• 대한핵의학회:학술대회논문집
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• 1971.11a
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• pp.86.3-86.3
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• 1971

• Journal of Physiology & Pathology in Korean Medicine
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• v.21 no.3
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• pp.626-633
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• 2007

To access the safety and efficacy of Chungyeoldodam-tang(CDT), a traditional herbal medicine prescription, on hypertension we examined various parameters involved in the pathogenesis of hypertension. CDT seems to be safe because CDT at the concentrations lower that 250 ug/ml showed no toxic effects in cultured human fibroblast and no toxic effects on liver function. The production of reactive oxygen species (ROS) were greatly decreased in CDT treated group compared with control, and angiotensin converting enzyme activities were reduced by CDT in a dose dependent manner. There was no differences in weight of hearts between control and CDT treated group. The blood pressure and pulse rate were significantly decreased. CDT greatly reduced the levels of plasma hormones including aldosterone, dopamine, and norepinephrine, but not epinephrine, and serum electrocytes including Na$^+$ and Cl$^-$, but not K$^+$. were also decreased. The levels of uric acid, BUN and creatinine were significantly decreased compared with control. These results suggested that CDT has suppressive effects on various pathologic factors in hypertension, and CDT has potential as a safe and effective therapeutics for hypertension.

• Journal of Physiology & Pathology in Korean Medicine
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• v.22 no.1
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• pp.162-170
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• 2008

Kamisungihwalhyul-tang(KSHT) has been used for many years as a therapeutic agent for cerebrovascular disease and hypertension in Oriental Medicine. But the effect of KSHT on hypertension and reactive oxygen is not well-known. This study was examined to investigate the effect of KSHT on hypertension and reactive oxygen. After administering KSHT extract to Sprague- Dawley Rat forinjected subcutaneous with deoxycorticosterone acetate(DOCA) 8 weeks, changes in blood pressure, pulse rate, 2,2-diphenyl-1-picrylhydrazyl, reactive oxygen species, angiotensin converting enzyme, aldosterone, catecholamine levels, electrolyte, uric acid, BUN, creatinine in plasma were examined, and immunohistochemical changes and scanning electron microscopic changes were observed. 2,2-diphenyl-1-picrylhydrazyl(DPPH) scavenging activity was increased, reactive oxygen species(ROS) was decreased in a KSHT concentration-dependent. Angiotensin converting enzyme(ACE) inhibitory activity was increased in a concentration-dependent by KSHT. KSHT significantly decreased the blood pressure and heart rate in DOCA-salt hypertensive rat. KSHT significantly decreased the levels of aldosterone in DOCA-salt hypertensive rat. KSHT significantly decreased the level of dopamine, norepinephrine, epinephrine in DOCA-salt hypertensive rat. $Na^+$, $K^+$ and Cl- were decreased significantly, $Ca^{2+}$ was increased significantly by KSHT. KSHT significantly decreased uric acid, BUN, creatinine.

• The Journal of Korean Obstetrics and Gynecology
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• v.34 no.4
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• pp.163-174
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• 2021

Objectives: The purpose of this study is to report the improvement of paralytic ileus caused by ovarian cancer after integrative Korean Medicine treatment. Methods: The patient who complained paralytic ileus caused by ovarian cancer was treated by acupuncture, electroacupunture, moxibustion, and herbal medicine for 13 days. The effect of treatment was evaluated by abdominal X-ray, dietary change of patient, Numeral Rating Scale (NRS) and blood examination including white blood cell (WBC), creactive protein(CRP), erythrocyte sedimentation rate (ESR), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and electrocytes. Results: After the treatment, the patient could have taken with her mouth. In addition, the clinical symptoms were improved with no adverse event. Conclusions: This case shows that paralytic ileus caused by ovarian cancer was improved after the integrative Korean Medicine treatment. Therefore, it can be effective an complementary option for paralytic ileus caused by ovarian cancer.