• 한국임상수의학회지
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• 제30권6호
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• pp.456-458
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• 2013

포획된 건강한 너구리들의 심전도의 기준값을 평가하는 것이 본 논문의 주된 목적이다. 41마리의 방목되고 있는 다 자란 너구리들이 강원대학교 야생동물구조센터에 의해 구조되었으며 본 논문에 이용되었다. 어떠한 화학적 보정도 사용하지 않고 6-유도 심전도를 측정하였다. 평균 심박수는 $146.10{\pm}43.31$ 박동수/분 이었다(95% 신뢰구간 132.84~159.36 박동수/분). 평균 호흡수는 $35.73{\pm}11.56$ 호흡수/분 이었다(95% 신뢰구간 32.19~39.27 호흡수/분). 평균 수축기 압력은 $136{\pm}29.26mmHg$ 이었다(95% 신뢰구간 127.99~145.91 mmHg). 모든 너구리들의 심전계의 특징들을 또한 평가하였다. P-파의 평균 너비와 높이는 $38.2{\pm}4.0ms$ (범위 28-40 ms) 와 $0.128{\pm}0.039mV$ (범위 0.09~0.20)이었다. QRS파의 평균 너비와 높이는 $48.5{\pm}7.2ms$ (범위 36-60 ms) 와 $1.330{\pm}0.650mV$ (범위 0.15~2.30)이었다. 평균전기축 (QRS)은 $-91^{\circ}{\sim}+96^{\circ}$ ($10^{\circ}{\sim}60^{\circ}$; 95% 신뢰구간)이었다. 평균 교정 QT 간격(QTc)은 $273.7{\pm}32.7ms$ (범위 212-333 ms)이었고, PR간격은 $76.1{\pm}10.0ms$ (범위 50-82 ms)이었다. 본 논문은 포획된 건강한 너구리들의 심전도(ECG)의 기준값을 제공하는 최초의 논문이다.

• 대한임상독성학회지
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• 제4권1호
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• pp.44-47
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• 2006

Symptoms of aspirin overdose may vary from acid-base disturbance, electrolyte abnormality, non-cardiogenic pulmonary edema, chemical hepatitis, seizure to cardiac toxicity. Cardiac adverse effects from aspirin are uncommon but there are reports of arrhythmia, cardiopulmonary arrest, and myocardial infarction. We report 2 cases of young women with aspirin overdose who exhibited ischemic changes on their ECGs a few hours after the ingestion with spontaneous recovery in a few days. First case, a 29 year old woman, presented to the emergency department 6 hours after ingesting 250 tablets of aspirin (325 mg/T). On examination, the temperature was $36.3^{\circ}C$: blood pressure, 105/72mmHg; Pulse, 111/min and respiratory rate, 24/min. Second case, a 27 year old woman, an hour after ingesting 60 tablets (325mg/T). On examination, the temperature was $36.0^{\circ}C$: blood pressure, 102/72 mmHg; pulse, 89/min and respiratory rate, 25/min. In both cases, ECG after 6 hours of ingestion had sinus tachycardia and developed T wave inversion on the anterior leads in the following ECGs. Their initial serum salicylate levels after 6 hours of ingestion were 71.2 mg/dL and 28.4 mg/dL respectively. These salicylate levels were resolving when these ECGs were observed. The ECG changes resolved in the following days and they were discharged without any further symptoms. Further studies are needed, but for the time being, when dealing with salicylate overdose, transient cardiac depression should be kept in mind to avoid adverse ischemic cardiac events.