• Journal of Haehwa Medicine
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• v.15 no.2
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• pp.9-16
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• 2006

Objectives : This study was designed to evaluate the clinical effects of herb medicine and acupuncture therapy on chronic bacterial prostatitis. Method : A clinical observation was made on two patients with chronic bacterial prostatitis diagnosed with DNA analysis. They were treated with herb medicine and acupuncture therapy. Before and after treatment we measured National Institutes of Health Chronic Prostatitis Symptom Index(NIH-CPSI) and WBC counts on expressed prostatic secretion(EPS). Results : According to DNA analysis, Streptococcus mitis and Veillonella was proved to be the cause for chronic bacterial prostatitis for each patients. After treatment, NIH-CPSI score improved from severe to mild, and WBC counts on EPS decreased considerably from many to under 10. Conclusion : The present result suggest that oriental medical therapy has effect on chronic bacterial prostatitis. Further clinical study about chronic bacterial prostatitis, and research on herbal medicine sensitive to each bacterium causing chronic bacterial prostatitis is needed.

• Journal of Physiology & Pathology in Korean Medicine
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• v.16 no.6
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• pp.1164-1169
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• 2002

The purpose of this study was to examine the correlation of chronic prostatitis with sexual dysfunction and WBC counts on expressed prostatic secretion(EPS) with symptoms of sexual dysfunction. From 2001. 9. 1 to 2002. 3. 31, chronic prostatitis patients(30 examples) treated for more than 4 weeks were compared with normal group(30 examples) about hypoactive sexual desire disorder, erectile dysfunction, orgasmic disorder and hematospermia. We investigated sexual dysfunction according to the degree of prostatitis, improvement rate of prostatitis and sexual dysfunction. Chronic prostatitis patients compared with normal group were increased significantly in decreased libido(73.3%), erectile dysfunction(51.1%), orgasmic disorder(48.7%) and hematospermia(16.7%). In WBC very many/HPF group compared with others. though sexual dysfunction was highly revealed, but there was no statistic significance. In improvement rate of prostatitis, total improvement rate was 76.7%, WBC 10-30/HPF group 77.8%, WBC many/HPF group 72.8% and WBC very many/HPF group 80%. But the medical cure effect was the highest in WBC 10-30/HPF group. In the improvement rate of sexual dysfunction, total improvement rate was 68.5%, hematospermia 100%, decreased libido 90.9%, erectile dysfunction 67.4% and orgasmic disorder 60.3%. As a result of considering the relation with improvement rate of prostatitis and sexual dysfunction, there was a statistical significance at the erectile dysfunction. orgasmic disorder. The results showed the chronic prostatitis had effects on sexual dysfunction but there was no correlation between the degree of chronic prostatitis with sexual dysfunction. It also showed that the treatment of prostatitis had effects on improvements of erectile dysfunction and orgasmic disorder.

• Journal of Preventive Medicine and Public Health
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• v.33 no.4
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• pp.449-458
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• 2000

Objectives : To determine the prevalence of prostatitis symptoms in the general population by questionnaire survey and to measure the effect of prostatitis symptoms on quality of life(QOL). Materials & Methods : A cross sectional community-based epidemiologic study was performed on 2,034 men, living in the Seoul metropolitan area using stepwise random sampling. Out of 2,034 interviewees, 1,356 men who were older than 40 and provided sufficient information were selected for this study. The questionnaires were completed by well trained interviewers. Contents of the questionnaires included demographic data, the Prostatitis Symptom Index(PSI), the International Prostate Symptom Score(IPSS), a general health questionnaire section and a sexual health questionnaire section. The PSI was composed of a sum of the scores from three questions about dysuria, penile pain and perineal pain and it ranged 0 to 12. Incidence of prostatitis symptoms was defined by a score of 4 or more and the reference group was defined as consisting of those with a score of 3 or less. The rate of incidence of prostatitis symptoms was assessed according to age and the difference of QOL between the prostatitis symptoms group and the reference group. Results : The overall positive rate of prostatitis symptoms measured by the PSI, in men older than 40, living in the Seoul metropolitan area, was 4.5%(61/1,356), adjusted to 4.8% by the relative proportion of this age group in the general population of the Seoul metropolitan area as compared to Korea and the World. The proportion of the group with prostatitis symptoms assessed by the PSI did not increase with age although the proportion of participants with moderate to severe lower urinary tract symptoms (LUTS) did increase with age. The group with prostatitis symptoms suffered from a much greater incidence of LUTS compared to the reference group (p<0.05). The QOL scores of the IPSS, and the general health and sexual health status of the group with prostatitis symptoms, were worse than those of the reference group.(p<0.05). Conclusions : The positive rate of prostatitis symptoms in men older than 40, living in the Seoul metropolitan area, was 4.8% and it didn't increase with age. The general QOL of the group with prostatitis symptoms was much worse than that of the reference group.

• The Journal of Internal Korean Medicine
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• v.31 no.4
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• pp.914-922
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• 2010

Objective : The purpose of this study is to report the clinical effect of herb medicine (Indongsoyeom-bang) and acupuncture therapy on Chronic Prostatitis/Chronic Pelvic Pain Syndrome. Methods : 15 patients diagnosed with Chronic Prostatitis/Chronic Pelvic Pain Syndrome were enrolled in this study. They were treated with herb medicine (Indongsoyeom-bang) and acupuncture therapy. To evaluate the therapeutic effect, before and after we measured Extract Prostatic Secretion (EPS), National Institutes of Health Chronic Prostatitis Symptom Index (NIHCPSI) and International Prostatitis Symptom Score (IPSS). Result : After treatment WBC numeral index by EPS test and NIH-CPSI and IPSS decreased. Conclusion : Herb medicine (Indongsoyeom-bang) and acupuncture therapy are effective in treating Chronic Pelvic Pain Syndrome. Further study of mechanism and efficacy is needed.

• The Journal of Korean Medicine
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• v.28 no.3 s.71
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• pp.156-164
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• 2007

Objectives : Chronic prostatitis is a common disease among adult men, yet it is very difficult to diagnosis and treat. This study was designed to evaluate the clinical effects of herb medicine, acupuncture, and herbal acupuncture therapy on chronic prostatitis. Methods : We investigated 15 chronic prostatitis patients with NIH-CPSI (National Institutes of Health Chronic Prostatitis Symptom Index). They were treated with herb medicine, acupuncture, and herbal acupuncture therapy. Results : After the treatment, NIH-CPSI decreased significantly. As the period of treatment for prostatitis was longer, the cure rate was higher respectively. Conclusions : These findings suggest that oriental medical treatment for chronic prostatitis may promote medical cure.

• Korean Journal of Clinical Pharmacy
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• v.28 no.2
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• pp.117-123
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• 2018

Background: Prostatitis, one of the most common diseases of the prostate, is a complex disease with various clinical features. This study aims to analyze the utilization and prescribing patterns of antibiotics in Korean patients with prostatitis between 2008 and 2015. Methods: We used the National Health Insurance Database complied from the Health Insurance Review and Assessment Service (HIRA). The outcomes included the number of claims, number of patients, medical cost, and length of stay for each year. In addition, the prescribing patterns of antibiotics, including fluoroquinolone, and low-dose use of ciprofloxacin and levofloxacin were investigated. Results: The total number of patients and medical cost increased by 9.5% and 51.7% from 2008 to 2015, respectively. Most prostatitis patients were classified as chronic prostatitis patients. The prescribing proportion of antibiotics for chronic prostatitis outpatients decreased from 71.0% to 66.9% from 2008 to 2015, and fluoroquinolone accounted for more than half of the total antibiotics. Over 80% of prescription of levofloxacin and ciprofloxacin was identified to be for low-dose use. Conclusion: Most of the patients with prostatitis experienced pain relief and condition improvement after antibiotic treatment; however, chronic prostatitis and chronic pelvic pain syndrome recur easily. Therefore, active disease management and further studies are needed to enhance our understanding of effective treatment for prostatitis.

• Journal of Acupuncture Research
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• v.31 no.4
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• pp.223-232
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• 2014

Objectives : The objective of this study was to report a effectiveness of meridian tendino-musculature acupuncture on the pelvic pain and dysuria in a patient with chronic prostatitis. Methods : A patient with Pelvic pain and Dysuria was treated with acupuncture and moxibustion. Before and After treatment we measured International Prostate Symptom Score(IPSS), National Institutes of Health-Chronic Prostatitis Symptom Index(NIH-CPSI) and Visual Analogue Scale(VAS). Results : International Prostate Symptom Score(IPSS), National Institutes of Health -Chronic Prostatitis Symptom Index(NIH-CPSI) and Visual Analogue Scale(VAS) scores were decreased considerably after 14 times treatment. Conclusions : It was suggesting that symptoms(pelvic pain and dysuria) of chronic prostatitis could be improved by acupuncture and moxibustion treatment in the view of the meridian tendino- musculature acupuncture.

• Journal of Physiology & Pathology in Korean Medicine
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• v.17 no.4
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• pp.958-961
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• 2003

The aim of this study was to evaluate the effect of Kamipaejangjihwang-tang on chronic prostatitis. Fifty six patients with chronic prostatitis were enrolled this study. We administerd Kamipaejangjihwang-tang to patient during 45 days. Before and after treatment we measured NIH-CPSI(NIH chronic prostatitis symptom score index). After treatment NIH-CPSI was decreased significantly. This result indicated Kamipaejangjihwang-tang be useful for treatment of chronic prostatitis.

• Journal of Haehwa Medicine
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• v.20 no.1
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• pp.91-104
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• 2011

Background : Although chronic non-bacterial prostatitis is increasing, it is hard to treat effectively. In western medicine, antimicrobials drug, ${\alpha}$-adreno-ceptor antagonists, anti-inflammatory drugs, tricyclic antidepressants and anticholinergic agents are used commonly, but chronic prostatitis/chronic pelvic pain syndromes is confusing and frustrating for urologist. IDS(Indongsoyeom-bang) is used in treatment of chronic prostatitis/chronic pelvic pain syndromes. And it is reported that GLS(Gleditsiae spina) and TOF(Toosendan fructus) components of IDS have significant effect on protection of the glandular epithelial cells. Objective : In this study was conducted to investigate the therapeutic effects and action machanism of IDS in the rat model of non-bacterial prostatitis induced by castration and testosterone treatment. Methods : We observed six experimental objects of normal group, control group, testosterone group, and IDS 50 mg/kg, 200mg/kg, 400mg/kg group. Rats were treated with 17 ${\beta}$-estradiol after castration for induction of experimental non-bacterial prostatitis, which is similar to human chronic prostatitis in histophatological profiles. IDS and testosterone were administered as an experimental specimen and a positive control, respectively. The prostates were evaluated by histological parameters including the epithelial score and epithelio-stromal ratio for glandular damage. Also, the prostates were observed by Hematological alterations of WBC, RBC, hemoglobin and platelet. Results : While prostates of control rats revealed severe acinar gland atrophy and stromal proliferation, the rats treated with IDS-50 showed a diminished range of the tissue damage. Epithelial score was improved in IDS than that of the control. The epithelio-stromal ratio was lower in IDS when compared to that of the control. Also, the examination of bloods were not observed hematological change. Conclusion : These finding suggests that IDS may protects the glandular epithelial cells. We concluded that IDS could be a useful remedy agent for treating chronic non-bacterial prostatitis.

• Journal of Microbiology
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• v.45 no.5
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• pp.453-459
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• 2007

We developed a multiplex PCR (mPCR) assay to simultaneously detect Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium, Ureaplasma urealyticum, Corynebacterium spp. and seudomona aeruginosa. This method employs a single tube and multiple specific primers which yield 200, 281, 346, 423, 542, and 1,427 bp PCR products, respectively. All the PCR products were easily detected by agarose gel electrophoresis and were sequenced to confirm the specificity of the reactions. To test this method, DNA extracted from urine samples was collected from 96 sexually transmitted disease or prostatitis patients at a local hospital clinical center, and were subjected to the mPCR assay. The resulting amplicons were cloned and sequenced to exactly match the sequences of known pathogenic isolates. N. gonorrhoeae and Corynebacterium spp. were the most frequently observed pathogens found in the STDs and prostatitis patients, respectively. Unexpectedly, P. aeruginosa was also detected in some of the STD and prostatitis samples. More than one pathogen species was found in 10% and 80.7% of STD and prostatitis samples, respectively, indicating that STD and prostatitis patients may have other undiagnosed and associates. The sensitivity of the assay was determined by sing purified DNA from six pathogenic laboratory strains and revealed that this technique could detect pathogenic DNA at concentrations ranging from 0.018 to $1.899\;pg/{\mu}l$. Moreover, the specificities of this assay were found to be highly efficient. Thus, this mPCR assay may be useful for the rapid diagnosis of causative infectious STDs and prostatitis. useful for the infectious STDs and prostatitis.