• Herbal Formula Science
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• v.14 no.1
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• pp.1-10
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• 2006

3 Slices of Zingiber officinale and 2 pieces of Zizyphus jujuba in BangYakHapPyun play a proper role in herbal prescription. Zingiber officinal is roled in protection force(衛) and Zizyphus jujuba is roled in management force(營). 3 Slices of Zingiber officinal and 2 pieces of Zizyphus jujuba in upper location of BangYakHapPyun harmonize management and protection forces(營衛氣). 3 Slices of Zingiber officinale and 2 pieces of Zizyphus jujuba in middle and lower location of BangYakHapPyun compromise and treat inner and outer body condition. 5 or 7 Slices of Zingiber officinale purge noxious vapor and alleviate Pinellia ternata(半夏). Arisaema amurense (南星) poison. Todays, 3-Yangs and 2- Yins an apriority world(先天). use 3 Slices of Zingiber officinale and 2 pieces of Zizyphus jujuba. In the future. 2-Yangs and 3-Yins in a posterior world(後天) may use 2 Slices of Zingiber officinale and 3 pieces of Zizyphus jujuba.

• Culinary science and hospitality research
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• v.14 no.4
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• pp.329-338
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• 2008

This study investigates the effects of cooking utensils and jujube(Zizyphus jujuba Mill. cv. Dongzao) paste on the quality characteristics of yakbab. Yakbab samples prepared with jujube paste were divided into a control(yakbab with 0% of jujube paste) and the groups with jujube paste added. The samples prepared with jujube paste were divided into JY1(yakbab with 2.60% of jujube paste), JY2(yakbab with 4.27% of jujube paste), JY3(yakbab with 5.88% of jujube paste), JY4(yakbab with 7.43% of jujube paste) and JY5(yakbab with 8.94% of jujube paste). The moisture content and the color score of pressure cooker treatment have higher than those of the pot. The moisture contents of JY2 and JY5 samples increased as compared to the other samples. The L(lightness) value scores of all samples with jujube paste added were higher than those of the others. Hardness, springiness and cohesiveness of JY4 sample showed higher than those of the control. Higher scores for color, moistness, mouth feel, sweet taste and overall taste were found in JY4 products as compared to the other samples.

• Natural Product Sciences
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• v.10 no.3
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• pp.93-95
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• 2004

Eleven triterpenoids, colubrinic acid (1), alphitolic acid (2), 3-O-cis-p-coumaroyl alphitolic acid (3), 3-O-trans-p-coumaroyl alphitolic acid (4), 3-O-cis-p-coumaroyl maslinic acid (5), 3-O-trans-p-coumaroyl maslinic acid (6), betulinic acid (7), oleanolic acid (8), betulonic acid (9), oleanonic acid (10), and zizyberenalic acid (11), were isolated from the fruits of Zizyphus jujuba Mill. A simple and rapid HPLC method, using a $C_{18}$ column, has been developed for the quantitative analysis of these compounds 1 (0.74%),2 (0.09%), 3 (0.19%), 4 (0.19%), 5 (0.08%),6 (0.08%), 7 (0.41%), 8 (0.05%), 9 (0.50%),10 (0.59%), and 11 (0.19%).

• Journal of Life Science
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• v.23 no.9
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• pp.1170-1176
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• 2013

Essential oils have been used to treat psychophysiological disorders, but their effects on human electroencephalographic (EEG) activity have not been thoroughly investigated. We evaluated the effects of essential oil of Zizyphus jujuba seeds, a Korean folk medicine known as San-Jo-In, on human EEG activity. For this purpose, essential oil was extracted from San-Jo-In by the supercritical carbon dioxide extraction method. The effect of its inhalation on EEG activity was evaluated by measuring the EEG power spectrum (25 indices) in 20 healthy participants. The results of the EEG power spectrum indicated that the values of the theta wave decreased significantly (p<0.05) in the left (from 17.277 to $13.854{\mu}V$) and right parietal (from 15.324 to $13.020{\mu}V$) regions compared to the other regions. During the inhalation of San-Jo-In oil, the EEG spectrum values of fast alpha, relative gamma, and spectral edge frequency increased 50% compared to those before inhalation. The values of the fast alpha wave increased significantly (p<0.05) in the left prefrontal (from 0.063 to $0.085{\mu}V$), right prefrontal (from 0.064 to $0.085{\mu}V$), and left frontal (from 0.073 to $0.100{\mu}V$) regions following inhalation of the San-Jo-In essential oil. The changes in the EEG activities following inhalation of San-Jo-In suggest that the oil can improve psychological well-being by increasing attention and relaxation.

• Korean Journal of Food Science and Technology
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• v.42 no.6
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• pp.733-738
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• 2010

The leaves of Zizyphus jujuba have been used for various purposes including medicine and nutrition. In this study, the conditions for the ethanol extraction of antioxidant from Zizyphus jujuba were optimized using response surface methodology (RSM). A Box-Behnken design containing 15 experimental runs with three replicates was employed to study the effects of solvent extraction conditions such as extraction temperature ($^{\circ}C$, $X_1$), extraction time (min, $X_2$), and ethanol concentration (%, $X_3$) on the extraction yield of antioxidants from Zizyphus jujuba. The yields of total polyphenols and total flavonoid, and electron donating activity (EDA) were considered as response variables. The second-order polynomial model gave a satisfactory description of the experimental results showing different patterns of extraction conditions with variation in the linear, quadratic, and interaction effects of the independent variables. Based on four-dimensional RSM, one of the optimized sets of conditions was 45% ethanol, $45^{\circ}C$, and an extraction time of 15 min. Under the optimal conditions, the predicted values were 177.64 mg/g dry basis, 35.99 mg/g dry basis, and 86.14% Vit.C equivalents for total polyphenols, total flavonoids, and EDA, respectively. The experimental values showed good agreements with the predicted values.

• Biomolecules & Therapeutics
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• v.23 no.4
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• pp.345-349
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• 2015

Betulinic acid, a pentacyclic triterpene isolated from Jujube tree (Zizyphus jujuba Mill), has been known for a wide range of biological and medicinal properties such as antibacterial, antimalarial, anti-inflammatory, antihelmintic, antinociceptive, and anticancer activities. In the study, we investigated the antiviral activity on influenza A/PR/8 virus infected A549 human lung adenocarcinoma epithelial cell line and C57BL/6 mice. Betulinic acid showed the anti-influenza viral activity at a concentration of $50{\mu}M$ without a significant cytotoxicity in influenza A/PR/8 virus infected A549 cells. Also, betulinic acid significantly attenuated pulmonary pathology including increased necrosis, numbers of inflammatory cells and pulmonary edema induced by influenza A/PR/8 virus infection compared with vehicle- or oseltamivir-treated mice in vivo model. The down-regulation of IFN-${\gamma}$ level, which is critical for innate and adaptive immunity in viral infection, after treating of betulinic acid in mouse lung. Based on the obtained results, it is suggested that betulinic acid can be the potential therapeutic agent for virus infection via anti-inflammatory activity.

• Journal of Physiology & Pathology in Korean Medicine
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• v.28 no.1
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• pp.29-34
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• 2014

Bone homeostasis is maintained by balance between bone resorbing-osteoclasts and bone forming-osteoblasts. Excessive osteoclastic bone resorption plays a critical role in bone destruction in pathological bone diseases such as osteoporosis, rheumatoid arthritis, and periodontal disease. Many compounds derived from natural products have pharmacological applications and have therapeutic value for treating or preventing several bone diseases characterized by excessive bone resorption. To discover new compounds that can act as anti-resorptive agents, we screened for natural compounds that regulate osteclast differentiation, and found that water extract of Ziziphus Jujuba Mill (WEZJ) has inhibitory effects on osteoclast differentiation. In this study, WEZJ clearly inhibits the osteoclast differentiation in the presence of receptor activator of nuclear factor kB (RANKL), macrophage colony-stimulating factor (M-CSF) without cytoxicity by blocking activation of nuclear factor of activated T cells (NFAT)c1, and c-Fos. In signaling pathway, the phosphorylation of Akt, p38, c-Jun N-terminal kinases (JNK), extracellular signal-regulated kinases (ERK) and the expression of osteoclast-associated receptor (OSCAR), tartrate-resistant acid phosphates (TRAP), Integrin av, Integrin b3, Cathepsin K are suppressed, too. These result suggest that WEZJ may have therapeutic value for treating or preventing several bone diseases characterized by excessive bone destruction.

• Korean Journal of Medicinal Crop Science
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• v.26 no.6
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• pp.477-481
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• 2018

Background: Recently, jujube (Zizyphus jujuba Mill.) has been attracting attention as a fruit, and its cultivation in rain shelter house is increasing to produce the high quality fresh jujube. This study was carried out to investigate the growth and fruit characteristics of jujube according to the types of rain shelter house. Methods and Results: The characteristics of 5-year-old Bokjo cultivar cultivated in 3 types of rain shelter house, multi span rain shelter house with roof vent (Type I), single span house with a column in the center and roof vent (Type II) and single span house with a column in the center and without roof vent (Type III), and open field were examined. The sprouting and blooming period were different among the types of rain shelter house. The diameter of main stem was higher in rain shelter houses than in the open field. There was no a significant difference in fruit number per leaf stem among the types of cultivation. The incidence of fruit cracking in open field cultivation which was 51.2% was much higher than that in Type I 21.6%, Type II 19.3%, and Type III 25.5%. The fruit size and weight in rain shelter houses, especially in Type III rain shelter house were higher than those in the open field and the soluble solids content of fruit in Type I and Type II was higher than in Type III rain shelter house and the open field. Conclusions: The results show that the growth and fruit quality of jujube were improved by cultivation in rain shelter house, and affected by the types of rain shelter house.

• Journal of Korean Society of Forest Science
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• v.82 no.3
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• pp.254-259
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• 1993

For the production of mycoplasma-free jujube trees from mycoplasma-infected trees in vitro micrografting visas carried out using apical meristems of in vitro grown plantlets as scions. The rootstocks were hypocotyl segments of in vitro germinated seedlings of Zizyphus jujuba Mill. which is widely used as rootstocks in the field grafting. Ten percent of scions showed normal growth and grew into plants. The presence of mycoplasma was tested using transmission electron microscopy and fluorescence microscopy. Mycoplasma was not found in the tissues of scion parts and seedlings, whereas it was found in in vitro grown plantlets. This suggests that the production of mycoplasmaa-free jujube trees is possible by the in vitro micrografting technique.

• Korean journal of applied entomology
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• v.4
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• pp.7-10
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• 1965

In an experiment to evaluate the various aspects of symptom of witches' broom of jujube tree with two different kinds of scions, taken from diseased plant and stem- grafted upon sound stocks-one cut before wintering(stored in cellar), the other after wintering, it was observed that the disease rate of those cut before wintering(Nov.) was $\98\%$ whereas those cut after wintering(March) showed much lower rate, $3\%$ initially and gradually increased up to $39\%$. In another experiment of diseased bud grafted into healthy seedling, the finding made in the following year was that 14 stocks(only one of which salt union by callusing) were infected out of the given 23- in the initial stage only 4, yet gradually increased to the number of 14. The shoots from the ground portion of the diseased stock were in general more quickly subjected to the disease than the others. Under natural condition, the diseased trees develop at first seemingly the same leaves as healthy ones; it is not until the branches and loaves grow to a considerable degree that the symptom appears. Once appearing, tile disease grows and the symptom continues to appear as late as in Sept. and early Oct., causing tile plant to develop the extraordinary branches and leaves of extremely reduced size, the typical symptom of witches' broom. Such phenomenon can be observed in the experiments of the foregoing paragraphs. And the suckers and roots of diseased plant are bound to be infected, it was found out with no exception. Viewing from the results of the above experiments and observation, it is believed that the low temperature during winter causes the virus in the above-ground portion of diseased plant to diminish or inactivated, and subsequently the virus in the roots moves up or multiply in the sprouting season.