A was not identified in the tuber of O. japonicus. Related to that, it may be possible to discriminate between Liriopis and Ophiopogonis Tuber using HPLC analysis.

• Korean Journal of Pharmacognosy
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• v.39 no.2
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• pp.75-79
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• 2008

Nerve growth factor (NGF) is a protein plays a major role in the development and maintenance of central and peripheral nervous system. Recent data suggest that reduced availability of NGF may play a significant role in the pathogenesis of diabetic $polyneuropathy.^{1)}$ In our previous study, steroidal saponin from Liriope platyphylla showed neurotrophic effect by stimulation of NGF synthesis and activation of tyrosine kinase $signaling.^{2)}$ In this study, we examined the neurotrophic effect of Liriope platyphylla (LP); which was from Mylyang(MYL) and Cheongyang(CHE), and Ophiopogon japonicus (CHI) on in vitro and in vivo model for the comparison of their NGF induction. We quantitatively analyzed spicatoside A in the LP and CHI by HPLC. And we investigated the correlation between the contents of spicatoside A and NGF induction efficacy on PC 12 cells and mouse serum. These results suggest that spicatoside A may enhance NGF induction in animal model.

• Archives of Pharmacal Research
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• v.28 no.11
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• pp.1236-1238
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• 2005

A new phenolic glycoside, ophiopojaponin D (1), together with two known compounds, was isolated from the tubers of a famous traditional Chinese herb-Ophiopogon japonicus Ker-Gawl. The spectroscopic and chemical data revealed their structures to be 3-tetradecyloxy-4­hydroxy-allylbenzene-4-O-$\alpha$-L-rhamnopyranosyl (1$\rightarrow$6)-$\beta$-D-glucopyranoside (1), 3, 4-dihy-droxy-allylbenzene-4-O-$\alpha$-L-rhamnopyranosyl (1$\rightarrow$6)-$\beta$-D-glucopyranoside (2) and L-pyro­glutamic acid (3).

• Proceedings of the Zoological Society Korea Conference
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• 2000.10a
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• pp.162.2-162
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• 2000

• Asian Journal of Turfgrass Science
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• v.7 no.1
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• pp.19-30
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• 1993

Experiments were conducted to investigate propagation, shade tolerance, cold resistance and growth rate of evergreen ground cover plants ; Vinca minor K , Ajuga reptans L., Ophiopogon japonicus ker. f nanus hort , and Hedera helix.. The results were as follows : 1.It is convenient to use the growing case for rice seed to grow and transplant Vinca minor seed-ling. The most proper density of transplanting Vinea was 180 plants per 1m$^2$. At the end of growing season, the coverage came up to 90% The rooting ability of Hedera helix was best to cut from April to May (temperature 15~23˚C). The seedling length of Parthenocissus quinguefohlia were irregular and ranged from 5 cm of 200cm. 2. Ajuga reptans L., Ophiopogon j. and Vinca minor L. grew better under 50% light intensity than full sunlight. Particularly, under full sunlight and aestival high temperature, there were a few withering plants in Ajuga reptans L. , and V Vilica minor L. 3. Of Vinca minor K., Ajuga reptans L. , Ophiopogon japonicus ker. f. nanus hort. and Hedera helix. acclimatized in open field, where temperature was from -7~8˚C. There were few plants had damage in low temperature incubator to -16˚C after field acclimatization. 4.Tendrils of Parthenocissus quinguefolia strongly clung to the wire netting stone fence but intruded into the gap and cranny of the precast concrete fence and so clung to, so that it needed to install the bending net on the precast concrete fence.

• Journal of the Korean Institute of Landscape Architecture
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• v.45 no.2
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• pp.68-75
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• 2017

Demand for dwarf mondo grass (DMG; Ophiopogon japonicus 'Nanus') as an ornamental garden plant is expected to grow in the future. The purpose of this study was to investigate the levels of shade tolerance and ground cover by growing DMG under a variety of shade conditions for 18 months (May 2015~October 2016). DMG plants grown in bare ground for 3 years in Jangheung-gun, Jeonnam were used for testing. In an experimental site created in Naju city in Jeonnam, the DMG was planted in planters ($70cm{\times}70cm{\times}24cm$) and covered with a shading curtain to block natural light. Shaded conditions were then arranged under different levels of shade (0%, 55% and 75%). When the plants were grown, growth (leaf size, the number of leaves, fresh weight and dry weight) and ground coverage of DMG were analyzed. According to the results, DMG growth in terms of leaf size and the number of leaves was statistically higher under zero shade (full sunlight), when compared to other shaded conditions. DMG's fresh and dry weights were significantly greater under 0% and 55% shade, compared to those under 75% shade. The degrees of shade tolerance required for normal growth of DMG were found in the range of 0~50%, meaning that more than 50% shade may decrease plant growth. There were no statistical differences in ground coverage rates of DMG under different levels of shade. When 220 tillers were planted per $1m^2$ of plot, up to 80% of the area was covered by DMG after 18 months. Since DMG requires nutrient-rich soil to grow, sufficient nitrogen fertilizers are proposed to accelerate the ground cover of DMG. As DMG remained alive over the winter in the experiments, this study also suggests that DMG can be planted in the southern temperate region.

• Journal of the Korean Institute of Landscape Architecture
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• v.40 no.4
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• pp.127-134
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• 2012

This study was carried out to suggest an experimental base in selecting the cold tolerance of plants. The cold tolerance of the plants were subject to laboratory low temperature treatments and cold processing time were evaluated using both electrolyte leakage and regrowth test. The Logistic model of nonlinear regression analysis was used to evaluate the lethal temperatures that were predicted with the range of $-16.1{\sim}-24.4^{\circ}C$. The order of low-temperature resistance was Sedum reflexum > S. spurium > Ophiopogon japonicus > S. album > S. takevimense > Dianthus chinensis. At the lowest temperature of $13.4^{\circ}C$ the electrolyte leakage value of the plants were lower than 50% demonstrating that they could be applied stably to the roof installed in Korea during the winter with the lowest temperature of $-13.5^{\circ}C$.

• Korean Journal of Pharmacognosy
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• v.34 no.1 s.132
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• pp.6-9
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• 2003

‘Maig Moon Dong(麥問冬)’ is one of the chinese crude drugs used mainly to cure a cough and sputum, etc. With regard to the botanical origin of ‘Maig Moon Dong’, it has been considered to be Liriope species of Liliaceae, but there has not been studied pharmacognostically. To clarify the botanical origin of Maig Moon Dong, we studied on the anatomical characteristics of Liriope and Ophiopogon species growing wild in Korea i.e. L. platyphylla, L. spicata, O. jaburan, O. japonicus and Maig Moon Dong from Korea. As a result, the botanical origin of Maig Moon Dong from Korea was proved as Liriope platyphylla and L. spicata.

• Natural Product Sciences
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• v.7 no.2
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• pp.33-37
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• 2001

Methanol extracts of eighty Chinese medicinal plants were investigated for platelet-activating factor (PAF) receptor binding inhibitory activity using rabbit platelet. Extracts of Cratoxylon ligustrinum, Kalimeris indica, Euonymus japonica, Ophiopogon japonicus, Gleditsia sinensis, Clausena lansium, Agave sisalana were found to exhibit significant inhibitory effects. Chloroform partition of the Methanol extract of Kalimeris indica was further fractionated by column chromatography to afford one strong active subfraction with 93.6% inhibition at a concentration of $100{\mu}g/ml$.