• 한국가스학회지
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• 제11권2호통권35호
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• pp.15-24
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• 2007

용기누출로 인한 가스 폭발사고의 영향을 분석하기 위해 API-581 절차에서 제시된 누출 시나리오를 사용하여 누출물질, 온도, 압력 및 용기의 종류 등을 변화시키면서 누출속도, 장치피해영역 및 상해영역을 산출하였다. 그 결과, 용기누출에서 누출속도, 장치피해영역 및 상해영역은 배관누출에서보다 상당히 큰 값을 가지며, 그 크기는 탱크>반응기>드럼>탑의 순서로 나타났다.

• Clinics in Shoulder and Elbow
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• 제18권1호
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• pp.28-35
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• 2015

Background: We assessed the effectiveness of arthroscopic capsular release for the treatment of adhesive capsulitis. Further, we tried to ascertain the clinical benefits, if any, of pancapsular release over selective capsular release, where the two differ by performing or not performing a posterior capsular release, respectively. Methods: Thirty-five consecutive patients with either primary or secondary adhesive capsulitis who failed conservative treatment for more than 6 months were enrolled in the study. A total of 16 patients allocated in group 1 received a pancapsular release that comprises the release of the rotator interval, anteroinferior capsular, and the posterior capsular release, whereas 19 patients in group 2 received a selective capsular release that comprises only the release of the rotator interval release and anteroinferior capsular release. The clinical outcomes, visual analogue scale (VAS) score, Constant score, and range of motion, were assessed preoperative and postoperatively. Results: In both groups, the preoperative VAS score, Constant score, and ROM showed a significant improvement by the 6-month follow-up. We found that the immediate postoperative internal rotation was significantly higher in group 1 than group 2. Despite significant differences seen between the two groups at the initial postoperative period, there were no significant differences in Constant score, VAS score, and the ROM at all the subsequent follow-ups between the two groups. Conclusions: Arthroscopic capsular release for the treatment of adhesive capsulitis is very effective. However, pancapsular release did not show any advantage over selective capsular release in terms of overall clinical outcome.

• 한국임상약학회지
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• 제1권1호
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• pp.23-30
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• 1991

The sustained-release beads containing terbutaline sulfate (TBS) were prepared by rotogranulation method. The drug was dusted on the non-pareil seeds in a CF-granulator. The sustained-release beads were obtained by coating the active beads with ethylcellulose or $Eudragits^{(R)}$, using in any case the same granulator employed for active beads preparation. The release characteristics of sustained-release beads were examined in vitro by rotating basket method applied to $Bricanyl^{(R)}$ durules which is a sustained-release TBS matrix tablet. The release of terbutaline from the beads in vitro was first-order, and the release rate was dependent on both the coat weight ratio and membrane hydrophilicity. Both surfaces of the beads before and after dissolution were smooth. The drug release pattern from the beads could be thought the diffusion through the polymer membrane. The release rate and the surface of the beads stored for 3 years at room temperature were the same with those of the initial beads.

• Nuclear Engineering and Technology
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• 제31권3호
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• pp.294-302
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• 1999

The influence of source term release parameters on offsite health effects was examined for the YGN 3&4 nuclear power plants. The release parameters considered in this study are release height, heat content, and release time. The effects of core inventory change as a function of fuel burnup was also examined. The health effects by the change of release parameters are early fatalities, cancer fatalities, and early fatality distance. The results showed that early fatalities and early fatality distance decrease as release height increases, although it does not have significant influence on cancer fatalities. The values of both early and late health effects decrease as heat content increases. As release time increases, health consequence shows maximum value in 2 hours of release time and then decreases rapidly. As fuel burnup increases, early fatalities decrease rapidly, while cancer fatalities increase rapidly. Both cases show little variation afterward. Early fatality distance is almost same in all fuel turnup history. The information obtained through this research is very useful in developing strategies for reducing offsite consequences when combined with the influence of weather conditions on offsite risks.

• Archives of Pharmacal Research
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• 제19권6호
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• pp.520-528
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• 1996

The involvement of the cyclic AMP (cAMP) effector system in the release of endogenous dopamine and acetylcholine from the rat neostriatum was assessed. Forskolin, an activator of adenylate cyclase, was used to enhance cAMP production, and the consequence of this enhancement on the spontaneous and potassium stimulated release of dopamine and acetylcholine was evaluated. Neostriatal slices were prepared from Fischer 344 rats and after a preincubation period the release of each endogenous neurotransmitter was measured from the same slice preparation. To measure acetylcholine release the slice acetylcholinesterase (AChE) activity was inhibited with physostigmine, but the release from slices with intact AChE activity was also determined (choline, instead of acetylcholine was detected in the medium). Under both conditions forskolin induced a significant dose-dependent increase in the potassium-evoked release of dopamine. In the same tissue preparations the release of neither acetylcholine (AChE inhibited) nor choline (AChE intact) was affected by forskolin. The results indicate that the CAMP second messenger system might be involved in neuronal mechanisms that enhance neostriatal dopamine release, but stimulation of this second messenger by forskolin does not further enhance neostriatal acetylcholine release.

• Journal of Pharmaceutical Investigation
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• 제21권4호
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• pp.237-245
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• 1991

Matrix type silicone rubber devices were designed for long-term implantable drug delivery system. Release controlling agents (RCA), i.e., polypropylene glycol, polyethylene glycol, were employed to control drug release from the devices. The release rate of drug from RCA dispersed silicone matrices was mainly dependent on hydrophilicity-hydrophobicity of drug and RCA. In the case of hydrophilic drug, the release from the RCA dispersed matrix was regulated by swelling kinetics. Especially when the relatively hydrophobic polypropylene glycol was used, swelling control mechanism induced zero-order release kinetics. Whereas, the release of hydrophobic drug was resulted from partition mechanism. The effect of RCA was to increase drug diffusivity.

• 한국수소및신에너지학회논문집
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• 제24권6호
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• pp.487-494
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• 2013

In this study, solutions for a liquid pool spreading model with continuous and instantaneous release are discussed based on the model used in the FERC's report. The effects of the release time on the liquid pool volume and radius are investigated for the continuous release. For the continuous release with the frictional resistance force in the liquid pool spreading model, the vaporization time decreases as the release time increases. On the other hand, for the continuous release without the frictional resistance force in the liquid pool spreading model, the vaporization time increases as the release time increases. These phenomena are deeply related to the pool radius. In addition, the effects of the initial pool radius for the instantaneous release in the liquid pool spreading model are discussed. For the case with the frictional resistance force in the liquid pool spreading model, as reducing release time in the model with the frictional resistance force for the continuous release, the solution for a continuous release approaches to that for an instantaneous release. On the contrary to this, the pool volume and radius for the instantaneous release without the frictional resistance force are totally different from those for the continuous release without the frictional resistance force.

• 오토저널
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• 제3권1호
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• pp.1-4
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• 1981

Clutch disc 의 facing은 사용할 때마다 마찰로 인하여 마멸된다. 마멸함에 따라 clutch cover의 구조상 clutch cover의 release lever가 올라와 clutch release bearing (thrust bearing)과의 간 극이 작아져서 드디어 이 간극이 없어지게 되면 release lever가 clutch release bearing을 누르게 되어 평상에도 clutch가 절반 정도로 떨어지는 상태로까지 됨으로써 clutch의 완전한 연결을 할 수 없어 slip이 일어나게 된다. 이상과 같은 문제점들을 해소하기 위하여 clutch의 control system을 수시로 조정하지 않으면 안되며 이러한 번거로움을 피하기 위하여 release lever가 올라옴으로써 release bearing과의 간극이 작아져서 자동적으로 일정한 간극을 유지하여 clutch의 slip을 방지하고 clutch기구의 내구성을 향상시키기 위한 것이 무조정식 release cylinder, 혹은 clutch adjuster이다. 이에 대한 신형식 두 종류의 구조, 작동 및 특징에 대하여 해설하여 본다.

• 한국가스학회지
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• 제10권4호
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• pp.52-62
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• 2006

본 연구에서는 배관누출에 의한 가스 폭발사고에서 누출 시나리오 선정방법과 사고결과 분석방법을 제시하고자 하였다. 이를 위해 온도, 압력, 누출물질 등 다양한 누출조건에서 누출속도, 장치피해영역 및 상해영역을 산출하고, 비교 분석하였다. 그 결과, 산출방법에 따라 사고 결과값이 다소 차이가 있었으나 파열인 경우에 최대값을 가지며, 이로부터 최악의 사고피해를 예측할 수 있었다. 그리고 누출공의 크기는 임의로 선정하기보다는 고장률을 고려한 가중평균법으로 사고피해를 예측하는 것이 바람직하다고 판단되었다.

• 약학회지
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• 제45권3호
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• pp.282-286
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• 2001

To investigate the different mechanism between ATP and compound 48/80 (C$_{48}$80/)-induced histamine release, we observed effects of calcium antagonists in histamine release of rat peritoneal mast cells. Verapamil and diltiazem (voltage-dependent calcium channel blocker) and TMB-8 (a blocker of intracellular calcium release) significantly inhibited ATP-induced histamine release, but did not inhibit $C_{48}$80/-induced histamine release. Econazole (a blocker of receptor-operated calcium channel) dose-dependently inhibited both ATP and $C_{48}$80/-induced histamine release, but inhibitory effect of econazole in ATP-induced histamine release was more potent than that in $C_{48}$80/-induced histamine. EGTA dose-dependently inhibited ATP and $C_{48}$80/-induced histamine release, but $C_{48}$80/-induced histamine release was slightly inhibited by high concentrations (>2 mM) of EGTA. These results suggest that ATP-induced histamine release is related to broth intracellular calcium release and extracellular calcium influx via voltage-dependent calcium channel and receptor-operated calcium channel. $C_{48}$80/-induced histamine release is related to extracellular calcium influx, especially by receptor-operated calcium channel rather than voltage-dependent calcium channel.