• 한국감성과학회:학술대회논문집
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• 한국감성과학회 1997년도 한국감성과학회 연차학술대회논문집
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• pp.157-162
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• 1997

The purpose of this study was to develop a sinusoidal rotatory chair systim for evaluating the vestibular function in patients suffered from vertigo with vestibualr disorders. The sinusoidal rotatory chair system is composed of a rotatory chair systim and softwares. Maximum velocity of the rotatiry chair was upto 60 degree per second and frequency range was 0.01 to 0.64 Hz. To evaluate the vestibular function in vertigo patients, vestibuloocular reflex was measured by sinusoidal rotation of the whole body about vertical axis in the darkness, and optokinetic nystagmus, visual vestibuloocular reflex , and visual supression test were also performed. Eye movement was measured by means of a electronystgmograph amplifier through Ag-AgCI surface electrodes. Gain, phase, and symmetry were obtained from analysis of the eye movement ineuced by vestibular or visual stimulation. In healthy adults, sinusoidal rotation of the shole body produced nystagmus, of which gain was directly proportional to the velocity of stimulation. The gain of visual vestibuloocular reflex or optokinetic nystagmus, and it was suppressed markedly by visual suppression test. These results suggest that the sinusoieal rotatory chair systim which was developed by this study can evaluate the vestibular function quantitatively, also this system is very useful to diagnose and to dstimate the vestibualr function during recovery from vertigo

• 한국감성과학회:학술대회논문집
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• 한국감성과학회 1999년도 추계학술대회 논문집
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• pp.111-114
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• 1999

Off-vertical axis rotator was developed to differentiate each function of the canal and otolith in the vestibular system and evaluate subjective symptoms during postural change. Eye movement induced by various types of rotation was measured in normal subjects. Nystagmus with fast component corresponding to direction of rotation was occurred by sinusoidal earth vertical axis rotation, and the gain of eye movement in vestibuloocular reflex (VOR) was lower than in visual vestibuloocular reflex (VVOR) and higher than in visual fixed vestibuloocular reflex (VFX). Degree of dizziness was proportioned to degree of gain. off-vertical axis rotation was produced severe dizziness than earth vertical axis rotation. These results suggest stimulation of the otolith should be minimized to make a stable and pleasant condition in work and travel.

• The Korean Journal of Physiology
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• 제21권1호
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• pp.91-101
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• 1987

The present experiment was carried out, in the rabbit and cat, in order to explore functional interrelationship between the vestibular semicircular canals and extraocular muscles, which are involved in the vestibulooculomotor reflex as the receptor and effector organ respectively. Semicircular canals were subjected to electrical stimulation, lymphatic fluid flow or acute freezing, and responses of the extraocular muscles were recorded in terms of changes in electromyographic activity and isometric tension. Electrical stimulation of a unilateral canal elicited contraction of the superio-medial muscle group (superior oblique, superior rectus and medial rectus muscles) in the ipsilateral eye and the inferio-lateral muscle group (inferior oblique, inferior rectus and lateral rectus muscles) in the contralateral eye. Thus a simple and distinct axiom was found in the pattern of the reflex-response of the extraocular muscles. Inhibition of the unilateral canals elicited the extraocular muscle responses contrary to those observed by excitation of the canal. Based on the present experimental results, it was demonstrated that the functional interrelations between the semicircular canals and extraocular muscles are rather equivalent in the frontal eyed cats (with binocular vision) and lateral eyed rabbits (with monocular vision). Therefore the previous thesis that the vestibuloocular relations vary from species to species awaits experimental reevaluation.

• Annals of Clinical Neurophysiology
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• 제22권2호
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• pp.67-74
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• 2020

Vestibular-evoked myogenic potentials (VEMPs) are useful for evaluating the vestibulocollic reflex arising mostly from the saccule and the vestibuloocular reflex originating from the utricle. VEMPs can vary with the characteristics of the applied stimuli and the effects of aging and diseases. VEMPs have been found to be useful for diagnosing superior canal dehiscence, but their usefulness for other clinical disorders remains unclear. This review discusses the principles of VEMP tests and summarizes the findings for VEMPs in common vestibular disorders.

• The Korean Journal of Physiology and Pharmacology
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• 제1권3호
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• pp.275-284
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• 1997

Unilateral labyrinthectorny (ULX) causes autonomic symptoms, ocular and postural asymmetries, which disappear over tune in the process of equilibrium recovery known as vestibular compensation. In the present study in order to elucidate mechanisms responsible for the effects of electrical stimulation on vestibular compensation and investigate the relationship between vestibular compensation and c-Fos expression in the medial vestibular nuclei following ULX, we measured spontaneous nystagmus, eye movement induced by sinusoidal rotation and c-Fos expression or to 72 hs after ULX in Sprague-Dawley rats. Experimental animals were divided into two groups: ULX group with ULX only, and electrical stimulation (ES) group with electrical stimulation of $-2{\sim}-5V$, 1.0ms, 100 Hz to the lesioned vestibular system for 4 hs/day. Spontaneous nystagmus following ULX disappeared by 72 hs in ULX group and 36 hs in ES group. In eye movement induced by sinusoidal rotation, normal pattern of eye movement by rotation toward the lesioned side was recovered 24 hs after ULX at rotation of 0.1 Hz and 6 hs after at 0.2 Hz, 0.5 Hz in ULX group. In ES group, the eye movement recovered after 12 hs at 0.1 Hz, 6 hs at 0.2 Hz, and 4 hs at 0.5 Hz. Directional Preponderance which represents the symmetry of bilateral vestibular functions showed significantly early recovery in ES group compared with that of ULX group. Expression or c-Fos immunoreactive cells in the bilateral medial vestibular nuclei was severely asymmetrical till 36 hs in ULX group, and then it became a symmetry and disappeared after 72 hs. However, ES group showed the symmetry of c-Fos expression after 6 hs, which was significantly early recovery in 25 group. All these findings suggest that electrical stimulation ameliorates recovery of vestibuloocular reflex following ULX by the restoration of the balance of the resting activity between bilateral medial vestibular nuclei. In addition, c-Fos expression in the medial vestibular nuclei could be used as a marker of vestibular compensation since c-Fos expression is closely related to the course of recovery following ULX.

• 한국감성과학회:학술대회논문집
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• 한국감성과학회 1999년도 춘계학술발표논문집 논문집
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• pp.237-242
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• 1999

The nature of the interactions between the vestibular and autonomic systems is complex and has not been fully defined. Vestibuloocular reflex induced by sinusoidal rotation and activity of the autonomic nerves in the heart were measured to investigate the interactions between the vestibular system and the autonomic nervous system in healthy adults. Eye movement induced by sinusoidal rotation of the whole body or optokinetic stimulation at 0.04 Hz was analyzed in gain, phase, and symmetry. EKG was measured during vestibular stimulation and analyzed in heart rate variability including mean R-R interval, standard deviation (SD) and coefficient of variance (CV) of R-R interval, and power spectrum of low frequency region (LF) and high frequency region (HF). Gain of eye movement was 0.65${\pm}$0.03 by ratatory stimulation, 0.70${\pm}$0.02 in optokinetic stimulation, 0.08${\pm}$0.02 in visual suppression, and 0.84${\pm}$0.04 in visual enhancement. In R-R interval, resting condition (control) was 0.82${\pm}$0.03 sec, and visual suppression showed significant increase and visual enhancement did significant decrease compared with control (p<0.01).CV was 0.06${\pm}$0.02 in control and visual enhancement increased significantly (p<0.05). In LF/HF control was 1.40${\pm}$0.23, which was not different from rotatory or optokinetic stimulation. But visual suppression decreased LF/HF significantly and visual enhancement increased significantly compared with control (p<0.01). These results suggest that degree of gain corresponds with LF/HF and increased gain in visual enhancement is deeply related to the activity of sympathetic nerves.

• 전력전자학회:학술대회논문집
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• 전력전자학회 2002년도 전력전자학술대회 논문집
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• pp.455-458
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• 2002

A control of the body posture and movement is maintained by the vestibular system, vision, and proprioceptors. Especially, vestibular system has a very important function that controls the eye movement through vestibuloocular reflex and contraction of skeletal muscles through vestibulospinal reflex. However, postural disturbance caused by loss of vestibular function results in nausea, vomiting, vertigo and loss of craving for life. Lose of vestibular function leads to abnormal reflex of eye movements named nystagmus. Analysis of the nystagmus is needed to diagnose the vertigo, which is performed by means of electronystagmography (ENG). The purpose of this study is to develop a computerized system for data processing and an algorithm for the automatic evaluation of the slow component velocity (SCV) of nystagmus Induced by optokinetic(OKN) stimulation system. A new algorithm using recursive least square method (RLSM) to detect SCV of nystagmus is suggested in this paper. This method allows a fast and precise evaluation of the nystagmus, through artifact rejection techniques. The results are depicted in this paper.

• 감성과학
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• 제1권1호
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• pp.181-197
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• 1998

전정기관은 자세의 조절에 관여하지만, 전정기관의 손상은 현기증 및 자세부조화를 초래한다. 본 연구에서는 현기증의 원인을 규명할 목적으로 전정기능을 평가할 수 있는 정현파 회전자극시스템을 개발하고자 하였다. 정현파 회전자극시스템은 회전의자와 구동 및 분석프로그램으로 구성하였으며, DC 서보모터로 구동되는 회전의자는 0.01-0.64 Hz의 주파수범위에서 60 ˚/sec의 초고속도로 정현파 회전한다. 현기증 환자에서 전정기능을 평가하기 위하여 전정안구반사, 시운동성 전정안구반사 및 시각의 억제에 의한 전정안구반사를 측정하여 안구운동의 이득, 위상, 대칭성 등을 산출하도록 정현파 회전자극시스템을 개발하였으며, 정상 성인에서 시험한 결과 신뢰성있는 성적을 얻었다. 따라서 본 시스템은 현기증 환자의 진단 및 치료정도를 판정할 수 있으르로 임상적으로 널리 사용할 수 있을 것으로 사료된다.

• 전력전자학회논문지
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• 제7권6호
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• pp.546-553
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• 2002

일상 생활에서 인간의 자세와 운동은 전정기관, 시각, 고유수용체에 의해 조절되어진다. 특히 전정기관은 정전안구반사를 통한 안구 운동과 전정척수반사를 통한 골격근의 수축 운동을 제어하는 매우 중요한 기능을 갖고 있다. 그러나 자세 조절기능의 손실로 인한 자세 부조화는 오심, 구토, 현기증을 초래하여 삶의 의욕을 상실케 만들고 안진이라 불리는 비정상적인 안구반사운동을 초래한다. 현기증 진단에 EOG를 이용한 안진의 분석이 필요하다. 본 연구의 목적은 데이터 처리를 위한 컴퓨터 시스템과 OKN 시뮬레이션 시스템에 의해 유발된 안진 서상속도의 자동평가 알고리즘을 개발하는데 있다. 본 논문에서는 RLSM을 이용하여 안진의 서상속도를 검출하는 새로운 알고리즘을 제안하였다. 이 방법은 눈 깜빡임과 같은 artifact에 둔감하여 안진의 빠르고 정확한 평가가 가능하다.

• The Korean Journal of Physiology and Pharmacology
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• 제5권2호
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• pp.123-131
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• 2001

To investigate the effects of electrical stimulation on vestibular compensation, which is the recovery of vestibular symptoms following unilateral labyrinthectomy (UL), intermittent electrical stimulation was applied to the injured vestibular portion in Sprague-Dawley rats. Vestibuloocular and vestibulospinal reflexes, electrical activity and expression of c-Fos protein in medial vestibular nuclei (MVN) were measured with time following UL. Spontaneous nystagmus occurred with frequency of $2.9{\pm}0.2$ beats/sec at 2 hours after UL and disappeared after 72 hours. Electrical stimulation decreased the frequency of nystagmus significantly till 24 hours after UL. Roll head deviation was $107{\pm}9.7^{\circ}$ at 2 hours after UL and the deviation was maintained till 72 hours, but electrical stimulation decreased the deviation significantly 6 hours after UL. Resting activity of type I neurons in ipsilateral MVN to the injured vestibular side decreased significantly compared with control at 6 and 24 hours after UL, but the activity of type I neurons was recovered to control level by electrical stimulation at 24 hours after UL. Gain of type I neurons induced by sinusoidal rotation of 0.1 Hz decreased significantly till 24 hours after UL, but electrical stimulation restored the activity at 24 hours. The gain of type II neurons decreased significantly at 6 hours after UL, but electrical stimulation restored the activity. Expression of c-Fos protein was asymmetric between bilateral MVN till 24 hours after UL, but the asymmetry disappeared by electrical stimulation 6 hours after UL. These results suggest that electrical stimulation to the injured vestibular portion facilitates vestibular compensation following UL by restoration of symmetry of neuronal activity between bilateral vestibular nuclei resulting from increased activity in ipsilateral vestibular nuclei to the injured side.