• Biomolecules & Therapeutics
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• 제27권3호
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• pp.283-289
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• 2019

Brain aging induces neuropsychological changes, such as decreased memory capacity, language ability, and attention; and is also associated with neurodegenerative diseases. However, most of the studies on brain aging are focused on neurons, while senescence in astrocytes has received less attention. Astrocytes constitute the majority of cell types in the brain and perform various functions in the brain such as supporting brain structures, regulating blood-brain barrier permeability, transmitter uptake and regulation, and immunity modulation. Recent studies have shown that SIRT1 and SIRT2 play certain roles in cellular senescence in peripheral systems. Both SIRT1 and SIRT2 inhibitors delay tumor growth in vivo without significant general toxicity. In this study, we investigated the role of tenovin-1, an inhibitor of SIRT1 and SIRT2, on rat primary astrocytes where we observed senescence and other functional changes. Cellular senescence usually is characterized by irreversible cell cycle arrest and induces senescence- associated ${\beta}$-galactosidase (SA-${\beta}$-gal) activity. Tenovin-1-treated astrocytes showed increased SA-${\beta}$-gal-positive cell number, senescence-associated secretory phenotypes, including IL-6 and IL-$1{\beta}$, and cell cycle-related proteins like phospho-histone H3 and CDK2. Along with the molecular changes, tenovin-1 impaired the wound-healing activity of cultured primary astrocytes. These data suggest that tenovin-1 can induce cellular senescence in astrocytes possibly by inhibiting SIRT1 and SIRT2, which may play particular roles in brain aging and neurodegenerative conditions.

• BMB Reports
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• 제52권9호
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• pp.533-539
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• 2019

Recent evidence from genetics, animal model systems and biochemical studies suggests that defects in membrane trafficking play an important part in the pathophysiology of Parkinson's disease (PD). Mutations in leucine-rich repeat kinase 2 (LRRK2) constitute the most frequent genetic cause of both familial and sporadic PD, and LRRK2 has been suggested as a druggable target for PD. Although the precise physiological function of LRRK2 remains largely unknown, mounting evidence suggests that LRRK2 controls membrane trafficking by interacting with key regulators of the endosomal-lysosomal pathway and synaptic recycling. In this review, we discuss the genetic, biochemical and functional links between LRRK2 and membrane trafficking. Understanding the mechanism by which LRRK2 influences such processes may contribute to the development of disease-modifying therapies for PD.

• 척추신경추나의학회지
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• 제15권1호
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• pp.147-155
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• 2020

Objectives : The aim of this study was to analyze changes in the gait pattern of a unilateral knee pain patient after treatment with Korean Medicine therapy. Methods : We conducted gait analysis 4 times over 11 days to analyze changes in gait parameters using gait analysis systems. Results : Velocity, cadence, step length, and stride length were all increased. On the collateral side, both stance phase and double support (%) decreased. These results are similar to those of hemiplegic patients with improvement patterns. Conclusions : Gait analysis could be used as a good evaluation tool for tracking improvements in knee pain.

• Animal cells and systems
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• 제8권Supplyment
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• pp.14-14
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• 2004

• Journal of Genetic Medicine
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• 제18권1호
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• pp.64-69
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• 2021

Primary cilium has a signal transduction function that is essential for brain development, and also determines cell polarity and acts as a mediator for important signaling systems, especially the Sonic Hedgehog (SHH) pathway. TBC1D32 is a ciliary protein, implicated in SHH signaling. Biallelic mutations in the TBC1D32 gene causes a kind of ciliopathy, heterogeneous developmental or degenerative disorders that affect multiple organs, including the brain. Here we report a boy who carried compound heterozygous variants in TBC1D32. The patient showed hypotonia, respiratory difficulty, and multiple anomalies at his birth. He was diagnosed with congenital hypopituitarism and treated with T4, hydrocortisone, and growth hormone. Despite the hormonal replacement, the patient needed long-term respiratory support with tracheostomy and nutritional support with a feeding tube. His developmental milestones were severely retarded. Hydrocephalus and strabismus developed and both required surgery, during the outpatient follow-up. Whole-exome sequencing indicated compound heterozygous variants, c.2200C>T (p.Arg734^*) and c.156-1G>T, in TBC1D32 gene. This is the first Korean case of TBC1D32-related ciliopathy and we reported detailed and sequential clinical features. This case demonstrated the utility of whole-exome sequencing and provided valuable clinical data on ultra-rare disease.

• Advances in robotics research
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• 제1권1호
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• pp.101-126
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• 2014

In this article we present modular neural control for a leg-wheel hybrid robot consisting of three legs with omnidirectional wheels. This neural control has four main modules having their functional origin in biological neural systems. A minimal recurrent control (MRC) module is for sensory signal processing and state memorization. Its outputs drive two front wheels while the rear wheel is controlled through a velocity regulating network (VRN) module. In parallel, a neural oscillator network module serves as a central pattern generator (CPG) controls leg movements for sidestepping. Stepping directions are achieved by a phase switching network (PSN) module. The combination of these modules generates various locomotion patterns and a reactive obstacle avoidance behavior. The behavior is driven by sensor inputs, to which additional neural preprocessing networks are applied. The complete neural circuitry is developed and tested using a physics simulation environment. This study verifies that the neural modules can serve a general purpose regardless of the robot's specific embodiment. We also believe that our neural modules can be important components for locomotion generation in other complex robotic systems or they can serve as useful modules for other module-based neural control applications.

• 한국지능시스템학회:학술대회논문집
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• 한국퍼지및지능시스템학회 1993년도 Fifth International Fuzzy Systems Association World Congress 93
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• pp.1017-1020
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• 1993

This paper describes a neo fuzzy neuron which was produced by a fusion of fuzzy logic and neuroscience. Some learning algorithms are presented. The guarantee for the global minimum on the error-weight space is proved by a reduction to absurdity. Enhanced is that the learning speed of the neo fuzzy neuron exceeds 100,000 times of that of conventional multi-layer neural networks.

• 인지과학
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• 제29권1호
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• pp.61-84
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• 2018

본 논문은 신경윤리의 철학적 의미와 인지 패러다임 안에서의 독자적 위치를 검토하고, 신경윤리의 쟁점들을 고찰하는 것을 목적으로 한다. 뇌과학의 발전은 인간 정신에 대한 보다 직접적인 탐구와 개입을 가능하게 하여 전통적인 물질과 정신의 경계를 약화시키고, 인간 본성에 대한 새로운 철학적 질문들을 제기한다. 신경윤리는 기존 법적, 사회적 체계에서 포괄하기 어려운 뇌과학과 관련된 윤리적 문제들을 다루기 위하여 학제적이고 통합적 관점을 취한다. 신경윤리의 쟁점들 중에는 일부 고전적 생명윤리 쟁점과 겹치는 부분도 있지만 뇌과학과의 관련성 안에서만 특수하게 발견할 수 있는 문제들이 더 많다. 신경윤리의 고유 쟁점은 대체로 두뇌활동의 관찰과 복호화를 통한 마음읽기와 두뇌활동에 대한 개입을 통한 인지향상과 관련되어 있는데, 이러한 문제들을 다루기 위해서는 생명윤리 하위 분야를 넘어서는 독자적 분야로서의 신경 윤리가 필요하다는 주장도 제기되고 있다. 최근 뇌과학 연구 동향과 발전 단계를 고려할 때, 국내에서도 본격적인 신경윤리 논의와 관련 분야 전문가들의 협력을 시작할 필요가 있다.

• Smart Structures and Systems
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• 제8권1호
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• pp.107-117
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• 2011

Biological sensory systems continuously monitor and analyze changes in real-world environments that are relevant to an animal's specific behavioral needs and goals. Understanding the sensory mechanisms and information processing principles that biological systems utilize for efficient sensory data acquisition may provide useful guidance for the design of smart-sensing systems in engineering applications. Weakly electric fish, which use self-generated electrical energy to actively sense their environment, provide an excellent model system for studying biological principles of sensory data acquisition. The electrosensory system enables these fish to hunt and navigate at night without the use of visual cues. To achieve reliable, real-time task performance, the electrosensory system implements a number of smart sensing strategies, including efficient stimulus encoding, multi-scale virtual sensor arrays, task-dependent filtering and online subtraction of sensory expectation.

• 한국정보과학회논문지:데이타베이스
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• 제30권2호
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• pp.145-156
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• 2003

현존하는 대부분의 내용 기반 이미지 검색 시스템은 칼라, 모양, 텍스처 특징을 이용한 유사도-기반 검색에 초점을 맞추고 있다. 신경과학 이미지 데이타베이스의 경우, 이미지에 대한 전역적 평균 특징 값을 기반으로 한 유사 이미지의 검색이 임상 병리학자들에게는 전혀 도움이 되지 않는 다는 것을 발견하였다. 신경과학 데이터베이스 상의 이미지에 대한 실용적인 내용 기반 검색을 실현하기 위해서는 이미지의 내부 내용이나 의미를 표현하는 일이 필요하다. 본 논문에서는 이러한 이미지들에 대해 보다 유용한 검색을 지원하기 위하여 이미지 내용과 그에 관련된 개념 지식을 표현하는 방법을 제시한다. 또한 객체지향 메시지 경로 식을 이용하여 이러한 고급 검색을 지원하기 위한 연산의 의미를 기술한다. 제안된 기법은 유연하고 확장 가능하므로 보다 강화된 내용 검색을 위해 이미지 내용에 대한 보다 많은 의미를 점진적으로 추가해 나갈 수 있다.