The Korean Journal of Physiology and Pharmacology
- 제1권5호
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- Pages.477-484
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- 1997
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- 1226-4512(pISSN)
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- 2093-3827(eISSN)
Blockade of Intrinsic Oscillatory Activity of Cerebellar Purkinje Cells by Apamin and Nickel
- Seo, Wha-Sook (Department of Nursing, College of Medicine Inha University) ;
- Strahlendorf, Jean-C. (Departments of Physiology, Texas Tech University Health Sciences Center) ;
- Strahlendorf, Howard-K. (Departments of Pharmacology, Texas Tech University Health Sciences Center)
- 발행 : 1997.10.21
초록
Intracellular recordings of oscillatory firing (bursting activity) were obtained from Purkinje cells (PCs) in rat cerebellar slices. Apamin inhibited post-burst hyperpolarizations (PBHs) progressively and finally terminated oscillatory firing activity of PCs. Apamin did not affect the amplitude or duration of the after-hyperpolarization (AHP) between spikes within the burst. In the voltage clamp mode, apamin shifted the whole-cell, quasi-steady state I/V relationship in an inward direction and abolished the zero slope resistance (ZSR) region by blocking outward current. Nickel (
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