대한약리학회지 (The Korean Journal of Pharmacology)

대한약리학회 (The Korean Society of Pharmacology)
권호 표지

Diphenylhydantoin 및 수종(數種)의 중추신경계(中樞神經系)에 작용(作用)하는 약물(藥物)이 흰쥐 대뇌피질절편(大腦皮質切片)의 산소소비량(酸素消費量) 및 non-inulin space $Na^+$, $K^+$농도(濃度)에 미치는 영향(影響)

The Effects of Diphenylhydantoin and Several other Agents Acting on CNS on the $QO_2$ and Non-inulin Space $Na^+$, $K^+$ Concentration in Cerebral Cortcial Slices of Rat

  • 마천일 (서울대학교 의과대학 약리학교실) ;
  • 임정규 (서울대학교 의과대학 약리학교실) ;
  • 박찬웅 (서울대학교 의과대학 약리학교실)
  • Mahr, Chun-Il (Department of Pharmacology, College of Medicine, Seoul National University) ;
  • Lim, Jung-Kyu (Department of Pharmacology, College of Medicine, Seoul National University) ;
  • Park, Chan-Woong (Department of Pharmacology, College of Medicine, Seoul National University)
  • 발행 : 1969.12.30
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초록

The effects of dephenylhydantoin, strychnine, coramine, d-amphetamine and chlorpromazine on $QO_2$ and non-inulin space $Na^+$, $K^+$ concentration of rat cerebral cortical slices incubated in pH 7.4 glycylglycine glucose saline was investigated. In general, there are decreased non-inulin space $Na^+$ concentration or increased non-inulin space $K^+$ concentration or both when the ratio of respiration to non-inulin space is greater than control group except in case of chlorpromazine $10^{-4}\;M$. And it is suggested that the ratio of respiration to non-inulin space is responsible more closely for the non-inulin space Na, K concentration than $QO_2$ expressed per tissue wet weight. Effects of diphenylhydantoin and several other agents on electrolytes and the electroshock seizure threshold are discussed.

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