• 한국가축번식학회지
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• 제25권2호
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• pp.113-118
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• 2001

본 연구는 $\alpha$-tocopherol과 selenium 첨가급여가 웅돈의 정액성상에 미치는 효과를 검토하였다. $\alpha$-tocopherol과 selenium 첨가급여가 웅돈의 정액량, 정자농도, 정자의 운동성, 기형정자율 그리고 수소이온농도(pH)에 미치는 영향을 조사한 결과 정액량과 수소이온농도는 처리간에 유의차가 없었으며(P＜0.05) 정자의 농도, 총정자수, 정자의 운동성은 첨가구가 대조구에 비하여 유의적으로 높았으며 기형정자율은 유의적으로 낮았다(P＜0.05). 한편, 정자 저장기간별 정자의 운동성은 대조구에 비하여 처리구에서 유의적으로 높은 정자운동성을 보였다(P＜0.05). 이러한 결과는 $\alpha$-tocopherol 과 selenium 의 사료내 첨가 급여는 웅돈정액성상에 영향을 미치는 것으로 사료된다.

• 한국가축번식학회지
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• 제14권2호
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• pp.141-146
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• 1990

12 crossbreed boars received 4 rations containing varying levels of lysine and DL-methionine. The results obtained from this study are summarized as follows ; 1. Semen volume, total sperm number of the treatment B, C and D were increased significantly (p<0.05) as compared with the treatment A but abnormal sperm percent of treatment B and C was decreased significantly (p<0.05) as compared with A. Sperm number and sperm mortility were not different from treatments. 2. Amino acids contents of sperm plasma were not different from treatments.

• 동의생리병리학회지
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• 제22권6호
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• pp.1562-1565
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• 2008

HCMCO5 is a herbal extract which comprises of eight different herbs. We studied whether this prescription has an acute toxicity in rats. SPF Sprague-Dawley male and female rats were administered orally with HMC05 extract of 2,000 mg/kg for 14days. We examined mortality, clinical signs, body weights and gross findings during the tests. The result showed no dead animals. We also could not find a significant body weight changes during the experimental period. In addition, no differences were found between control and HMC05 treated groups in clinical signs and other findings. These results indicate that HMC05 extract did not show any toxic effects, and oral ADL value was over 2,000 mg/kg in SD rats.

• 한국미생물·생명공학회지
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• 제25권5호
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• pp.454-458
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• 1997

To develop a yellow pigment for a food-additive, a strain producing a water-soluble yellow pigment was isolated from phylloplane of tree leaf. The strain PY123 was identified a Bacillus sp. based on morphological and biochemical characterization such as a bacillus form, mortility, spore formation, Gram positive, and catalase production. The pigment production of the strain PY123 was increased about 3 times in patato broth containing 1% sucrose and 0.1 mM CoCl$_{2}$ than in only potato broth after incubation at 30$circ$C, for 2 days. When 0.1 mM CoCl$_{2}$, was added in potato broth containing 1% sucrose at late log phase during incubation of the strain PY123, cell growth was not inhibited, and the period at maximal pigment production of the strain PY123 was about 12hrs faster than in potato broth containing 1% sucrose and 0.1 mM CoCl$_{2}$, simultaniously.

• 대한기관식도과학회지
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• 제2권2호
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• pp.253-257
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• 1996

Deep neck infections were flirty common and a source of considerable morbidity and mortality. Although the advent of antibiotics has reduced the overall number of deep neck infections, they still occur in the general population. There are several new groups of patients at risk for deep neck infections, such as immunocompromised individuals, those with underlying diseases. Prevention of the severe sequale that may be associated with deep neck infections- mediastinitis, airway obstruction, carotid artery hemorrhage, aspiration pneumonia, septicemia - requires a knowledge of various portals of entry for infection, the presenting sign and symptoms, the possible microbiologic features, appropriate laboratory and radiologic workups, therapeutic techniques, and the ongoing medical management. A prompt diagnosis and institution of therapy will shorten the course of required treatment and reduce morbility and mortility. The authors have experienced one case of acute mediastinitis in deep neck infection patient with diabetes mellitus.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1994년도 춘계학술대회 and 제3회 신약개발 연구발표회
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• pp.243-243
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• 1994

Although active systemic anaphylaxis and passive cutaneous anaphylaxis have been empolyed to study anaphylactic hypersensitivity, it is difficult and time-consuming to induce these reactions in experimental animals. In recent, Jun et al have found a simple method to induced anaphylactic hypersensitivity such as anaphylactic shock(AS) and cutaneous reaction(CR) using compound48/80. Cortex mori (Morus alba L.), the root bark of mulberry tree has been used as an antiphlogistic, diuretic, and expectorant in herbal medicine. The purpose of this study was to determine whether the methanol extract of Cortex mori could inhibit the compound 48/80-induced AS and CR. To induce AS, various doses of compound 48/80 (5, 7.5, 10, 15$\mu\textrm{g}$/gm B.W.) were injected intraperitoneally (i.p.) into ICR mice. The animals were pretreated by three injection(i.p.) of Cortex mori before compound 48/80 administration. Peripheral blood was collected from the right ventricle to estimate the level of serum histamine at 15 minutes after the injctin(i.p.) of various concentration of compound48/80. Mortility rate, mean death time and mesenteric mast cell degranulation rate were evaluated over a 72 hour period. To estimate the effect of Cortex mori on compound 48/80-induced cutaneous reaction, various doses of compound 48/80 with or without Cortex mori were injected intradermally(i.d.) into the shaved flank of Sprague-Dawley rats, and the blue cutaneous patchs induced by Evans'blue injection at the compound 48/80 alone and Cortex mori plus compound 48/80 injection sites were observed. As a Parameter of these reactions, the levels of histamine in the supernatant, calcium uptake and intracellular CAMP of RPMC were measured. supernatant, 1)compound 48/80-induced mortility rate, mean death time, mesenteric mast cell degranulation rate, and serum histamine level in ICR mice were significantly inhibited by pretreatment of Cortex mori, 2) cutaneous reaction inducd by compound48/80 was well developed in Sprague-Dawley rat, but Cortex mori inhibited the compound 48/80-induced blue patch formation remarkably, 3) the compound 48/80-induced degranulation, histamine release and calcium uptake of RPMC pretreated with Cortex mori were significantly inhibited, compared to those of control without Cortex mori pretreatment, and 4)the level of cAMP of RPMC was reduced bythe increased concentration of compound 48/80, pretreatment of Cortex mori not only inhibited the compound 48/80-induced reduction of CAMP but also significantly increased the level of cAMP naturally, from the above results, it is suggested that Cortex mori has an some substances with an ability to inhibits the compound 48/80-induced AS,CR, and mast cell activation.

• 한국임상수의학회지
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• 제5권1호
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• pp.9-21
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• 1988

Gastro-intestinal mortility and transit time of barium sulfate after electroacupuncture were investigated in normal dogs and administration of xylatine in dogs. Electroacupuncture was performed with a current of 1.5 volt and 20 Hz at the acupoints of Tsu San Li(right(+) left(-) in dogs for 30 minutes. The results were as follows: 1. After electroacupuncture stimnlation in normal dogs, rates of stomach contractions was not changed, but amplitudes of stomach motility was markadly increased. The electroacupuncture stimulation tasted about 60 minutes after the end of electroacupuncture. 2. The stomach contractions was markedly increased, while the amplitudes of stomach motility was sligltly decreased by the administration of xylazine in dogs. 3. The rates of stomach contractions and amplitudes of motility were markedly increased after administration of xylazine in the electroacupuncture stimulated dogs. 4. Gastric emptying time o barium sulfate after electroacupuncture stimulation in dogs was highly significantly decreased compared with that of normal dogs(p < 0.01). 5. Small bowel transit time of barium sulfate after electroacupuncture stimulation in dogs was highly significantly decreased compared with that of normal dogs (p < 0.01). 6. Gastroduodenal transit time of barium sulfate after administration of xylazine following electroacupuncture stimulation dogs was blighty significantly decreased compared to that of dogs dosed with xylazine (p< 0.01). 7. Small bowel transit time of barium sulfate after administration of xylazine following electroacupuncture stimulation dogs markedly decreased compared to that of dogs dosed with xylazine (p < 0.05).

• 종양간호연구
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• 제2권1호
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• pp.61-71
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• 2002

Gastric Carcinoma is very plentiful and significant disease in Korean community. The reason is that Gastric Carcinoma is not a simply finding disease with unclear symptoms for early detection. Early detection and early medical treatment of a cancer patient is an important instrument of reducing the mortility rate. The purpose of this study is to identify the effect of audiovisual information with videotape infulencing on knowledge and attitude of early detection of gastric carcinoma. The research design was a non-equivalent control group, pre-post test. The subjects of this study were 52 members of D-taxi drivers which was located in Pusan. The subjects were twenty six experimental group and twenty six control group. The experimental group was collected from January 15, 1999 to January 26, 1999. The control group was collected from the research was 28 minutes video program which was turning out the form of documentary on the based practical experience. And also the experimental tool was used measurung instrument which measured a dependent, variable throughout the consulatation of an percentage, average, standard deviation, ${\chi}^2-test$ and t-test using spss/pc program. The result of this research were as follows : 1)" The experimental group which was offered the video program, should be higher in knowledge of early detection of the gastric carcinoma than the control group" was supported. (t= -7.754, p=.000) 2) "The experimental group which was offered the video program, should be higher in attitude of the early detection of the gastric carcinoma than the control group" was supported. (t=-4.321, p=.000) Therefore, in conclusion, this study that the audiovisual information with videotape influencing on knowledge and attitude of early detection of gastric carcionma was very representational experience throughout the video of documentary form on the based practical experience was much effected the change of the knowledge and the attitude regarding to the early detection of the gastric carcinoma was verified.

• 사상체질의학회지
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• 제25권4호
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• pp.343-358
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• 2013

Objectives This study aimed to observe the effect of Hyangsayangwi-tang on the cisplatin-induced gastrointestinal dysfunctions in rats. Methods Four groups(each of 8 rats per group) were used in this study. Saline and distilled water treated control rats are Intact vehicle control group. Delayed gatrointestinal mortility was induced by intraperitoneal treatment of cisplatin 2mg/kg, once a week for 5 weeks(Cisplatin control group). Hyangsayangwi-tang aqueous extracts(HY) were orally administered in a volume of 5ml/kg, once a day for 14 days from 4th ciplatin treatmernt(HY group). Ondansetron 1mg/kg was subcutaneously treated, in a volume of 1ml/kg, as same as HY(ondansetron group). We measured the body weights, intestinal charcoal transit ratio, fecal parameters, fundus MDA, GSH contents and SOD, CAT activities, TPH and MAO activities, pyloric gastrin and serotonin contents with their immunoraective cells, colonic serotonin-immunoreactive cells, the histopathology of pylorus, fundus mucosa and colon. Results and Conclusions (1) The body weight gains, the small intestinal charcoal transfer rates, the fecal parameters(numbers, weights and water contents) were increased in HY, ondansetron group. (2) The inhibit of fundus antioxidant defense systems by cisplatin were decreased in HY, ondansetron group. (3) The pyloric TPH activities were increased and the pyloric MAO activities were decreased in HY group. (4) The pyloric gastric contents and the gastrin-immunoreactive cells were increased in HY group. And the pyloric serotonin contents and the pyloric and colonic serotonin-immunoreactive cells were decreased in HY group. (5) The pyloru atrophic changes and the gastric surface erosive damage regions by cisplatin were favorably inhibited by treatment of HY. HY, a representative Soeumin prescription improve GI dysfunctions and constipation retarded by cisplatin through modulations of GI enterochromaffin cells, serotonin and gastrin-producing cells and antioxidative systems. Especially HY showed the highest favorable effects more than those of ondansetron.