• 대한한방부인과학회지
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• 제18권4호
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• pp.119-135
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• 2005

Purpose : This study was investigated, in order to improve that reliability of disease mechanism diagnosis, which were used for the object diagnosis of Oriental medicine in the dept. of Oriental OB&GY, Oriental Medical hospital of Dong-Eui University, amend to a disease mechanism item of Questionnaires and indexes of disease mechanism, we were thought that the results were more pointed to the condition of appropriate disease mechanism, as a result of put a results of Questionnaires and belongs to indexes of disease mechanism together, we　suggested to call it a　'weight of disease mechanism', because It was possible to　mark a different degrees of indexes of disease mechanism in the same points.　Methods : We analyzed the results of Questionnaires about 3354 outpatients who　had OB&GY disease in the Oriental Medical hospital of Dong-Eui University from April 2000 to March 2004. Results : 1. weight of disease mechanism is 10 score according to disease mechanism score and the standard of reliability. 2. The standard of reliability is same 11 disease mechanism item except stagnated blood, cold syndrome, dry- ness, phlegm. Conclusion : Weight of disease mechanism which show satisfaction the conditions of standard of reliability, appear the results of Questionnaires, against previous study investigated reliability of Questionnaires make it through the standard of reliability.

• 대한한의학회지
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• 제26권2호
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• pp.126-139
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• 2005

Objective: This study was undertaken to examine the reliability of disease mechanism diagnosis, estimate the disease mechanism items of questionnaires and inquire about the relation of disease mechanisms to the oriental OB & GY diagnosis program. Questionnaires and abridged questionnaires were used for the object diagnosis of oriental medicine in the dept of Oriental OB & GY, Oriental Medical Hospital of Dong-Eui University. Methods: We analyzed the results of questionnaires about 1706 outpatients who had OB & GY disease in the Oriental Medical Hospital of Dong-Eui University from April 2000 to March 2004. Results: 1. The reliability of Oriental OB & GY questionnaires between $90\%$ and $95\%$ were 9 cases, between $85\%$ and $90\%$ were 3 cases, and under $85\%$were 3 cases. Abridged questionnaires were lower than original questionnaires, but 12 cases of a total 15 cases of disease mechanism were above $85\%$. Therefore, both abridged questionnaires and original questionnaires had similar results. 2. Abridged questionnaires were usually lower than existing questionnaires in the comparison of disease mechanism output frequency and that of disease mechanism average score. Therefore, the results of abridged questionnaires seemed to be poorer than those of existing questionnaires, but a great difference wasn't seen. 3. Disease mechanism that was over $50\%$ in the rate of pure question per disease mechanism was 10 cases $(66.7\%)$. Disease mechanism that contributed to producing disease mechanism result and in which pure question was over relevance calculation 0.9 was also 10 cases $(66.7\%)$. In abridged questionnaires, the duplication of questions per disease mechanism Was decreased, the rate of pure questions was increased, and the number of related disease mechanisms was decreased by abridgment of the questionnaires' questions. 4. The calculation of disease mechanism went with the increase of the duplication of questions in many cases, but Tam­Umhe, Kihe-Hyule, Kihe-Umhe, and Shin-Tam went with disease mechanism in many cases despite no duplication of questions. Conclusions: About the reliability of Oriental OB & GY questionnaires, 12 of a total 15 cases of disease mechanism were above $85\%$; therefore both abridged questionnaires and original questionnaires had similar results.

• 동의생리병리학회지
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• 제19권5호
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• pp.1146-1153
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• 2005

This study was investigated so that reliability of disease mechanism diagnosis would be examined, the estimation about disease mechanism item of Questionnaires and the relations of disease mechanism would be inquired about 'health diagnosis program' Questionnaires which were used for the object diagnosis of Oriental medicine in the department of Oriental OB&GY, Oriental Medical hospital of Dong-Eui University. We analyzed the results of Questionnaires for 3354 outpatients who had OB & GY disease in the Oriental Medical hospital of Dong-Eui University from April 2000 to March 2004. The diagnosis Questionnaires(after DSOM (r) S.1.1) was the figures 188, the health diagnosis Questionnaires (after DSOM (r) S.1.1) was the figures 137. phiegm deficiency of qi was used in DSOM (r) R.1.1 as it is. The reliability of DSOM (r) S.1.1 was usually higher than DSOM (r) R.1.1 in deficiency of qi blood stasis insufficiency of Yang heat syndrom damp, 5 case disease mechanism. The reliability of DSOM (r) S.1.1 was usually lower than DSOM (r) R.1.1 in blood deficiency stagnation of qi coldness damp dryness liver heart spleen kidney, 8 case disease mechanism. but the great difference wasn't seen, therefore both DSOM (r) S.1.1 and DSOM (r) R.1.1 had similar result. A meeting point both DSOM (r) S.1.1 and DSOM (r) R.1.1 was above 90% in liver spleen blood stasis blood deficiency, 4 case disease mechanism with the exception of phlegm deficiency of Yim nothing of fluctuations of question. A meeting point of coldness that was 82.47% was lowest, A meeting point of the rest disease mechanism was above 85%. The effect that contributed in producing disease mechanism result and in which pure question was over relevance calculation 0.9, insufficiency of Yang damp phlegm that contributed in producing disease mechanism result was lower comparatively in DSOM (r) R.1.1. But the effect that contributed in producing disease mechanism result and in which pure question was over relevance calculation 0.9 except spleen kidney phlegm in DSOM (r) S.1.1

• 대한한의학원전학회지
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• 제24권5호
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• pp.131-145
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• 2011

I had come at the conclusion of the development history of Disease Bi(痞病) reflected in Yi Cheon (李梴)'s work, "Euhakibmun(醫學入門)" in the respects of the causes, mechanism, symptoms, differential diagnosis and treatments. The causes of Disease Bi(痞病) mentioned at "Euhakibmun(醫學入門)" followed the Ju Dan-Gyeo(朱丹溪)'s theory. The mechanism of it went after the viewpoints of "Nae-Gyeong(內經)", Jang Jung-Gyeong(張仲景), Yi Dong-Won(李東垣) and Wang Ho-Go(王好古). The symptoms of it kept the Ju Dan-Gyeo(朱丹溪)'s theory. Yi Cheon distinguished Disease Bi(痞病) from Gyeol-Hyung(結胸) according to Jang Jung-Gyeong's theory. He knew it from abdominal dropsy(脹滿) according to Ju Dan-Gyeo's theory. He also divided it into two respects of deficiency(虛) and excessive(實) from Yi Dong-Won's viewpoint. Jang Jung-Gyeong first suggested that treatments of it could be selected according to the difference of deficiency, excessive(實), cold(寒), hot(熱), sputum(痰), fluid(飮), blood(血) and food(食). Yi Dong-Won insisted many doctors could make a mistake because they only used herbs for Gi(氣藥) instead of herbs for blood(血藥) together. Wang Ho-Go(王好古) maintained his opinion that treatments of both digestion(消導) and assistance(補益), remedies of bitter and hot herbs can recover patients from Disease Bi(痞病). Yi Cheon followed their theories properly.

• 대한한의학원전학회지
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• 제20권2호
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• pp.289-313
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• 2007

Many of newly emerging diseases such as hypertension, stroke, diabetes, obesity, and atoptic dermatities are categorized into "Fire heat-disease(火熱病)" according to oriental medicine. It is because factors such as stress, overeating, and high fat diet are major causes of heat in the human body. Sun Yi-Kui(孫一奎), a well-known oriental medical doctor during Ming Dynasty's "Jia Jing Wan Li Nian Jian"(嘉靖萬歷年間 : A.D $1522^{\sim}1619$), established new theories on "Fire heat-disease-mechanism(火熱病機)". This study aims to investigate Dr. Sun's "Fire heat-disease-mechanism(火熱病機)"theory. For this purpose, I thoroughly examined the concepts of "Dong-Qj(動氣)", "Ming-Men(命門)", king fire(君火) and minister fire(相火) as well as pathological theory on "Fire heat(火熱)". In addition, I compared Sun's theory with those of Li Dong-yuan and Zhu dan-Xi.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 2008년도 Proceedings of the Convention
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• pp.49-52
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• 2008

Parkinson's disease is characterized by motor disturbances and dopaminergic neurodegeneration. parkin and PINK1, two most critical Parkinson's disease-associated genes, have been intensively studied to address the underlying molecular pathogenesis of the disease, but our understanding still remains unclear. Through generation and characterization of Drosophila mutants for PINK1, we show that PINK1 is required for mitochondrial integrity and function in both indirect flight muscles and dopaminergic neurons. Surprisingly, we find that PINK1 mutants share striking phenotypic similarities with parkin mutants. Indeed, transgenic expression of parkin dramatically ameliorates all PINK1 loss-of-function phenotypes, but not vice versa, implicating that Parkin acts downstream of PINK1 in maintaining mitochondrial integrity and function in both muscles and dopaminergic neurons. With the establishment of the PINK1-Parkin pathway, we are trying to further investigate the detailed molecular relationship between PINK1 and Parkin using both mammalian dopaminergic neuronal cells for biochemical analysis and Drosophila model animal for genetic analysis. We believe that elucidating the molecular function of Parkinson's disease-associated genes will be of big help for the ultimate understanding of the pathogenic mechanism of this disease and also for the development of effective drugs for Parkinson's disease.

• 동의생리병리학회지
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• 제24권2호
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• pp.177-186
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• 2010

This study is about researching DongEuiBoGam by analysing with pattern identification of modern Traditional Korean medical patholgy as more logical, systematic and standardized theory. Disease pattern mechanisms of essence, spirit, qi and blood in NaeGyungPyeb of DongEuiBoGam are these. In Essence, this explain mechanism of disease patterns those are seminal emission, dream emission, spermatorrhea, white ooze. These disease pattern's mechanisms are kidney yang deficiency, kidney yin deficiency, heart yang deficiency, heart yin deficiency, heart qi deficiency, spleen qi deficiency and so on. On viewpoints of viscera and bowels they are related with heart, kidney, spleen. And most of them are deficiency from deficiency-excess Pattern Identification. Classifying disease pattern of qi is about upward, downward movement and more concentrated deficiency than excess pattern. Fright palpitations can be classified heart deficiency with timidity, heart blood and qi deficiency, heart qi deficiency, heart blood deficiency, heart qi movement stagnation, water qi intimidating the heart, phlegm-fire harassing the heart, phlegm clouding the pericardium, and so on. Palpitations can be classified heart blood deficiency, heart yin deficiency, heart deficiency with timidity, heart spleen blood deficiency, spleen qi deficiency, phlegm-fire harassing the heart, intense heart fire, and so on. Forgetfulness can be classified heart spleen blood deficiency, heart spleen qi deficiency, kidney essence deficiency, heart qi deficiency, non-interaction between the heart and kidney, etc. for deficiency pattern, phlegm clouding the pericardium for excess pattern. In Blood just say inside bleeding pattern's category, there are nose bleeding, flopping syncope, qi counterflow, blood vomiting, hemoptysis, spitting of blood, bloody stool, hematuria, and so on. Like these, this study identify pattern of disease in DongEuiBoGam by mechanism of disease theory.

• 대한약침학회지
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• 제14권2호
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• pp.75-80
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• 2011

Objectives & Methods: This research may accounts for Self Targeting Therapy (STT) which is a peculiar operation of Mountain Ginseng Pharmacopuncture. The objectives include analysis of its mechanism and reporting of clinical cases. Results: 1. STT of Mountain Ginseng Pharmacopuncture refers to the function of curing and making a diagnosis of the disease by oneself. 2. The mechanism of STT is to pursue the latent illness and make the remedial action by oneself. In this process, the symptom of latent disease is outwardly expressed. 3. The most popular symptom expressed is manifestation of pecular sensation along the specific meridians. Then followed headache, dizziness, powerless and etc. Diverse symptoms can be expressed by a patient. 4. If the revealed symptoms are carefully observed, the cause of the disease or the patient state can be diagnosed easily. Conclusion: The mechanism of STT of Mountain Ginseng Pharmacopuncture can be a great asset in clinical trials. Other studies on STT of Mountain Ginseng Pharmacopuncture should be followed in the future.

• 과학기술학연구
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• 제14권2호
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• pp.165-198
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• 2014

이 연구는 비만(obesity)이 어떻게 독립적인 질병지위(status of disease)를 획득하게 되었는지 살펴봄으로써 질병 탄생의 메커니즘을 찾아보고자 하였다. 세계보건기구(WHO)는 1996년과 1997년에 "비만은 분명히 치료가 필요한 병"이라고 경고하였다. 그러나 그 이전까지 비만은 비(非)표준 비(非)정상의 신체 상태로 분류되었고 질병의 범주에 속하지 않았다. 이 논문은 비만이라는 질병의 탄생 메커니즘을 알아보기 위해 비만의 역사적 질병 담론 형성 과정과 병리학적 역학적 실재성을 고찰하였다. 연구 결과, 의료계가 BMI(Body Mass Index: 체질량지수)를 조정하고 정상 신체 범주를 좁히는 한편, 치수차별주의(sizism)를 제도화하였음을 확인하였다. 특히, 의료계가 비만의 신체 상태를 고혈압, 당뇨병 등 의료비 지출이 큰 만성적 고위험 질병과 결부(結付)짓는 비만공포증(fatphobia)을 유포함으로써 비만에 독립적인 질병지위를 부여하는 강력한 의료적 통제관리 메커니즘을 형성한 것으로 확인되었다. 이 논문은 이러한 고찰을 통해 비만과 같은 비(非)감염성 질병은, 실재의 병리학적 요인보다 문화적 사회경제적인 비(非)의료적 요인이 더 강력하게 개입하여 탄생할 수 있다는 함의를 발견하였다.

• 대한추나의학회지
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• 제3권1호
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• pp.111-123
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• 2002

Objectives : There have been many studies of the effect of Bee Venom therapy about arthritis, but no one study was reported about its whole functional mechanism to musculo-skeletal system. This study was designed to investigate the effect, Indication, and side effect of Bee Venom therapy on musculo-skeletal disease by literature review of articles. Results : The effects of Bee Venom therapy to musculo-skeletal system are divided to Anti_inflammatory effect and Anti-nociceptive effect. Anti_inflammatory effect is achieved through competitive chemotaxis, immuno-regulation, increasing of cortisol secretion by stimulating hypothalamus-pituitary gland-adrenal cortex axis. Anti-nociceptive effect is achieved by Anti-inflammatory mechanism and it works similar to anti-nociceptive effect of the acupuncture acting on central and peripheral nociceptive transduction system. The Bee Venom therapy could cause severe side effect, for example, hypersensitivity and anaphylaxis, injury to central nerve system and cardiovascular system, peripheral blood system, and renal dysfunction. Conclusions : With its Anti-inflammatory and Anti-nociceptive mechanism, Bee Venom therapy is considered that has good effects to autoimmune disease, chronic inflammation of various musculo-skeletal disease and various pain syndrome. But the clinician must be careful for its side effects.