• 제목/요약/키워드: nanti-inflammatory effects

검색결과 1건 처리시간 0.015초

마우스 대식세포(RAW 264.7 cell)에 대한 소함흉탕(小陷胸湯)의 항염증효과 (Anti-inflammatory Effect of Sohamhyung-tang in RAW 264.7 Cells)

  • 김재은;윤현정;최달영;박선동
    • 동의생리병리학회지
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    • 제24권1호
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    • pp.61-66
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    • 2010
  • Inflammation is a double-edge sword, functioning as a response against external stimuli, but excessive inflammation can lead to a harmful result. Inflammation is important in the development of vascular diseases, such as atherosclerosis and restenosis. Sohamhyung-tang(SHHT) is one of major herbal prescriptions from "Sanghanron", treating congested heat in thorax. It can be seen as an origin of several prescriptions for Hyungbi(胸痺, thoracic congestion), with its major component Trichosanthes semen. This study was done to determine whether SHHT reduces the production of nitrite, index of NO, and pro-inflammatory cytokines in Lipopolysaccharide(LPS)-induced RAW 264.7 cells. The results show that SHHT inhibited LPS-induced production of NO and PGE2, and iNOS and COX-2 expression, meaning SHHT has a significant anti-inflammatory effect. Based on these results, we suggest that SHTT can be used for prevention and treatment of diseases which starts from chronic inflammatory reactions.