• Clinical and Experimental Pediatrics
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• 제57권11호
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• pp.479-483
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• 2014

Purpose: The efficacy of antibiotic therapy for acute sinusitis is controversial. This study aimed to compare the efficacies of amoxicillin with nasal irrigation and nasal irrigation alone for acute sinusitis in children. Methods: This randomized, double-blind, controlled study included 80 children aged 4-15 years with a clinical presentation of acute sinusitis. Patients were randomly assigned to receive either amoxicillin (80 mg/kg/day) in 3 divided doses orally for 14 days with saline nasal irrigation (for 5 days) and 0.25% phenylephrine (for 2 days) or the same treatment without amoxicillin. Clinical improvements in their initial symptoms were assessed on days 3, 14, 21, and 28. Results: On day 3, patients in the amoxicillin with nasal irrigation group showed significant clinical improvement (P=0.001), but there was no significant difference in the degree of improvement between the amoxicillin with nasal irrigation and nasal irrigation alone groups during follow-up (P>0.05). In addition, no significant differences were seen in age, sex, and degree of improvement between groups (P>0.05). Conclusion: High-dose amoxicillin with saline nasal irrigation relieved acute sinusitis symptoms faster and more often than saline nasal irrigation alone. However, antibiotic treatment for acute sinusitis confers only a small therapeutic benefit over nasal irrigation.

• 동의생리병리학회지
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• 제22권6호
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• pp.1606-1610
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• 2008

Magnoliae Flos, Xanthii Fructus and Menthae Herba have long been used for treatment of nasal disease in Korea. The 70%-ethanol extracts of Magnoliae Flos, Xanthii Fructus and Menthae Herba were used externally in order to investigate the effects on a few strains of microbe, nasal alergy and inflammation, rhinitis and sinusitis. When the proportion of Magnoliae Flos : Xanthii Fructus : Menthae Herba was 2 : 2 : 1, the results showed great significance compared to the control group(non-extracts) in treatment of various nasal disorder.

• 사상체질의학회지
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• 제19권3호
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• pp.283-292
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• 2007

1. Objectives This study evaluates the effect of oriental medical treatment on a chronic sinusitis patient. 2. Methods The patient was teated with acupuncture, nasal cavity irrigation, and Yangdokbackho-tang(陽毒白虎湯). Previous western medical methods were excluded in order to provide therapeutic methods different from pre-existing ones because we needed different, long-term treatment plan from previous treatment. We applied acupuncture 15 times during treatment period and instructed the patient to carry out nasal cavity irrigation at home. 3. Results & Conclusions Combined application of oriental treatment including administration of Yangdokbackho-tang and nasal irrigation showed remarkable clinical effects on symptom, physical examination and radiological finding.

• Archives of Plastic Surgery
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• 제34권6호
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• pp.785-791
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• 2007

Purpose: Paraffin has been used to augment depressed nasal contour for many years by illegally. Reported complications of nasal paraffinoma were skin thinning, displacement of nasal profile, redness, chronic inflammation and malignant change to skin cancer. The current authors report results of the secondary rhinoplasty after excision of nasal paraffinoma. Methods: Through the open rhinoplasty incision, paraffinoma was removed under direct vision. Saline irrigation and meticulous hemostasis were performed. Simultaneously, the secondary depressed nasal deformity was corrected with autogenous dermofat graft harvested from inferior gluteal fold. The dermofat was fixed to the nasofrontal area with bolster suture, and the interdormal area of the tip. Results: A total of 13 patients underwent secondary augmentation with autogenous dermofat graft after removal of paraffinoma from 2000 to 2004. The mean follow-up period was 15 months. There were no postoperative complications. All patients were satisfied with their surgical results. However, there were 10 to 20 percent resorption of the grafted dermofat. Conclusion: It is suggest that autogenous dermofat be one of good materials for the correction of the secondary deformity after removal of nasal paraffinoma. In addition, autogenous dermofat graft presented easy harvesting and manipulation for transfer, high survival rate by firm fixation to the recipient site and stable surgical results.

• Journal of Rhinology
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• 제25권2호
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• pp.103-107
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• 2018

Pregnancy rhinitis is a relatively common condition. It is characterized by the presence of nasal symptoms, especially nasal congestion, not present prior to pregnancy, but typically present during the last 6 or more weeks of pregnancy, without other signs of respiratory tract infection or any known allergic causes, and disappearing completely within 2 weeks after delivery. Nasal saline irrigation, intranasal steroid spray, and oral antihistamines are usually recommended as the first line of treatment for rhinitis. However, most pregnant women refuse medical treatment for pregnancy rhinitis because of the fear of teratogenicity. Severe pregnancy rhinitis increases the risk of snoring, which has been suggested as having adverse effects on the fetus. In cases where the patients are unable to control their symptoms, pregnancy rhinitis can negatively affect the quality of life (QOL) as well as the pregnancy outcome. Therefore, special caution is required for determining the appropriate diagnosis and treatment modalities for pregnancy rhinitis. Here, we report for the first time, the successful treatment of pregnancy rhinitis that was unresponsive to conservative management and medical therapy by using microdebrider-assisted inferior turbinoplasty at the final stages of pregnancy, along with a review of the relevant literature.

• Applied Microscopy
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• 제37권4호
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• pp.219-230
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• 2007

마우스의 코 안으로 5% $ZnSO_4$용액을 점적하는 것이 코중격 후각상피에 미치는 영향과, 그 이후 후각수용세포가 재생되는 과정을 주사전자현미경과 투과전자현미경을 사용하여 형태학적으로 조사하였고, 그 결과는 다음과 같다. 1. 5% $ZnSO_4$용액을 점적한 후 6시간에서 24시간 사이에 코중격 후각상피층은 일부의 기저세포들을 제외하고는 완전하게 탈락되었다. 2. $ZnSO_4$처리 후 3일군에서는 코중격 후각상피세포들 중 부분적으로 남아 있던 기저세포들의 세포분열로 형성된 새로운 후각상피세포들로 후각상피층은 2층으로 나타났다. 또한 새롭게 형성된 후각상피세포들의 상부 세포막에는 미세응모가 돌출되었다. 3. 5% $ZnSO_4$용액을 점적하고 5일이 경과된 코중격 후각수용세포들에서는 다수의 중심소체와 기저소체가 관찰되었고, 상부 세포막에는 미세응모들 사이에 섬모들이 줄지어 나타났다. 또한 새롭게 형성된 코중격 후각수용세포들에서 처음으로 후각소포의 초기 형태가 나타났으며, 1주가 경과된 후각상피층에는 전형적인 형태의 후각소포를 관찰할 수 있었다. 4. 5% $ZnSO_4$용액 점적 후 2주가 경과된 경우, 성숙한 형태의 후각소포를 가지고 있는 후각수용세포가 관찰되었다. 이와 같은 결과는 5% $ZnSO_4$용액의 처리가 마우스 코중격의 후각상피층을 완전하게 박리시킬 수 있으므로 포유류 신경조직의 재생연구를 위해 유용한 실험적 모델임을 뒷받침한다, 또한 새롭게 재생되는 후각수용세포의 상부 세포막이 처음에는 미세응모로 표면적을 넓히고, 시간이 경과함에 따라 일렬로 배열된 섬모들로 대치되며, 그 후 섬모를 포함한 상부세포막이 부분적으로 돌출하고, 마지막으로 전형적인 후각소포로 발달한다.

• Korean Journal of Ophthalmology
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• 제32권6호
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• pp.433-437
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• 2018

Purpose: Various absorbable anti-adhesion agents have been used to prevent postoperative synechia formation after endonasal surgery. The purpose of this study was to evaluate the anti-adhesion effects of HyFence and Mediclore after endonasal dacryocystorhinostomy (DCR) compared to a mixed solution of hyaluronic acid and sodium carboxymethylcellulose (Guardix-Sol). Methods: In this retrospective study, endonasal DCR and silicone tube intubation were performed on 198 eyes of 151 patients. Three different anti-adhesion adjuvants were applied to the osteotomy site in the nasal cavity after standard endonasal DCR procedures. The subjects were classified into three respective groups: group A (71 eyes, Guardix-Sol 1.5 g), group B (89 eyes, HyFence 1.5 mL), and group C (38 eyes, Mediclore 1 cc). The three groups were evaluated by asking patients about subjective symptoms and by performing lacrimal irrigation tests and endoscopic examinations. Results: There were no statistically significant differences in age, sex, timing of tube removal, or follow-up period among the three groups. There were no statistically significant differences in success rates among the three groups (p = 0.990, 91.5% [65 / 71], 92.1% [82 / 89], and 92.1% [35 / 38], respectively). Conclusions: HyFence and Mediclore are safe and effective adjunctive modalities following endonasal DCR compared to Guardix-Sol. Therefore, these agents can be considered good alternatives to Guardix-Sol to increase the success rate of endonasal DCR in treating patients with poor prognosis.