• Journal of Physiology & Pathology in Korean Medicine
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• v.33 no.6
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• pp.334-340
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• 2019

In order to promote scientification of Korean medicine, two hypothetical scenarios were proposed methodologically. Firstly, the scientification of Korean medicine requires a comprehensive understanding of the process and reality, and new logical procedures and the methods of observation and experiment. Secondly, transformation to revised Korean medicine is to replace traditional Korean medicine with biochemistry-based Western medicine, that is a method of reconstructing the recognition foundation describing symptoms and diseases using anatomical platforms and analytical tools. But there are areas of human training and practice that are not subject to scientification, and there are incommensurable parts as for the methodology between western medicine too. And additionally arbitrary rejection by uniform science with a political reason was done. So these various backgrounds and factors should be considered for the scientification of Korean medicine. And before that, reflection and agreement on the understanding and attitude of the method of scientification within the Korean medical community is necessary.

• Journal of Physiology & Pathology in Korean Medicine
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• v.33 no.6
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• pp.303-310
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• 2019

In order to search for the causes of having difficulty with the scientification task of the Korean medicine, the definition and conception of science were reviewed first and then formalization of reasoning scheme and a practical method of scientification were proposed. Science in its definition is meant by foundation of method and system for production of scientific knowledge not by knowledge of science itself. The formation of science is composed of complex processes including not only scientific knowledge but also politicosocial output containing activity of scientist society, spreading of social value and intercommunication. The production of scientific knowledge of Korean medicine is begun from logicality of the differential diagnosis and treatment theory through abductive verification of analogical inference by yinyang and 5 phase theory. For the commensurability between the various heterogenic theories within Korean medicine, the scientific activity of collecting, compiling, analyzing, distributing, and discussing the significant knowledge gained through abductive verification in the experiment and clinical process should be formed broadly. Based on these knowledge database, organization of scientist society with Korean medicine, life science, medical engineering, social expansion and generalization of pattern conception, and then social propagation and contribution for national health should be driven forward.

• Journal of Society of Preventive Korean Medicine
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• v.16 no.3
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• pp.53-73
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• 2012

Objectives : The inclusion of Korean Medicine in the national health care system led to the need of a serious discussion on its modernization. This paper looked at how these discussions were progressed. Especially, a difference in the meaning of 'science' in the 1950s and the 1990s was observed. Methods : Articles related to the medical dispute between Korean and Western Medicine in "EE LIM", especially the ones from the 1950s, were selected, classified and analyzed. Research papers on Evidence-Based Medicine were also analyzed. Evidence-Based Medicine was a new medical research methodology in the 1990s. Articles on Evidence-Based Medicine were searched and selected from journal databases: DBpia, KISS, RISS, and OASIS. Results : The problem of establishment of modernity of Korean Medicine in the recent times was addressed in the context of scientification and systematization. Accordingly, the academic societies of Korean Medicine aimed for scientification. But efforts to secure the identity of Korean Medicine opposed to western science were also made. Meanwhile, Evidence-Based Medicine established in 1992 presented a different concept of science. This led to a new means of acknowledgement of Korean Medicine in the modern society. Conclusions : The modernization process of Korean Medicine up to now was a course of scientification. But as this process did not fully reflect its characteristics, the modernization of Korean Medicine still remains a pending question. A modern study methodology that fully reflects the identity of Korean Medicine needs to be established.

• The Korea Journal of Herbology
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• v.29 no.1
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• pp.45-52
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• 2014

Objectives : The aim of this study was to investigate the effects water extract of fermented new korean medicinal mixture, combinations of Mori Folium, Adenophorae Radix, Phllostachyos Folium and Citri Pericarpium (F-MAPC), on adipocyte differentiation, adipogenesis and glucose uptake using undiffernentiated 3T3-L1 adipocytes and L6 myoblasts. Methods : Each herb and those mixture were respectively fermented and then extracted with water. We carried on MTT assay for check-up on cell toxicity, Oil Red O staining for determination of cell differentiation and intracelluar adipogenesis. Western blot analysis for measurement of pAMPK and pACC, $C/EBP{\alpha}$, $PPAR{\gamma}$ and Glut-4 protein expressions were performed. Results : F-MAPC showed significant inhibitory activity on adipocyte differentiation in 3T3-L1 preadipocytes without affecting cell toxicity as assessed by measuring fat accumulation, and this effect was 2 fold higher in 0.2 mg/ml F-MAPC than that of the same dose of each fermented herbal extract alone. In addition, these effects were associated with modulation of adipogenic transcription factors, such as $C/EBP{\alpha}$, $PPAR{\gamma}$, as well as stimulated phosphorylations of AMPK and ACC. Translocation of Glut-4 was significantly increased by 10.2% in L6 cells treated with 0.2 mg/ml F-MAPC compared with that of control. Conclusions : These results demonstrate that F-MAPC may be an ideal candidate for therapy of obesity and diabetes by disturbing the differentiation into adipocytes, as well as the inducement of intramuscular glucose uptake from blood.

• The Korea Journal of Herbology
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• v.29 no.4
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• pp.77-82
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• 2014

Objectives : The effects of ethanol extract of Plantago asiatica L. were investgated on adipocyte differentiation, lipopogenesis, lipolysis and apoptosis using differnentiated 3T3-L1 adipocytes. Methods : Plantago asiatica L. was extracted with ethanol (CCE). We carried on MTT assay for cell proliferation, Oil Red O staining for determination of cell differentiation and intracelluar adipogenesis. TUNEL staining assay for cell apoptosis, and Western blot analysis for measurement of pAMPK and pACC, $C/EBP{\alpha}$, $PPAR{\gamma}$ protein expressions were performed. Results : The addition of CCE up to 0.2 mg/ml into cell culture media showed no cytotoxicity. Treatment of 0.2 mg/ml CCE significantly inhibited differentiation in 3T3-L1 preadipocytes. Lipid accumulation of the CCE treated cells was decreased compared with that of control. Induction of cell apoptosis was increased in CCE treated cells compared with that of control. AMPK and ACC levels of the cells with 0.2 mg/ml CCE were led to phosphorylation and also expressions of $C/EBP{\alpha}$ and $PPAR{\gamma}$, as adipogenic transcription factors, were suppressed compared with those of control. Conclusions : Taken together, these results provide evidence that CCE has a regulatory role in lipid metabolism that is related to differentiation into adipocytes, adipogenesis and apoptosis.

• Journal of Physiology & Pathology in Korean Medicine
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• v.33 no.5
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• pp.261-266
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• 2019

In order to cope with various issues about access to public health system of Korean medicine and reformation of college curriculum and argument of pseudoscience on Korean medicine etc., a new definition of Korean medicine was devised. Two ways of approach were tried through analysis of precedent cases of definition on traditional medicine firstly and analysis on concept and logic of Korean medicine secondly. As a result, Korean medicine can be defined as a science of theories and application techniques for maintaining health and diagnosing, treating and preventing conditions、causes、prognosis of diseases or damages based on the correlative and complicated understanding about the structure and function of mind and body out of human lives under the environment and society. This definition can be used as a basis to derive legal rights or scope in area of research and education policies and social institutions of the Korean medicine and to confront scientification criticism hereafter.

• The Journal of Korean Medicine
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• v.35 no.3
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• pp.70-92
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• 2014

Objectives: Due to advance of science and IT technology, high tech imaging equipment like ultrasonography, CT, MRI and PET scan is constantly being developed and progressed; use of these techniques is needed for Korean medicine. Methods: Historical study was undertaken on the evidence of using ultrasonography. Normal organs and various sorts of diseases were also observed by ultrasonography. Results: Korean medicine judges disease of internal organs and condition of health by symptoms of functional disease and organic disease based on anatomical theory. Ultrasonography based on anatomical theory is non-invasive and free from radiation exposure and can be performed directly from clinical practice in real-time. Ultrasonography can be a big help for securing the stability of the internal organs in inserting needles in the thorax and abdomen as well as diagnosing functional and organic diseases based on anatomical theory. Conclusion: We look forward to a great development of scientification and objectification of Korean medicine by using and researching imaging equipment based on anatomical theory as well as ultrasonography.

• Journal of Society of Preventive Korean Medicine
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• v.5 no.1
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• pp.57-75
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• 2001

This study was conducted to improve the current regulation guidelines for developing traditional Korean medicines with effectiveness and productivity, in order to cope with the upcoming ICH on specifications on oriental herbal drugs. Also, major purposes of this study are to motivate R&D and to pioneer foreign markets for domestic herbal drug companies. First, after examining concepts of traditional Korean medicines and comparing the numbers and differentiation of herbal drugs registered on Pharmacopeia among Korea, China, and Japan, the current new drug development requirements for traditional Korean medicines were reviewed in detail, followed by comparison of foreign regulation systems including USA, EU, China, and Japan. Second, empirical cases on failure of development for new traditional Korean medicines under the current regulation system in the domestic companies including Dong-A, Kwangdong, and Samchondang, were collected and analyzed. As a result, hanbangsaengyak, the new category for traditional Korean medicines was newly developed on the basis of scientification of data between saengyak and hanyak, from the perspectives of harmonization between oriental medicine and western medicine and of balance between food and drug, in terms of industrialization, publicity, modernization, and effectiveness of administration. In addition, the new regulation requirements for the new hanbangsaengyak preparations were discussed by establishing principles of reinforcing preclinical test and of simplifying clinical trials in Korea. Finally, the further researches to articulate the complete specifications for pre-clinical and clinical requirements for traditional Korean medicines were strongly suggested.

• Journal of Korean Medical classics
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• v.25 no.3
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• pp.57-78
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• 2012

Objective: Although the government acknowledged Korean Medical Doctors as official health care providers since 1951, criticism regarding its modernity persisted. This paper focuses on the medical dispute between Korean and Western Medicine in 1950s risen from the problem of modernization of Korean Medicine. Method: This paper looked into the medical dispute between Korean and Western Medicine in 1950s through "EE LIM". "EE LIM" is a scholarly journal published by Korean Medical doctor Bae Won-Sik. Articles regarding the medical dispute between Korean and Western Medicine were selected, categorized and analyzed. Result: The main questions against Korean Medicine were: whether it was scientific or not, and whether there was a possibility of systematization. Several opinions were brought up on these issues. 1) Some people criticized Korean Medicine as being unscientific based on modern science. 2) Others emphasized the identity of Korean Medicine against the critics. 3) Another group of people wanted to study Korean Medicine using modern methods and obtain merits from both sides. Conclusion: The different understanding of the term 'science' led to diverse discussions on the direction of Korean Medicine's progression. The narrow meaning of science only considers Korean Medicine as an object of modern scientific and medical study. But if the meaning is broadened, containing empirical aspects, Korean Medicine can be included as a category of science based on its clinical utility.

• Journal of Physiology & Pathology in Korean Medicine
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• v.26 no.5
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• pp.773-777
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• 2012

Since 2010, in general hospital, they can install western medical post, traditional Korean medical post, and dental post. So the environment is made for the Cooperative medical system between traditional Korean medicine(TKM) and western medicine(WM) to be performed. So we found out about how doctors think about TKM and what is needed for TKM & WM cooperative system to work well. When we found out about how recognition changed about TKM during their medical school years and after they became doctors, positive answer increased from 25.6% to 30%, negative answer decreased from 41.9% to 32.0%, severely negative increased from 9.3% to 16%. They changed to positive about TKM after they became doctors. But severely negative also increased. The element they lose faith in TKM is their doubt about the scientific aspects of TKM. On the other hand, severely negative recognition was also raised. 73.8% of respondents thought the most effective treatment of TKM was for myalgia. 33.3% of them answered the chance to encounter TKM was the mass media, indicating its limitation. 60.5% of them considered major reason for negative evaluation of TKM is its non-scientific aspects and only 30.9% said TKM treatment could be recommended to patients at the hospital. Doctors in WM for recognition on TKM is mostly negative and major reason is its non-scientific aspects. As the solution to this problem, scientification of TKM is suggested through research projects. These connections must be resolved to smoothly work interdisciplinary system of TKM and WM.