• 동의생리병리학회지
• /
• 제23권2호
• /
• pp.278-287
• /
• 2009

Ji-San, the founder of HyungSang medicine, emphasized food intake and detoxification by stating, "Korean medicine begins with detoxification." Toxin accumulates in one's body unless the internal and external conditions stay in their harmony. The accumulation of toxin is also caused by western medication or one-sided diet, and detoxification should be considered in those cases. HwangRyunHaeDok-Tang reduces fire and heat, and the lesion is likely to locate in the upper body. BangPoongTongSung-San can be used for systemic disease. IkWoon-San also reduces fire and heat but mainly focuses on promoting urination. InSamPaeDok-San has an effect of curing the external symptoms of SangHan(傷寒), in addition to detoxification. SeoGakJiHwang-Tang, SoDok-Eum, and SeoGakSoDok-Eum can resolve the heat-toxin when it is located on the surface. SibJeonDaeBo-Tang enhances the detoxifying function of human body. GhamDu-Tang and JaGeum-Jung have a general effect on detoxification.

• 대한한방내과학회지
• /
• 제26권4호
• /
• pp.864-874
• /
• 2005

This study was done as a general survey on oriental medical approaches for the detoxification and treatment of narcotics addiction. The treatment of narcotics addiction comprises the detoxification and the restoration of normal health. Medical detoxification in common use nowadays is largely divided into substitution therapy using opiate detoxicants and symptomatic therapy using non-opiate detoxicants. Experimentation was done on the supposition that non-opiate detoxicants provide a more viable therapy than opiate detoxicants in the treatment of narcotics addiction, because opiate detoxicants also produce a great dependency on a narcotic. At present, although the medication of oriental medicine that includes non-opiate detoxicants is not more effective in the detoxification than the opiate detoxicants, withdrawal symptoms are slight and few and there is a very low ratio of relapse, so treatment and restoration are relatively brief. Results of this survey suggest that detoxicants derived from oriental medical approaches are safe and effective, though further development of therapy with such detoxicants will be needed to provide reliable methods of treating narcotics addiction. Based on this survey, it is hoped that many more studies will be done on the issue of medication in the field of narcotics addiction treatment.

• 미생물학회지
• /
• 제28권2호
• /
• pp.134-144
• /
• 1990

In order to examine that what kind of system correlated with cadmium detoxification mechanism in Klebsiella aerogenes ATCC 10031, we tried to investigate the effect of phosphate upon the detoxification and also elucidate whether the cadmium phosphate and/or polymeric Cd-Pi complex is formed actually in cell or not. As the results, it was shown that growing pattern had long lag adaptive phase of 12 hr to 24 hr, at the concentrations of 0.02 mM and 0.08 mM cadmium, respectively. Cadmium was accumulated more highly in the fraction of cell wall and membrane than in those of cytoplasm. In case of phosphate starving cells added cadmium, inorganic polyphosphate system was primarily correlated with Cd-detoxification during the lag phase for the accommodation to cadmium, on the other hand, Cd:Sulfide complex system secondarily correlated it during the stationary phase. These results implied that polyphosphate system and Cd:sulfide complex system, these two systems were operated compensatively each other. Considering the results obsdrved with EM and examined tha changes of sulfide and polyphosphate amount, it was reflected that Cd:S complex was located at the cell surface. In the results of $in-vivo^{31}$P NMR spectra in the cells with cadmium pressure, several phosphate signals arose newly from the polyphosphate region with moving chemical shift of it. This phinomenon strongly implied the actual existence of Dd:Pi comples and /or Cd:poly-P complex in the cell and also the cellular compartmentalization of cadmium detoxifying mechanism.

• KSBB Journal
• /
• 제24권5호
• /
• pp.415-419
• /
• 2009

본 연구에서는 리그노셀룰로스 가수분해물과 유사한 조성을 갖는 합성 용액을 이용하여 무독화 실험을 진행하였다. 생물학적 무독화 방법으로는 peroxidase와 laccase와 같은 효소를 이용하였고, 이온교환과 흡착과 같은 물리화학적 방법으로는 이온교환수지와 활성탄을 이용하였다. 효소 중 peroxidase는 페놀계 화합물의 제거에 탁월한 효율을 보였으며, 5-HMF와 furfural은 활성탄에 의해 거의 모두 제거되었고, 아세트산은 음이온교환수지를 사용하는 것이 가장 효율적이었다. 활성탄과 이온교환수지는 다소간의 당손실을 일으켰다. 무독화 방법은 당화액에 포함되어 있는 저해물질의 조성을 고려하여 결정되어야 한다.

• 혜화의학회지
• /
• 제22권2호
• /
• pp.37-45
• /
• 2014

Recently, interest in detoxification therapies is increasing. Coffee enema has been most frequently used as one of detoxification therapies. However, there is lack of scientific basis for coffee enema, regarding its clinical efficacy and safety respectively. This study aimed to produce the general features of coffee enema such as definition, protocols, clinical applications and efficacies, and side effects. Total 37 articles coffee enema were collected from 7 databases including PubMed, and reviewed thoroughly. The majority of papers were review studies or case reports for effects/side-effects of coffee enema. The quality of papers was generally poor, and no randomized controlled clinical trial (RCT) was exist. This study shows the current status of coffee enema-related study, and suggests the demand for RCT study to develop the evidence-based detoxification therapy using coffee enema.

• BMB Reports
• /
• 제34권5호
• /
• pp.440-445
• /
• 2001

Pesticide waste and chemical stockpiles are posing a potential threat to both Vie environment and human health. There is currently a great effort toward developing effective and economical methods for the detoxification of these toxic organophosphates. In terms of safety and economy, enzymatic biodegradation has been recommended as the most promising tool to detoxify these toxic materials. To develop an enzymatic degradation method to detoxify such toxic organophosphorus compounds, a gene encoding organophosphorus acid anhydrolase (OPAA) from genomic DNA of Alteromonas haloplanktis C was subcloned and expressed. The enzyme consists of a single polypeptide chain with a molecular weight of 48 kDa. It demonstrates strong hydrolyzing activity on sarin, an acetylcholinesterase inhibitor. Moreover, its high activity is sustained for a considerable length of time. It is projected that the recombinant OPAA can be applied as an enzymatic tool that can be used not only for the detoxification of pesticide wastes, but also for the demilitarization of chemical stockpiles.

• BMB Reports
• /
• 제47권7호
• /
• pp.405-410
• /
• 2014

ZBTB3 belongs to the Zinc finger and BTB/POZ domain containing transcription factor family; however, its biological role has rarely been studied. We demonstrate for the first time, to our knowledge, that ZBTB3 is an essential factor for cancer cell growth via the regulation of the ROS detoxification pathway. Suppression of ZBTB3 using two different short hairpin RNAs in human melanoma, lung carcinoma, and breast carcinoma results in diminished cell growth. In addition, we found that suppression of ZBTB3 activates a caspase cascade, including caspase-9, -3, and PARP leading to cellular apoptosis, resulting from failed ROS detoxification. We identified that ZBTB3 plays an important role in the gene expression of ROS detoxification enzymes. Our results reveal that ZBTB3 may play a critical role in cancer cell growth via the ROS detoxification system. Therefore, therapeutic strategies that target ZBTB3 could be used in selective cancer treatments.

• 한국수산과학회지
• /
• 제33권6호
• /
• pp.546-549
• /
• 2000

PSP 분해 활성 세균을 이용한 마비성패류독의 생물학적 제독 방법을 확립하기 위하여 진주담치 및 해수에서 마비성패류독 분해능이 있는 균주를 분리하였으며, 분리 균주의 독소 분해 활성 및 세균학적 특성 시험을 실시한 결과는 다음과 같다. 남해안 패류양식장에서 채취한 진주담치 및 해수 중에서 마비성패류독 분해능이 있는 8균주를 분리하였으며, 분리균주 중 $GTX 1{\~}4$ 혼합물 전반에 대하여 폭넓은 분해 활성을 나타낸 CW-6를 시험 균주로 선발하였다. 선발 균주 CW-6는 배양 3일만에 18nmole/g의 GTX2를 완전히 분해하는 강한 독소 분해 활성을 나타내었다. 선발 균주 CW-6는 생화학적 특성 시험 결과, Enterobacter속으로 동정되어 Enterobacter sp. CW-6로 명명하였으며, 이 균주는 $20{\~}40^{\circ}C,\;pH 7{\~}9$에서 왕성하게 증식하는 전형적인 중온세균의 특징과 염분농도 $6{\%}$에서도 최적 증식의 $46.8{\%}$ 정도 증식 가능한 내염성을 나타내었다.

• 한국수산과학회지
• /
• 제33권6호
• /
• pp.550-553
• /
• 2000

해수에서 분리한 마비성패류독 분해 균주 Enterobactersp. CW-6 균주의 마비성 패류독소 최적 분해 온도 및 시험 균주의 독소 분해과정 중의 독소 함량 및 구성성분을 조사한 결과는 다음과 같다. 시험 균주는 배양 적온으로 확인된 $30, 35^{\circ}C$에서 배양 5일만에 각각 최초 첨가 독력의 $56.8, 44.1{\%}$, 12일 후에는 $93.0, 79.5{\%}$를 분해하였다. 그러나, 배양 적온에서 벗어날수록 균주의 독소 분해 활성은 감소하여 $20^{\circ}C$에서는 배양 12일 후에도 최초 독력의 $69.0{\%}$가 잔존하였다. 시험 균주 Enterobacter sp. CW-6는 $30^{\circ}C$에서의 조독소를 이용한 분해 활성 측정에서 초기 농도 38.2nmole/g의 마비성패류독을 배양 8일 및 12일째 각각 $88.4, 92.7{\%}$ 분해하였다. 정제 독소를 이용한 분해 시험에서, 조독소 분해과정 중에 일시적으로 증가하는 STX group은 GTX2, 3에서 전환된 것으로 확인되었다. 시험 균주 Enterobactersp. CW-6는 정제 독소에 대해서도 강한 분해 활성을 나타내었으며, 최초 농도 47 nmole/g 의 GTX1과 37 nmole/g GTX4를 분해 과정 12일 후에 각각 $100, 90.8{\%}$ 분해하였으며, GTX2, 3 혼합물에 대하여는 최초농도 25.6 nmole/g의 독소를 12일 후에 $66.4{\%}$까지 분해하였다.

• 자원리싸이클링
• /
• 제29권1호
• /
• pp.35-42
• /
• 2020

최근 인체 유해성이 높은 석면 함유 제품의 다량 폐기로 인해 석면 함유 폐기물(asbestos-containing waste: ACW)이 계속해서 발생하고 있으며, 매립지 부족 등의 이유로 석면 무해화 및 재활용 기술 개발이 요구되고 있다. 마이크로웨이브를 이용한 열처리는 석면 함유 폐기물 무해화에 가장 효율적인 방법이나 석면이 상온에서 마이크로웨이브를 흡수하지 않는 한계점을 가지고 있다. 본 연구에서는 상온에서 마이크로웨이브를 흡수하여 발열하는 무기 발열체인 SiC 플레이트 사이에 석면 함유 폐기물를 위치시킨 상태에서 마이크로웨이브 열처리를 진행하는 방법으로 석면 함유 폐기물를 무해화 하였다. 효율적인 열처리를 위하여 석면 함유 폐기물를 파쇄 및 분쇄 공정을 통해 분말화하여 무해화 열처리 실험을 진행 하였으며, 열처리 조건에 따른 무해화 특성을 파악하기 위하여 마이크로웨이브 열처리 온도와 시간 변수를 조절하였다. 열처리 후 석면 함유 폐기물는 XRD와 SEM을 이용한 결정구조 및 미세구조 분석을 통하여 무해화 특성을 분석 하였다. SiC 플레이트를 적용한 마이크로웨이브 열처리 방법은 단시간 내에 목표 온도까지 가열이 가능하며 최종적으로 1,200℃에서는 60분 이상, 1,300℃에서는 10 분 이상의 마이크로웨이브 열처리를 진행하였을 때 결정구조와 미세구조상에서 석면이 완전히 제거되는 것을 확인하였다.