• Journal of Ginseng Research
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• v.18 no.1
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• pp.39-43
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• 1994

This study was performed to investigate the effect of ginseng saponin from Korean red ginseng on the learning and memory. Total (50, 100 mg/kg, bw) and panaxadiol saponin (15, 30 mg/kg, bw) treated groups did not show the difference of the time score and the number of error in comparison with control group. Panaxatriol saponin (15, 30 mg/kg, bw) significantly decreased both the time score and the number of error in water maze test. These results indicate that panaxatriol saponin from Korean red ginseng may improve the learning ability of rat in water multiple T-maze.

• Animal cells and systems
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• v.7 no.4
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• pp.303-307
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• 2003

The aim of this study is to investigate whether alcohol alters learning and memory processes pertaining to emotional and spatial factors using the active avoidance and T-maze task in zebrafish. In the active avoidance task, zebrafish were trained to escape from one compartment to another to avoid electric shocks (unconditioned stimulus) following a conditioned light signal. Acquisition of active avoidance task appeared to be normal in zebrafish that were treated with 1% alcohol for 30 min for 17 days until the end of the behavioral test, and retention ability of learned behavior, tested 2 days later, was the same as control group. In the T-maze task, the time to find a reservoir was compared. While the latency was similar during the 1 st training session between control and alcohol-treated zebrafish, it was significantly longer in alcohol-treated zebrafish during retention test 24 h later. Furthermore, when alcohol was treated 30 min after 2nd session without prior treatment, zebrafish demonstrated similar retention ability compared to control. These results suggest that chronic alcohol treatment alters spatial learning of zebrafish, but not emotional learning.

• Journal of Physiology & Pathology in Korean Medicine
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• v.17 no.4
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• pp.1050-1053
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• 2003

This study was carried out to investigate effects of Kamiguibi-tang extract on learning ability of ethanol-treated rats. The rats were divided into 3 groups; normal, control and sample group. Control group administered ethanol at a dose of 3g/kg bw.(25 v/v %), while sample group administered the Kamiguibi-tang extract(200mg/kg) 30 min. before treating same dose of ethanol as control group orally. All groups were subjected to trials of straight channel on the 1 st day and to those of multiple T-maze during the following 3 days. The time required in normal group for the straight or T-maze of the 2nd and 3rd trials was significantly shorter than that of the 1 st, while the control group showed no significance. But in the straight channel or multiple T-maze trials, the sample group showed significant decrease in the time required against the control group and also showed significant decrease in the number of selecting errors.

• Advances in Traditional Medicine
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• v.7 no.1
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• pp.41-45
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• 2007

The roots of the plant Korean ginseng have been extensively used in the traditional Chinese herbal medicine. The effects of chronic administration of Korean ginseng extract (KGE) were investigated on two different anxiety models: the elevated T-maze (for inhibitory avoidance and escape measurements) and the open field test (OFT). Diazepam (1 mg/kg), KGE (10, 30 and 100 mg/kg) were administered orally for 15 days. On the 14th day, mice were previously exposed for 30 min to one of the open arms of the T-maze, 24 h before the test. On 15th day, mice had two exposures to the enclosed and open arm of the elevated T-maze followed by exposure to the open field apparatus. The number of line crossings in the apparatus was used to assess locomotor changes. Cumulative Concentration Response Curve of 5-HT was plotted using rat fundus which were pre-treated in a similar way. Treatment with Diazepam (1 mg/kg) and KGE (10, 30 and 100 mg/kg) significantly (P < 0.05) impaired inhibitory avoidance performance but did not impair escape latency. In OFT, diazepam facilitated locomotion as compared to vehicle and other treatment groups. KGE at any of the selected doses did not impair locomotion. Concentration response curve of 5-HT was shifted towards the right with suppression of maxima in rats treated with KGE. The results suggest that KGE exerts anxiolytic like behaviour in a specific subset of defensive behaviour, particularly those related to generalized anxiety disorder.

• Korean Journal of Medicinal Crop Science
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• v.11 no.3
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• pp.232-235
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• 2003

To investigate effect of fruits of Hovenia dulcis Thunb. on learning ability of ethanol-induced rats, we divided rats into 3 groups; normal, control and sample groups. Control group administered ethanol at a dose 3 g/kg bw. (25 v/v %), while sample group administered the water extract of fruits of Hovenia dulcis Thunb. 30 min. before treating same dose of ethanol as control group orally. All groups were subjected to trials of straight channel on the 1st day and to those of multiple T-maze during the following 3 days. The time required in normal group for the straight channel of the 2nd and the 3rd trials was significantly shorter than that of the 1st, while control group showed no significance. In the time required for the multiple T-maze trials of control group, there were no significance. But in the straight channel or multiple T-maze trials, the sample group showed significant decrease in the time required against control group, and also showed significant decrease in the number of selecting errors.

• Journal of Digital Convergence
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• v.12 no.6
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• pp.349-354
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• 2014

A maze-escaping method with cooperating work of robots alongside one another will be proposed in this paper. Educational robots can communicate each other using Zigbee; however, they can't solve problems together due to their lack of arithmetic function. The robots walk upright controlled by a motion program; furthermore, they recognize an intersection or a dead-end in the use of distant sensors with sending data and receiving commands from the central control system. The maze-search algorithms were modified so that all robots can effectively navigate the maze.

• Journal of Food Hygiene and Safety
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• v.30 no.1
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• pp.120-125
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• 2015

The objective of this study is to investigate the effect of MSG on cognitive function and anxiety by the T-maze and elevated-plus-maze test and repeated oral dose toxicity in SD rat of MSG. The rats were treated with MSG of control group, low group (3 g/kg) and high group (5 g/kg) intragastrically for 4 weeks, respectively. We examined the body weight, the clinical signs, T-maze, Elevated-plus-maze, hematological analysis and serum biochemical analysis, we also observed the histopathological changes of liver, kidney in rats. No significant differences in body weights, biochemical analysis and histopathological observations between control and MSG treatment group were found. In the elevated plus maze (EPM), MSG-treatment group has more open arm visited than controls. MSG-treatment group has been more activated in T-maze test. These data indicate the continuous high MSG intake could be increased the anxiety and could be decreased cognitive ability. In conclusion, MSG is physiologically safety, but high MSG intake could be increased the anxiety and could be decreased cognitive ability in juvenile rat.

• Advances in Traditional Medicine
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• v.6 no.3
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• pp.179-185
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• 2006

We investigated the effects of chronic administration of different extracts of ginger rhizome [pet ether extract (PE); toluene fraction (TF) of pet ether extract] on anxiety models: the elevated T-maze (ETM) (for inhibitory avoidance and escape measurements) and the open field test. Ondansetron (1 mg/kg), FE (10, 30 &100 mg/kg) and TF (10 & 30 mg/kg) were administered orally for 15 days. On the $14^{th}$ day mice were previously exposed for 30 min to one of the open arms of the T-maze, 24 h before the test. On $15^{th}$ day mice had two exposures to the enclosed and open arm of the ETM followed by exposure to the open field apparatus. The number of line crossings in the apparatus was used to assess locomotor changes. Cumulative Concentration Response Curve of 5-HT was plotted using rat fundus which were pretreated in a similar way. Treatment with Ondansetron (1 mg/kg), PE (100 mg/kg), TF (10 mg/kg) and TF (30 mg/kg) significantly (P<0.05) impaired inhibitory avoidance performance but did not impair escape latency. Concentration response curve of 5-HT was shifted towards the right with suppression of maxima in rats treated with PE and TF. The results suggest that PE and TF of Ginger rhizome exerts anxiolytic like behaviour in a specific subset of defensive behaviour, particularly those related to generalized anxiety disorder.

• Korean Journal of Veterinary Research
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• v.31 no.4
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• pp.419-424
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• 1991

This study was carried out to investigate; the alpha-fetoprotein, urea and free fatty acid in amniotic fluids and water filled multiple T-maze test of fetuses affected by Ethylenethiourea. The S.P.F. Sprague-Dawley female rats(10 weeks) were used in this study and these animals were divided into four groups; control group I (10mg/kg/day), group II(30mg/kg/day), group III(50mg/kg/day). The results obtained were summarized as follows; 1. In the water filled multiple T-maze test of F1 male rats, The time and errors from start point to goal point of 30mg/kg group are significantly(p<0.001) increased from control group in 3rd day of test. In F1 female rats of 2nd day and 3rd day of water filled multiple T-maze test, The time and some errors in 30mg/kg group are significantly (p<0.05) increased from control group. 2. Alpha-fetoprotein values of all treated groups(10mg/kg, 30mg/kg and 50mg/kg) were significantly(p<0.001) decreased from control values in the amniotic fluids. 3. Urea values of ammniotic fluids in 50mg/kg group are significantly increased from control group. 4. Free fatty acid values of ammniotic fluids in 50mg/kg group are significantly increased from control group.

• Journal of International Academy of Physical Therapy Research
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• v.4 no.1
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• pp.479-487
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• 2013

This study is intended to examine the tDCS and Morris Water maze training in Alzheimer's disease(AD) rats on Tau protein expression. Experiment groups were divided into four groups and assigned 16 rats to each group. Group I was a control group(AD induced by scopolamine); Group II was a experimental control group(AD injured by scopolamine and treatment tacrine); Group III was a group of tDCS application after AD injured by scopolamine; Group IV was a group of morris water maze training after AD injured by scopolamine. In cognition test, the outcome of group II was significantly lower than the groups(p<.001). and group III, IV were significantly low result at 14 days(p<.05). In histological finding, the experimental groups were destroy of micro vessels and finding of cell atropy and swelling. Group III, IV were decreased in degeneration of liver and kidney cells. In immuno- histochemistric response of BDNF and tau protein in hippocampus, BDNF expression of Group II was more increase than the other groups. and increase of BDNF expression was III, IV were higher than group I at 21 days. Tau protein expression of Group II was more decrease than the other groups. and decrease of Tau protein expression was III, IV were lower than group I at 21 days. These result suggest that improved tDCS and morris water maze training after scopolamine induced is associated with dynamically altered expression of BDNF and Tau protein in hippocampus and that is related with cognitive function.