• 대한수의학회지
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• 제34권3호
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• pp.435-439
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• 1994

The present observation was focussed mainly on the histopathological and immunohistochemical finding of the tumor developing from the outside of rat uterus wall. In gross finding, this tumor were a oval form mass and 0.75cm and 1cm in greatest demension. The sectioned surface showed uniform, solid, gray-white. In histopathological finding, the tumor showed the form of lymphoid nodule-like structure and was composed of the cells with karryorrhexis, karyolysis and necrosis in the central zone, mature cells in the paracentral zone, and concentric layers of compressed, flattened and atrophied smooth muscle fibers by the proliferating of the cells closely resembling endometrial stromal ells in the peripheral zone and a few smaller nodule-like structure in certain areas of the peripheral zone. In immunohistochemical observations, the proliferating cells presents only among the concentric layers of the smooth muscle fibers in the peripheral zone. Labeling index of proliferating cells in the peripheral zone was $4.34{\pm}1.28%$. These tumor cells did not metastasized in another orgns and labeling index was low, So it was concluded that this tumor was benign stomal sarcoma.

• Journal of Oral Medicine and Pain
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• 제20권1호
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• pp.67-77
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• 1995

A Case of pemphigus bulgaris in buccal mucosa of 48 years old Korean female was reported. Final diagnosis was determined by evaluation of clinical and histopathological finding. The patient could be treated successfully by administration of prednisolone, injection of bethametasone, application of oramedy and irradiation of soft laser.

• 약학회지
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• 제38권6호
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• pp.756-762
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• 1994

To investigate the acute toxicity of Elfvingia applanata$(P_{ers})K_{ARST}$, it was extracted with hot water. EA, the aqueous extract from the carpophores of E. applanata, was lyophilized and a dark brownish powder was obtained. The acute toxicity of EA was investigated in ICR mice of both sexes. Five groups of mice were administered orally and intraperitoneally with 375, 750, 1,500, 3,000, 6,000 mg/kg(p.o.) and 312.5, 625, 1,250, 2,500, 5,000 mg/kg (i.p.) of EA Abnormal clinical signs related to EA were not observed and no deaths occurred. $LD_{50}$ values administered orally and intraperitoneally were evaluated to be over 6,000 mg/kg and over 5,000 mg/kg, respectively. Gross finding of necropsy revealed no evidence of specific toxicity related to EA. There were no significant changes in body weights, serum biochemical values and histopathological changes compared with control group.

• Asian Pacific Journal of Cancer Prevention
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• 제16권4호
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• pp.1535-1538
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• 2015

Background: The objectives of the study were to: 1) determine the frequency of incidental malignancy in unsuspected/grossly normal looking gall bladders; 2) determine the frequency of malignancy in suspected/grossly abnormal looking gall bladders. Materials and Methods: This prospective, cross sectional study was carried out at a tertiary care hospital in Pakistan, during a four year period (Jan 2009-dec2012). All the cholecystectomy cases performed for gallstone diseases were examined initially by a surgeon and later on by a pathologist for macroscopic abnormalities and accordingly assigned to one of the three categories i.e. grossly normal, suspicious, abnormal/malignant. Frequency of incidental carcinoma in these categories was observed after receiving the final histopathology report. Results: A total of 426 patients underwent cholecystectomy for cholelithiasis, with a 1:4 male: female ratio. Mean age of the patients was 45 years with a range of 17-80 years. The frequency of incidental gallbladder carcinoma was found to be 0.70 %(n=3). All the cases of gallbladder carcinoma were associated with some macroscopic abnormality. Not a single case of incidental carcinoma gallbladder was diagnosed in 383 'macroscopically normal looking' gallbladders. Conclusions: Incidental finding of gall bladder cancer was not observed in any of macroscopically normal looking gall bladders and all the cases reported as carcinoma gallbladder had some gross abnormality that made them suspicious. We suggest histopathologic examination of only those gall bladders with some gross abnormality.

• 동의생리병리학회지
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• 제24권6호
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• pp.1042-1052
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• 2010

This study aimed to evaluate the protective effects of Mundongcheongpye-eum (MCE) on elastase-induced lung injury. The extract of MCE was treated to A549 cells and elastase-induced lung injury mice model. Then, various parameters such as cell-based cyto-protective activity and histopathological finding were analyzed. MCE showed a protective effect on elastase-induced cytotoxicity in A549 cells. This effect was correlated with analysis for caspase 3 levels, collagen and elastin contents, protein level of cyclin B1, Cdc2, and Erk1/2, and gene expression of TNF-${\alpha}$ and IL-$1{\beta}$ in A549 cells. MCE treatment also revealed the protective effect on elastase-induced lung injury in mice model. This effect was evidenced via histopathological finding including immunofluence stains against elastin, collagen, caspase 3, and protein level of cyclin B1, Cdc2, and Erk1/2 in lung tissue. These data suggest that MCE has a pharmaceutical properties on lung injury. This study would provide an scientific evidence for the efficacy of MCE for clinical application to patients with chronic obstructive pulmonary disease.

• Journal of Chest Surgery
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• 제30권8호
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• pp.780-785
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• 1997

종격동 종양은 그 발생 위치가 심장과 대혈관, 식도, 그리고 신경조직 등과 같이 인체에 중요한 조직과 인접해 있는 점과 수술적 치료가 비교적 용이하고 그 결과 또한 우수하여 흉부외과 영역에서 매우 흥미있는 질환으로 관심을 끌어 왔다. 저자는 울산의대 서울중앙병원 흉부외과에서 1990년 1월부터 1995년 6월까지 5년 6개월간 수술적 치료를 받은 원발성 종격동 종양 87명을 대상으로 연령과 성별, 진단방법, 임상적 징후 및 증상, 크기, 해부학적 위 치, 수술소견, 병리조직학적 진단에 대하여 관찰하고 전산화 단층촬영(U)소견과 병리조직학적으로 침윤성 을 보였던 종격동 종양에서의 임상적 의의를 분석하여 종격동 종양에 대한 적절한 외과적 치료지침을 얻고자 하였다. 종양의 발생 부위는 전상부 종격동이 50명(57%)으로 가장 많았으며 후부 종격동 30명(35%), 중부 종격동 7 명(8%)순이었다. 병리조직학적 분류로 보면 흉부종 27명(31%), 원발성 낭종 19명(22%), 신경성 종양 19명 (22%), 기형종 10명(10%)순이었다. 병리조직학적으로 침윤성을 보인 경우는 17명(20%)이었으며 전상부 종격 동에 14명(16%), 후부 종격동에 3명(4%)이었다. 종격동 종양 \ulcorner대한 전산화 단층촬영은 87명 모두 시행하였으며, 주위 조직에 침윤성을 보인 경우는 15명(17%)이었다. 종양의 외과적 치료로 완전 절제 80명(92%), 부분 절제 6명(7%), 개흉후 조직검사 1명(2%)을 시행하였다 수술 소견상 14명(16%)에서 주위 조직의 침윤이 의심 되었다. 종양의 크기는 전체 평균 6.0$\pm$3.2 cm 전상부 종격동 종양 6.2$\pm$3.1 cm 중부 종격동 종양 3.9$\pm$ 1.1 cm 후부 종격동 종양 5.8그2.6 cm등이었다. 양성 종양의 크기는 평균 5.5$\pm$2.6 cm 악성종양의 크기는 7.3$\pm$ 4.6 cm이었다. 수술소견상 침윤이 의심된 경우들의 평균 크기는 7.2$\pm$3.8 cm이었고, 소견상 침윤이 의심 된 경우들의 평균 크기는 8.0$\pm$3.8 cm이었다. 병리조직학적으로 침윤성을 보였덜 17명과 CT소견상 침윤성을 보였던 15명과의 상관성은 민감도 (sensitivity) 35%, 특이도(specificity) 87%, 예측도(predictability) 35%이며, 수술소견상 침윤성을 보였던 14명과 의 상관성은 민감도 53%,특이도 93%, 예측도 64%이었다. 또한 종양의 크기와 악성도와의 상관관계에서 크기가 클수록 악성일 가능성이 증가하는 통계적으로 의의 있는 유의성이 있었다. 결론적으로 종격동 종양에 대한 수 珦\ulcorner진단으로 또는 수술시 예측할 수 있는 침윤성은 낭성 종양을 제외 한 경우 병리조직학적 진단과의 일치성이 낮아 종격동 종양의 수술적 치료는 종양을 포함하여 가능한 범위까지 광범위하게 절제하는 것이 수술 결과를 좋게 하는 방법이라고 사료된다.

• 한국수산과학회지
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• 제34권3호
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• pp.173-178
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• 2001

저분자 alginate인 HAG-10, HAG-50, HAG-100 및 alginate를 랫드에 35일간 섭취시켰을 때, 혈청중의 지질성분과 동맥경화지수의 측정으로 특성이 가장 좋은 저분자 alginate인 HAG-50의 안전성을 확보하기 위해 랫드에 경구급성독성실험을 실시하였다. 혈청중 total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides 및 phospholipid 함량과 동맥경화지수는$5\%$ 와 $10\%$HAG-50에서 모두 유의적으로 뚜렷히 감소하여 지질대사 개선효과를 나타내었다. HAG-50의 경구급성독성실험을 검토한 결과, 투여할 수 있는 최고 용량인 랫드 체중 kg당 5.0g의 용량에서도 암$\cdot$수 모두 일반상태의 이상 반응과 폐사 및 병리$\cdot$조직학적 이상을 나타내는 예는 전혀 관찰되지 않아서 $LD_{50}$치의 산출이 불가능하였으므로 HAG-50은 아주 안전한 제재임이 검증되었다. 이상의 결과를 종합해 볼 때, 평균분자량 50,000 정도의 저분자 alginate인 HAG-50이 가장 우수한 지질대사 개선효과의 기능적 특성을 발휘하였으며, 경구급성독성실험 에서도 독성이 전혀 없었고, alginate가 가지고 있는 고유의 생리적 기능을 유지 향상시키면서 이용에 제한이 되고 있는 점성을 줄이고 용해도를 높혀서 alginate의 이용성을 높일 수 있는 새로운 형태의 식품소재라고 사료된다.

• 한국수의병리학회지
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• 제6권1호
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• pp.27-39
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• 2002

The purpose of this study was to investigate to protective effects against porcine epidemic diarrhea virus (PEDV) infection in piglets by administration of the PEDV antiserum orally at 2 hrs, 24hrs and 36hrs after birth. six piglets administered the antiserum were experimentally infected with PEDV at five-day-old. Control group were four piglets infected with PEDV only. Clinical signs and gross, histopathological lesion and immunohistochemical findings were examined. The results obtained were as follows; 1. In clinical signs, piglets of the control group appeared the typical signs of severe watery diarrhea, depression and anorexia but piglets of the PEDV antiserum treated group recovered progressively. In mortality, control group showed 75%, but PEDV antiserum treated group showed 16.7%, respectively. 2. In gross findings, piglets of the control group appeared the typical findings of congestion, distension of lumen, containing curdes of undigested milk in stomach. But piglets of the PEDV antiserum treated group appeared milder than those of control group. 3. In histopathological findings, piglets of the control group appeared the typical findings of villous atrophy and fusion, congesion, exfoliation, vacuolation, squamation, loss of cilia and proliferation of crypt. But piglets of the PEDV antiserum treated group appeared milder than those of control group. 4. In immunohistochemical findings, piglets of the PEDV antiserum treated group showed more intensive in reaction for IgG and IgG than those of control group. The recation for IgA was stronger than that of IgG. It was concluded that oral administration of PEDV antiserum to piglets was effective in preventing PEDV infection and reduced their mortality.

• Journal of Chest Surgery
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• 제9권2호
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• pp.311-314
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• 1976

This is a report of leiomyoma in the esophagus. patient had suffered from mild intermittent dysphagia on eating without any other complaints. This complaint had been going for 45 days, but was not progressed. The esophagogram revealed an ovoid walnut-sized smooth filling defect in the midportion of the esophagus. The mucosal folds of the esophagus were not destroyed. A benign intramural tumor of the esophagus, such as leiomyoma, was suspected with X-ray finding and clinical features. On Aug. 13, 1976 a thoracotomy was performed at right 4th intercostal space. A firm, irregular shaped mass in the wall of the esophagus was enucleated by blunt dissection without any injury of the mucosa of the esophagus. The diagnosis of leiomyoma was confirmed with histopathological finding. Postoperative course was uneventful.

• Journal of Chest Surgery
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• 제20권1호
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• pp.195-198
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• 1987

We experienced a case of esophageal leiomyoma recently in department of Thoracic and Cardiovascular Surg., Pusan Baik Hospital, Inje Medical College. Patient had suffered from dysphagia and chest discomfort for 2 years. The esophagogram showed an ovoid smooth filling defect in lower portion of the esophagus, mucosal fold of esophagus was not destroyed. A benign intramural tumor of the esophagus such as leiomyoma was suspected with X-ray finding and clinical features. Open thoracotomy was performed through the left 8th intercostal space. A firm egg sized mass in the well of lower esophagus was enucleated by blunt dissection with caution to avoid injury of the mucosa of the esophagus. The diagnosis of leiomyoma was confirmed with histopathological finding. Postoperative course was uneventful.