The Korean Journal of Physiology and Pharmacology
- Volume 5 Issue 2
- /
- Pages.133-138
- /
- 2001
- /
- 1226-4512(pISSN)
- /
- 2093-3827(eISSN)
Effects of Pretreatment of Serotonin Synthesis Inhibitor p-chlorophenylalanine on Lipopolysaccharide-induced Anorexia in Rats
- Park, So-Young (Department of Physiology, Yeungnam University College of Medicine) ;
- Kim, Byung-Suck (Department of Physiology, Yeungnam University College of Medicine) ;
- Back, Seoung-Sook (Department of Physiology, Yeungnam University College of Medicine)
- Published : 2001.04.21
Abstract
In the present study, we investigated the effect of pretreatment of p-chlorophenylalanine (PCPA), inhibitor of serotonin synthesis, on lipopolysaccharide (LPS)-induced anorexia in rats. First of all, effects of PCPA injection on food intake and body weight in rats were investigated. During 4 days of PCPA injection (300 mg/kg BW once a day), food intake was decreased by 33% and daily gain in body weight was inhibited compared with controls. Twenty-four hours after last PCPA injection, food intake and gain in body weight returned toward almost normal. Pair-feeding to PCPA (PCPAP) injection revealed that body weight of rats in PCPA group was not different from rats in PCPAP groups. To quantify the effects of LPS on food intake and body weight, we administered varying doses