• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.25 no.2
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• pp.53-64
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• 2014

Tic disorder is a childhood neuropsychological disorder characterized by abrupt, involuntary, and repetitive stereotyped muscle movement or vocal sound. Tourette's disorder shows a chronic prognosis, and can last for life if no treatment is applied. Although tic disorder has been known for ages, the underlying cause is still not well known. Non-pharmacological treatments have long been used for the tic disorder, but few clinical studies were conducted. However, the European Society for the Study of Tourette's Syndrome recently issued non-pharmacologic guidelines for treatment of tic disorders based on the research findings obtained so far. In addition, guidelines for non-pharmacologic evidence-based treatment were reported in Canada, North America. By synthesizing the newly reported foreign guidelines for treatment and review articles, the aim of this study is to investigate the non-pharmacologic therapies used for treatment of tic disorder or Tourette's disorder.

• Journal of Acupuncture Research
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• v.25 no.2
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• pp.179-187
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• 2008

Objectives : The purpose of this study is to review the acupuncture treatment studies of tic disorder in traditional chinese medicine. Methods : We reviewed the 16 studies about acupuncture treatment of tic disorder which were published from 2005 through 2007. We selected those studies from CNKI(中國知識基礎設施工程 http://www.cnki.net). Results : Selected 16 studies were divided into 8 case reports and 8 control studies. CCMD(6 studies) and DSM(4 studies) were frequently used in the diagnosis of tic disorder. Acupuncture points frequently used were 百會(Baekhoe, $GV_{20}$), 太衝(Taechung, $LR_3$), 風池(Pungji, $GB_{20}$), 合谷(Hapgok, $LI_4$), 神門(Sinmun, $HT_7$), 三陰交(Sameumgyo, $SP_6$), 內關(Naegwan, $PC_6$) and so on. According to specific parts of symptom, some acupuncture points were added. Most of studies reported that acupuncture treatments of tic disorder were very effective. Conclusions : There have been reported many acupuncture treatment studies of tic disorder in traditional chinese medicine. We believe that these studies could be applied to the clinical practices in Korea.

• Journal of TMJ Balancing Medicine
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• v.11 no.1
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• pp.25-36
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• 2021

It was observed that the effectiveness of Yin-yang balancing therapy of the tempromandibular joint (YBT) or functional cerebrospinal therapy (FCS) in three cases: an acute and a chronic motor tic disorder and a Tourrette's disorder (TD). These three cases were mainly managed with cervical balancing appliance for the Yin-yang Balancing on tempromandibular joint (TMJ) and pelvic balance therapy. They were treated concurrently with acupuncture, cupping and herb-medicine. Clinical outcome measurement was based on subjective measures with visual analogue scale (VAS), Yale Global Tic Severity Scale (YGTTS) and clinical observations for 235, 279 and 273 days respectively. The patient showed positive changes after the treatment and this effect maintained over the follow-up period. Although it is not clear whether the effect is sustained afterwards or not, a positive effect on the motor tic disorders and TD was observed. And so, furthermore strict clinical and structural researches for verification on YBT is expected.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.24 no.2
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• pp.90-95
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• 2013

Botulinum toxin, a neurotoxin, is known to be an inhibitor of cholinergic neuromuscular transmission. Recently, it was reported that the administration of botulinum toxin is effective for the treatment of focal neurological motor disorders such as cervical dystonia, blepharospasm, hemifacial spasm, spasmodic dysphonia, and writer's cramp. Several case studies reported that the botulinum toxin was administered for the treatment of motor tic or vocal tic. It was found that this toxin reduces the frequency and severity of the tic as well as the premonitory urge and symptoms. In our case study, a noticeable decrease of motor tic symptom was observed after an intramuscular injection of 300mg of botulinum toxin in an 18-year-old patient with Tourette's disorder who showed only a little improvement of motor tic and vocal tic symptoms after treatment with antipsychotic drugs for several years. This case is reported in our study and literature survey was undertaken for reviewing similar cases. In our study, an 18-year-old boy diagnosed with Tourette's disorder based on Diagnostic and Statistical Manual of Mental Disorders, fourth edition presented with the following scores : the Clinical Global Impression scale, Yale Global Tic Severity Scale (motor/vocal/severity), Premonitory Urge Score, Korean Attention-Deficit Hyperactivity Disorder Rating scale, and Kovac Depression scale which were performed prior to the treatment were 5, 21/5/50, 100, 17, and 18 points, respectively. Two weeks after the injection of botulinum toxin, the scores were 4, 17/5/40, 50, 16, and 19 points, respectively. Eight weeks after the injection of botulinum toxin, they had become 3, 15/5/30, 25, 16, and 20 points, respectively, which clearly indicates a noticeable decrease of motor tic symptom.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.31 no.1B
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• pp.21-27
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• 2011

When execute runoff forecasting, can not remove perfectly uncertainty of forecasting results. But, reduce uncertainty by various techniques analysis. This study applied various forecasting techniques for runoff prediction's accuracy elevation in Gongju basin. statics techniques is ESP, Period Average & Moving average, Exponential Smoothing, Winters, Auto regressive moving average process. Authoritativeness estimation with results of runoff forecasting by each techniques used MAE (Mean Absolute Error), RMSE (Root Mean Squared Error), RRMSE (Relative Root Mean Squared Error), Mean Absolute Percentage Error (MAPE), TIC (Theil Inequality Coefficient). Result that use MAE, RMSE, RRMSE, MAPE, TIC and confirm improvement effect of runoff forecasting, ESP techniques than the others displayed the best result.

• Journal of Haehwa Medicine
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• v.28 no.1
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• pp.13-25
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• 2019

Objectives : This study analyzed domestic case reports of syndrome differentiation and herbal medicine treatment for tic disorder published from 2000 to 2018 and aimed to seize the latest trend of Korean herbal medicine treatment according to syndrome differentiation. Methods : We searched herbal medicine treatment of tic disorder through five major Korean academic literature databases; NDSL, KTKP, KISS, RISS, DBPIA. Results : 12 articles were included in this study from 49 articles. These studies were analyzed by year, evaluation criteria, Korean treatments, treatment effects, syndrome differentiation, herbal medication, duration of medication, and type of herbal medicine. Treatment results were assessed by YGTSS. Most cases accompanied Korean integrative treatments and only one case report used herbal medicine alone. Most common type of syndrome differentiation for patients was spleen. Duration of medication varied according to each case and decoction was the most used type of herbal medication. Conclusions : It has been reported that herbal medicine treatment according to the syndrome differentiation could be effective in treating tic disorder. This study suggests that additional studies will be required to justify classification of syndrome differentiation and the sole effectiveness of herbal medicine on tic disorder.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2020.08a
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• pp.96-96
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• 2020

Soybean seeds are important sources of non-nutritive health promoting metabolites. The contents of these metabolites are affected by both genetic and environmental factors. In the present study, the contents of five common isoflavones including daidzin, genistin, glycitin, malonyldaidzin, and malonylgenistin were analyzed in 72 soybeans of different seed coat colors, diversity, and of different origins including China (22), Japan (9), USA (12), India (4), and Korea (25). The average total isoflavone content (TIC) was maximum in Indian soybeans (3302.36 ㎍/g) and minimum in Chinese landraces (1214.95 ㎍/g). The Korean landraces had higher average TIC (2148.05 ㎍/g) than the USA genetic materials (1580.23 ㎍/g) and Japanese landraces (1485.99 ㎍/g). The content of malonylgenistin was in the range of 54.31 - 2385.68 ㎍/g in the entire population, and was the most abundant isoflavone irrespective of origin although there was content variation among individual soybeans. Besides, glycitin was the least concentrated isoflavone, and its content ranged from 0.00 to 79.79 ㎍/g. With respect to seed coat color, green soybeans from all countries displayed the maximum malonylgenistin and TIC contents. Exceptions were those of Korean and Indian origins where black and yellowish-green soybeans presented the highest malonylgenistin and TIC contents, respectively. In multivariate analysis, 92.72% of the variance was explained by the first two principal components, and the soybeans were grouped in to three clusters based on isoflavone contents. Overall, our findings signify the importance of seed coat color and origin as discriminant parameters, and provide wide spectrum of routes for breeding soybean cultivars.

• Journal of the Korean Society for Precision Engineering
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• v.25 no.12
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• pp.13-19
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• 2008

• Journal of Chest Surgery
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• v.23 no.6
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• pp.1067-1073
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• 1990

To clarify the changes of left ventricular function under normothermia, the time interval between the onset of ischemia and the beginning of contracture of left ventricle[TIC] were recorded in newborn piglet. Myocardial performance was assessed using intraventricular balloon to determine compliance and systolic function after 5 to 10 minutes interval per-fusing normothermic substrate free Krebs solution as a perfusate. The time to onset TIC was 29.5\ulcorner1.7 minutes and peak ischemic contracture was 46.7\ulcorner4.0 minutes[p<0.01]. In myocardial performance, systolic function of left ventricle[defined as cardiac contractility] was kept until 25 minutes of perfusion, but was decreased abruptly after 30 minutes of perfusion[p<0.0018] and diastolic function of left ventricle[defined as diastolic compliance] was kept until 15 minutes of perfusion, but was decreased after 20 minutes of perfusion [p=0.00\ulcorner9]. This study demonstrated maximal time of the tolerance to normothermic global ischemia and functional changes of left ventricle using Krebs perfusate under the same condition.

• Korean Journal of Biological Psychiatry
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• v.5 no.1
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• pp.134-137
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• 1998

Authors report a case of separation anxiety disorder, which developed as a side effect during haloperidol treatment of Tourette syndrome(TS). In this case, 14 years old boy developed attention deficit symptoms during his infancy. At 4th grade of primary school, he developed vocal tic, motor tic, and coprolalia. With 5mg/day of haloperidol treatment his symptoms of TS were subsided. During the treatment, he developed features of separation anxiety disorder, including dependence, pleading, clinging, and sadness. Symptoms of attention deficit and separation anxiety disorder were improved by 25mg/day of imipramine treatment. During haloperidol treatment of TS, careful observation may be needed whether separation anxiety disorder-like symptom develops.