• 동의생리병리학회지
• /
• 제22권5호
• /
• pp.1152-1157
• /
• 2008

Hyperlipidemia has been treated as one of the most important etiological cause factor in 21th century. The cortex and root of Acanthopanax sessiliflorus (AR), a herbal medicine, have been used for several diseases including cardiovascular diseases in Oriental countries. Recently, we reported that AR has anti-hyperlipidemic action. BS-01 was made using extract from AR. For these reasons, we investigated the effects of BS-01 as anti-hyperlipidemic drug through measurement of body weights, cholesterol levels, total lipid, phospholipid in serum. In our results, mice induced by high fat diet elevated body weight level compared to naive group. And total lipid in serum was also elevated by induction of hyperlipidemia. In BS-01 group, body weight of mice was lowered significantly compared to that of control group. Oral administration of BS-01 decreased total cholesterol and triglyceride level back to that of naive mice. HDL and LDL cholesterol levels were not affected by BS-01. In addition, total lipid level, which elevated by induction of hyperlipidemia was also lowered by oral administration of BS-01. Finally, free fatty acid level was lowered in BS-01 group. These results demonstrate that BS-01 lowered body weight and titers involved in hyperlipdemia such as total cholesterol, triglyceride, free fatty acid and total lipid. In these results, we demonstrate that BS-01 has anti-hyperlipidemic action.

• Archives of Pharmacal Research
• /
• 제29권3호
• /
• pp.256-264
• /
• 2006

Salicornia herbacea L. (Chenopodiaceae) has been used as a seasoned vegetable by living in coastal areas. S. herbacea (SH) has been demonstrated to stimulate cytokine production, nitric oxide release, and to show anti-oxidative effect. In a series of investigations to develop potential anti-diabetic and/or anti-hyperlipidemic agents from Korean indigenous plants, 50% ethanol extract of Salicornia herbacea was found to prevent the onset of the hyperglycemia and hyperlipidemia induced by high fat diet in ICR mice. At 6 week old, the ICR mice were randomly divided into five groups; two control and three treatment groups. The control mice were to receive either a regular diet (RD) or high-fat diet (HFD), and the treatment groups were fed a high fat diet with either 350 mg/kg, 700 mg/kg of SH (SH350 and SH700) or 250 mg/kg of met-formin (MT250) for a 10-week period. SH not only reduced body weight but also corrected associated hyperglycemia and hyperlipidemia in a dose dependent manner. SH exerted beneficial effects on the plasma glucose and lipid homeostasis possibly ascribed to its specific effects on lipogenesis related genes (SREBP1a, FAS, GAPT), and PEPCK, glucose 6-phosphatase gene expressions in liver. Ethanol extract of S. herbacea has potential as a preventive agent for type 2 diabetes (and possibly hyperlipidemia) and deserves future clinical trial.

• Food Science and Biotechnology
• /
• 제18권1호
• /
• pp.172-178
• /
• 2009

Fermented ginseng (FG) is an ethanol extract of ginseng radix processed with $\beta$-galactosidase. It was hypothesized that FG may exert anti-hyperlipidemic and anti-diabetic activities through modulating AMP-activated protein kinase (AMPK) in HepG2 human hepatoma cells. In this study, we showed that AMPK phosphorylation was stimulated by FG. These effects were abolished by pretreatment with an AMPK inhibitor, compound C. In addition, FG regulated the expression of genes associated with lipogenesis and lipolysis, thus causing suppression of hepatic triglyceride accumulation. In vivo study using db/db mice, FG reduced fasting plasma glucose, HbAlc, and insulin resistance index, when compared to diabetic control. FG also increased the phospho-AMPK and glucose transporter 4 (GLUT4) expressions in liver and skeletal muscle, respectively. In liver, expressions of lipogenic gene were decreased whereas expressions of lipolytic genes were induced, when compared to diabetic control. Taken together, we may suggest that FG ameliorates hyperglycemia and hyperlipidemia through activation of AMPK and could be developed as a health functional food or therapeutic agent for type 2 diabetic patients.

• Mycobiology
• /
• 제39권3호
• /
• pp.187-193
• /
• 2011

Botryosphaeran, a water-soluble exopolysaccharide of the ${\beta}-(1{\rightarrow}3;1{\rightarrow}6)$-D-glucan type that has been isolated from the culture medium of Botryosphaeria rhodina MAMB-05 grown in submerged fermentation using glucose as the sole carbon source, was previously demonstrated to be non-genotoxic in peripheral blood and bone marrow, and exhibited strong anticlastogenic activity. In the present study, the effects of botryosphaeran were investigated in streptozotocin-induced diabetic rats as well as in high-fat diet-fed hyperlipidemic Wistar rats. The plasma glucose level was reduced by 52% in the diabetic group of rats after administration of 12 mg botryosphaeran/kg body weight of the rats (b.w.)/day by gavage over 15 days. A reduction in the median ration intake was accompanied by an increase in the median body weight gain, as well as the efficiency of food conversion. These results demonstrate that botryosphaeran has protective effects by reducing the symptoms of cachexia in Diabetes mellitus. Botryosphaeran administered by gavage at a concentration of 12 mg botryosphaeran/kg b.w./day over 15 days also reduced the plasma levels of total cholesterol and low density lipoprotein-cholesterol by 18% and 27%, respectively, in hyperlipidemic rats. Based on these findings, we conclude that botryosphaeran possesses hypoglycemic and hypocholesterolemic properties in conditions of diabetes mellitus and hyperlipidemia, respectively, and may be used as an oral anti-diabetic agent.

• 약학회지
• /
• 제50권5호
• /
• pp.332-337
• /
• 2006

Type 2 diabetes mellitus is a chronic and hard to control disease. In order to develop the therapeutic agent for type 2 DM, many researchers investigated natural products using an in vitro and in vivo assay. In this study, we tried to explore the anti-diabetic activity and mechanisms of ginsam, which is a vinegar-processed ginseng radix. The db/db mice were randomly divided into four groups. The diabetes control (DC) group was orally administrated with distilled water, ginseng radix (GR) or ginsam (GS) was administrated orally at a dose of 150 mg/kg, and the positive control group was orally injected with metformin (MET) at a dose of 300 mg/kg for 5 weeks in db/db mice and measured body weight and blood glucose level every week. All treatment groups decreased the plasma glucose levels compared with diabetic control and GS group significantly lowered the insulin resistance index. GS group also reduced the plasma lipid levels mainly due to reduce the lipogenesis and increase the lipolysis in the fat tissue. In addition, GS group increased the GLUT4 mRNA expression levels in the fat and muscle tissues by 10 fold probably due to increase a $PPAR_{-\gamma}$ mRNA expression in fat tissue. Taken together, GS showed the anti-hyperglycemic and anti-hyperlipidemic activities and those activities may ascribe to over-expression of GLUT4 mRNA level and decrease the lipogenesis in fat tissue.

• 동의생리병리학회지
• /
• 제25권2호
• /
• pp.264-269
• /
• 2011

This study was designed to investigate the effects of Cinnamomi Cortex extract (CC) on hypercholesterolemia induced by Estradiol valerate (EV) in female rats. We investigated the effects of CC on Changes in body weights for 5 weeks. In addition, we examined the effects on fasting blood glucose (FBS) and tested oral glucose tolerance test after oral administration of CC for 5 weeks. We also investigated the effects on levels of total cholesterol, HDL-cholesterol and LDL-cholesterol in serum. Treatment with CC restored weight gain rates suppressed by EV significantly. CC did not affect serum glucose level and glucose tolerance. Levels of total cholesterol and triglyceride were lowered by administration of CC compared to EV treated control respectively. These result suggest that CC can lower serum cholesterol level then prevent weight loss induced by EV. We also suggest the possibility as anti-hyperlipidemic agent of CC.

• 한국식품과학회지
• /
• 제46권6호
• /
• pp.743-749
• /
• 2014

본 연구에서는 수경재배 인삼의 전초를 이용하여 식초를 제조하여 진세노사이드의 패턴 및 함량 변화를 확인하고자 하였으며, 고지방 식이로 유도된 비만 쥐에 수경재배 인삼 식초를 투여하여 체중, 체지방 및 지질대사를 분석함으로써 항비만 식품으로서 가능성을 확인하고자 하였다. 실험 결과 수경재배 인삼으로 식초 제조 시 산도는 $5.60{\pm}0.24%$이었으며, 초산 발효 과정에서 진세노사이드 Re가 감소하고 진세노사이드 Rg2가 약 4배 수준 증가하는 것으로 확인되었다. 수경재배 인삼 식초의 항비만 효과를 확인하기 위해 4주령 C57BL/6J mice에 고지방 식이를 투여하면서 수경재배 인삼 식초 및 녹차추출물을 8주간 투여하였다. 실험식이 종료 후 체중 변화를 비교한 결과 수경재배 인삼초투여군(HGV) 및 녹차추출물투여군(GT)은 고지방식이군(HFD)과 비교하여 유의적인 체중감소효과가 관찰되었다. 체성분 분석결과 복부지방 및 피하지방의 함량이 낮은 것을 확인할 수 있었으며, 개복 후 복부 주위의 지방을 적출하여 무게 측정 시 고지방식이군(HFD)과 비교하여 수경재배 인삼초투여군(HGT) 및 녹차추출물 투여군(GT)은 각각 85.5, 83.3% 낮아진 것으로 확인되었다. 혈중지질프로파일 분석 결과 수경재배 인삼초투여군(HGV) 및 녹차추출물투여군(GT)은 중성지방, 총콜레스테롤, LDL 콜레스테롤이 고지방식이군(HFD)과 비교하여 유의적으로 낮아졌으며, HDL 콜레스테롤이 증가된 것으로 확인되었다. 고지방 식이에 의한 간 독성을 관찰하기 위해 AST 및 ALT 효소 활성을 측정하였으며, 수경재배 인삼초투여군(HGV)은 고지방식이군(HFD)과 비교하여 각각 67.3, 75.1%, 녹차추출물투여군(GT)은 각각 68.4, 75.1% 감소 효과가 관찰되었다. 이와 같은 결과를 통해 수경재배 인삼으로 식초 제조 시 흡수율이 우수한 proginseonside Rg2의 함량이 증가되어 생리활성 강화 효과를 기대할 수 있으며, 체지방 축적을 억제하고 혈청 지질 조성을 개선시킴으로써 항비만 식품소재로 가치가 있을 것으로 생각된다.